JP2005534330A - アルブミン融合繊毛様神経栄養因子 - Google Patents

アルブミン融合繊毛様神経栄養因子 Download PDF

Info

Publication number
JP2005534330A
JP2005534330A JP2004526896A JP2004526896A JP2005534330A JP 2005534330 A JP2005534330 A JP 2005534330A JP 2004526896 A JP2004526896 A JP 2004526896A JP 2004526896 A JP2004526896 A JP 2004526896A JP 2005534330 A JP2005534330 A JP 2005534330A
Authority
JP
Japan
Prior art keywords
protein
albumin
biologically active
active peptide
cntf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004526896A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005534330A5 (https=
Inventor
マティアス、ユルス
トマス、バイメル
ハンス‐ペーター、ハウザー
ダレル、スリープ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albumedix Ltd
Original Assignee
Delta Biotechnology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delta Biotechnology Ltd filed Critical Delta Biotechnology Ltd
Publication of JP2005534330A publication Critical patent/JP2005534330A/ja
Publication of JP2005534330A5 publication Critical patent/JP2005534330A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76Albumins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/31Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2004526896A 2002-08-07 2003-08-06 アルブミン融合繊毛様神経栄養因子 Pending JP2005534330A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40183302P 2002-08-07 2002-08-07
PCT/EP2003/008710 WO2004015113A2 (en) 2002-08-07 2003-08-06 Albumin-fused ciliary neurotrophic factor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010089560A Division JP2010213707A (ja) 2002-08-07 2010-04-08 アルブミン融合繊毛様神経栄養因子

Publications (2)

Publication Number Publication Date
JP2005534330A true JP2005534330A (ja) 2005-11-17
JP2005534330A5 JP2005534330A5 (https=) 2006-08-24

Family

ID=31715745

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2004526896A Pending JP2005534330A (ja) 2002-08-07 2003-08-06 アルブミン融合繊毛様神経栄養因子
JP2010089560A Withdrawn JP2010213707A (ja) 2002-08-07 2010-04-08 アルブミン融合繊毛様神経栄養因子

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010089560A Withdrawn JP2010213707A (ja) 2002-08-07 2010-04-08 アルブミン融合繊毛様神経栄養因子

Country Status (6)

Country Link
EP (1) EP1529108A2 (https=)
JP (2) JP2005534330A (https=)
KR (1) KR20050065519A (https=)
AU (1) AU2003271043A1 (https=)
CA (1) CA2496002A1 (https=)
WO (1) WO2004015113A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0329681D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
GB0329722D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
DK2330200T3 (en) 2004-12-23 2017-07-24 Albumedix As GENE EXPRESSION TECHNIQUE
CN102462662A (zh) * 2010-08-16 2012-05-23 重庆富进生物医药有限公司 脂质体包裹重组人睫状神经营养因子

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000502901A (ja) * 1995-12-30 2000-03-14 デルタ、バイオテクノロジー、リミテッド 成長ホルモンおよび血清アルブミンに対する組換え融合タンパク質

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2719593B1 (fr) * 1994-05-06 1996-05-31 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur préparation et composition pharmaceutique les contenant.
EP2206720A1 (en) * 2000-04-12 2010-07-14 Human Genome Sciences, Inc. Albumin fusion proteins
US6927040B2 (en) * 2000-06-30 2005-08-09 Zymogenetics, Inc. Interferon-like protein Zcyto21

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000502901A (ja) * 1995-12-30 2000-03-14 デルタ、バイオテクノロジー、リミテッド 成長ホルモンおよび血清アルブミンに対する組換え融合タンパク質

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
EUR. J. BIOCHEM., vol. 231, JPN6009021147, 1995, pages 563 - 569, ISSN: 0001313675 *
INT. J. OBES., vol. 24, no. 1, JPN6009021142, 2000, pages 102 - 328, ISSN: 0001313677 *
INT. J. OBES., vol. 25, no. 2, JPN6009021149, 2001, pages 111 - 291, ISSN: 0001313674 *
PROC. NATL. ACAD. SCI. USA., vol. 89, JPN6009021145, 1992, pages 1904 - 1908, ISSN: 0001313676 *
PROC. NATL. ACAD. SCI. USA., vol. 98, no. 8, JPN6009021143, 2001, pages 4652 - 4657, ISSN: 0001313678 *

Also Published As

Publication number Publication date
KR20050065519A (ko) 2005-06-29
JP2010213707A (ja) 2010-09-30
WO2004015113A2 (en) 2004-02-19
WO2004015113A3 (en) 2004-05-06
CA2496002A1 (en) 2004-02-19
EP1529108A2 (en) 2005-05-11
AU2003271043A1 (en) 2004-02-25

Similar Documents

Publication Publication Date Title
JP6059802B2 (ja) 長時間作用型glp−1ペプチドの使用
ES2643641T3 (es) Polipéptidos de hormona del crecimiento y métodos de producción y uso de los mismos
CN102197049B (zh) 胰岛淀粉样多肽衍生物
CN103649115B (zh) 多肽
US20080293638A1 (en) Albumin-fused ciliary neurotrophic factor
KR20150124955A (ko) 사람 성장 호르몬 유사체를 사용한 소아 성장 호르몬 결핍증의 치료 방법
AU2003200839A1 (en) Extended glucagon-like peptide-1 analogs
JP2016519130A (ja) 治療ペプチド
JP2010528092A (ja) 代謝疾患の治療における治療剤としての非アシル化グレリン
CN116322739A (zh) Glp-1r激动剂/fgf21融合蛋白
KR102696075B1 (ko) 고혈당증의 치료 및 예방을 위한 펩타이드
US20190276510A1 (en) Use of fibroblast growth factor 1 (fgf1)-vagus nerve targeting chimeric proteins to treat hyperglycemia
US10689430B2 (en) Insulin receptor partial agonists
JP2010213707A (ja) アルブミン融合繊毛様神経栄養因子
JP6948331B2 (ja) Gdf11での処置は、体重増加を防止し、耐糖能を改善し、そして脂肪肝を低減する
JP6031121B2 (ja) 非アシル化グレリンを使用したグレリンレベル及びグレリン/非アシル化グレリン比の調節
US20070218504A1 (en) Human leptin-derived polypeptides and uses thereof
KR20150110677A (ko) N 말단 절단된 인슐린 유사체
TW201441253A (zh) 具有n端電荷修飾之促胰島素肽衍生物
CN116113639A (zh) 活性降低的glp-1r激动肽
CN114144426A (zh) 餐时或基础胰岛素类似物通过内部二硒桥的稳定化
US9314506B2 (en) Methods for increasing insulin secretion by co-stimulation of corticotropin-releasing factor receptors
WO2025087301A1 (en) Circular rna encoding glp-1 and the use thereof
EP3720467B1 (en) Methods for treatment of neuropathic pain
JP2017532292A (ja) ミリストイル化レプチン関連ペプチド及びその使用

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060703

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060703

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090508

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090806

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090813

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091109

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20091208

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20100524

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20100723