JP2005533799A - 新規なるキヌクリジンカルバミン酸誘導体およびそれを含む医薬組成物 - Google Patents

新規なるキヌクリジンカルバミン酸誘導体およびそれを含む医薬組成物 Download PDF

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Publication number
JP2005533799A
JP2005533799A JP2004514785A JP2004514785A JP2005533799A JP 2005533799 A JP2005533799 A JP 2005533799A JP 2004514785 A JP2004514785 A JP 2004514785A JP 2004514785 A JP2004514785 A JP 2004514785A JP 2005533799 A JP2005533799 A JP 2005533799A
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JP
Japan
Prior art keywords
ylmethyl
azoniabicyclo
octane
optionally substituted
group
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Pending
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JP2004514785A
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English (en)
Japanese (ja)
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JP2005533799A5 (https=
Inventor
マリア・プラト・キノネス
マリア・アントニア・ブイル・アルベロ
マリア・ドロルス・フェルナンデス・フォルネル
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Almirall AG
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Almirall Prodesfarma AG
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Publication of JP2005533799A publication Critical patent/JP2005533799A/ja
Publication of JP2005533799A5 publication Critical patent/JP2005533799A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2004514785A 2002-06-21 2003-06-18 新規なるキヌクリジンカルバミン酸誘導体およびそれを含む医薬組成物 Pending JP2005533799A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200201439A ES2203327B1 (es) 2002-06-21 2002-06-21 Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.
PCT/EP2003/006472 WO2004000840A2 (en) 2002-06-21 2003-06-18 Quinuclidine derivatives and pharmaceutical compositions containing the same

Publications (2)

Publication Number Publication Date
JP2005533799A true JP2005533799A (ja) 2005-11-10
JP2005533799A5 JP2005533799A5 (https=) 2006-07-06

Family

ID=29797397

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004514785A Pending JP2005533799A (ja) 2002-06-21 2003-06-18 新規なるキヌクリジンカルバミン酸誘導体およびそれを含む医薬組成物

Country Status (21)

Country Link
US (3) US7435742B2 (https=)
EP (1) EP1515968A2 (https=)
JP (1) JP2005533799A (https=)
CN (1) CN100363363C (https=)
AR (1) AR040275A1 (https=)
AU (1) AU2003279384A1 (https=)
BR (1) BR0312169A (https=)
CA (1) CA2490082A1 (https=)
EC (1) ECSP045484A (https=)
ES (1) ES2203327B1 (https=)
IL (1) IL165775A0 (https=)
MX (1) MXPA04012272A (https=)
NO (1) NO20050217L (https=)
NZ (1) NZ537252A (https=)
PE (1) PE20040579A1 (https=)
RU (1) RU2321588C2 (https=)
TW (1) TW200401776A (https=)
UA (1) UA85541C2 (https=)
UY (1) UY27850A1 (https=)
WO (1) WO2004000840A2 (https=)
ZA (1) ZA200410211B (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009544659A (ja) * 2006-07-26 2009-12-17 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ Ｍ３アンタゴニストとしてのキヌクリジン誘導体
JP2010519299A (ja) * 2007-02-23 2010-06-03 セラヴァンス， インコーポレーテッド ムスカリン受容体アンタゴニストとして有用な第四級アンモニウムジフェニルメチル化合物
JP2011504890A (ja) * 2007-11-28 2011-02-17 ラボラトリオス・サルバト・ソシエダッド・アノニマ （ｒ）−３−フルオロフェニル−３，４，５−トリフルオロベンジルカルバミン酸１−アザビシクロ［２．２．２］オクト−３−イルエステルの安定な結晶性塩
JP5293192B2 (ja) * 2007-02-09 2013-09-18 アステラス製薬株式会社 アザ架橋環化合物
JP2014517808A (ja) * 2011-03-18 2014-07-24 ジェンザイム・コーポレーション グルコシルセラミド合成酵素阻害剤
JPWO2022145408A1 (https=) * 2020-12-28 2022-07-07

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4445704B2 (ja) 2000-12-22 2010-04-07 アルミラル・ソシエダッド・アノニマ キヌクリジンカルバメート誘導体およびｍ３アンダゴニストとしてのそれらの使用
ES2203327B1 (es) 2002-06-21 2005-06-16 Almirall Prodesfarma, S.A. Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.
ES2204295B1 (es) 2002-07-02 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de quinuclidina-amida.
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
AU2005235419B2 (en) * 2004-04-22 2010-11-04 Boehringer Ingelheim International Gmbh Pharmaceutical combinations containing benzoxazine for treating respiratory diseases
JP2008505118A (ja) * 2004-06-30 2008-02-21 グラクソ　グループ　リミテッド ムスカリン性アセチルコリン受容体アンタゴニスト
ES2246170B1 (es) * 2004-07-29 2007-04-01 Almirall Prodesfarma, S.A. Nuevo procedimiento para preparar derivados de carbamato de quinuclidinio.
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
CN101208316B (zh) 2005-08-15 2012-05-09 贝林格尔·英格海姆国际有限公司 制备β-模拟物的方法
DE102006028286A1 (de) * 2006-06-20 2007-12-27 Wirsich, Konrad, Dipl.-Ing. (FH) Drehmoment- und rutschfest verbundene aus zwei Teilen bestehende Schaltzahnräder
EP2080507A1 (en) * 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Pharmaceutical formulations comprising an anticholinergic drug
US8742131B2 (en) * 2010-01-28 2014-06-03 Theron Pharmaceuticals, Inc. 7-azoniabicyclo [2.2.1] heptane derivatives, methods of production, and pharmaceutical uses thereof
EP2631674A1 (de) * 2012-02-23 2013-08-28 ELMOS Semiconductor AG Verfahren und Sensorsystem zur Vermessung der Eigenschaften einer Übertragungsstrecke eines Messsystems zwischen Sender und Empfänger
MA37975B2 (fr) 2012-09-11 2021-03-31 Genzyme Corp Inhibiteurs de synthase de glucosylcéramide
EP3023424B1 (en) * 2013-07-13 2019-02-27 Beijing Shuobai Pharmaceutical Co., Ltd. Quinine compounds, and optical isomers, preparation method and medical use thereof
US10570127B1 (en) 2018-11-05 2020-02-25 Renexxion, Llc Material and methods for the treatment of gastro-intestinal disorders
CN114040762A (zh) 2019-02-04 2022-02-11 建新公司 使用葡糖神经酰胺合酶(gcs)的抑制剂治疗纤毛疾病
TW202142236A (zh) 2020-02-03 2021-11-16 美商健臻公司 用於治療與溶體儲積症相關的神經症狀之方法
US12527775B2 (en) 2020-03-26 2026-01-20 Shionogi & Co., Ltd. Heteroaromatic derivatives having serotonin receptor binding activity
KR20230043024A (ko) 2020-07-24 2023-03-30 젠자임 코포레이션 벤글루스타트를 포함하는 제약 조성물

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04500521A (ja) * 1988-11-01 1992-01-30 ファイザー・インコーポレーテッド ムスカリンレセプター拮抗薬
WO1995006635A1 (en) * 1993-09-02 1995-03-09 Yamanouchi Pharmaceutical Co., Ltd. Carbamate derivative and medicine containing the same
WO1995021820A1 (en) * 1994-02-10 1995-08-17 Yamanouchi Pharmaceutical Co., Ltd. Novel carbamate derivative and medicinal composition containing the same
WO1998005641A1 (en) * 1996-08-01 1998-02-12 Banyu Pharmaceutical Co., Ltd. Fluorinated 1,4-disubstituted piperidine derivatives
WO2001004118A2 (en) * 1999-07-14 2001-01-18 Almirall Prodesfarma S.A. Quinuclidine derivatives and their use as muscarinic m3 receptor ligands
WO2002000652A1 (es) * 2000-06-27 2002-01-03 Laboratorios S.A.L.V.A.T., S.A. Carbamatos derivados de arilalquilaminas
JP2004530641A (ja) * 2000-12-22 2004-10-07 アルミラル・プロデスフアルマ・アクチエンゲゼルシヤフト キヌクリジンカルバメート誘導体およびｍ３アンダゴニストとしてのそれらの使用
JP2005516954A (ja) * 2001-12-20 2005-06-09 ラボラトリオス・エセ・ア・エレ・ベ・ア・テ・ソシエダッド・アノニマ １−アルキル−１−アゾニアビシクロ［２．２．２］オクタンカルバメート誘導体およびムスカリンレセプターアンタゴニストとしてのそれらの使用

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GB1246606A (en) 1969-04-28 1971-09-15 Starogardzkie Zakl Farma Dibenzo-azepine derivatives
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GB9202443D0 (en) 1992-02-05 1992-03-18 Fujisawa Pharmaceutical Co A novel substituted-acetamide compound and a process for the preparation thereof
NO2005012I1 (no) * 1994-12-28 2005-06-06 Debio Rech Pharma Sa Triptorelin og farmasoytisk akseptable salter derav
ATE205490T1 (de) 1995-10-13 2001-09-15 Banyu Pharma Co Ltd Substituierte heteroaromatische derivate
AUPN862996A0 (en) 1996-03-13 1996-04-04 Fujisawa Pharmaceutical Co., Ltd. A novel substituted-acetamide compound
IL156558A0 (en) 2000-12-28 2004-01-04 Almirall Prodesfarma Ag Novel quinuclidine derivatives and medicinal compositions containing the same
ES2203327B1 (es) 2002-06-21 2005-06-16 Almirall Prodesfarma, S.A. Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.
ES2204295B1 (es) 2002-07-02 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de quinuclidina-amida.

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04500521A (ja) * 1988-11-01 1992-01-30 ファイザー・インコーポレーテッド ムスカリンレセプター拮抗薬
WO1995006635A1 (en) * 1993-09-02 1995-03-09 Yamanouchi Pharmaceutical Co., Ltd. Carbamate derivative and medicine containing the same
WO1995021820A1 (en) * 1994-02-10 1995-08-17 Yamanouchi Pharmaceutical Co., Ltd. Novel carbamate derivative and medicinal composition containing the same
WO1998005641A1 (en) * 1996-08-01 1998-02-12 Banyu Pharmaceutical Co., Ltd. Fluorinated 1,4-disubstituted piperidine derivatives
WO2001004118A2 (en) * 1999-07-14 2001-01-18 Almirall Prodesfarma S.A. Quinuclidine derivatives and their use as muscarinic m3 receptor ligands
WO2002000652A1 (es) * 2000-06-27 2002-01-03 Laboratorios S.A.L.V.A.T., S.A. Carbamatos derivados de arilalquilaminas
JP2004530641A (ja) * 2000-12-22 2004-10-07 アルミラル・プロデスフアルマ・アクチエンゲゼルシヤフト キヌクリジンカルバメート誘導体およびｍ３アンダゴニストとしてのそれらの使用
JP2005516954A (ja) * 2001-12-20 2005-06-09 ラボラトリオス・エセ・ア・エレ・ベ・ア・テ・ソシエダッド・アノニマ １−アルキル−１−アゾニアビシクロ［２．２．２］オクタンカルバメート誘導体およびムスカリンレセプターアンタゴニストとしてのそれらの使用

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009544659A (ja) * 2006-07-26 2009-12-17 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ Ｍ３アンタゴニストとしてのキヌクリジン誘導体
JP5293192B2 (ja) * 2007-02-09 2013-09-18 アステラス製薬株式会社 アザ架橋環化合物
JP2010519299A (ja) * 2007-02-23 2010-06-03 セラヴァンス， インコーポレーテッド ムスカリン受容体アンタゴニストとして有用な第四級アンモニウムジフェニルメチル化合物
JP2011504890A (ja) * 2007-11-28 2011-02-17 ラボラトリオス・サルバト・ソシエダッド・アノニマ （ｒ）−３−フルオロフェニル−３，４，５−トリフルオロベンジルカルバミン酸１−アザビシクロ［２．２．２］オクト−３−イルエステルの安定な結晶性塩
JP2014517808A (ja) * 2011-03-18 2014-07-24 ジェンザイム・コーポレーション グルコシルセラミド合成酵素阻害剤
JP2017141255A (ja) * 2011-03-18 2017-08-17 ジェンザイム・コーポレーション グルコシルセラミド合成酵素阻害剤
JPWO2022145408A1 (https=) * 2020-12-28 2022-07-07
WO2022145408A1 (ja) * 2020-12-28 2022-07-07 塩野義製薬株式会社 セロトニン受容体結合活性を有する環状アミン誘導体
JP7741820B2 (ja) 2020-12-28 2025-09-18 塩野義製薬株式会社 セロトニン受容体結合活性を有する環状アミン誘導体

Also Published As

Publication number Publication date
PE20040579A1 (es) 2004-09-08
ZA200410211B (en) 2005-09-06
EP1515968A2 (en) 2005-03-23
ECSP045484A (es) 2005-01-28
AR040275A1 (es) 2005-03-23
MXPA04012272A (es) 2005-04-08
US20060094751A1 (en) 2006-05-04
US20090054480A1 (en) 2009-02-26
UY27850A1 (es) 2003-11-28
CA2490082A1 (en) 2003-12-31
CN100363363C (zh) 2008-01-23
TW200401776A (en) 2004-02-01
AU2003279384A1 (en) 2004-01-06
NZ537252A (en) 2006-07-28
WO2004000840A3 (en) 2004-02-19
UA85541C2 (ru) 2009-02-10
WO2004000840A2 (en) 2003-12-31
IL165775A0 (en) 2006-01-15
BR0312169A (pt) 2005-03-29
US7435742B2 (en) 2008-10-14
CN1675206A (zh) 2005-09-28
NO20050217L (no) 2005-03-18
US20090005412A1 (en) 2009-01-01
RU2005101409A (ru) 2005-11-20
RU2321588C2 (ru) 2008-04-10
ES2203327A1 (es) 2004-04-01
ES2203327B1 (es) 2005-06-16

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