JP2005532841A - 血管注入のための組織モニタリング装置 - Google Patents
血管注入のための組織モニタリング装置 Download PDFInfo
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Abstract
Description
注入システムによって、血管外遊走や組織懐死、浸潤、静脈炎そして血管の炎症などの注入合併症をモニタリングすることが可能である。
Δψ=Α・Δσ …(1)
模型となる臓器や組織形状への検出感度の認識そして電極の配列は、Αが特異値分解によって割り出されたマトリックスAの擬似反比例である方程式(1)による伝導性の偏差を決定する。
Δσ=А・Δψ …(2)
検出感度マトリックスAは、文献や実験から得られた伝導性値を使ったシミュレート測定によって割り出される。いくつかの応用において、伝導性値は徐々に変化し、マトリックスの列の値を割り出すための異なった伝導性値によって表面ポテンシャル分布が割り出されうる。代わりの例としては、図12から17に関して以下に論じられているより効率的な有限要素解析を使って検出感度がそのまま計算されうる。
∇・[δ’(P)・∇U’(P)]=0 at object B ……(3)
δ’(P)(∂U’(P)/∂η)=J P∈S ……(4)
∫SU‘(P)ds=0 ……(5)
U(P)が電圧でδ(P)がBの特別許可である場合
δ’(P)=δ(P)+jωε(P) ……(6)
SはBの表面境界である
伝導性分布σが実数で領域の間中陽性であり、vはポテンシャル分布であり、ηは外見上普通であり、Jは適用された溶液であり、Ωは勢力の領域である。そして、∂Ωはドメイン境界を指定するところにおいて境界値問題は定められる。境界値問題は、方程式(7)に示される形の方程式線系システムを生む有限要素法(FEM)を使って解決可能である。
Yν=c ……(7)
Yがグローバル弾性マトリックスである場合、vは成分結節におけるポテンシャル分布を示しており、cは結節点にて適用された有効な電流である。
ΔZ=−∫ΩΔσ(∇u(σ)/Iu)・(∇v(σ+Δσ)/Iv)dΩ …(8)
uが領域にわたるポテンシャル分布の際、電流Iuはσの伝導性とともに電極A,Bへ適用される。似たように、電流Ivがσ+△σの伝導性とともに電極C,Dに適用されたときの範囲にわたるポテンシャルがvである。方程式(8)は、伝導性σの推定と順方向の分析におけるu与えられた電流Iuの計算を可能にすることによって逆問題の解決を助ける。計算したポテンシャル分布uと測定したポテンシャル分布vの間の差異は、数値データ△Zを与える。数値データ△Zを使用すると、伝導性分布△σは解決できる。感度法はとても一般的で、どのような伝導性分布においても感度の測定を直接可能にする。他のより少ない最適度の方法では、均質伝導性エリアにおける感度の計算のみが可能である。
φ=1/2(f−V)T(f−V) …(9)
φの最小化は、方程式(10)に示されるガウス・ニュートン反復法である。
Δσk=−[f’(σk)Tf’(σk)]−1f’(σk)T[f(σk)−V]…(10)
φ反復法はたちが悪く、ノイズ・データによってさらに悪化する。
σn+1=σn+(Jn *Jn+R)−1Jn *(Vmeasured−F(σn)) …(11)
Jnは伝導性σnとともに計算したヤコビアン法である。Vmeasuredは電圧測定のベクトルであり、順方向の解答F(σn)は、伝導性σnの限定要素モデルからの予想される電圧である。マトリックスRは電導性内の急激な変化を不利にする規定化されたマトリックスであり、人工的にスムーズなイメージを生産する代わりに再構成に当たって不安定を修正する。全マトリックス逆問題を解決するには(1718)、順方向の測定から得られた情報が使われる。目下の注入パターンIの一部と測定電圧Vの一部を所与として、逆問題は伝導性分布を計算する。目下の注入パターンIと伝導性分布σ1722を所与として、順方向問題1720は電圧Fを計算する。
110 注入機器
112 導管
114 管
116 カニューレ
118 センサーカバー(組織接触部分)
120 センサー
122 フィルム防壁カバー
124 制御ユニット
126 センサー信号経路
132 注入制御機
134 注入ポンプ
Claims (10)
- 1つ又はそれ以上のセンサー素子(120)と、患者の肌と連結することが可能な付着性層(314)とを結合させる柔軟な膜を含むフィルム防壁カバー(118)、及び前記フィルム防壁カバー内の1つ又はそれ以上のセンサー素子を連結することが可能な制御ユニット(124)を備えており、
前記センサー素子を制御することが可能な制御ユニットは、3次元空間での組織状態を示す1つ又はそれ以上のパラメーターを検出し、組織状態を判断すべく、検出された1つ又はそれ以上のパラメーターに対して3次元パターン認識処理を行うことを特徴とする組織モニタリング装置。 - フィルム防壁カバーの下にある患者の組織の視覚的検査を可能にすべく、前記柔軟な膜は少なくとも部分的に透明であることを特徴とする請求項1に記載の組織モニタリング装置。
- 前記フィルム防壁カバーは感染から保護する通気性防壁フィルムであり、静脈内カテーテルを保護することが可能な構造部材として機能することを特徴とする請求項1に記載の組織モニタリング装置。
- (1)組織状態を判断すべく、前記制御ユニットがインピーダンス信号に対して1つ又はそれ以上の次元でパターン認識処理を行うことが可能な生体インピーダンスセンサー、
(2)組織状態を判断すべく、前記制御ユニットが前記インピーダンス信号及び光学信号に対して1つ又はそれ以上の次元でパターン認識処理を行うことが可能な生体インピーダンスセンサー及び光学センサー、
(3)3次元空間でインピーダンス信号を収集するように構成されたセンサー素子を複数含む生体インピーダンスセンサー、及び前記インピーダンス信号に対して3次元トモグラフィ処理を行うことが可能である前記制御ユニット内で実行可能なトモグラフィ・プロセッサ、
(4)3次元空間でインピーダンス信号を収集するように構成されたセンサー素子を複数含む生体インピーダンスセンサー、及び前記インピーダンス信号に対して対象認識処理を行うことが可能である前記制御ユニット内で実行可能なトモグラフィ・プロセッサ、
(5)3次元空間でインピーダンス信号を収集するように構成されたセンサー素子を複数含む生体インピーダンスセンサー、及び前記インピーダンス信号の空間でのマッピングを行うことが可能である前記制御ユニット内で実行可能な高速再生技術トモグラフィ・プロセッサ、
(6)3次元空間で光学信号を収集するように構成されたセンサー素子を複数含む光学センサー、赤外線発生器と光学検知器を含んでいるセンサー素子、及び前記光学信号に対して3次元トモグラフィ処理を行うことが可能である前記制御ユニット内で実行可能なトモグラフィ・プロセッサ、
(7)光学信号を収集するように構成されたセンサー素子を複数含む光学センサー、及び前記光学信号の空間でのマッピングを行うことが可能である前記制御ユニット内で実行可能でありトモグラフィ・プロセッサ、
(8)電解質異常を検出すべく、電解質レベルの分析化学測定を行うことが可能な生体センサー、
(9)過去の情報やリアルタイムで得られる現在の情報を含むセンサー情報を保存することが可能な記憶装置、及び現在のデータ、参照データ、基準データ、情報傾向、前もって設定されたパラメーター、自動比較の結果、病状調整のための患者の状態情報、環境情報、カニューレの位置と動作の情報、そして注入液の流れの情報を含む群における1つ又はそれ以上のカテゴリーの情報を比較することが可能な分析プロセッサ、及び
(10)幾何学構成における同間隔の電極を含んでいるセンサー電極配列、及び経時的に監視すべく分光合成を生成する複数の参照ポイントからのデータを分析する前記制御ユニット内で実行可能な多周波数分析プロセッサ
から成る群から選択されるセンサーをさらに備えることを特徴とする請求項1に記載の組織モニタリング装置。 - (1)血管注入操作における1つ又はそれ以上の浸潤、血管外遊走、血液凝固、及び静脈炎、
(2)組織水和、
(3)人工組織又は自然組織の組織移植片における組織懐死または拒絶反応、
(4)創縫合、及び
(5)人工組織又は自然組織の組織移植片における組織懐死または拒絶反応
から成る群から選択される状態を検知するためのセンサー情報の分析処理が、前記制御ユニット内でさらに行われることを特徴とする請求項1に記載の組織モニタリング装置。 - 前記制御ユニット内に、組織測定及び組織特性を遠隔監視すべく、遠隔受信機へ診断情報を送信することが可能な伝達装置をさらに備えることを特徴とする請求項1に記載の組織モニタリング装置。
- 柔軟な薄層カバー(118)、
前記柔軟な薄層カバーと結合する1つ又はそれ以上のセンサー素子(120)、
前記柔軟な薄層カバーと連結する柔軟な膜、及び
前記柔軟な薄層カバー及び柔軟な膜と連結する付着性層(314)を備え、
前記付着性層によって患者の肌に取り付けられることを特徴とする装置。 - 前記1つ又はそれ以上のセンサー素子は、
前記柔軟な薄層カバーと一体化されているパターン化された伝導性インク、及び
1つ又はそれ以上のセンサー素子を形成すべく、前記パターン化された伝導性インクと組み合わせて選択的にパターン化された誘電性絶縁体
をさらに備えることを特徴とする請求項7に記載の装置。 - (1)組織状態を判断すべく、制御ユニットが、インピーダンス信号に対して1つ又はそれ以上の次元でパターン認識処理を行うことが可能な生体インピーダンスセンサー、
(2)組織状態を判断すべく、制御ユニットが、前記インピーダンス信号及び光学信号に対して1つ又はそれ以上の次元でパターン認識処理を行うことが可能な生体インピーダンスセンサー及び光学センサー、
(3)3次元空間でインピーダンス信号を収集するように構成されたセンサー素子を複数含む生体インピーダンスセンサー、及び前記インピーダンス信号に対して3次元トモグラフィ処理を行うことが可能である制御ユニット内で実行可能なトモグラフィ・プロセッサ、
(4)3次元空間でインピーダンス信号を収集するように構成されたセンサー素子を複数含む生体インピーダンスセンサー、及び前記インピーダンス信号に対して対象認識処理を行うことが可能である前記制御ユニット内で実行可能なトモグラフィ・プロセッサ、
(5)3次元空間でインピーダンス信号を収集するように構成されたセンサー素子を複数含む生体インピーダンスセンサー、及び前記インピーダンス信号の空間でのマッピングを行うことが可能である制御ユニット内で実行可能な高速再生技術トモグラフィ・プロセッサ、
(6)3次元空間で光学信号を収集するように構成されたセンサー素子を複数含む光学センサー、赤外線発生器と光学検知器を含んでいるセンサー素子、及び前記光学信号に対して3次元トモグラフィ処理を行うことが可能である制御ユニット内で実行可能なトモグラフィ・プロセッサ、
(7)光学信号を収集するように構成されたセンサー素子を複数含む光学センサー、及び前記光学信号の空間でのマッピングを行うことが可能である制御ユニット内で実行可能でありトモグラフィ・プロセッサ、
(8)電解質異常を検出すべく、電解質レベルの分析化学測定を行うことが可能な生体センサー、
(9)過去の情報やリアルタイムで得られる現在の情報を含むセンサー情報を保存することが可能な記憶装置、及び現在のデータ、参照データ、基準データ、情報傾向、前もって設定されたパラメーター、自動比較の結果、病状調整のための患者の状態情報、環境情報、カニューレの位置と動作の情報、そして注入液の流れの情報を含む群における1つ又はそれ以上のカテゴリーの情報を比較することが可能な分析プロセッサ、
(10)幾何学構成における同間隔の電極を含んでいるセンサー電極配列、及び経時的に監視すべく分光合成を生成する複数の参照ポイントからのデータを分析する制御ユニット内で実行可能な多周波数分析プロセッサ、
(11)シリコンベースの光学インターフェロメーターを使用して検体の結合プロセスを検出することが可能な電流バイオセンサー、及び
(12)炭素や酵素試薬用のプラチニウム触媒を含むイオン選択性インク浸透性インクを使用して、検体の電解質結合プロセスを検知することが可能なイオン選択性バイオセンサー
から成る群から選択されるセンサーをさらに備えることを特徴とする請求項7に記載の装置。 - 内部空間を有する柔軟なフレーム(122)、
前記柔軟なフレームと連結し、前記内部空間に広がり、前記柔軟なフレームの内部空間を通して見ることができるように、少なくとも部分的に透明である柔軟な保護フィルム(332)、
前記柔軟なフレーム及び柔軟な保護フィルムの1つ又はそれ以上の位置と一体化されている1つ又はそれ以上のセンサー素子(120)
を備えることを特徴とするフィルム防壁カバー。
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US35109402P | 2002-01-25 | 2002-01-25 | |
US10/227,150 US7184820B2 (en) | 2002-01-25 | 2002-08-23 | Tissue monitoring system for intravascular infusion |
PCT/US2003/001790 WO2003063680A2 (en) | 2002-01-25 | 2003-01-21 | Tissue monitoring system for intravascular infusion |
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JP4565839B2 JP4565839B2 (ja) | 2010-10-20 |
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JP (1) | JP4565839B2 (ja) |
KR (1) | KR20040095210A (ja) |
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WO2003063680A2 (en) | 2003-08-07 |
US7184820B2 (en) | 2007-02-27 |
US20030216663A1 (en) | 2003-11-20 |
US7169107B2 (en) | 2007-01-30 |
CA2474255A1 (en) | 2003-08-07 |
JP4565839B2 (ja) | 2010-10-20 |
AU2003217230B2 (en) | 2008-09-18 |
WO2003063680A3 (en) | 2004-02-26 |
EP1467650A4 (en) | 2008-10-22 |
US20030216630A1 (en) | 2003-11-20 |
EP1467650A2 (en) | 2004-10-20 |
US6980852B2 (en) | 2005-12-27 |
US20030216662A1 (en) | 2003-11-20 |
KR20040095210A (ko) | 2004-11-12 |
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