JP2005531528A5 - - Google Patents
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- Publication number
- JP2005531528A5 JP2005531528A5 JP2003581759A JP2003581759A JP2005531528A5 JP 2005531528 A5 JP2005531528 A5 JP 2005531528A5 JP 2003581759 A JP2003581759 A JP 2003581759A JP 2003581759 A JP2003581759 A JP 2003581759A JP 2005531528 A5 JP2005531528 A5 JP 2005531528A5
- Authority
- JP
- Japan
- Prior art keywords
- tiotropium
- formulation
- pharmaceutical
- preparation according
- ion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 12
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical class O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 239000000825 pharmaceutical preparation Substances 0.000 claims 9
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 7
- 238000009472 formulation Methods 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 229940037001 sodium edetate Drugs 0.000 claims 7
- 229960000686 benzalkonium chloride Drugs 0.000 claims 6
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- 229940110309 tiotropium Drugs 0.000 claims 5
- 239000013543 active substance Substances 0.000 claims 3
- 239000008139 complexing agent Substances 0.000 claims 3
- -1 methanesulfonate ion Chemical class 0.000 claims 3
- MQLXPRBEAHBZTK-SEINRUQRSA-M tiotropium bromide hydrate Chemical group O.[Br-].C[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 MQLXPRBEAHBZTK-SEINRUQRSA-M 0.000 claims 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 150000003839 salts Chemical group 0.000 claims 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
- LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical group C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 229960001484 edetic acid Drugs 0.000 claims 1
- 229960000443 hydrochloric acid Drugs 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 229960000257 tiotropium bromide Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10216036A DE10216036A1 (de) | 2002-04-11 | 2002-04-11 | Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz |
| PCT/EP2003/003438 WO2003084519A2 (de) | 2002-04-11 | 2003-04-02 | Aerosolformulierung für die inhalation enthaltend ein tiotropiumsalz |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005531528A JP2005531528A (ja) | 2005-10-20 |
| JP2005531528A5 true JP2005531528A5 (enExample) | 2006-05-25 |
Family
ID=28458728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003581759A Pending JP2005531528A (ja) | 2002-04-11 | 2003-04-02 | チオトロピウム塩を含有する吸入用エアロゾル製剤 |
Country Status (32)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102070630B (zh) | 2003-11-03 | 2013-04-17 | 贝林格尔.英格海姆国际有限公司 | 结晶噻托碘铵、包含该结晶噻托碘铵的药物制剂及其用途 |
| WO2007017438A1 (en) * | 2005-08-06 | 2007-02-15 | Boehringer Ingelheim International Gmbh | Use of tiotropium salts in the treatment of severe persistant asthma |
| US20070088030A1 (en) | 2005-10-10 | 2007-04-19 | Barbara Niklaus-Humke | Aerosol formulations for the inhalation of beta-agonists |
| EP1905440A1 (de) * | 2006-09-06 | 2008-04-02 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verwendung einer pharmazeutischen Zusammensetzung enthaltend ein Anticholinergikum zur Abtötung von Mikroorganismen und zur Behandlung von Atemwegsinfektionen |
| EP2044967A1 (de) * | 2007-10-01 | 2009-04-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Zerstäuber |
| JP6335798B2 (ja) | 2012-02-28 | 2018-05-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規噴射剤含有チオトロピウム製剤 |
| RU2493827C1 (ru) * | 2012-10-03 | 2013-09-27 | Шолекс Девелопмент Гмбх | Стабильный комбинированный раствор фенотерола гидробромида и ипратропия бромида |
| WO2015065223A1 (ru) * | 2013-10-28 | 2015-05-07 | Шолекс Девелопмент Гмбх | Стабильный раствор фенотерола гидробромида |
| WO2015065219A1 (ru) * | 2013-10-28 | 2015-05-07 | Шолекс Девелопмент Гмбх | Раствор ипратропия бромида |
| GB201507686D0 (en) * | 2015-05-05 | 2015-06-17 | Norton Healthcare Ltd | A stable tiotropium nebuliser solution |
| AU2017363041A1 (en) * | 2016-11-16 | 2019-04-11 | Glenmark Specialty S.A. | Nebulized tiotropium |
| US20210290568A1 (en) * | 2020-03-19 | 2021-09-23 | Cai Gu Huang | Inhalable formulation of a solution containing levalbuterol tartrate |
| CN114259481A (zh) * | 2021-11-26 | 2022-04-01 | 南京华盖制药有限公司 | 一种奥达特罗复方吸入溶液 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3931041C2 (de) | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| SG45171A1 (en) | 1990-03-21 | 1998-01-16 | Boehringer Ingelheim Int | Atomising devices and methods |
| IL107120A (en) | 1992-09-29 | 1997-09-30 | Boehringer Ingelheim Int | Atomising nozzle and filter and spray generating device |
| DE19536903C2 (de) | 1995-10-04 | 1998-09-10 | Boehringer Ingelheim Int | Vorrichtung zum Haltern eines fluidischen Bauteils |
| DE19536902A1 (de) | 1995-10-04 | 1997-04-10 | Boehringer Ingelheim Int | Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung |
| DE19545226C1 (de) | 1995-12-05 | 1997-06-19 | Boehringer Ingelheim Int | Sperrspannwerk für einen federbetätigten Abtrieb |
| DE19653969A1 (de) * | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole |
| DE19742439C1 (de) | 1997-09-26 | 1998-10-22 | Boehringer Ingelheim Int | Mikrostrukturiertes Filter |
| DE19847968A1 (de) * | 1998-10-17 | 2000-04-20 | Boehringer Ingelheim Pharma | Verschlußkappe und Behälter als Zweikammer-Kartusche für Vernebler zur Erzeugung von Aerosolen |
| UA78690C2 (uk) * | 2000-10-31 | 2007-04-25 | Boehringer Ingelheim Pharma | Лікарська композиція для інгаляційного застосування у вигляді розчину із сіллю тіотропію |
-
2002
- 2002-04-11 DE DE10216036A patent/DE10216036A1/de not_active Withdrawn
-
2003
- 2003-02-04 UA UA20041109194A patent/UA78994C2/uk unknown
- 2003-04-02 KR KR1020047016052A patent/KR100997219B1/ko not_active Expired - Lifetime
- 2003-04-02 WO PCT/EP2003/003438 patent/WO2003084519A2/de not_active Ceased
- 2003-04-02 CA CA2473815A patent/CA2473815C/en not_active Expired - Fee Related
- 2003-04-02 EP EP03718724A patent/EP1496876B1/de not_active Expired - Lifetime
- 2003-04-02 DK DK03718724T patent/DK1496876T3/da active
- 2003-04-02 RS YUP-879/04A patent/RS50923B/sr unknown
- 2003-04-02 EP EP08152138A patent/EP1949892A1/de not_active Withdrawn
- 2003-04-02 ES ES03718724T patent/ES2303897T3/es not_active Expired - Lifetime
- 2003-04-02 ME MEP-2008-543A patent/ME00359B/me unknown
- 2003-04-02 AU AU2003222791A patent/AU2003222791B2/en not_active Expired
- 2003-04-02 BR BR0309080-9A patent/BR0309080A/pt not_active Application Discontinuation
- 2003-04-02 EA EA200401305A patent/EA007228B1/ru not_active IP Right Cessation
- 2003-04-02 MX MXPA04009818A patent/MXPA04009818A/es active IP Right Grant
- 2003-04-02 CN CNB038082330A patent/CN1309378C/zh not_active Ceased
- 2003-04-02 PL PL03371204A patent/PL371204A1/xx not_active Application Discontinuation
- 2003-04-02 SI SI200331206T patent/SI1496876T1/sl unknown
- 2003-04-02 PT PT03718724T patent/PT1496876E/pt unknown
- 2003-04-02 DE DE50309414T patent/DE50309414D1/de not_active Expired - Lifetime
- 2003-04-02 JP JP2003581759A patent/JP2005531528A/ja active Pending
- 2003-04-02 HR HRP20040932AA patent/HRP20040932B1/hr not_active IP Right Cessation
- 2003-04-02 AT AT03718724T patent/ATE389391T1/de active
- 2003-04-09 PE PE2003000359A patent/PE20030970A1/es not_active Application Discontinuation
- 2003-04-09 MY MYPI20031314A patent/MY137249A/en unknown
- 2003-04-09 UY UY27754A patent/UY27754A1/es not_active Application Discontinuation
- 2003-04-10 TW TW092108240A patent/TWI344851B/zh not_active IP Right Cessation
- 2003-04-11 AR ARP030101267A patent/AR039286A1/es not_active Application Discontinuation
- 2003-07-07 SA SA03240192A patent/SA03240192B1/ar unknown
-
2004
- 2004-07-19 ZA ZA200405721A patent/ZA200405721B/en unknown
- 2004-09-23 NO NO20044001A patent/NO334915B1/no not_active IP Right Cessation
- 2004-10-08 CO CO04100971A patent/CO5611150A2/es active IP Right Grant
- 2004-10-11 EC EC2004005358A patent/ECSP045358A/es unknown
-
2008
- 2008-06-11 CY CY20081100623T patent/CY1108133T1/el unknown
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