CN1309378C - 包含噻托铵盐的用于吸入的气雾制剂 - Google Patents
包含噻托铵盐的用于吸入的气雾制剂 Download PDFInfo
- Publication number
- CN1309378C CN1309378C CNB038082330A CN03808233A CN1309378C CN 1309378 C CN1309378 C CN 1309378C CN B038082330 A CNB038082330 A CN B038082330A CN 03808233 A CN03808233 A CN 03808233A CN 1309378 C CN1309378 C CN 1309378C
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical preparation
- tiotropium
- formulation
- milligrams
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Nozzles (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10216036.8 | 2002-04-11 | ||
| DE10216036A DE10216036A1 (de) | 2002-04-11 | 2002-04-11 | Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1646108A CN1646108A (zh) | 2005-07-27 |
| CN1309378C true CN1309378C (zh) | 2007-04-11 |
Family
ID=28458728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB038082330A Ceased CN1309378C (zh) | 2002-04-11 | 2003-04-02 | 包含噻托铵盐的用于吸入的气雾制剂 |
Country Status (32)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1682541T3 (da) | 2003-11-03 | 2010-06-28 | Boehringer Ingelheim Int | Fremgangsmåde til fremstilling af tiotropiumsalte |
| EP1915158A1 (en) * | 2005-08-06 | 2008-04-30 | Boehringer Ingelheim International GmbH | Use of tiotropium salts in the treatment of severe persistant asthma |
| TWI389692B (zh) | 2005-10-10 | 2013-03-21 | Boehringer Ingelheim Int | 用以吸入β-共效劑的氣溶膠調配物 |
| EP1905440A1 (de) * | 2006-09-06 | 2008-04-02 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verwendung einer pharmazeutischen Zusammensetzung enthaltend ein Anticholinergikum zur Abtötung von Mikroorganismen und zur Behandlung von Atemwegsinfektionen |
| EP2044967A1 (de) * | 2007-10-01 | 2009-04-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Zerstäuber |
| JP6335798B2 (ja) | 2012-02-28 | 2018-05-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規噴射剤含有チオトロピウム製剤 |
| RU2493827C1 (ru) * | 2012-10-03 | 2013-09-27 | Шолекс Девелопмент Гмбх | Стабильный комбинированный раствор фенотерола гидробромида и ипратропия бромида |
| WO2015065223A1 (ru) * | 2013-10-28 | 2015-05-07 | Шолекс Девелопмент Гмбх | Стабильный раствор фенотерола гидробромида |
| WO2015065219A1 (ru) * | 2013-10-28 | 2015-05-07 | Шолекс Девелопмент Гмбх | Раствор ипратропия бромида |
| GB201507686D0 (en) * | 2015-05-05 | 2015-06-17 | Norton Healthcare Ltd | A stable tiotropium nebuliser solution |
| US20180133151A1 (en) * | 2016-11-16 | 2018-05-17 | Glenmark Specialty S.A. | Nebulized tiotropium |
| CN115209872B (zh) * | 2020-03-19 | 2024-08-02 | 广州谷森制药有限公司 | 含有酒石酸左旋沙丁胺醇的可吸入制剂 |
| CN114259481A (zh) * | 2021-11-26 | 2022-04-01 | 南京华盖制药有限公司 | 一种奥达特罗复方吸入溶液 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1323186A (zh) * | 1998-10-17 | 2001-11-21 | 贝林格尔英格海姆法玛公司 | 喷雾器用的二室管状容器 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3931041C2 (de) | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| SG45171A1 (en) | 1990-03-21 | 1998-01-16 | Boehringer Ingelheim Int | Atomising devices and methods |
| IL107120A (en) | 1992-09-29 | 1997-09-30 | Boehringer Ingelheim Int | Atomising nozzle and filter and spray generating device |
| DE19536903C2 (de) | 1995-10-04 | 1998-09-10 | Boehringer Ingelheim Int | Vorrichtung zum Haltern eines fluidischen Bauteils |
| DE19536902A1 (de) | 1995-10-04 | 1997-04-10 | Boehringer Ingelheim Int | Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung |
| DE19545226C1 (de) | 1995-12-05 | 1997-06-19 | Boehringer Ingelheim Int | Sperrspannwerk für einen federbetätigten Abtrieb |
| DE19653969A1 (de) * | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole |
| DE19742439C1 (de) | 1997-09-26 | 1998-10-22 | Boehringer Ingelheim Int | Mikrostrukturiertes Filter |
| HRP20030338B1 (en) * | 2000-10-31 | 2011-09-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg. | Inhalative solution formulation containing a titropium salt |
-
2002
- 2002-04-11 DE DE10216036A patent/DE10216036A1/de not_active Withdrawn
-
2003
- 2003-02-04 UA UA20041109194A patent/UA78994C2/uk unknown
- 2003-04-02 PL PL03371204A patent/PL371204A1/xx not_active Application Discontinuation
- 2003-04-02 EP EP03718724A patent/EP1496876B1/de not_active Expired - Lifetime
- 2003-04-02 EA EA200401305A patent/EA007228B1/ru not_active IP Right Cessation
- 2003-04-02 KR KR1020047016052A patent/KR100997219B1/ko not_active Expired - Lifetime
- 2003-04-02 WO PCT/EP2003/003438 patent/WO2003084519A2/de not_active Ceased
- 2003-04-02 PT PT03718724T patent/PT1496876E/pt unknown
- 2003-04-02 HR HRP20040932AA patent/HRP20040932B1/hr not_active IP Right Cessation
- 2003-04-02 CN CNB038082330A patent/CN1309378C/zh not_active Ceased
- 2003-04-02 SI SI200331206T patent/SI1496876T1/sl unknown
- 2003-04-02 ME MEP-2008-543A patent/ME00359B/me unknown
- 2003-04-02 CA CA2473815A patent/CA2473815C/en not_active Expired - Fee Related
- 2003-04-02 AT AT03718724T patent/ATE389391T1/de active
- 2003-04-02 ES ES03718724T patent/ES2303897T3/es not_active Expired - Lifetime
- 2003-04-02 DE DE50309414T patent/DE50309414D1/de not_active Expired - Lifetime
- 2003-04-02 BR BR0309080-9A patent/BR0309080A/pt not_active Application Discontinuation
- 2003-04-02 EP EP08152138A patent/EP1949892A1/de not_active Withdrawn
- 2003-04-02 JP JP2003581759A patent/JP2005531528A/ja active Pending
- 2003-04-02 MX MXPA04009818A patent/MXPA04009818A/es active IP Right Grant
- 2003-04-02 DK DK03718724T patent/DK1496876T3/da active
- 2003-04-02 RS YUP-879/04A patent/RS50923B/sr unknown
- 2003-04-02 AU AU2003222791A patent/AU2003222791B2/en not_active Expired
- 2003-04-09 MY MYPI20031314A patent/MY137249A/en unknown
- 2003-04-09 UY UY27754A patent/UY27754A1/es not_active Application Discontinuation
- 2003-04-09 PE PE2003000359A patent/PE20030970A1/es not_active Application Discontinuation
- 2003-04-10 TW TW092108240A patent/TWI344851B/zh not_active IP Right Cessation
- 2003-04-11 AR ARP030101267A patent/AR039286A1/es not_active Application Discontinuation
- 2003-07-07 SA SA03240192A patent/SA03240192B1/ar unknown
-
2004
- 2004-07-19 ZA ZA200405721A patent/ZA200405721B/en unknown
- 2004-09-23 NO NO20044001A patent/NO334915B1/no not_active IP Right Cessation
- 2004-10-08 CO CO04100971A patent/CO5611150A2/es active IP Right Grant
- 2004-10-11 EC EC2004005358A patent/ECSP045358A/es unknown
-
2008
- 2008-06-11 CY CY20081100623T patent/CY1108133T1/el unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1323186A (zh) * | 1998-10-17 | 2001-11-21 | 贝林格尔英格海姆法玛公司 | 喷雾器用的二室管状容器 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1078793 Country of ref document: HK |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20070411 |
|
| CX01 | Expiry of patent term | ||
| IW01 | Full invalidation of patent right |
Decision date of declaring invalidation: 20220803 Decision number of declaring invalidation: 57504 Granted publication date: 20070411 |
|
| IW01 | Full invalidation of patent right |