ECSP045358A - Formulacion de aerosol para inhalación que contiene una sal de tiotripio - Google Patents
Formulacion de aerosol para inhalación que contiene una sal de tiotripioInfo
- Publication number
- ECSP045358A ECSP045358A EC2004005358A ECSP045358A ECSP045358A EC SP045358 A ECSP045358 A EC SP045358A EC 2004005358 A EC2004005358 A EC 2004005358A EC SP045358 A ECSP045358 A EC SP045358A EC SP045358 A ECSP045358 A EC SP045358A
- Authority
- EC
- Ecuador
- Prior art keywords
- aerosol formulation
- tiotripe
- salt
- inhalation containing
- inhalation
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000000443 aerosol Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 239000013543 active substance Substances 0.000 abstract 2
- 208000006673 asthma Diseases 0.000 abstract 1
- 239000003380 propellant Substances 0.000 abstract 1
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical compound O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 abstract 1
- 229940110309 tiotropium Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Nozzles (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se refiere a una formulación de aerosol, exenta de gas propulsor, de una sal farmacéuticamente aceptable de tiotropio, disuelta en agua. La formulación de acuerdo con la invención es apropiada, en especial, para nebulizar la sustancia activa por medio de un pulverizador, con el fin de administrar la sustancia activa mediante inhalación, en el caso de presentarse las indicaciones de asma y/o COPD.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10216036A DE10216036A1 (de) | 2002-04-11 | 2002-04-11 | Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP045358A true ECSP045358A (es) | 2004-11-26 |
Family
ID=28458728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2004005358A ECSP045358A (es) | 2002-04-11 | 2004-10-11 | Formulacion de aerosol para inhalación que contiene una sal de tiotripio |
Country Status (32)
| Country | Link |
|---|---|
| EP (2) | EP1496876B1 (es) |
| JP (1) | JP2005531528A (es) |
| KR (1) | KR100997219B1 (es) |
| CN (1) | CN1309378C (es) |
| AR (1) | AR039286A1 (es) |
| AT (1) | ATE389391T1 (es) |
| AU (1) | AU2003222791B2 (es) |
| BR (1) | BR0309080A (es) |
| CA (1) | CA2473815C (es) |
| CO (1) | CO5611150A2 (es) |
| CY (1) | CY1108133T1 (es) |
| DE (2) | DE10216036A1 (es) |
| DK (1) | DK1496876T3 (es) |
| EA (1) | EA007228B1 (es) |
| EC (1) | ECSP045358A (es) |
| ES (1) | ES2303897T3 (es) |
| HR (1) | HRP20040932B1 (es) |
| ME (1) | ME00359B (es) |
| MX (1) | MXPA04009818A (es) |
| MY (1) | MY137249A (es) |
| NO (1) | NO334915B1 (es) |
| PE (1) | PE20030970A1 (es) |
| PL (1) | PL371204A1 (es) |
| PT (1) | PT1496876E (es) |
| RS (1) | RS50923B (es) |
| SA (1) | SA03240192B1 (es) |
| SI (1) | SI1496876T1 (es) |
| TW (1) | TWI344851B (es) |
| UA (1) | UA78994C2 (es) |
| UY (1) | UY27754A1 (es) |
| WO (1) | WO2003084519A2 (es) |
| ZA (1) | ZA200405721B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20100149T1 (hr) | 2003-11-03 | 2010-04-30 | Boehringer Ingelheim International Gmbh | Postupak priprave tiotropijevih soli |
| AU2006277968A1 (en) * | 2005-08-06 | 2007-02-15 | Boehringer Ingelheim International Gmbh | Use of tiotropium salts in the treatment of severe persistant asthma |
| US20070088030A1 (en) | 2005-10-10 | 2007-04-19 | Barbara Niklaus-Humke | Aerosol formulations for the inhalation of beta-agonists |
| EP1905440A1 (de) * | 2006-09-06 | 2008-04-02 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verwendung einer pharmazeutischen Zusammensetzung enthaltend ein Anticholinergikum zur Abtötung von Mikroorganismen und zur Behandlung von Atemwegsinfektionen |
| EP2044967A1 (de) * | 2007-10-01 | 2009-04-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Zerstäuber |
| WO2013127738A1 (de) | 2012-02-28 | 2013-09-06 | Boehringer Ingelheim International Gmbh | Neue treibgashaltige tiotropium-formulierung |
| RU2493827C1 (ru) * | 2012-10-03 | 2013-09-27 | Шолекс Девелопмент Гмбх | Стабильный комбинированный раствор фенотерола гидробромида и ипратропия бромида |
| WO2015065223A1 (ru) * | 2013-10-28 | 2015-05-07 | Шолекс Девелопмент Гмбх | Стабильный раствор фенотерола гидробромида |
| WO2015065219A1 (ru) * | 2013-10-28 | 2015-05-07 | Шолекс Девелопмент Гмбх | Раствор ипратропия бромида |
| GB201507686D0 (en) * | 2015-05-05 | 2015-06-17 | Norton Healthcare Ltd | A stable tiotropium nebuliser solution |
| BR112019009278A2 (pt) * | 2016-11-16 | 2019-10-01 | Glenmark Specialty S.A. | método para administrar brometo de tiotrópio e método para tratar uma doença inflamatória ou obstrutiva de via aérea |
| WO2021188809A1 (en) * | 2020-03-19 | 2021-09-23 | Cai Gu Huang | Inhalable formulation of a solution containing levalbuterol tartrate |
| CN114259481A (zh) * | 2021-11-26 | 2022-04-01 | 南京华盖制药有限公司 | 一种奥达特罗复方吸入溶液 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3931041C2 (de) | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| SG45171A1 (en) | 1990-03-21 | 1998-01-16 | Boehringer Ingelheim Int | Atomising devices and methods |
| IL107120A (en) | 1992-09-29 | 1997-09-30 | Boehringer Ingelheim Int | Atomising nozzle and filter and spray generating device |
| DE19536902A1 (de) | 1995-10-04 | 1997-04-10 | Boehringer Ingelheim Int | Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung |
| DE19536903C2 (de) | 1995-10-04 | 1998-09-10 | Boehringer Ingelheim Int | Vorrichtung zum Haltern eines fluidischen Bauteils |
| DE19545226C1 (de) | 1995-12-05 | 1997-06-19 | Boehringer Ingelheim Int | Sperrspannwerk für einen federbetätigten Abtrieb |
| DE19653969A1 (de) * | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole |
| DE19742439C1 (de) | 1997-09-26 | 1998-10-22 | Boehringer Ingelheim Int | Mikrostrukturiertes Filter |
| DE19847968A1 (de) * | 1998-10-17 | 2000-04-20 | Boehringer Ingelheim Pharma | Verschlußkappe und Behälter als Zweikammer-Kartusche für Vernebler zur Erzeugung von Aerosolen |
| UA78690C2 (uk) * | 2000-10-31 | 2007-04-25 | Boehringer Ingelheim Pharma | Лікарська композиція для інгаляційного застосування у вигляді розчину із сіллю тіотропію |
-
2002
- 2002-04-11 DE DE10216036A patent/DE10216036A1/de not_active Withdrawn
-
2003
- 2003-02-04 UA UA20041109194A patent/UA78994C2/uk unknown
- 2003-04-02 CA CA2473815A patent/CA2473815C/en not_active Expired - Fee Related
- 2003-04-02 PT PT03718724T patent/PT1496876E/pt unknown
- 2003-04-02 MX MXPA04009818A patent/MXPA04009818A/es active IP Right Grant
- 2003-04-02 AT AT03718724T patent/ATE389391T1/de active
- 2003-04-02 DK DK03718724T patent/DK1496876T3/da active
- 2003-04-02 JP JP2003581759A patent/JP2005531528A/ja active Pending
- 2003-04-02 EP EP03718724A patent/EP1496876B1/de not_active Expired - Lifetime
- 2003-04-02 RS YUP-879/04A patent/RS50923B/sr unknown
- 2003-04-02 KR KR1020047016052A patent/KR100997219B1/ko not_active Expired - Lifetime
- 2003-04-02 WO PCT/EP2003/003438 patent/WO2003084519A2/de not_active Ceased
- 2003-04-02 CN CNB038082330A patent/CN1309378C/zh not_active Ceased
- 2003-04-02 AU AU2003222791A patent/AU2003222791B2/en not_active Expired
- 2003-04-02 ME MEP-2008-543A patent/ME00359B/me unknown
- 2003-04-02 PL PL03371204A patent/PL371204A1/xx not_active Application Discontinuation
- 2003-04-02 DE DE50309414T patent/DE50309414D1/de not_active Expired - Lifetime
- 2003-04-02 EA EA200401305A patent/EA007228B1/ru not_active IP Right Cessation
- 2003-04-02 ES ES03718724T patent/ES2303897T3/es not_active Expired - Lifetime
- 2003-04-02 HR HRP20040932AA patent/HRP20040932B1/hr not_active IP Right Cessation
- 2003-04-02 EP EP08152138A patent/EP1949892A1/de not_active Withdrawn
- 2003-04-02 BR BR0309080-9A patent/BR0309080A/pt not_active Application Discontinuation
- 2003-04-02 SI SI200331206T patent/SI1496876T1/sl unknown
- 2003-04-09 PE PE2003000359A patent/PE20030970A1/es not_active Application Discontinuation
- 2003-04-09 MY MYPI20031314A patent/MY137249A/en unknown
- 2003-04-09 UY UY27754A patent/UY27754A1/es not_active Application Discontinuation
- 2003-04-10 TW TW092108240A patent/TWI344851B/zh not_active IP Right Cessation
- 2003-04-11 AR ARP030101267A patent/AR039286A1/es not_active Application Discontinuation
- 2003-07-07 SA SA03240192A patent/SA03240192B1/ar unknown
-
2004
- 2004-07-19 ZA ZA200405721A patent/ZA200405721B/en unknown
- 2004-09-23 NO NO20044001A patent/NO334915B1/no not_active IP Right Cessation
- 2004-10-08 CO CO04100971A patent/CO5611150A2/es active IP Right Grant
- 2004-10-11 EC EC2004005358A patent/ECSP045358A/es unknown
-
2008
- 2008-06-11 CY CY20081100623T patent/CY1108133T1/el unknown
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