JP2005531321A - マーカー遺伝子 - Google Patents

マーカー遺伝子 Download PDF

Info

Publication number
JP2005531321A
JP2005531321A JP2004518691A JP2004518691A JP2005531321A JP 2005531321 A JP2005531321 A JP 2005531321A JP 2004518691 A JP2004518691 A JP 2004518691A JP 2004518691 A JP2004518691 A JP 2004518691A JP 2005531321 A JP2005531321 A JP 2005531321A
Authority
JP
Japan
Prior art keywords
aldolase
nephrotoxicity
gene expression
egf
clusterin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004518691A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005531321A5 (enExample
Inventor
サラ−ディーヌ・チボ
オリヴィエ・グレネ
ジョルジュ・イムベール
ジャンヌ・ケラン
フランク・シュテットラー
カート・ダグラス・ウルフガング
Original Assignee
ノバルティス アクチエンゲゼルシャフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ノバルティス アクチエンゲゼルシャフト filed Critical ノバルティス アクチエンゲゼルシャフト
Publication of JP2005531321A publication Critical patent/JP2005531321A/ja
Publication of JP2005531321A5 publication Critical patent/JP2005531321A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2004518691A 2002-07-04 2003-07-03 マーカー遺伝子 Pending JP2005531321A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0215509.1A GB0215509D0 (en) 2002-07-04 2002-07-04 Marker genes
PCT/EP2003/007111 WO2004005544A2 (en) 2002-07-04 2003-07-03 Marker genes for determining renal toxicity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009233624A Division JP2010042019A (ja) 2002-07-04 2009-10-07 マーカー遺伝子

Publications (2)

Publication Number Publication Date
JP2005531321A true JP2005531321A (ja) 2005-10-20
JP2005531321A5 JP2005531321A5 (enExample) 2006-08-17

Family

ID=9939850

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2004518691A Pending JP2005531321A (ja) 2002-07-04 2003-07-03 マーカー遺伝子
JP2009233624A Pending JP2010042019A (ja) 2002-07-04 2009-10-07 マーカー遺伝子

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009233624A Pending JP2010042019A (ja) 2002-07-04 2009-10-07 マーカー遺伝子

Country Status (10)

Country Link
US (1) US20060008804A1 (enExample)
EP (2) EP1925677A3 (enExample)
JP (2) JP2005531321A (enExample)
CN (1) CN1688715A (enExample)
AU (1) AU2003250879B2 (enExample)
BR (1) BR0312405A (enExample)
CA (1) CA2493860A1 (enExample)
GB (1) GB0215509D0 (enExample)
IL (1) IL165883A0 (enExample)
WO (1) WO2004005544A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012508382A (ja) * 2008-11-10 2012-04-05 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後のための方法および組成物
JP2012510058A (ja) * 2008-11-22 2012-04-26 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後のための方法および組成物
JP2012524883A (ja) * 2008-08-14 2012-10-18 ホスピタル クリニク アイ プロビンシアル デ バルセロナ 腎臓障害生物マーカとしてのwnt1
JP2013031375A (ja) * 2011-07-29 2013-02-14 Medichrome:Kk 遺伝子発現変動解析による化学物質の毒性評価方法
JP2016504017A (ja) * 2012-10-24 2016-02-12 リージェンメドティーエックス, エルエルシー 腎細胞集団及びその使用
JP2016515514A (ja) * 2013-03-15 2016-05-30 ライフライン サイエンティフィック インコーポレイテッドLifeline Scientific, Inc. 臓器または組織の生存性を判定するためのグルコースセンサを備えた搬送装置

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004500879A (ja) 2000-06-16 2004-01-15 バイオジェン インコーポレイテッド 腎の調節エレメントおよびそれらの使用方法
DK1401869T3 (da) 2001-06-01 2008-04-28 Biogen Idec Inc Molekyler og fremgangsmåder til inhibering af udskillkelse af kim 1
CA2512138C (en) 2002-12-30 2013-07-16 Biogen Idec Ma Inc. Kim-1 antagonists and use to modulate immune system
US20050272101A1 (en) * 2004-06-07 2005-12-08 Prasad Devarajan Method for the early detection of renal injury
CA2565701A1 (en) * 2004-05-06 2005-11-17 Jonathan M. Barasch Ngal for reduction and amelioration of ischemic and nephrotoxic injuries
DK1831699T3 (da) * 2004-12-20 2010-03-15 Antibodyshop As Bestemmelse af neutrofil gelatine-associeret lipocalin (NGAL) som en diagnostisk markør for nyresygdomme
EP1865985B1 (en) 2005-03-02 2010-08-25 Biogen Idec MA Inc. Kim-1 antibodies for treatment of th2-mediated conditions
US20070037232A1 (en) * 2005-03-31 2007-02-15 Barasch Jonathan M Detection of NGAL in chronic renal disease
US20070087387A1 (en) 2005-04-21 2007-04-19 Prasad Devarajan Method for the Early Detection of Renal Disease Using Proteomics
US7700299B2 (en) 2005-08-12 2010-04-20 Hoffmann-La Roche Inc. Method for predicting the response to a treatment
US20080090304A1 (en) * 2006-10-13 2008-04-17 Barasch Jonathan Matthew Diagnosis and monitoring of chronic renal disease using ngal
PL2035835T3 (pl) * 2006-05-30 2012-05-31 Antibodyshop As Sposoby szybkiej oceny ciężkości urazu
WO2008017306A1 (en) * 2006-08-07 2008-02-14 Antibodyshop A/S Diagnostic test to exclude significant renal injury
EP2137538B1 (en) * 2007-03-21 2014-04-09 Bioporto Diagnostics A/s Diagnostic test for renal injury
EP2479571A3 (en) 2007-03-26 2012-09-26 Novartis AG Predictive renal safety biomarkers and biomarker signatures to monitor kidney function
US20090104649A1 (en) 2007-06-11 2009-04-23 Garovic Vesna D Markers for preeclampsia
US8846036B2 (en) 2007-10-19 2014-09-30 Abbott Laboratories Antibodies that bind to mammalian NGAL and uses thereof
EP2215481B2 (en) * 2007-11-15 2017-01-18 Bioporto Diagnostics A/S Diagnostic use of individual molecular forms of a biomarker
EP2075343A1 (en) * 2007-12-21 2009-07-01 Gert Mayer A method of diagnosing a progressive disease
US8338096B2 (en) * 2008-04-15 2012-12-25 Rainer Oberbauer Markers of acute kidney failure
US7977110B2 (en) 2008-06-02 2011-07-12 Children's Hospital Medical Center Method for distinguishing between kidney dysfunctions
WO2010054025A1 (en) * 2008-11-05 2010-05-14 Abbott Laboratories Neutrophil gelatinase-associated lipocalin (ngal) protein isoforms enriched from urine and recombinant chinese hamster ovary (cho) cells and related compositions, antibodies, and methods of enrichment, analysis and use
EP2379752B1 (fr) * 2009-01-19 2015-09-30 Biomérieux S.A. Procedes pour determiner la susceptibilite a contracter une infection nosocomiale chez un patient et pour etablir un pronostic d'evolution d'un syndrome septique
DK2391653T3 (en) * 2009-01-28 2015-02-09 Ind Tech Res Inst Biomarkers associated nephropathy
WO2011017685A1 (en) * 2009-08-07 2011-02-10 Rules-Based Medicine, Inc. Methods and devices for detecting kidney transplant rejection
ES2530866T3 (es) 2009-12-21 2015-03-06 Mayo Foundation Marcador temprano de proteinuria en pacientes tratados con un tratamiento anti-VEGF
US9476868B2 (en) 2009-12-23 2016-10-25 Hill's Pet Nutrition, Inc. Compositions and methods for diagnosing and treating kidney disorders in a canine
JP2013529907A (ja) 2010-05-24 2013-07-25 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク Ngalタンパク質変異体及びその使用
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2857499A1 (en) 2010-10-01 2015-04-08 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CA2831613A1 (en) 2011-03-31 2012-10-04 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CA2845117A1 (en) * 2011-09-14 2013-03-21 Basf Se Means and methods for assessing kidney toxicity
PT3682905T (pt) 2011-10-03 2022-04-07 Modernatx Inc Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações
ES2923757T3 (es) 2011-12-16 2022-09-30 Modernatx Inc Composiciones de ARNm modificado
WO2013151664A1 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
EP2925337B1 (en) 2012-11-21 2019-07-03 The Trustees of Columbia University in the City of New York Mutant ngal proteins and uses thereof
PT2922554T (pt) 2012-11-26 2022-06-28 Modernatx Inc Arn modificado nas porções terminais
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
US10077439B2 (en) 2013-03-15 2018-09-18 Modernatx, Inc. Removal of DNA fragments in mRNA production process
WO2014182330A1 (en) 2013-05-06 2014-11-13 Hitachi Chemical Company Ltd Devices and methods for capturing target molecules
KR20160067219A (ko) 2013-10-03 2016-06-13 모더나 세라퓨틱스, 인코포레이티드 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
WO2015153860A1 (en) * 2014-04-04 2015-10-08 Somalogic, Inc. Glomerular filtration rate biomarkers and uses thereof
WO2015160805A1 (en) * 2014-04-15 2015-10-22 The Brigham And Women's Hospital, Inc. Circulating kim-1 levels for detection of pathologies associated with injury to, or cancer of, the kidney
US10712349B2 (en) 2014-04-15 2020-07-14 The Brigham And Women's Hospital, Inc. Circulating KIM-1 levels for detection of pathologies associated with injury to, or cancer of, the kidney
US10801066B2 (en) 2014-09-05 2020-10-13 American University Of Beirut Determination of risk for development of cardiovascular disease by measuring urinary levels of podocin and nephrin messenger RNA
WO2016077537A1 (en) * 2014-11-12 2016-05-19 Hitachi Chemical Co., Ltd. Method and device for diagnosing organ injury
WO2016208776A1 (ja) 2015-06-25 2016-12-29 株式会社国際電気通信基礎技術研究所 多器官連関システムを基盤とした予測装置、及び予測プログラム
JP6624704B2 (ja) 2015-08-31 2019-12-25 日立化成株式会社 尿路上皮疾患の評価のための分子法
CN114594268A (zh) 2016-03-29 2022-06-07 无限生物制药公司 用以预防或治疗肾脏疾病的活性组分的候选物质的筛选装置和筛选方法
JP6332780B2 (ja) 2016-03-29 2018-05-30 株式会社国際電気通信基礎技術研究所 医薬組成物又は食品組成物、及び有効成分の体内での効果の評価方法
EP3472347B1 (en) * 2016-06-17 2023-01-04 F. Hoffmann-La Roche AG In vitro nephrotoxicity screening assay
US12174201B2 (en) 2017-10-12 2024-12-24 Cedars-Sinai Medical Center Prognosis and progression biomarkers for chronic kidney disease

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012760A2 (en) * 1998-08-28 2000-03-09 Incyte Pharmaceuticals, Inc. Toxicological response markers
WO2001094636A2 (en) * 2000-06-05 2001-12-13 Genetics Inst Compositions, kits, and methods for identification and modulation of type i diabetes
WO2001098539A2 (en) * 2000-06-21 2001-12-27 Hitachi Chemical Co., Ltd. Gene markers for lung cancer
WO2002010453A2 (en) * 2000-07-31 2002-02-07 Gene Logic, Inc. Molecular toxicology modeling

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA951461B (en) * 1994-02-22 1996-01-24 Univ Illinois Genes and genetic elements associated with sensitivity to platimun-based drugs
US6586389B1 (en) * 1998-01-22 2003-07-01 Administrators Of The Tulane Educational Fund Cubilin protein, DNA sequences encoding cubilin and uses thereof
WO2000047761A2 (en) * 1999-02-12 2000-08-17 Phase-1 Molecular Toxicology, Inc. High-throughput toxicological testing using cultured organisms and cells
US20010034023A1 (en) * 1999-04-26 2001-10-25 Stanton Vincent P. Gene sequence variations with utility in determining the treatment of disease, in genes relating to drug processing
AU1466001A (en) * 1999-11-05 2001-05-14 Phase-1 Molecular Toxicology Methods of determining individual hypersensitivity to an agent
US20020037508A1 (en) * 2000-01-19 2002-03-28 Michele Cargill Human single nucleotide polymorphisms
JP2004500879A (ja) * 2000-06-16 2004-01-15 バイオジェン インコーポレイテッド 腎の調節エレメントおよびそれらの使用方法
AU2001271998A1 (en) * 2000-07-13 2002-01-30 The Johns Hopkins University School Of Medicine Detection and treatment of polycystic kidney disease
AU2001281322A1 (en) * 2000-07-13 2002-01-30 Biogen, Inc. Methods of identifying renal protective factors
DE10056802B4 (de) * 2000-11-14 2005-06-16 Epigenomics Ag Verfahren zur Detektion von Methylierungszuständen zur toxikologischen Diagnostik
CA2440008A1 (en) * 2001-01-29 2002-08-29 Phase-1 Molecular Toxicology, Inc. Rat toxicologically relevant genes and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012760A2 (en) * 1998-08-28 2000-03-09 Incyte Pharmaceuticals, Inc. Toxicological response markers
WO2001094636A2 (en) * 2000-06-05 2001-12-13 Genetics Inst Compositions, kits, and methods for identification and modulation of type i diabetes
WO2001098539A2 (en) * 2000-06-21 2001-12-27 Hitachi Chemical Co., Ltd. Gene markers for lung cancer
WO2002010453A2 (en) * 2000-07-31 2002-02-07 Gene Logic, Inc. Molecular toxicology modeling

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012524883A (ja) * 2008-08-14 2012-10-18 ホスピタル クリニク アイ プロビンシアル デ バルセロナ 腎臓障害生物マーカとしてのwnt1
JP2012508382A (ja) * 2008-11-10 2012-04-05 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後のための方法および組成物
JP2012510058A (ja) * 2008-11-22 2012-04-26 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後のための方法および組成物
JP2015064381A (ja) * 2008-11-22 2015-04-09 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後のための方法および組成物
JP2013031375A (ja) * 2011-07-29 2013-02-14 Medichrome:Kk 遺伝子発現変動解析による化学物質の毒性評価方法
JP2016504017A (ja) * 2012-10-24 2016-02-12 リージェンメドティーエックス, エルエルシー 腎細胞集団及びその使用
JP2019141067A (ja) * 2012-10-24 2019-08-29 インリージェン 腎細胞集団及びその使用
US11369639B2 (en) 2012-10-24 2022-06-28 Prokidney Renal cell populations and uses thereof
US12409191B2 (en) 2012-10-24 2025-09-09 Prokidney Renal cell populations and uses thereof
JP2016515514A (ja) * 2013-03-15 2016-05-30 ライフライン サイエンティフィック インコーポレイテッドLifeline Scientific, Inc. 臓器または組織の生存性を判定するためのグルコースセンサを備えた搬送装置
US10420337B2 (en) 2013-03-15 2019-09-24 Lifeline Scientific, Inc. Transporter with a glucose sensor for determining viability of an organ or tissue

Also Published As

Publication number Publication date
WO2004005544A3 (en) 2004-04-22
AU2003250879B2 (en) 2007-07-26
CN1688715A (zh) 2005-10-26
EP1925677A2 (en) 2008-05-28
IL165883A0 (en) 2006-01-15
CA2493860A1 (en) 2004-01-15
EP1521847A2 (en) 2005-04-13
WO2004005544A2 (en) 2004-01-15
AU2003250879A1 (en) 2004-01-23
US20060008804A1 (en) 2006-01-12
EP1925677A3 (en) 2008-07-02
BR0312405A (pt) 2005-04-26
GB0215509D0 (en) 2002-08-14
JP2010042019A (ja) 2010-02-25

Similar Documents

Publication Publication Date Title
JP2010042019A (ja) マーカー遺伝子
EP1064404B1 (en) P53-regulated genes
CN101679525B (zh) 用于监测肾功能的预测性的肾安全性生物标志物和生物标志物标签
US8329410B2 (en) Method for diagnosing kidney disease comprising detecting the level of annexin A2
Hakkola et al. Cytochrome P450 3A expression in the human fetal liver: evidence that CYP3A5 is expressed in only a limited number of fetal livers
JP2005531321A5 (enExample)
Yang et al. The secreted micropeptide C4orf48 enhances renal fibrosis via an RNA-binding mechanism
Radrizzani et al. Differential expression of CPD1 during postnatal development in the mouse cerebellum
Cheval et al. Plasticity of mouse renal collecting duct in response to potassium depletion
US20200241005A1 (en) Compositions and methods for the diagnosis and treatment of diseases of the liver
JP2004187620A (ja) 腎疾患の疾患マーカーおよびその利用
US7060457B2 (en) Aberrant glutamate transporters and methods of use
CA2440008A1 (en) Rat toxicologically relevant genes and uses thereof
US7579152B2 (en) SENP1 as a marker of cancer development and target for cancer therapy
JP2004505637A (ja) ガン関連sim2遺伝子
JP2005529603A (ja) 糖尿病を予防、治療、および診断するための組成物および方法
US20050079496A1 (en) Methods for diagnosing and treating neoplasias using nf-at transcriptions factors
KR102242286B1 (ko) 중간엽줄기세포의 신장섬유화 치료효과 예측용 바이오마커 조성물
KR102337954B1 (ko) 뇌졸중 치료용 조성물 및 이를 스크리닝하는 방법
EP1619504A1 (en) Novel use of the kinases RSK4 and PAK5
JP2006518998A (ja) Pac−1(dusp2)を使用する炎症性疾患の診断方法及び治療方法
HK1084699A (en) Marker genes for determining renal toxicity
KR20090034932A (ko) 파킨슨씨 질환 치료 및 진단을 위한 gprc 변형체의 동정 및 용도
AU2002333399A1 (en) Methods for diagnosing and treating neoplasias using NF-AT transcription factors
WO2001088193A2 (en) Follicle stimulating hormone stimulated genes and uses thereof

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060628

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060628

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090707

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091007

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20091110

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100209

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100217

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100310

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100317

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100506