CA2493860A1 - Marker genes for determining renal toxicity - Google Patents
Marker genes for determining renal toxicity Download PDFInfo
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- CA2493860A1 CA2493860A1 CA002493860A CA2493860A CA2493860A1 CA 2493860 A1 CA2493860 A1 CA 2493860A1 CA 002493860 A CA002493860 A CA 002493860A CA 2493860 A CA2493860 A CA 2493860A CA 2493860 A1 CA2493860 A1 CA 2493860A1
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- aldolase
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
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- Immunology (AREA)
- Biotechnology (AREA)
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- Physics & Mathematics (AREA)
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- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| GBGB0215509.1A GB0215509D0 (en) | 2002-07-04 | 2002-07-04 | Marker genes |
| GB0215509.1 | 2002-07-04 | ||
| PCT/EP2003/007111 WO2004005544A2 (en) | 2002-07-04 | 2003-07-03 | Marker genes for determining renal toxicity |
Publications (1)
| Publication Number | Publication Date |
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| CA2493860A1 true CA2493860A1 (en) | 2004-01-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA002493860A Abandoned CA2493860A1 (en) | 2002-07-04 | 2003-07-03 | Marker genes for determining renal toxicity |
Country Status (10)
| Country | Link |
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| US (1) | US20060008804A1 (enExample) |
| EP (2) | EP1925677A3 (enExample) |
| JP (2) | JP2005531321A (enExample) |
| CN (1) | CN1688715A (enExample) |
| AU (1) | AU2003250879B2 (enExample) |
| BR (1) | BR0312405A (enExample) |
| CA (1) | CA2493860A1 (enExample) |
| GB (1) | GB0215509D0 (enExample) |
| IL (1) | IL165883A0 (enExample) |
| WO (1) | WO2004005544A2 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2412734A1 (en) | 2000-06-16 | 2001-12-27 | Biogen, Inc. | Renal regulatory elements and methods of use thereof |
| DE60224275T2 (de) | 2001-06-01 | 2008-12-11 | Biogen Idec Ma Inc., Cambridge | Moleküle und verfahren zur inhibierung der freisetzung von kim-1 |
| AU2003299925B2 (en) | 2002-12-30 | 2011-10-27 | Biogen Ma Inc. | KIM-1 antagonists and use to modulate immune system |
| WO2005107793A2 (en) * | 2004-05-06 | 2005-11-17 | The Trustees Of Columbia University | Ngal for reduction and amelioration of ischemic and nephrotoxic injuries |
| US20050272101A1 (en) * | 2004-06-07 | 2005-12-08 | Prasad Devarajan | Method for the early detection of renal injury |
| ES2622467T3 (es) * | 2004-12-20 | 2017-07-06 | Antibodyshop A/S | Determinación de lipocalina asociada a gelatinasa de neutrófilos (NGAL) como marcador diagnóstico para trastornos renales |
| CN103751780A (zh) | 2005-03-02 | 2014-04-30 | 比奥根艾迪克Ma公司 | 用于治疗th2介导的疾病的kim-1抗体 |
| US20070037232A1 (en) * | 2005-03-31 | 2007-02-15 | Barasch Jonathan M | Detection of NGAL in chronic renal disease |
| US20070087387A1 (en) | 2005-04-21 | 2007-04-19 | Prasad Devarajan | Method for the Early Detection of Renal Disease Using Proteomics |
| US7700299B2 (en) | 2005-08-12 | 2010-04-20 | Hoffmann-La Roche Inc. | Method for predicting the response to a treatment |
| US20080090304A1 (en) * | 2006-10-13 | 2008-04-17 | Barasch Jonathan Matthew | Diagnosis and monitoring of chronic renal disease using ngal |
| ATE539351T1 (de) | 2006-05-30 | 2012-01-15 | Antibodyshop As | Verfahren zur schnellen beurteilung der schwere eines traumas |
| EP2064553B2 (en) * | 2006-08-07 | 2023-06-07 | Antibodyshop A/S | Diagnostic test to exclude significant renal injury |
| EP2137538B1 (en) | 2007-03-21 | 2014-04-09 | Bioporto Diagnostics A/s | Diagnostic test for renal injury |
| CN103399155A (zh) * | 2007-03-26 | 2013-11-20 | 诺瓦提斯公司 | 用于监测肾功能的预测性的肾安全性生物标志物和生物标志物标签 |
| US20090104649A1 (en) | 2007-06-11 | 2009-04-23 | Garovic Vesna D | Markers for preeclampsia |
| US8846036B2 (en) | 2007-10-19 | 2014-09-30 | Abbott Laboratories | Antibodies that bind to mammalian NGAL and uses thereof |
| CN101910845A (zh) * | 2007-11-15 | 2010-12-08 | 比奥波托诊断股份公司 | 个体分子形式的生物标志的诊断用途 |
| EP2075343A1 (en) * | 2007-12-21 | 2009-07-01 | Gert Mayer | A method of diagnosing a progressive disease |
| EP2279270B1 (en) * | 2008-04-15 | 2014-06-18 | Oberbauer, Rainer | Markers of acute kidney failure |
| US7977110B2 (en) | 2008-06-02 | 2011-07-12 | Children's Hospital Medical Center | Method for distinguishing between kidney dysfunctions |
| ES2341419B1 (es) * | 2008-08-14 | 2011-05-03 | Hospital Clinic I Provincial De Barcelona | Wnt1 como biomarcador de daño renal. |
| US8394606B2 (en) * | 2008-11-05 | 2013-03-12 | Abbott Laboratories | Neutrophil gelatinase-associated lipocalin (NGAL) protein isoforms enriched from urine and recombinant chinese hamster ovary (CHO) cells and related compositions, antibodies, and methods of enrichment, analysis and use |
| EP2913676A1 (en) * | 2008-11-10 | 2015-09-02 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| JP5735922B2 (ja) * | 2008-11-22 | 2015-06-17 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後のための方法 |
| CN102301008B (zh) * | 2009-01-19 | 2015-05-13 | 生物梅里埃公司 | 用于确定患者发生医院内感染的易感性以及确立败血性综合征进展的预后的方法 |
| DK2391653T3 (en) * | 2009-01-28 | 2015-02-09 | Ind Tech Res Inst | Biomarkers associated nephropathy |
| CA2770189A1 (en) * | 2009-08-07 | 2011-02-10 | Rules-Based Medicine, Inc. | Methods and devices for detecting kidney transplant rejection |
| ES2530866T3 (es) | 2009-12-21 | 2015-03-06 | Mayo Foundation | Marcador temprano de proteinuria en pacientes tratados con un tratamiento anti-VEGF |
| AU2010336392B2 (en) | 2009-12-23 | 2014-01-23 | Hill's Pet Nutrition, Inc. | Compositions and methods for diagnosing and treating kidney disorders in a canine |
| JP2013529907A (ja) | 2010-05-24 | 2013-07-25 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | Ｎｇａｌタンパク質変異体及びその使用 |
| EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| CN103429606A (zh) | 2010-10-01 | 2013-12-04 | 现代治疗公司 | 设计核酸及其使用方法 |
| CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| JP5804629B2 (ja) * | 2011-07-29 | 2015-11-04 | 株式会社メディクローム | 遺伝子発現変動解析による化学物質の毒性評価方法 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| KR20140074293A (ko) * | 2011-09-14 | 2014-06-17 | 바스프 에스이 | 신장 독성을 평가하기 위한 수단 및 방법 |
| KR20190099538A (ko) | 2011-10-03 | 2019-08-27 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드, 및 핵산, 및 이들의 용도 |
| EP4144378A1 (en) | 2011-12-16 | 2023-03-08 | ModernaTX, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| AU2013243954A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| CN104937095B (zh) * | 2012-10-24 | 2019-06-07 | 因瑞金公司 | 肾细胞群及其用途 |
| WO2014081980A2 (en) | 2012-11-21 | 2014-05-30 | The Trustees Of Columbia University In The City Of New York | Mutant ngal proteins and uses thereof |
| DK2922554T3 (en) | 2012-11-26 | 2022-05-23 | Modernatx Inc | Terminalt modificeret rna |
| US10420337B2 (en) | 2013-03-15 | 2019-09-24 | Lifeline Scientific, Inc. | Transporter with a glucose sensor for determining viability of an organ or tissue |
| WO2014152030A1 (en) | 2013-03-15 | 2014-09-25 | Moderna Therapeutics, Inc. | Removal of dna fragments in mrna production process |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| JP6297676B2 (ja) | 2013-05-06 | 2018-03-20 | 日立化成株式会社 | 標的分子を捕捉するためのデバイス及び方法 |
| BR112016007255A2 (pt) | 2013-10-03 | 2017-09-12 | Moderna Therapeutics Inc | polinucleotídeos que codificam receptor de lipoproteína de baixa densidade |
| WO2015153860A1 (en) * | 2014-04-04 | 2015-10-08 | Somalogic, Inc. | Glomerular filtration rate biomarkers and uses thereof |
| US10712349B2 (en) | 2014-04-15 | 2020-07-14 | The Brigham And Women's Hospital, Inc. | Circulating KIM-1 levels for detection of pathologies associated with injury to, or cancer of, the kidney |
| WO2015160805A1 (en) * | 2014-04-15 | 2015-10-22 | The Brigham And Women's Hospital, Inc. | Circulating kim-1 levels for detection of pathologies associated with injury to, or cancer of, the kidney |
| US10801066B2 (en) | 2014-09-05 | 2020-10-13 | American University Of Beirut | Determination of risk for development of cardiovascular disease by measuring urinary levels of podocin and nephrin messenger RNA |
| EP3218521B1 (en) * | 2014-11-12 | 2019-12-25 | Hitachi Chemical Co., Ltd. | Method for diagnosing organ injury |
| CN108271422A (zh) | 2015-06-25 | 2018-07-10 | 株式会社国际电气通信基础技术研究所 | 基于器官间串扰系统的预测装置及预测程序 |
| DE112016003948T5 (de) | 2015-08-31 | 2018-05-09 | City Of Sapporo | Molekulare verfahren zum beurteilen einer urothelialen erkrankung |
| CN114778845A (zh) | 2016-03-29 | 2022-07-22 | 无限生物制药公司 | 药物组合物或食品组合物及评价活性成分体内效果的方法 |
| EP3438282A4 (en) * | 2016-03-29 | 2020-05-06 | Advanced Telecommunications Research Institute International | METHOD FOR SCREENING CANDIDATE SUBSTANCES FOR AN ACTIVE COMPONENT TO PREVENT OR TREAT AT LEAST ONE SELECTED DISEASE IN THE KIDNEY HYPOFUNCTION GROUP, CHRONIC KIDNEY DISEASE AND KIDNEY DEFICIENCY |
| JP7012033B2 (ja) * | 2016-06-17 | 2022-02-10 | エフ．ホフマン－ラ ロシュ アーゲー | インビトロ腎毒性スクリーニングアッセイ |
| EP3695224A4 (en) * | 2017-10-12 | 2021-12-29 | Cedars-Sinai Medical Center | Prognosis and progression biomarkers for chronic kidney disease |
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| WO1995022612A2 (en) * | 1994-02-22 | 1995-08-24 | Board Of Trustees Of The University Of Illinois | Genes and genetic elements associated with sensitivity to platinum-based drugs |
| WO1999037757A1 (en) * | 1998-01-22 | 1999-07-29 | Administrators Of The Tulane Educational Fund | Cubilin protein, dna sequences encoding cubilin and uses thereof |
| WO2000012760A2 (en) * | 1998-08-28 | 2000-03-09 | Incyte Pharmaceuticals, Inc. | Toxicological response markers |
| EP1153137A2 (en) * | 1999-02-12 | 2001-11-14 | Phase-1 Molecular Toxicology Inc. | High-throughput toxicological testing using cultured organisms and cells |
| US20010034023A1 (en) * | 1999-04-26 | 2001-10-25 | Stanton Vincent P. | Gene sequence variations with utility in determining the treatment of disease, in genes relating to drug processing |
| WO2001032928A2 (en) * | 1999-11-05 | 2001-05-10 | Phase-1 Molecular Toxicology | Methods of determining individual hypersensitivity to an agent |
| US20020037508A1 (en) * | 2000-01-19 | 2002-03-28 | Michele Cargill | Human single nucleotide polymorphisms |
| EP1290227B1 (en) * | 2000-06-05 | 2009-08-12 | Genetics Institute, LLC | Compositions, kits, and methods for identification and modulation of type i diabetes |
| CA2412734A1 (en) * | 2000-06-16 | 2001-12-27 | Biogen, Inc. | Renal regulatory elements and methods of use thereof |
| US7214781B2 (en) * | 2000-06-21 | 2007-05-08 | Hitachi Chemical Research Center, Inc. | Gene markers for lung cancer |
| CA2395781C (en) * | 2000-07-13 | 2010-04-13 | The Johns Hopkins University School Of Medicine | Detection and treatment of polycystic kidney disease |
| WO2002006537A2 (en) * | 2000-07-13 | 2002-01-24 | Curagen Corporation | Methods of identifying renal protective factors |
| EP1364049A2 (en) * | 2000-07-31 | 2003-11-26 | Gene Logic, Inc. | Molecular toxicology modeling |
| DE10056802B4 (de) * | 2000-11-14 | 2005-06-16 | Epigenomics Ag | Verfahren zur Detektion von Methylierungszuständen zur toxikologischen Diagnostik |
| JP2004535776A (ja) * | 2001-01-29 | 2004-12-02 | フェイズ − １ モレキュラー トクシコロジー、インコーポレイテッド | ラット毒性関連遺伝子及びその使用 |
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- 2003-07-03 BR BR0312405-3A patent/BR0312405A/pt not_active IP Right Cessation
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- 2003-07-03 WO PCT/EP2003/007111 patent/WO2004005544A2/en not_active Ceased
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Also Published As
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| IL165883A0 (en) | 2006-01-15 |
| US20060008804A1 (en) | 2006-01-12 |
| BR0312405A (pt) | 2005-04-26 |
| EP1521847A2 (en) | 2005-04-13 |
| CN1688715A (zh) | 2005-10-26 |
| JP2005531321A (ja) | 2005-10-20 |
| EP1925677A2 (en) | 2008-05-28 |
| AU2003250879B2 (en) | 2007-07-26 |
| WO2004005544A2 (en) | 2004-01-15 |
| AU2003250879A1 (en) | 2004-01-23 |
| GB0215509D0 (en) | 2002-08-14 |
| EP1925677A3 (en) | 2008-07-02 |
| JP2010042019A (ja) | 2010-02-25 |
| WO2004005544A3 (en) | 2004-04-22 |
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