CA2493860A1 - Marker genes for determining renal toxicity - Google Patents
Marker genes for determining renal toxicity Download PDFInfo
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- CA2493860A1 CA2493860A1 CA002493860A CA2493860A CA2493860A1 CA 2493860 A1 CA2493860 A1 CA 2493860A1 CA 002493860 A CA002493860 A CA 002493860A CA 2493860 A CA2493860 A CA 2493860A CA 2493860 A1 CA2493860 A1 CA 2493860A1
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- aldolase
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| PCT/EP2003/007111 WO2004005544A2 (en) | 2002-07-04 | 2003-07-03 | Marker genes for determining renal toxicity |
Publications (1)
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| CA2493860A1 true CA2493860A1 (en) | 2004-01-15 |
Family
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Family Applications (1)
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| CA002493860A Abandoned CA2493860A1 (en) | 2002-07-04 | 2003-07-03 | Marker genes for determining renal toxicity |
Country Status (10)
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| EP (2) | EP1925677A3 (enExample) |
| JP (2) | JP2005531321A (enExample) |
| CN (1) | CN1688715A (enExample) |
| AU (1) | AU2003250879B2 (enExample) |
| BR (1) | BR0312405A (enExample) |
| CA (1) | CA2493860A1 (enExample) |
| GB (1) | GB0215509D0 (enExample) |
| IL (1) | IL165883A0 (enExample) |
| WO (1) | WO2004005544A2 (enExample) |
Families Citing this family (62)
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| JP2004500879A (ja) | 2000-06-16 | 2004-01-15 | バイオジェン インコーポレイテッド | 腎の調節エレメントおよびそれらの使用方法 |
| DK1401869T3 (da) | 2001-06-01 | 2008-04-28 | Biogen Idec Inc | Molekyler og fremgangsmåder til inhibering af udskillkelse af kim 1 |
| CA2512138C (en) | 2002-12-30 | 2013-07-16 | Biogen Idec Ma Inc. | Kim-1 antagonists and use to modulate immune system |
| US20050272101A1 (en) * | 2004-06-07 | 2005-12-08 | Prasad Devarajan | Method for the early detection of renal injury |
| CA2565701A1 (en) * | 2004-05-06 | 2005-11-17 | Jonathan M. Barasch | Ngal for reduction and amelioration of ischemic and nephrotoxic injuries |
| DK1831699T3 (da) * | 2004-12-20 | 2010-03-15 | Antibodyshop As | Bestemmelse af neutrofil gelatine-associeret lipocalin (NGAL) som en diagnostisk markør for nyresygdomme |
| EP1865985B1 (en) | 2005-03-02 | 2010-08-25 | Biogen Idec MA Inc. | Kim-1 antibodies for treatment of th2-mediated conditions |
| US20070037232A1 (en) * | 2005-03-31 | 2007-02-15 | Barasch Jonathan M | Detection of NGAL in chronic renal disease |
| US20070087387A1 (en) | 2005-04-21 | 2007-04-19 | Prasad Devarajan | Method for the Early Detection of Renal Disease Using Proteomics |
| US7700299B2 (en) | 2005-08-12 | 2010-04-20 | Hoffmann-La Roche Inc. | Method for predicting the response to a treatment |
| US20080090304A1 (en) * | 2006-10-13 | 2008-04-17 | Barasch Jonathan Matthew | Diagnosis and monitoring of chronic renal disease using ngal |
| PL2035835T3 (pl) * | 2006-05-30 | 2012-05-31 | Antibodyshop As | Sposoby szybkiej oceny ciężkości urazu |
| WO2008017306A1 (en) * | 2006-08-07 | 2008-02-14 | Antibodyshop A/S | Diagnostic test to exclude significant renal injury |
| EP2137538B1 (en) * | 2007-03-21 | 2014-04-09 | Bioporto Diagnostics A/s | Diagnostic test for renal injury |
| EP2479571A3 (en) | 2007-03-26 | 2012-09-26 | Novartis AG | Predictive renal safety biomarkers and biomarker signatures to monitor kidney function |
| US20090104649A1 (en) | 2007-06-11 | 2009-04-23 | Garovic Vesna D | Markers for preeclampsia |
| US8846036B2 (en) | 2007-10-19 | 2014-09-30 | Abbott Laboratories | Antibodies that bind to mammalian NGAL and uses thereof |
| EP2215481B2 (en) * | 2007-11-15 | 2017-01-18 | Bioporto Diagnostics A/S | Diagnostic use of individual molecular forms of a biomarker |
| EP2075343A1 (en) * | 2007-12-21 | 2009-07-01 | Gert Mayer | A method of diagnosing a progressive disease |
| US8338096B2 (en) * | 2008-04-15 | 2012-12-25 | Rainer Oberbauer | Markers of acute kidney failure |
| US7977110B2 (en) | 2008-06-02 | 2011-07-12 | Children's Hospital Medical Center | Method for distinguishing between kidney dysfunctions |
| ES2341419B1 (es) * | 2008-08-14 | 2011-05-03 | Hospital Clinic I Provincial De Barcelona | Wnt1 como biomarcador de daño renal. |
| WO2010054025A1 (en) * | 2008-11-05 | 2010-05-14 | Abbott Laboratories | Neutrophil gelatinase-associated lipocalin (ngal) protein isoforms enriched from urine and recombinant chinese hamster ovary (cho) cells and related compositions, antibodies, and methods of enrichment, analysis and use |
| CN104330574B (zh) * | 2008-11-10 | 2017-04-12 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
| EP2364370B1 (en) * | 2008-11-22 | 2014-09-03 | Astute Medical, Inc. | Methods for prognosis of acute renal failure |
| EP2379752B1 (fr) * | 2009-01-19 | 2015-09-30 | Biomérieux S.A. | Procedes pour determiner la susceptibilite a contracter une infection nosocomiale chez un patient et pour etablir un pronostic d'evolution d'un syndrome septique |
| DK2391653T3 (en) * | 2009-01-28 | 2015-02-09 | Ind Tech Res Inst | Biomarkers associated nephropathy |
| WO2011017685A1 (en) * | 2009-08-07 | 2011-02-10 | Rules-Based Medicine, Inc. | Methods and devices for detecting kidney transplant rejection |
| ES2530866T3 (es) | 2009-12-21 | 2015-03-06 | Mayo Foundation | Marcador temprano de proteinuria en pacientes tratados con un tratamiento anti-VEGF |
| US9476868B2 (en) | 2009-12-23 | 2016-10-25 | Hill's Pet Nutrition, Inc. | Compositions and methods for diagnosing and treating kidney disorders in a canine |
| JP2013529907A (ja) | 2010-05-24 | 2013-07-25 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | Ｎｇａｌタンパク質変異体及びその使用 |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2857499A1 (en) | 2010-10-01 | 2015-04-08 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| JP5804629B2 (ja) * | 2011-07-29 | 2015-11-04 | 株式会社メディクローム | 遺伝子発現変動解析による化学物質の毒性評価方法 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| CA2845117A1 (en) * | 2011-09-14 | 2013-03-21 | Basf Se | Means and methods for assessing kidney toxicity |
| PT3682905T (pt) | 2011-10-03 | 2022-04-07 | Modernatx Inc | Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações |
| ES2923757T3 (es) | 2011-12-16 | 2022-09-30 | Modernatx Inc | Composiciones de ARNm modificado |
| WO2013151664A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| AU2013334276B2 (en) | 2012-10-24 | 2019-07-04 | ProKidney IPCo, LLC | Renal cell populations and uses thereof |
| EP2925337B1 (en) | 2012-11-21 | 2019-07-03 | The Trustees of Columbia University in the City of New York | Mutant ngal proteins and uses thereof |
| PT2922554T (pt) | 2012-11-26 | 2022-06-28 | Modernatx Inc | Arn modificado nas porções terminais |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US10420337B2 (en) | 2013-03-15 | 2019-09-24 | Lifeline Scientific, Inc. | Transporter with a glucose sensor for determining viability of an organ or tissue |
| US10077439B2 (en) | 2013-03-15 | 2018-09-18 | Modernatx, Inc. | Removal of DNA fragments in mRNA production process |
| WO2014182330A1 (en) | 2013-05-06 | 2014-11-13 | Hitachi Chemical Company Ltd | Devices and methods for capturing target molecules |
| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| WO2015153860A1 (en) * | 2014-04-04 | 2015-10-08 | Somalogic, Inc. | Glomerular filtration rate biomarkers and uses thereof |
| WO2015160805A1 (en) * | 2014-04-15 | 2015-10-22 | The Brigham And Women's Hospital, Inc. | Circulating kim-1 levels for detection of pathologies associated with injury to, or cancer of, the kidney |
| US10712349B2 (en) | 2014-04-15 | 2020-07-14 | The Brigham And Women's Hospital, Inc. | Circulating KIM-1 levels for detection of pathologies associated with injury to, or cancer of, the kidney |
| US10801066B2 (en) | 2014-09-05 | 2020-10-13 | American University Of Beirut | Determination of risk for development of cardiovascular disease by measuring urinary levels of podocin and nephrin messenger RNA |
| WO2016077537A1 (en) * | 2014-11-12 | 2016-05-19 | Hitachi Chemical Co., Ltd. | Method and device for diagnosing organ injury |
| WO2016208776A1 (ja) | 2015-06-25 | 2016-12-29 | 株式会社国際電気通信基礎技術研究所 | 多器官連関システムを基盤とした予測装置、及び予測プログラム |
| JP6624704B2 (ja) | 2015-08-31 | 2019-12-25 | 日立化成株式会社 | 尿路上皮疾患の評価のための分子法 |
| CN114594268A (zh) | 2016-03-29 | 2022-06-07 | 无限生物制药公司 | 用以预防或治疗肾脏疾病的活性组分的候选物质的筛选装置和筛选方法 |
| JP6332780B2 (ja) | 2016-03-29 | 2018-05-30 | 株式会社国際電気通信基礎技術研究所 | 医薬組成物又は食品組成物、及び有効成分の体内での効果の評価方法 |
| EP3472347B1 (en) * | 2016-06-17 | 2023-01-04 | F. Hoffmann-La Roche AG | In vitro nephrotoxicity screening assay |
| US12174201B2 (en) | 2017-10-12 | 2024-12-24 | Cedars-Sinai Medical Center | Prognosis and progression biomarkers for chronic kidney disease |
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| ZA951461B (en) * | 1994-02-22 | 1996-01-24 | Univ Illinois | Genes and genetic elements associated with sensitivity to platimun-based drugs |
| US6586389B1 (en) * | 1998-01-22 | 2003-07-01 | Administrators Of The Tulane Educational Fund | Cubilin protein, DNA sequences encoding cubilin and uses thereof |
| CA2340589A1 (en) * | 1998-08-28 | 2000-03-09 | Incyte Pharmaceuticals, Inc. | Toxicological response markers |
| WO2000047761A2 (en) * | 1999-02-12 | 2000-08-17 | Phase-1 Molecular Toxicology, Inc. | High-throughput toxicological testing using cultured organisms and cells |
| US20010034023A1 (en) * | 1999-04-26 | 2001-10-25 | Stanton Vincent P. | Gene sequence variations with utility in determining the treatment of disease, in genes relating to drug processing |
| AU1466001A (en) * | 1999-11-05 | 2001-05-14 | Phase-1 Molecular Toxicology | Methods of determining individual hypersensitivity to an agent |
| US20020037508A1 (en) * | 2000-01-19 | 2002-03-28 | Michele Cargill | Human single nucleotide polymorphisms |
| AU2001275346A1 (en) * | 2000-06-05 | 2001-12-17 | General Hospital Corporation | Compositions, kits, and methods for identification and modulation of type i diabetes |
| JP2004500879A (ja) * | 2000-06-16 | 2004-01-15 | バイオジェン インコーポレイテッド | 腎の調節エレメントおよびそれらの使用方法 |
| EP1356093A2 (en) * | 2000-06-21 | 2003-10-29 | Hitachi Chemical Co., Ltd. | Gene markers for lung cancer |
| AU2001271998A1 (en) * | 2000-07-13 | 2002-01-30 | The Johns Hopkins University School Of Medicine | Detection and treatment of polycystic kidney disease |
| AU2001281322A1 (en) * | 2000-07-13 | 2002-01-30 | Biogen, Inc. | Methods of identifying renal protective factors |
| JP2004522411A (ja) * | 2000-07-31 | 2004-07-29 | ジーン ロジック インコーポレイテッド | 分子毒性学モデリング |
| DE10056802B4 (de) * | 2000-11-14 | 2005-06-16 | Epigenomics Ag | Verfahren zur Detektion von Methylierungszuständen zur toxikologischen Diagnostik |
| CA2440008A1 (en) * | 2001-01-29 | 2002-08-29 | Phase-1 Molecular Toxicology, Inc. | Rat toxicologically relevant genes and uses thereof |
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Also Published As
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| WO2004005544A3 (en) | 2004-04-22 |
| AU2003250879B2 (en) | 2007-07-26 |
| CN1688715A (zh) | 2005-10-26 |
| EP1925677A2 (en) | 2008-05-28 |
| IL165883A0 (en) | 2006-01-15 |
| JP2005531321A (ja) | 2005-10-20 |
| EP1521847A2 (en) | 2005-04-13 |
| WO2004005544A2 (en) | 2004-01-15 |
| AU2003250879A1 (en) | 2004-01-23 |
| US20060008804A1 (en) | 2006-01-12 |
| EP1925677A3 (en) | 2008-07-02 |
| BR0312405A (pt) | 2005-04-26 |
| GB0215509D0 (en) | 2002-08-14 |
| JP2010042019A (ja) | 2010-02-25 |
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