JP2005528414A - 肝臓癌および他の癌疾患の処置用エポチロン誘導体 - Google Patents
肝臓癌および他の癌疾患の処置用エポチロン誘導体 Download PDFInfo
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- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Silicon Polymers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37706302P | 2002-05-01 | 2002-05-01 | |
| PCT/EP2003/004581 WO2003092683A1 (en) | 2002-05-01 | 2003-04-30 | Epothilone derivative for the treatment of hepatoma and other cancer diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005528414A true JP2005528414A (ja) | 2005-09-22 |
| JP2005528414A5 JP2005528414A5 (enExample) | 2006-06-08 |
Family
ID=29401440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004500867A Pending JP2005528414A (ja) | 2002-05-01 | 2003-04-30 | 肝臓癌および他の癌疾患の処置用エポチロン誘導体 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US20050282873A1 (enExample) |
| EP (1) | EP1503756B1 (enExample) |
| JP (1) | JP2005528414A (enExample) |
| KR (1) | KR20040106422A (enExample) |
| CN (1) | CN1649585A (enExample) |
| AT (1) | ATE439130T1 (enExample) |
| AU (1) | AU2003227702B2 (enExample) |
| BR (1) | BR0309711A (enExample) |
| CA (1) | CA2483826C (enExample) |
| CY (1) | CY1109607T1 (enExample) |
| DE (1) | DE60328772D1 (enExample) |
| DK (1) | DK1503756T3 (enExample) |
| ES (1) | ES2330324T3 (enExample) |
| IL (1) | IL164783A (enExample) |
| MX (1) | MXPA04010853A (enExample) |
| NO (1) | NO20045249L (enExample) |
| NZ (1) | NZ536178A (enExample) |
| PL (1) | PL211114B1 (enExample) |
| PT (1) | PT1503756E (enExample) |
| RU (1) | RU2358730C2 (enExample) |
| SI (1) | SI1503756T1 (enExample) |
| WO (1) | WO2003092683A1 (enExample) |
| ZA (1) | ZA200408492B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2358730C2 (ru) * | 2002-05-01 | 2009-06-20 | Новартис Аг | Производное эпотилона для лечения гепатомы и других раковых заболеваний |
| BRPI0414043A (pt) * | 2003-09-02 | 2006-10-24 | Novartis Ag | tratamento de cáncer com epotilonas |
| US8394365B2 (en) * | 2003-09-17 | 2013-03-12 | Nektar Therapeutics | Multi-arm polymer prodrugs |
| EP1640004A1 (en) * | 2004-09-24 | 2006-03-29 | Schering Aktiengesellschaft | Use of epothilones in the treatment of bone metastases and bone tumors or cancers |
| US20060134214A1 (en) * | 2004-11-18 | 2006-06-22 | Ismat Ullah | Enteric coated bead comprising epothilone or epothilone analog, and preparation and administration thereof |
| US20060121511A1 (en) | 2004-11-30 | 2006-06-08 | Hyerim Lee | Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents |
| JP2008536479A (ja) | 2005-02-11 | 2008-09-11 | ユニバーシティ オブ サザン カリフォルニア | ジスルフィド架橋を有するタンパク質の発現法 |
| EP2029156A4 (en) | 2006-05-01 | 2010-07-21 | Univ Southern California | COMBINATION THERAPY FOR CANCER TREATMENT |
| MX2008004267A (es) * | 2008-03-28 | 2009-09-28 | Posi Visionary Solutions Llp | Metoclopramida de liberacion prolongada de 12 horas. |
| MX2008004268A (es) * | 2008-03-28 | 2009-09-28 | Posi Visionary Solutions Llp | Metoclopramida de liberacion prolongada de 24 horas. |
| US8802394B2 (en) | 2008-11-13 | 2014-08-12 | Radu O. Minea | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
| CN101747326B (zh) * | 2010-01-12 | 2012-07-25 | 山东大学 | 18元大环内酯类埃博霉素化合物及其应用 |
| WO2011146638A1 (en) | 2010-05-18 | 2011-11-24 | Cerulean Pharma Inc. | Compositions and methods for treatment of autoimmune and other diseases |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204388B1 (en) * | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6660758B1 (en) * | 1996-12-13 | 2003-12-09 | The Scripps Research Institute | Epothilone analogs |
| US6194181B1 (en) * | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| US6302838B1 (en) * | 1998-02-25 | 2001-10-16 | Novartis Ag | Cancer treatment with epothilones |
| ATE254615T1 (de) * | 1999-02-22 | 2003-12-15 | Biotechnolog Forschung Gmbh | C-21 modifizierte epothilone |
| GB9918429D0 (en) * | 1999-08-04 | 1999-10-06 | Novartis Ag | Organic compounds |
| RU2358730C2 (ru) * | 2002-05-01 | 2009-06-20 | Новартис Аг | Производное эпотилона для лечения гепатомы и других раковых заболеваний |
-
2003
- 2003-04-30 RU RU2004135307/15A patent/RU2358730C2/ru not_active IP Right Cessation
- 2003-04-30 MX MXPA04010853A patent/MXPA04010853A/es active IP Right Grant
- 2003-04-30 AU AU2003227702A patent/AU2003227702B2/en not_active Ceased
- 2003-04-30 AT AT03725129T patent/ATE439130T1/de active
- 2003-04-30 SI SI200331688T patent/SI1503756T1/sl unknown
- 2003-04-30 JP JP2004500867A patent/JP2005528414A/ja active Pending
- 2003-04-30 PL PL371727A patent/PL211114B1/pl not_active IP Right Cessation
- 2003-04-30 EP EP03725129A patent/EP1503756B1/en not_active Expired - Lifetime
- 2003-04-30 NZ NZ536178A patent/NZ536178A/en not_active IP Right Cessation
- 2003-04-30 CA CA2483826A patent/CA2483826C/en not_active Expired - Fee Related
- 2003-04-30 DK DK03725129T patent/DK1503756T3/da active
- 2003-04-30 US US10/512,504 patent/US20050282873A1/en not_active Abandoned
- 2003-04-30 WO PCT/EP2003/004581 patent/WO2003092683A1/en not_active Ceased
- 2003-04-30 DE DE60328772T patent/DE60328772D1/de not_active Expired - Lifetime
- 2003-04-30 PT PT03725129T patent/PT1503756E/pt unknown
- 2003-04-30 ES ES03725129T patent/ES2330324T3/es not_active Expired - Lifetime
- 2003-04-30 KR KR10-2004-7017468A patent/KR20040106422A/ko not_active Ceased
- 2003-04-30 BR BR0309711-0A patent/BR0309711A/pt active Search and Examination
- 2003-04-30 CN CNA038097702A patent/CN1649585A/zh active Pending
-
2004
- 2004-10-20 ZA ZA200408492A patent/ZA200408492B/en unknown
- 2004-10-21 IL IL164783A patent/IL164783A/en not_active IP Right Cessation
- 2004-11-30 NO NO20045249A patent/NO20045249L/no not_active Application Discontinuation
-
2008
- 2008-03-11 US US12/046,017 patent/US20080161369A1/en not_active Abandoned
-
2009
- 2009-11-11 CY CY20091101180T patent/CY1109607T1/el unknown
Non-Patent Citations (5)
| Title |
|---|
| JPN5001008509, Ｊ． Ｂｉｏ． Ｃｈｅｍ．, 1997, Ｖｏｌ． ２７２, ２５３４−２５４１ * |
| JPN5001008510, Ａｎｇｅｗ． Ｃｈｅｍ． Ｉｎｔ． Ｅｄ． Ｅｎｇｌ．, 1997, Ｖｏｌ． ３６, ２０９３−２０９６ * |
| JPN5001008513, Ｃａｎｃｅｒ Ｒｅｓ, 1995, Ｖｏｌ． ５５, ２３２５−２３３３ * |
| JPN5001008516, Ｎａｔｕｒｅ, 1997, Ｖｏｌ．３８７, ２６８−２７２ * |
| JPN5001008520, Ｊ． Ｂｉｏｌ． Ｃｈｅｍ．, 1997, Ｖｏｌ．２７２, １７１１８−１７１２５ * |
Also Published As
| Publication number | Publication date |
|---|---|
| IL164783A0 (en) | 2005-12-18 |
| CN1649585A (zh) | 2005-08-03 |
| RU2358730C2 (ru) | 2009-06-20 |
| PL211114B1 (pl) | 2012-04-30 |
| AU2003227702B2 (en) | 2007-07-26 |
| ES2330324T3 (es) | 2009-12-09 |
| CA2483826C (en) | 2012-04-17 |
| MXPA04010853A (es) | 2005-02-14 |
| US20080161369A1 (en) | 2008-07-03 |
| RU2004135307A (ru) | 2005-09-10 |
| NZ536178A (en) | 2007-10-26 |
| EP1503756B1 (en) | 2009-08-12 |
| IL164783A (en) | 2011-08-31 |
| PL371727A1 (en) | 2005-06-27 |
| DK1503756T3 (da) | 2009-11-16 |
| WO2003092683A1 (en) | 2003-11-13 |
| NO20045249L (no) | 2005-01-26 |
| AU2003227702A1 (en) | 2003-11-17 |
| HK1073601A1 (en) | 2005-10-14 |
| SI1503756T1 (sl) | 2010-01-29 |
| DE60328772D1 (de) | 2009-09-24 |
| CA2483826A1 (en) | 2003-11-13 |
| ZA200408492B (en) | 2006-09-27 |
| US20050282873A1 (en) | 2005-12-22 |
| CY1109607T1 (el) | 2014-08-13 |
| ATE439130T1 (de) | 2009-08-15 |
| PT1503756E (pt) | 2009-10-28 |
| BR0309711A (pt) | 2005-02-09 |
| EP1503756A1 (en) | 2005-02-09 |
| KR20040106422A (ko) | 2004-12-17 |
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