JP2005527558A5 - - Google Patents
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- Publication number
- JP2005527558A5 JP2005527558A5 JP2003579837A JP2003579837A JP2005527558A5 JP 2005527558 A5 JP2005527558 A5 JP 2005527558A5 JP 2003579837 A JP2003579837 A JP 2003579837A JP 2003579837 A JP2003579837 A JP 2003579837A JP 2005527558 A5 JP2005527558 A5 JP 2005527558A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- formulation
- hydrogen
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000009472 formulation Methods 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 210000000988 bone and bone Anatomy 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 230000008468 bone growth Effects 0.000 claims 3
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 229910052805 deuterium Inorganic materials 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 125000001118 alkylidene group Chemical group 0.000 claims 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000011612 calcitriol Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 239000004053 dental implant Substances 0.000 claims 1
- 125000005345 deuteroalkyl group Chemical group 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 230000011164 ossification Effects 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000003239 periodontal effect Effects 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 claims 1
- 0 C[C@@](CCC1)(C(*)CC2)[C@@]2C1=CC=C1C(*)(*)[C@@](*)[C@@](*)[C@@](*)C1 Chemical compound C[C@@](CCC1)(C(*)CC2)[C@@]2C1=CC=C1C(*)(*)[C@@](*)[C@@](*)[C@@](*)C1 0.000 description 5
- UHMPCVGLSKFXHR-ORJZRCFFSA-N C[C@@H](CCCC(C)(C)O)C(CC1)[C@@](C)(CCC2)C1/C2=C/C=C(C[C@H](C1=C)O)C[C@H]1O Chemical compound C[C@@H](CCCC(C)(C)O)C(CC1)[C@@](C)(CCC2)C1/C2=C/C=C(C[C@H](C1=C)O)C[C@H]1O UHMPCVGLSKFXHR-ORJZRCFFSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/105,826 US20030195175A1 (en) | 2002-03-25 | 2002-03-25 | Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone |
| PCT/US2003/007443 WO2003082300A1 (en) | 2002-03-25 | 2003-03-12 | Use of carbon-2-modified-vitamin d analogs to induce the formation of new bone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005527558A JP2005527558A (ja) | 2005-09-15 |
| JP2005527558A5 true JP2005527558A5 (https=) | 2006-04-06 |
Family
ID=28673538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003579837A Pending JP2005527558A (ja) | 2002-03-25 | 2003-03-12 | 新しい骨の形成を誘導するための炭素−２−修飾−１９−ノル−ビタミンｄ類似化合物の使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US20030195175A1 (https=) |
| EP (1) | EP1494680B1 (https=) |
| JP (1) | JP2005527558A (https=) |
| KR (1) | KR100983953B1 (https=) |
| CN (1) | CN100531739C (https=) |
| AT (1) | ATE406901T1 (https=) |
| AU (1) | AU2003220169B2 (https=) |
| BR (1) | BR0308701A (https=) |
| CA (1) | CA2480125C (https=) |
| DE (1) | DE60323351D1 (https=) |
| DK (1) | DK1494680T3 (https=) |
| ES (1) | ES2312764T3 (https=) |
| HK (1) | HK1079996B (https=) |
| IL (1) | IL164275A0 (https=) |
| MX (1) | MXPA04009288A (https=) |
| NZ (1) | NZ535843A (https=) |
| PL (1) | PL372346A1 (https=) |
| PT (1) | PT1494680E (https=) |
| WO (1) | WO2003082300A1 (https=) |
| ZA (1) | ZA200408153B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005027928A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | 2-alkylidene-19-nor-vit amin d derivatives for the treatment of hypocalcemic tetany or hyproparathyroidism |
| WO2005027914A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | 2-alkylidene-19-nor-vitamin d derivatives for the treatment of frailty, muscle damage or sarcopenia |
| NZ545393A (en) * | 2003-09-19 | 2009-10-30 | Wisconsin Alumni Res Found | 2-Alkylidene-19-nor-vitamin D derivatives for the treatment of osteopenia or male osteoporosis |
| WO2005027919A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | 2-alkylidene-19-nor-vitamin d derivatives for the treatment of a second hip fracture |
| CA2539361A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and an estrogen agonist/antagonist |
| US7214671B2 (en) * | 2004-02-19 | 2007-05-08 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 for the prophylaxis of bone diseases |
| CA2563872C (en) * | 2004-05-07 | 2014-11-25 | Wisconsin Alumni Research Foundation | Method of forming mesenchymal stem cells from embryonic stem cells |
| WO2006061683A1 (en) * | 2004-12-09 | 2006-06-15 | Pfizer Products Inc. | 2-alkylidene-19-nor-vitamin d derivatives for the treatment of osteogenesis imperfecta |
| US7803789B2 (en) * | 2006-02-02 | 2010-09-28 | Wisconsin Alumni Research Foundation | Vitamin D analog—RAK, methods and uses thereof |
| US7528122B2 (en) * | 2006-02-02 | 2009-05-05 | Wisconsin Alumni Research Foundation | Vitamin D analog—NEL, methods and uses thereof |
| WO2010120698A1 (en) * | 2009-04-17 | 2010-10-21 | Vidasym, Llc | Vitamin d receptor agonists and uses thereof |
| JP6971966B2 (ja) * | 2015-08-05 | 2021-11-24 | ウイスコンシン アラムニ リサーチ ファンデーション | カルシトリオールの２−メチレン類似体および関連化合物の合成および生物活性 |
| CN111588506B (zh) * | 2020-01-02 | 2022-01-25 | 南京医科大学 | 一种含维生素c的钛种植体存储液的应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US584928A (en) * | 1897-06-22 | Schlag | ||
| US4666634A (en) * | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| IL74617A (en) * | 1985-03-15 | 1988-11-15 | Yeda Res & Dev | Compositions comprising a vitamin d derivative and method for the local treatment of bone fractures in animals |
| US5246925A (en) * | 1989-03-09 | 1993-09-21 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D compounds for use in treating hyperparathyroidism |
| CA1333616C (en) * | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
| US5556645A (en) * | 1990-01-12 | 1996-09-17 | Bockman; Richard | Methods of enhancing wound healing and tissue repair |
| US5086191A (en) * | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| DE69400495T2 (de) * | 1993-04-05 | 1997-04-30 | Wisconsin Alumni Res Found | 19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle |
| US5565589A (en) * | 1993-11-03 | 1996-10-15 | Wisconsin Alumni Research Foundation | 17-formyl-5,6-trans-vitamin D compounds |
| US5428029A (en) * | 1993-11-24 | 1995-06-27 | Hoffmann-La Roche Inc. | Vitamin D3 fluorinated analogs |
| JP3372259B2 (ja) * | 1995-09-21 | 2003-01-27 | ウィスコンシン・アルムニ・リサーチ・ファウンデーション | カルシトリオール誘導体およびそれらの用途 |
| US5976142A (en) * | 1996-10-16 | 1999-11-02 | Chin; Martin | Apparatus and method for distraction osteogenesis of small alveolar bone |
| US6306844B1 (en) * | 1997-03-17 | 2001-10-23 | Wisconsin Alumni Research Foundation | Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US5945410A (en) * | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| ES2320603T3 (es) * | 1997-07-30 | 2009-05-25 | Emory University | Sistemas de expresion, vectores, adn, proteinas de mineralizacion osea novedosos. |
| WO2002005823A2 (en) * | 2000-07-14 | 2002-01-24 | Wisconsin Alumni Research Foundation | USE OF 2-METHYLENE-19-NOR-20(S)-1α,25-DIHYDROXYVITAMIN D3 TO INCREASE BONE STRENGTH |
-
2002
- 2002-03-25 US US10/105,826 patent/US20030195175A1/en not_active Abandoned
-
2003
- 2003-03-12 NZ NZ535843A patent/NZ535843A/xx not_active IP Right Cessation
- 2003-03-12 EP EP03716465A patent/EP1494680B1/en not_active Expired - Lifetime
- 2003-03-12 CA CA002480125A patent/CA2480125C/en not_active Expired - Fee Related
- 2003-03-12 BR BR0308701-8A patent/BR0308701A/pt not_active Application Discontinuation
- 2003-03-12 MX MXPA04009288A patent/MXPA04009288A/es active IP Right Grant
- 2003-03-12 JP JP2003579837A patent/JP2005527558A/ja active Pending
- 2003-03-12 IL IL16427503A patent/IL164275A0/xx not_active IP Right Cessation
- 2003-03-12 PT PT03716465T patent/PT1494680E/pt unknown
- 2003-03-12 PL PL03372346A patent/PL372346A1/xx unknown
- 2003-03-12 WO PCT/US2003/007443 patent/WO2003082300A1/en not_active Ceased
- 2003-03-12 ES ES03716465T patent/ES2312764T3/es not_active Expired - Lifetime
- 2003-03-12 DE DE60323351T patent/DE60323351D1/de not_active Expired - Lifetime
- 2003-03-12 US US10/509,065 patent/US20050203071A1/en not_active Abandoned
- 2003-03-12 HK HK06100147.6A patent/HK1079996B/zh not_active IP Right Cessation
- 2003-03-12 KR KR1020047015427A patent/KR100983953B1/ko not_active Expired - Fee Related
- 2003-03-12 AT AT03716465T patent/ATE406901T1/de active
- 2003-03-12 CN CNB038119684A patent/CN100531739C/zh not_active Expired - Fee Related
- 2003-03-12 AU AU2003220169A patent/AU2003220169B2/en not_active Ceased
- 2003-03-12 DK DK03716465T patent/DK1494680T3/da active
-
2004
- 2004-10-08 ZA ZA200408153A patent/ZA200408153B/xx unknown
-
2010
- 2010-12-02 US US12/958,879 patent/US20110112056A1/en not_active Abandoned
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