CN100531739C - 碳2位修饰的19-去甲-维生素d类似物在制备诱导新骨生成药物中的应用 - Google Patents

碳2位修饰的19-去甲-维生素d类似物在制备诱导新骨生成药物中的应用 Download PDF

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CN100531739C
CN100531739C CNB038119684A CN03811968A CN100531739C CN 100531739 C CN100531739 C CN 100531739C CN B038119684 A CNB038119684 A CN B038119684A CN 03811968 A CN03811968 A CN 03811968A CN 100531739 C CN100531739 C CN 100531739C
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group
compound
hydrogen
vitamin
bone
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CN1655797A (zh
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赫克托·F.·德鲁卡
J.·韦斯利·派克
尼茹帕玛·K.·舍弗德
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Wisconsin Alumni Research Foundation
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Wisconsin Alumni Research Foundation
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)
CNB038119684A 2002-03-25 2003-03-12 碳2位修饰的19-去甲-维生素d类似物在制备诱导新骨生成药物中的应用 Expired - Fee Related CN100531739C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/105,826 2002-03-25
US10/105,826 US20030195175A1 (en) 2002-03-25 2002-03-25 Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone

Publications (2)

Publication Number Publication Date
CN1655797A CN1655797A (zh) 2005-08-17
CN100531739C true CN100531739C (zh) 2009-08-26

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CNB038119684A Expired - Fee Related CN100531739C (zh) 2002-03-25 2003-03-12 碳2位修饰的19-去甲-维生素d类似物在制备诱导新骨生成药物中的应用

Country Status (20)

Country Link
US (3) US20030195175A1 (https=)
EP (1) EP1494680B1 (https=)
JP (1) JP2005527558A (https=)
KR (1) KR100983953B1 (https=)
CN (1) CN100531739C (https=)
AT (1) ATE406901T1 (https=)
AU (1) AU2003220169B2 (https=)
BR (1) BR0308701A (https=)
CA (1) CA2480125C (https=)
DE (1) DE60323351D1 (https=)
DK (1) DK1494680T3 (https=)
ES (1) ES2312764T3 (https=)
HK (1) HK1079996B (https=)
IL (1) IL164275A0 (https=)
MX (1) MXPA04009288A (https=)
NZ (1) NZ535843A (https=)
PL (1) PL372346A1 (https=)
PT (1) PT1494680E (https=)
WO (1) WO2003082300A1 (https=)
ZA (1) ZA200408153B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100413507C (zh) * 2003-09-19 2008-08-27 威斯康星州男校友研究基金会 治疗骨质稀少或雄性骨质疏松的2-亚烷基-19-去甲-维生素d衍生物
RU2326674C2 (ru) * 2003-09-19 2008-06-20 Пфайзер Продактс Инк. Производные 2-алкилиден-19-нор-витамина d для лечения слабости, поражения мышц или саркопении
BRPI0414448A (pt) * 2003-09-19 2006-11-14 Pfizer Prod Inc composições farmacêuticas e métodos compreendendo combinações de derivados de 2-alquilideno-19-nor-vitamina d e um agonista/antagonista de estrogênio
WO2005027928A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. 2-alkylidene-19-nor-vit amin d derivatives for the treatment of hypocalcemic tetany or hyproparathyroidism
WO2005027919A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. 2-alkylidene-19-nor-vitamin d derivatives for the treatment of a second hip fracture
US7214671B2 (en) * 2004-02-19 2007-05-08 Wisconsin Alumni Research Foundation Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 for the prophylaxis of bone diseases
KR20070015588A (ko) 2004-05-07 2007-02-05 위스콘신 얼럼나이 리서어치 화운데이션 배아 줄기 세포로부터 중간엽 줄기 세포를 형성하는 방법
WO2006061683A1 (en) * 2004-12-09 2006-06-15 Pfizer Products Inc. 2-alkylidene-19-nor-vitamin d derivatives for the treatment of osteogenesis imperfecta
US7803789B2 (en) * 2006-02-02 2010-09-28 Wisconsin Alumni Research Foundation Vitamin D analog—RAK, methods and uses thereof
US7528122B2 (en) 2006-02-02 2009-05-05 Wisconsin Alumni Research Foundation Vitamin D analog—NEL, methods and uses thereof
WO2010120698A1 (en) * 2009-04-17 2010-10-21 Vidasym, Llc Vitamin d receptor agonists and uses thereof
CA2991260A1 (en) * 2015-08-05 2017-02-09 Wisconsin Alumni Research Foundation Synthesis and biological activity of 2-methylene analogs of calcitriol and related compounds
CN111588506B (zh) * 2020-01-02 2022-01-25 南京医科大学 一种含维生素c的钛种植体存储液的应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997011053A1 (en) * 1995-09-21 1997-03-27 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
WO1998041500A1 (en) * 1997-03-17 1998-09-24 Wisconsin Alumni Research Foundation 2-alkyl-19-nor-vitamin d compounds
WO1998041501A1 (en) * 1997-03-17 1998-09-24 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin d compounds
WO2001074766A1 (en) * 2000-03-31 2001-10-11 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin d compounds and their therapeutic uses
WO2002005823A2 (en) * 2000-07-14 2002-01-24 Wisconsin Alumni Research Foundation USE OF 2-METHYLENE-19-NOR-20(S)-1α,25-DIHYDROXYVITAMIN D3 TO INCREASE BONE STRENGTH
WO2002005824A1 (en) * 2000-07-14 2002-01-24 Wisconsin Alumni Research Foundation USE OF 2α-METHYL-19-NOR-20(S)-1α,25-DIHYDROXYVITAMIN D3 TO INCREASE BONE STRENGTH

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US584928A (en) * 1897-06-22 Schlag
US4666634A (en) * 1984-12-05 1987-05-19 Chugai Seiyaku Kabushiki Kaisha vitamin D3 derivatives having a substituent at 2-position
IL74617A (en) * 1985-03-15 1988-11-15 Yeda Res & Dev Compositions comprising a vitamin d derivative and method for the local treatment of bone fractures in animals
US5246925A (en) * 1989-03-09 1993-09-21 Wisconsin Alumni Research Foundation 19-nor-vitamin D compounds for use in treating hyperparathyroidism
CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
US5556645A (en) * 1990-01-12 1996-09-17 Bockman; Richard Methods of enhancing wound healing and tissue repair
US5086191A (en) * 1991-05-28 1992-02-04 Wisconsin Alumni Research Foundation Intermediates for the synthesis of 19-nor vitamin D compounds
EP0619306B1 (en) * 1993-04-05 1996-09-11 Wisconsin Alumni Research Foundation 19-Nor-vitamin D3 compounds with substituent at 2-position
US5565589A (en) * 1993-11-03 1996-10-15 Wisconsin Alumni Research Foundation 17-formyl-5,6-trans-vitamin D compounds
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
US5976142A (en) * 1996-10-16 1999-11-02 Chin; Martin Apparatus and method for distraction osteogenesis of small alveolar bone
ATE417927T1 (de) * 1997-07-30 2009-01-15 Univ Emory Neue knochenmineralisierungsproteine, dna, vektoren, expressionssysteme

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997011053A1 (en) * 1995-09-21 1997-03-27 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
WO1998041500A1 (en) * 1997-03-17 1998-09-24 Wisconsin Alumni Research Foundation 2-alkyl-19-nor-vitamin d compounds
WO1998041501A1 (en) * 1997-03-17 1998-09-24 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin d compounds
WO2001074766A1 (en) * 2000-03-31 2001-10-11 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin d compounds and their therapeutic uses
WO2002005823A2 (en) * 2000-07-14 2002-01-24 Wisconsin Alumni Research Foundation USE OF 2-METHYLENE-19-NOR-20(S)-1α,25-DIHYDROXYVITAMIN D3 TO INCREASE BONE STRENGTH
WO2002005824A1 (en) * 2000-07-14 2002-01-24 Wisconsin Alumni Research Foundation USE OF 2α-METHYL-19-NOR-20(S)-1α,25-DIHYDROXYVITAMIN D3 TO INCREASE BONE STRENGTH

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
New 1a,25-Dihydroxy-19-norvitamin D3 Compounds of HighBiological Activity: Synthesis and Biological Evaluation of2-Hydroxymethyl,2-Methyl,and 2-Methylene Analogs. Sicinski,Rafal R.,Prahl,Jean M.,Smith,Connie M.J.Med.Chem,Vol.41 No.23. 1998 *

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US20110112056A1 (en) 2011-05-12
WO2003082300A1 (en) 2003-10-09
ATE406901T1 (de) 2008-09-15
HK1079996A1 (zh) 2006-04-21
EP1494680A1 (en) 2005-01-12
JP2005527558A (ja) 2005-09-15
DK1494680T3 (da) 2008-11-17
BR0308701A (pt) 2005-01-18
US20030195175A1 (en) 2003-10-16
ES2312764T3 (es) 2009-03-01
CN1655797A (zh) 2005-08-17
PT1494680E (pt) 2008-10-21
IL164275A0 (en) 2005-12-18
KR100983953B1 (ko) 2010-09-27
AU2003220169A1 (en) 2003-10-13
CA2480125C (en) 2009-12-29
AU2003220169B2 (en) 2008-09-11
PL372346A1 (en) 2005-07-11
ZA200408153B (en) 2006-03-29
HK1079996B (zh) 2010-04-01
NZ535843A (en) 2006-03-31
EP1494680B1 (en) 2008-09-03
MXPA04009288A (es) 2005-06-08
DE60323351D1 (de) 2008-10-16
CA2480125A1 (en) 2003-10-09
US20050203071A1 (en) 2005-09-15
KR20040095346A (ko) 2004-11-12

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