DK1494680T3 - Anvendelse af carbon-2-modificerede-19-nor-vitamin-D-analoger til at inducere dannelsen af ny knogle - Google Patents

Anvendelse af carbon-2-modificerede-19-nor-vitamin-D-analoger til at inducere dannelsen af ny knogle

Info

Publication number
DK1494680T3
DK1494680T3 DK03716465T DK03716465T DK1494680T3 DK 1494680 T3 DK1494680 T3 DK 1494680T3 DK 03716465 T DK03716465 T DK 03716465T DK 03716465 T DK03716465 T DK 03716465T DK 1494680 T3 DK1494680 T3 DK 1494680T3
Authority
DK
Denmark
Prior art keywords
carbon
new bone
bone
modified
analogs
Prior art date
Application number
DK03716465T
Other languages
Danish (da)
English (en)
Inventor
J Wesley Pike
Nirupama K Shevde
Hector F Deluca
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=28673538&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1494680(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Application granted granted Critical
Publication of DK1494680T3 publication Critical patent/DK1494680T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)
DK03716465T 2002-03-25 2003-03-12 Anvendelse af carbon-2-modificerede-19-nor-vitamin-D-analoger til at inducere dannelsen af ny knogle DK1494680T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/105,826 US20030195175A1 (en) 2002-03-25 2002-03-25 Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone
PCT/US2003/007443 WO2003082300A1 (en) 2002-03-25 2003-03-12 Use of carbon-2-modified-vitamin d analogs to induce the formation of new bone

Publications (1)

Publication Number Publication Date
DK1494680T3 true DK1494680T3 (da) 2008-11-17

Family

ID=28673538

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03716465T DK1494680T3 (da) 2002-03-25 2003-03-12 Anvendelse af carbon-2-modificerede-19-nor-vitamin-D-analoger til at inducere dannelsen af ny knogle

Country Status (20)

Country Link
US (3) US20030195175A1 (https=)
EP (1) EP1494680B1 (https=)
JP (1) JP2005527558A (https=)
KR (1) KR100983953B1 (https=)
CN (1) CN100531739C (https=)
AT (1) ATE406901T1 (https=)
AU (1) AU2003220169B2 (https=)
BR (1) BR0308701A (https=)
CA (1) CA2480125C (https=)
DE (1) DE60323351D1 (https=)
DK (1) DK1494680T3 (https=)
ES (1) ES2312764T3 (https=)
HK (1) HK1079996B (https=)
IL (1) IL164275A0 (https=)
MX (1) MXPA04009288A (https=)
NZ (1) NZ535843A (https=)
PL (1) PL372346A1 (https=)
PT (1) PT1494680E (https=)
WO (1) WO2003082300A1 (https=)
ZA (1) ZA200408153B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100413507C (zh) * 2003-09-19 2008-08-27 威斯康星州男校友研究基金会 治疗骨质稀少或雄性骨质疏松的2-亚烷基-19-去甲-维生素d衍生物
RU2326674C2 (ru) * 2003-09-19 2008-06-20 Пфайзер Продактс Инк. Производные 2-алкилиден-19-нор-витамина d для лечения слабости, поражения мышц или саркопении
BRPI0414448A (pt) * 2003-09-19 2006-11-14 Pfizer Prod Inc composições farmacêuticas e métodos compreendendo combinações de derivados de 2-alquilideno-19-nor-vitamina d e um agonista/antagonista de estrogênio
WO2005027928A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. 2-alkylidene-19-nor-vit amin d derivatives for the treatment of hypocalcemic tetany or hyproparathyroidism
WO2005027919A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. 2-alkylidene-19-nor-vitamin d derivatives for the treatment of a second hip fracture
US7214671B2 (en) * 2004-02-19 2007-05-08 Wisconsin Alumni Research Foundation Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 for the prophylaxis of bone diseases
KR20070015588A (ko) 2004-05-07 2007-02-05 위스콘신 얼럼나이 리서어치 화운데이션 배아 줄기 세포로부터 중간엽 줄기 세포를 형성하는 방법
WO2006061683A1 (en) * 2004-12-09 2006-06-15 Pfizer Products Inc. 2-alkylidene-19-nor-vitamin d derivatives for the treatment of osteogenesis imperfecta
US7803789B2 (en) * 2006-02-02 2010-09-28 Wisconsin Alumni Research Foundation Vitamin D analog—RAK, methods and uses thereof
US7528122B2 (en) 2006-02-02 2009-05-05 Wisconsin Alumni Research Foundation Vitamin D analog—NEL, methods and uses thereof
WO2010120698A1 (en) * 2009-04-17 2010-10-21 Vidasym, Llc Vitamin d receptor agonists and uses thereof
CA2991260A1 (en) * 2015-08-05 2017-02-09 Wisconsin Alumni Research Foundation Synthesis and biological activity of 2-methylene analogs of calcitriol and related compounds
CN111588506B (zh) * 2020-01-02 2022-01-25 南京医科大学 一种含维生素c的钛种植体存储液的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US584928A (en) * 1897-06-22 Schlag
US4666634A (en) * 1984-12-05 1987-05-19 Chugai Seiyaku Kabushiki Kaisha vitamin D3 derivatives having a substituent at 2-position
IL74617A (en) * 1985-03-15 1988-11-15 Yeda Res & Dev Compositions comprising a vitamin d derivative and method for the local treatment of bone fractures in animals
US5246925A (en) * 1989-03-09 1993-09-21 Wisconsin Alumni Research Foundation 19-nor-vitamin D compounds for use in treating hyperparathyroidism
CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
US5556645A (en) * 1990-01-12 1996-09-17 Bockman; Richard Methods of enhancing wound healing and tissue repair
US5086191A (en) * 1991-05-28 1992-02-04 Wisconsin Alumni Research Foundation Intermediates for the synthesis of 19-nor vitamin D compounds
EP0619306B1 (en) * 1993-04-05 1996-09-11 Wisconsin Alumni Research Foundation 19-Nor-vitamin D3 compounds with substituent at 2-position
US5565589A (en) * 1993-11-03 1996-10-15 Wisconsin Alumni Research Foundation 17-formyl-5,6-trans-vitamin D compounds
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
JP3372259B2 (ja) * 1995-09-21 2003-01-27 ウィスコンシン・アルムニ・リサーチ・ファウンデーション カルシトリオール誘導体およびそれらの用途
US5976142A (en) * 1996-10-16 1999-11-02 Chin; Martin Apparatus and method for distraction osteogenesis of small alveolar bone
US5843928A (en) * 1997-03-17 1998-12-01 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin D compounds
US5945410A (en) * 1997-03-17 1999-08-31 Wisconsin Alumni Research Foundation 2-alkyl-19-nor-vitamin D compounds
US6306844B1 (en) * 1997-03-17 2001-10-23 Wisconsin Alumni Research Foundation Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength
US6392071B1 (en) * 1997-03-17 2002-05-21 Wisconsin Alumni: Research Foundation 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
ATE417927T1 (de) * 1997-07-30 2009-01-15 Univ Emory Neue knochenmineralisierungsproteine, dna, vektoren, expressionssysteme
MXPA03000406A (es) * 2000-07-14 2003-06-06 Wisconsin Alumni Res Found Uso de 2-metilen-19-nor-20(s)-1 alfa,25-dihidroxivitamina d3 para incrementar la resistencia de los huesos.

Also Published As

Publication number Publication date
US20110112056A1 (en) 2011-05-12
WO2003082300A1 (en) 2003-10-09
ATE406901T1 (de) 2008-09-15
HK1079996A1 (zh) 2006-04-21
EP1494680A1 (en) 2005-01-12
JP2005527558A (ja) 2005-09-15
BR0308701A (pt) 2005-01-18
US20030195175A1 (en) 2003-10-16
ES2312764T3 (es) 2009-03-01
CN1655797A (zh) 2005-08-17
PT1494680E (pt) 2008-10-21
IL164275A0 (en) 2005-12-18
KR100983953B1 (ko) 2010-09-27
AU2003220169A1 (en) 2003-10-13
CA2480125C (en) 2009-12-29
AU2003220169B2 (en) 2008-09-11
PL372346A1 (en) 2005-07-11
ZA200408153B (en) 2006-03-29
HK1079996B (zh) 2010-04-01
NZ535843A (en) 2006-03-31
EP1494680B1 (en) 2008-09-03
CN100531739C (zh) 2009-08-26
MXPA04009288A (es) 2005-06-08
DE60323351D1 (de) 2008-10-16
CA2480125A1 (en) 2003-10-09
US20050203071A1 (en) 2005-09-15
KR20040095346A (ko) 2004-11-12

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