JP2007517037A5 - - Google Patents
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- JP2007517037A5 JP2007517037A5 JP2006547316A JP2006547316A JP2007517037A5 JP 2007517037 A5 JP2007517037 A5 JP 2007517037A5 JP 2006547316 A JP2006547316 A JP 2006547316A JP 2006547316 A JP2006547316 A JP 2006547316A JP 2007517037 A5 JP2007517037 A5 JP 2007517037A5
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- JP
- Japan
- Prior art keywords
- carbons
- alkyl
- carbon atoms
- group
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000217 alkyl group Chemical group 0.000 claims 82
- 125000004432 carbon atom Chemical group C* 0.000 claims 70
- 150000001875 compounds Chemical class 0.000 claims 62
- 125000000753 cycloalkyl group Chemical group 0.000 claims 27
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 25
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 21
- 150000003839 salts Chemical class 0.000 claims 21
- 229910052799 carbon Inorganic materials 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 15
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 14
- 125000003342 alkenyl group Chemical group 0.000 claims 14
- 125000003545 alkoxy group Chemical group 0.000 claims 14
- 125000004414 alkyl thio group Chemical group 0.000 claims 14
- 229910052794 bromium Inorganic materials 0.000 claims 14
- 229910052801 chlorine Inorganic materials 0.000 claims 14
- 229910052731 fluorine Inorganic materials 0.000 claims 14
- 229910052740 iodine Inorganic materials 0.000 claims 14
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 7
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 7
- 125000005103 alkyl silyl group Chemical group 0.000 claims 7
- 125000000304 alkynyl group Chemical group 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- DQFBYFPFKXHELB-UHFFFAOYSA-N Chalcone Natural products C=1C=CC=CC=1C(=O)C=CC1=CC=CC=C1 DQFBYFPFKXHELB-UHFFFAOYSA-N 0.000 claims 1
- 206010014561 Emphysema Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 235000005513 chalcones Nutrition 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 230000005980 lung dysfunction Effects 0.000 claims 1
- IXQYPXRYRSEMAA-UHFFFAOYSA-N n-(1,3-diphenylprop-2-enylidene)hydroxylamine Chemical group C=1C=CC=CC=1C(=NO)C=CC1=CC=CC=C1 IXQYPXRYRSEMAA-UHFFFAOYSA-N 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53373303P | 2003-12-30 | 2003-12-30 | |
| PCT/US2004/043148 WO2005066116A1 (en) | 2003-12-30 | 2004-12-21 | Disubstituted chalcone oximes as selective agonists of rarϝ retinoid receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007517037A JP2007517037A (ja) | 2007-06-28 |
| JP2007517037A5 true JP2007517037A5 (https=) | 2008-02-14 |
Family
ID=34748950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006547316A Pending JP2007517037A (ja) | 2003-12-30 | 2004-12-21 | ＲＡＲγレチノイド受容体の選択的アゴニストとしての二置換カルコンオキシム |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7476673B2 (https=) |
| EP (1) | EP1704139A1 (https=) |
| JP (1) | JP2007517037A (https=) |
| CA (1) | CA2552090A1 (https=) |
| MX (1) | MXPA06007560A (https=) |
| WO (1) | WO2005066116A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2881137B1 (fr) * | 2005-01-27 | 2007-03-02 | Servier Lab | Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2008112483A2 (en) * | 2007-03-09 | 2008-09-18 | Sanofi-Aventis | Substituted dihydro and tetrahydro oxazolopyrimidinones, preparation and use thereof |
| CA2751820A1 (en) * | 2009-02-10 | 2010-08-19 | Nippon Soda Co., Ltd. | Nitrogen-containing compounds and harmful organism control agents |
| CN101941919B (zh) * | 2009-07-07 | 2014-07-02 | 天津药物研究院 | 一种制备顺式肟及肟醚衍生物的方法 |
| GB0915523D0 (en) | 2009-09-07 | 2009-10-07 | Genome Res Ltd | Cells and methods for obtaining them |
| AR078171A1 (es) | 2009-09-15 | 2011-10-19 | Sanofi Aventis | Dihidrobenzocicloalquiloximetil-oxazolopirimidinonas sustituidas, preparacion y uso de las mismas |
| MX2012006776A (es) | 2009-12-14 | 2012-10-05 | Merck Patent Gmbh | Inhibidores de la esfingosina quinasa. |
| CA2784647A1 (en) | 2009-12-17 | 2011-07-14 | Merck Patent Gmbh | Inhibitors of sphingosine kinase |
| TWI645851B (zh) * | 2015-09-10 | 2019-01-01 | 國立大學法人岡山大學 | 視黃醇類ｘ受體促效劑之用途 |
| EP3380086B1 (en) | 2015-11-25 | 2021-10-13 | IO Therapeutics, Inc. | Cyp26-resistant rar-alpha selective agonists in the treatment of cancer |
| TW201906816A (zh) | 2017-07-06 | 2019-02-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 吲哚甲醯胺類衍生物、其製備方法及其在醫藥上的應用 |
| WO2019014468A1 (en) | 2017-07-13 | 2019-01-17 | Io Therapeutics, Inc. | RECEPTOR SUBTYPE AND RETINOID COMPOUNDS AND SELECTIVE REXINOIDS OF A FUNCTION IN COMBINATION WITH IMMUNE MODULATORS FOR ANTICANCER IMMUNOTHERAPY |
| US10363272B2 (en) | 2017-08-31 | 2019-07-30 | Io Therapeutics, Inc. | RAR selective agonists in combination with immune modulators for cancer immunotherapy |
| EP3683206A4 (en) | 2017-09-12 | 2021-01-13 | Jiangsu Hengrui Medicine Co., Ltd. | DEUTERIUM ATOM SUBSTITUTED INDOLFORMAMIDE DERIVATIVE, MANUFACTURING METHOD FOR ITS AND MEDICAL APPLICATIONS THEREOF |
| CA3077331A1 (en) | 2017-09-28 | 2019-04-04 | Johnson & Johnson Consumer Inc. | Cosmetic compositions and method of treating the skin |
| CN112142745B (zh) * | 2019-06-27 | 2023-03-21 | 杭州和正医药有限公司 | 一种酪蛋白激酶1ε抑制剂、药物组合物及其应用 |
| WO2023097259A1 (en) * | 2021-11-23 | 2023-06-01 | Io Therapeutics, Inc. | METHODS OF USING RARγ AGONISTS FOR CANCER TREATMENT |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4001618B2 (ja) | 1991-12-18 | 2007-10-31 | ザ ソールク インスチチュート フォア バイオロジカル スタディズ | レチノイド受容体によって仲介される過程の修飾方法およびそれに有用な化合物 |
| US5455265A (en) * | 1993-02-11 | 1995-10-03 | Allergan, Inc. | Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors |
| WO1996011210A1 (en) * | 1994-10-07 | 1996-04-18 | Fujisawa Pharmaceutical Co., Ltd. | Cyclic hexapeptides having antibiotic activity |
| US5599967A (en) * | 1994-12-29 | 1997-02-04 | Allergan | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity |
| US6008204A (en) * | 1995-09-01 | 1999-12-28 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
| US5723666A (en) * | 1996-06-21 | 1998-03-03 | Allergan | Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
| US5739338A (en) * | 1996-11-05 | 1998-04-14 | Allergan | N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity |
| US5760276A (en) * | 1997-03-06 | 1998-06-02 | Allergan | Aryl-and heteroarylcyclohexenyl substituted alkenes having retinoid agonist, antagonist or inverse agonist type biological activity |
| US6037488A (en) * | 1997-04-19 | 2000-03-14 | Allergan Sales, Inc. | Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity |
| US5919970A (en) * | 1997-04-24 | 1999-07-06 | Allergan Sales, Inc. | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity |
| US6048873A (en) * | 1998-10-01 | 2000-04-11 | Allergan Sales, Inc. | Tetrahdroquinolin-2-one 6 or 7-yl, tetrahdroquinilin-2-thione 6 or 7-yl pentadienoic acid and related derivatives having retinoid-like biological activity |
| AU4228000A (en) * | 1999-04-14 | 2000-11-14 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease |
| US6313168B1 (en) * | 1999-12-15 | 2001-11-06 | Allergan Sales, Inc. | Use of retinoid receptor antagonists in the treatment of cartilage and bone pathologies |
| US6403810B2 (en) * | 2000-07-10 | 2002-06-11 | Hoffmann-La Roche Inc. | Thiophene derivatives |
| US6303785B1 (en) * | 2000-08-29 | 2001-10-16 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
| SI1324970T1 (sl) | 2000-10-02 | 2009-02-28 | Hoffmann La Roche | Retinoidi za zdravljenje emfizema |
| US20030003517A1 (en) | 2001-03-22 | 2003-01-02 | Klein Elliott S. | Methods of detecting dissociated nuclear hormone receptor ligands |
| US20020193403A1 (en) * | 2001-05-03 | 2002-12-19 | Allergan Sales, Inc. | Methods of treating hyperlipidemia |
| JP2007518719A (ja) * | 2003-12-26 | 2007-07-12 | アラーガン インコーポレイテッド | ＲＡＲγレチノイド受容体アンタゴニスト活性を有する二置換カルコンオキシム |
-
2004
- 2004-12-17 US US11/015,994 patent/US7476673B2/en not_active Expired - Fee Related
- 2004-12-21 JP JP2006547316A patent/JP2007517037A/ja active Pending
- 2004-12-21 EP EP04815251A patent/EP1704139A1/en not_active Withdrawn
- 2004-12-21 CA CA002552090A patent/CA2552090A1/en not_active Abandoned
- 2004-12-21 WO PCT/US2004/043148 patent/WO2005066116A1/en not_active Ceased
- 2004-12-21 MX MXPA06007560A patent/MXPA06007560A/es not_active Application Discontinuation
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