JP2007514773A5 - - Google Patents
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- Publication number
- JP2007514773A5 JP2007514773A5 JP2006545571A JP2006545571A JP2007514773A5 JP 2007514773 A5 JP2007514773 A5 JP 2007514773A5 JP 2006545571 A JP2006545571 A JP 2006545571A JP 2006545571 A JP2006545571 A JP 2006545571A JP 2007514773 A5 JP2007514773 A5 JP 2007514773A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- carbon atoms
- carbons
- independently
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims 168
- 125000000217 alkyl group Chemical group 0.000 claims 162
- 150000001875 compounds Chemical class 0.000 claims 71
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 60
- 229910052799 carbon Inorganic materials 0.000 claims 40
- 229910052794 bromium Inorganic materials 0.000 claims 39
- 229910052801 chlorine Inorganic materials 0.000 claims 39
- 229910052740 iodine Inorganic materials 0.000 claims 39
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 34
- 125000003545 alkoxy group Chemical group 0.000 claims 31
- 125000004414 alkyl thio group Chemical group 0.000 claims 30
- 229910052731 fluorine Inorganic materials 0.000 claims 30
- 125000001072 heteroaryl group Chemical group 0.000 claims 30
- 125000001624 naphthyl group Chemical group 0.000 claims 30
- 125000004076 pyridyl group Chemical group 0.000 claims 30
- 125000001544 thienyl group Chemical group 0.000 claims 30
- 125000002541 furyl group Chemical group 0.000 claims 29
- 150000001768 cations Chemical class 0.000 claims 28
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 27
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 19
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 125000000304 alkynyl group Chemical group 0.000 claims 15
- 125000000753 cycloalkyl group Chemical group 0.000 claims 15
- 125000002883 imidazolyl group Chemical group 0.000 claims 15
- 125000002971 oxazolyl group Chemical group 0.000 claims 15
- 125000003373 pyrazinyl group Chemical group 0.000 claims 15
- 125000003226 pyrazolyl group Chemical group 0.000 claims 15
- 125000002098 pyridazinyl group Chemical group 0.000 claims 15
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 15
- 125000000335 thiazolyl group Chemical group 0.000 claims 15
- 125000003342 alkenyl group Chemical group 0.000 claims 13
- 229910052736 halogen Inorganic materials 0.000 claims 13
- 150000002367 halogens Chemical class 0.000 claims 13
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 7
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 5
- 101150065749 Churc1 gene Proteins 0.000 claims 5
- 102100038239 Protein Churchill Human genes 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- -1 furyl compound Chemical class 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 2
- 229920002554 vinyl polymer Polymers 0.000 claims 2
- 150000002500 ions Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000004665 trialkylsilyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53046203P | 2003-12-17 | 2003-12-17 | |
| PCT/US2004/042897 WO2005058798A2 (en) | 2003-12-17 | 2004-12-17 | Compounds having selective cytochrome p450rai-1 or selective cytochrome p450rai-2 inhibitory activity and methods of obtaining the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007514773A JP2007514773A (ja) | 2007-06-07 |
| JP2007514773A5 true JP2007514773A5 (https=) | 2008-02-14 |
Family
ID=34700138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006545571A Pending JP2007514773A (ja) | 2003-12-17 | 2004-12-17 | 選択的シトクロムｐ４５０ｒａｉ−１または選択的シトクロムｐ４５０ｒａｉ−２阻害活性を有する化合物およびそれを得る方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7226951B2 (https=) |
| EP (1) | EP1699775A2 (https=) |
| JP (1) | JP2007514773A (https=) |
| CA (1) | CA2550123A1 (https=) |
| MX (1) | MXPA06006819A (https=) |
| WO (1) | WO2005058798A2 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7226951B2 (en) * | 2003-12-17 | 2007-06-05 | Allergan, Inc. | Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same |
| WO2005058301A1 (en) * | 2003-12-17 | 2005-06-30 | Allergan, Inc. | Methods for treating retinoid responsive disorders using selective inhibitors of cyp26a and cyp26b |
| JP2009108036A (ja) * | 2007-09-28 | 2009-05-21 | Fujifilm Corp | 新規アセチレン化合物、その製造方法、それを構成単位として含むポリマー、該化合物及び／又は該ポリマーを含む組成物、該組成物を硬化させてなる硬化物 |
| EP2321266A2 (en) * | 2008-08-15 | 2011-05-18 | F. Hoffmann-La Roche AG | Substituted aminotetralines |
| ES2335849B1 (es) * | 2008-10-03 | 2011-03-22 | Consejo Superior De Investigaciones Cientificas (Csic) | Derivados de cromano y sus usos como inhibidores de la actividad de las proteinas desacoplantes. |
| BRPI0921038A2 (pt) * | 2008-11-17 | 2019-09-24 | Hoffmann La Roche | ácido naftilacéticos |
| RU2011124149A (ru) * | 2008-11-17 | 2012-12-27 | Ф.Хоффманн-Ля Рош Аг | Нафтилуксусные кислоты |
| CN102216273A (zh) * | 2008-11-17 | 2011-10-12 | 霍夫曼-拉罗奇有限公司 | 用作crth2拮抗剂或部分激动剂的萘乙酸 |
| CA2848540A1 (en) | 2011-09-15 | 2013-03-21 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Therapeutic compounds |
| US8470884B2 (en) | 2011-11-09 | 2013-06-25 | Hoffmann-La Roche Inc. | Alkenyl naphthylacetic acids |
| US9000044B2 (en) | 2012-02-28 | 2015-04-07 | Hoffmann-La Roche Inc. | Substituted naphthylacetic acids |
| CN104364239B (zh) | 2012-06-13 | 2017-08-25 | 霍夫曼-拉罗奇有限公司 | 二氮杂螺环烷烃和氮杂螺环烷烃 |
| MX368615B (es) | 2012-09-25 | 2019-10-09 | Hoffmann La Roche | Derivados bicíclicos como inhibidores de la autotaxina (atx) que son inhibidores de la producción de ácido lisofosfatídico (lpa) y el uso de los mismos. |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| DK3074400T3 (en) | 2013-11-26 | 2018-01-15 | Hoffmann La Roche | Octahydro-cyclobuta [1,2-c; 3,4-c '] dipyrrole derivatives as autotaxin inhibitors |
| WO2015109318A2 (en) | 2014-01-17 | 2015-07-23 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Therapeutic methods |
| EA032357B1 (ru) | 2014-03-26 | 2019-05-31 | Ф. Хоффманн-Ля Рош Аг | Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) |
| CA2937616A1 (en) | 2014-03-26 | 2015-10-01 | F. Hoffmann-La Roche Ag | Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| TWI653227B (zh) * | 2014-07-11 | 2019-03-11 | Dow Agrosciences Llc | 用於製備４－（１－（４－（全氟乙氧基）苯基）－１ｈ－１，２，４－三唑－３－基）苯甲醯疊氮化物之改良方法 |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| CN105481723B (zh) * | 2015-04-29 | 2017-08-25 | 中国农业大学 | 一种非均相催化的烷基/苄基/芳基脲类化合物的制备方法 |
| CA2992889A1 (en) | 2015-09-04 | 2017-03-09 | F. Hoffmann-La Roche Ag | Phenoxymethyl derivatives |
| WO2017050732A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
| BR112017026682A2 (pt) | 2015-09-24 | 2018-08-14 | Hoffmann La Roche | novos compostos bicíclicos como inibidores de dupla ação de atx/ca |
| AU2016328436B2 (en) | 2015-09-24 | 2020-05-14 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual ATX/CA inhibitors |
| JP6876685B2 (ja) | 2015-09-24 | 2021-05-26 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ａｔｘ阻害剤としての二環式化合物 |
| JP2019509262A (ja) * | 2016-02-03 | 2019-04-04 | ガルデルマ・リサーチ・アンド・デヴェロップメント | 新規二芳香族プロピニル化合物、それらを含む薬学的および化粧用組成物ならびにそれらの使用 |
| US10231947B2 (en) | 2017-01-23 | 2019-03-19 | Arizona Board Of Regents On Behalf Of Arizona State University | Isochroman compounds and methods of use thereof |
| US10238655B2 (en) | 2017-01-23 | 2019-03-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Dihydroindene and tetrahydronaphthalene compounds |
| US10238626B2 (en) | 2017-01-23 | 2019-03-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
| RU2019132254A (ru) | 2017-03-16 | 2021-04-16 | Ф. Хоффманн-Ля Рош Аг | Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca |
| JP7090099B2 (ja) | 2017-03-16 | 2022-06-23 | エフ．ホフマン－ラ ロシュ アーゲー | Ａｔｘインヒビターとしての新規二環式化合物 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3699149A (en) | 1968-10-14 | 1972-10-17 | Daiichi Seiyaku Co | Phenyl esters of t-amcha |
| DK159967C (da) * | 1977-12-22 | 1991-06-03 | Hoffmann La Roche | Analogifremgangsmaade til fremstilling af terapeutisk aktive stilbenderivater |
| US4326055A (en) | 1977-12-22 | 1982-04-20 | Hoffmann-La Roche Inc. | Stilbene derivatives |
| JPS58121242A (ja) * | 1982-01-11 | 1983-07-19 | Mitsubishi Petrochem Co Ltd | トラン−４−酢酸誘導体及びトラン−４−酢酸誘導体を有効成分とする抗炎症剤 |
| US5202471A (en) | 1990-02-06 | 1993-04-13 | Allergan, Inc. | Alkyl, alkoxy and thioalkoxy substituted diphenyl acetylenes having retinoid like activity |
| JP2002504066A (ja) * | 1994-12-29 | 2002-02-05 | アラーガン、セイルズ、インコーポレイテッド | ５または８置換テトラヒドロナフチルまたはジヒドロナフチル基と、アリールまたはヘテロアリール基とでジ置換された、レチノイド様生物学的活性を有するアセチレン |
| US5599967A (en) | 1994-12-29 | 1997-02-04 | Allergan | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity |
| US5952345A (en) | 1995-09-01 | 1999-09-14 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
| US5675024A (en) * | 1995-11-22 | 1997-10-07 | Allergan | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity |
| US5723666A (en) | 1996-06-21 | 1998-03-03 | Allergan | Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
| US6313168B1 (en) * | 1999-12-15 | 2001-11-06 | Allergan Sales, Inc. | Use of retinoid receptor antagonists in the treatment of cartilage and bone pathologies |
| US6380256B1 (en) * | 2000-08-29 | 2002-04-30 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
| US6252090B1 (en) * | 2000-08-29 | 2001-06-26 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
| US6291677B1 (en) * | 2000-08-29 | 2001-09-18 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
| US6313107B1 (en) | 2000-08-29 | 2001-11-06 | Allergan Sales, Inc. | Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI |
| US6303785B1 (en) * | 2000-08-29 | 2001-10-16 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
| US6369261B1 (en) * | 2000-08-29 | 2002-04-09 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
| ES2256288T3 (es) * | 2000-08-29 | 2006-07-16 | Allergan, Inc. | Compuestos con actividad como inhibidores de citocromo p450rai. |
| US6369225B1 (en) * | 2000-08-29 | 2002-04-09 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
| US6387951B1 (en) * | 2000-08-29 | 2002-05-14 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
| US7226951B2 (en) | 2003-12-17 | 2007-06-05 | Allergan, Inc. | Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same |
-
2004
- 2004-12-16 US US11/014,460 patent/US7226951B2/en not_active Expired - Fee Related
- 2004-12-17 MX MXPA06006819A patent/MXPA06006819A/es unknown
- 2004-12-17 EP EP04815022A patent/EP1699775A2/en not_active Withdrawn
- 2004-12-17 WO PCT/US2004/042897 patent/WO2005058798A2/en not_active Ceased
- 2004-12-17 JP JP2006545571A patent/JP2007514773A/ja active Pending
- 2004-12-17 CA CA002550123A patent/CA2550123A1/en not_active Abandoned
-
2007
- 2007-03-23 US US11/728,313 patent/US7638648B2/en not_active Expired - Fee Related