FR2881137B1 - Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2881137B1
FR2881137B1 FR0500842A FR0500842A FR2881137B1 FR 2881137 B1 FR2881137 B1 FR 2881137B1 FR 0500842 A FR0500842 A FR 0500842A FR 0500842 A FR0500842 A FR 0500842A FR 2881137 B1 FR2881137 B1 FR 2881137B1
Authority
FR
France
Prior art keywords
preparing
pharmaceutical compositions
compositions containing
containing same
novel heterocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0500842A
Other languages
English (en)
Other versions
FR2881137A1 (fr
Inventor
Cecile Parmenon
Massuard Marie Claude Viaud
Jerome Guillard
Catherine Dacquet
Alain Ktorza
Daniel Henri Caignard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0500842A priority Critical patent/FR2881137B1/fr
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Priority to ZA200706249A priority patent/ZA200706249B/xx
Priority to CA002596156A priority patent/CA2596156A1/fr
Priority to KR1020077018500A priority patent/KR20070103447A/ko
Priority to JP2007552679A priority patent/JP2008528560A/ja
Priority to CNA2006800064774A priority patent/CN101133028A/zh
Priority to EA200701477A priority patent/EA200701477A1/ru
Priority to US11/883,107 priority patent/US20090124656A1/en
Priority to EP06709171A priority patent/EP1844015A2/fr
Priority to PCT/FR2006/000174 priority patent/WO2006079719A2/fr
Priority to BRPI0607087-6A priority patent/BRPI0607087A2/pt
Priority to MX2007008995A priority patent/MX2007008995A/es
Priority to ARP060100288A priority patent/AR052891A1/es
Priority to AU2006208812A priority patent/AU2006208812A1/en
Publication of FR2881137A1 publication Critical patent/FR2881137A1/fr
Application granted granted Critical
Publication of FR2881137B1 publication Critical patent/FR2881137B1/fr
Priority to MA30148A priority patent/MA29257B1/fr
Priority to NO20074347A priority patent/NO20074347L/no
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Nutrition Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR0500842A 2005-01-27 2005-01-27 Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2881137B1 (fr)

Priority Applications (16)

Application Number Priority Date Filing Date Title
FR0500842A FR2881137B1 (fr) 2005-01-27 2005-01-27 Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
BRPI0607087-6A BRPI0607087A2 (pt) 2005-01-27 2006-01-26 derivados de oximas heterocìclicos, o respectivo processo de preparo e as composições farmacêuticas que os contêm
KR1020077018500A KR20070103447A (ko) 2005-01-27 2006-01-26 헤테로시클릭 옥심 유도체, 이의 제조 방법 및 이를함유하는 약제학적 조성물
JP2007552679A JP2008528560A (ja) 2005-01-27 2006-01-26 新規な複素環式オキシム誘導体、それらの製造方法及びそれらを含む医薬組成物
CNA2006800064774A CN101133028A (zh) 2005-01-27 2006-01-26 新的杂环肟化合物、其制备方法和含有其的药物组合物
EA200701477A EA200701477A1 (ru) 2005-01-27 2006-01-26 Новые гетероциклические соединения оксима, способ их получения и фармацевтические композиции, которые их содержат
US11/883,107 US20090124656A1 (en) 2005-01-27 2006-01-26 Heterocyclic Oxime Compounds a Process for Their Preparation and Pharmaceutical Compositions Containing Them
EP06709171A EP1844015A2 (fr) 2005-01-27 2006-01-26 Nouveaux derives d'oximes heterocycliques, leurs procede de preparation , les compositions pharmaceutiques qui les contiennent et leurs utilisation pour le traitement de l'obesite
ZA200706249A ZA200706249B (en) 2005-01-27 2006-01-26 Novel heterocyclic oxime derivatives, method for preparing same and pharmaceutical compositions containing same
CA002596156A CA2596156A1 (fr) 2005-01-27 2006-01-26 Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
MX2007008995A MX2007008995A (es) 2005-01-27 2006-01-26 Nuevos derivados de oximas heterociclicas, metodo para su preparacion, composiciones farmaceuticas que los contienen y su uso para el tratamiento de la obesidad.
ARP060100288A AR052891A1 (es) 2005-01-27 2006-01-26 Compuestos de oxima heterociclica, un procedimiento para su preparacion y composiciones farmaceuticas que los contienen
AU2006208812A AU2006208812A1 (en) 2005-01-27 2006-01-26 Novel heterocyclic oxime derivatives, method for preparing same and pharmaceutical compositions containing same
PCT/FR2006/000174 WO2006079719A2 (fr) 2005-01-27 2006-01-26 Nouveaux derives d'oximes heterocycliques, leur procede de preparation, les compositions pharmaceutiques qui les contiennent et leur utilisation pour le traitement de l’obesite
MA30148A MA29257B1 (fr) 2005-01-27 2007-08-17 Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
NO20074347A NO20074347L (no) 2005-01-27 2007-08-27 Nye heterocykliske oksimforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0500842A FR2881137B1 (fr) 2005-01-27 2005-01-27 Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2881137A1 FR2881137A1 (fr) 2006-07-28
FR2881137B1 true FR2881137B1 (fr) 2007-03-02

Family

ID=34954346

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0500842A Expired - Fee Related FR2881137B1 (fr) 2005-01-27 2005-01-27 Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (16)

Country Link
US (1) US20090124656A1 (fr)
EP (1) EP1844015A2 (fr)
JP (1) JP2008528560A (fr)
KR (1) KR20070103447A (fr)
CN (1) CN101133028A (fr)
AR (1) AR052891A1 (fr)
AU (1) AU2006208812A1 (fr)
BR (1) BRPI0607087A2 (fr)
CA (1) CA2596156A1 (fr)
EA (1) EA200701477A1 (fr)
FR (1) FR2881137B1 (fr)
MA (1) MA29257B1 (fr)
MX (1) MX2007008995A (fr)
NO (1) NO20074347L (fr)
WO (1) WO2006079719A2 (fr)
ZA (1) ZA200706249B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2909379B1 (fr) * 2006-11-30 2009-01-16 Servier Lab Nouveaux derives heterocycliques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
WO2010024841A1 (fr) 2008-08-25 2010-03-04 Dupont Electronic Polymers L.P. Nouveaux propanoates et leurs procédés de préparation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602130A (en) * 1987-03-20 1997-02-11 Allergan Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity
KR900016822A (ko) * 1990-04-20 1990-11-14 하라 레이노스께 슬라이드 프로젝터
FR2804431A1 (fr) * 2000-02-02 2001-08-03 Adir Nouveaux derives heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2830012B1 (fr) * 2001-09-21 2003-10-31 Servier Lab Nouveaux derives heterocycliques, leur procede de preparation et les compositions pharamaceutiques qui les contiennent
WO2004072041A1 (fr) * 2003-02-12 2004-08-26 Care X S.A. Tetrahydroquinoleines utilisees comme agonistes des recepteurs hepatiques
US7476673B2 (en) * 2003-12-30 2009-01-13 Allergan, Inc. Disubstituted chalcone oximes as selective agonists of RARγ retinoid receptors

Also Published As

Publication number Publication date
KR20070103447A (ko) 2007-10-23
BRPI0607087A2 (pt) 2009-08-04
AU2006208812A1 (en) 2006-08-03
AR052891A1 (es) 2007-04-11
FR2881137A1 (fr) 2006-07-28
CN101133028A (zh) 2008-02-27
JP2008528560A (ja) 2008-07-31
MX2007008995A (es) 2007-09-18
NO20074347L (no) 2007-08-27
WO2006079719A3 (fr) 2006-09-28
WO2006079719A2 (fr) 2006-08-03
US20090124656A1 (en) 2009-05-14
EP1844015A2 (fr) 2007-10-17
EA200701477A1 (ru) 2008-02-28
CA2596156A1 (fr) 2006-08-03
MA29257B1 (fr) 2008-02-01
ZA200706249B (en) 2008-11-26

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Effective date: 20091030