JP2005527512A5 - - Google Patents
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- Publication number
- JP2005527512A5 JP2005527512A5 JP2003574126A JP2003574126A JP2005527512A5 JP 2005527512 A5 JP2005527512 A5 JP 2005527512A5 JP 2003574126 A JP2003574126 A JP 2003574126A JP 2003574126 A JP2003574126 A JP 2003574126A JP 2005527512 A5 JP2005527512 A5 JP 2005527512A5
- Authority
- JP
- Japan
- Prior art keywords
- medicament
- bryostatin
- medicament according
- agent
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 claims 48
- 239000003795 chemical substances by application Substances 0.000 claims 23
- MJQUEDHRCUIRLF-TVIXENOKSA-N bryostatin 1 Chemical class C([C@@H]1CC(/[C@@H]([C@@](C(C)(C)/C=C/2)(O)O1)OC(=O)/C=C/C=C/CCC)=C\C(=O)OC)[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H](O1)C[C@H](OC(C)=O)C(C)(C)[C@]1(O)C[C@@H]1C\C(=C\C(=O)OC)C[C@H]\2O1 MJQUEDHRCUIRLF-TVIXENOKSA-N 0.000 claims 15
- 229940079593 drug Drugs 0.000 claims 13
- 150000002596 lactones Chemical class 0.000 claims 13
- 229930192344 Neristatin Chemical class 0.000 claims 10
- 239000003937 drug carrier Substances 0.000 claims 9
- 229960005539 bryostatin 1 Drugs 0.000 claims 8
- 230000003931 cognitive performance Effects 0.000 claims 8
- 208000024827 Alzheimer disease Diseases 0.000 claims 7
- 239000012190 activator Substances 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 claims 6
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 claims 6
- 241001465754 Metazoa Species 0.000 claims 5
- 230000000324 neuroprotective effect Effects 0.000 claims 4
- 208000037259 Amyloid Plaque Diseases 0.000 claims 3
- 102000004310 Ion Channels Human genes 0.000 claims 3
- 208000012902 Nervous system disease Diseases 0.000 claims 3
- 229960005520 bryostatin Drugs 0.000 claims 3
- AVJAOOKIOFJJOC-VXOITNNESA-N bryostatin 18 Chemical compound C([C@H]1O[C@@](C([C@@H](OC(=O)C(C)(C)C)C1)(C)C)(O)C[C@@H]1C/C(C[C@H](/C=C/C2(C)C)O1)=C/C(=O)OC)[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]1C\C(=C\C(=O)OC)C[C@@]2(O)O1 AVJAOOKIOFJJOC-VXOITNNESA-N 0.000 claims 3
- MUIWQCKLQMOUAT-AKUNNTHJSA-N bryostatin 20 Natural products COC(=O)C=C1C[C@@]2(C)C[C@]3(O)O[C@](C)(C[C@@H](O)CC(=O)O[C@](C)(C[C@@]4(C)O[C@](O)(CC5=CC(=O)O[C@]45C)C(C)(C)C=C[C@@](C)(C1)O2)[C@@H](C)O)C[C@H](OC(=O)C(C)(C)C)C3(C)C MUIWQCKLQMOUAT-AKUNNTHJSA-N 0.000 claims 3
- 230000002708 enhancing effect Effects 0.000 claims 3
- 230000007505 plaque formation Effects 0.000 claims 3
- 206010021143 Hypoxia Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000025966 Neurological disease Diseases 0.000 claims 2
- 241000288906 Primates Species 0.000 claims 2
- 208000029028 brain injury Diseases 0.000 claims 2
- 230000009134 cell regulation Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000001146 hypoxic effect Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 230000000926 neurological effect Effects 0.000 claims 2
- 208000000412 Avitaminosis Diseases 0.000 claims 1
- 208000001408 Carbon monoxide poisoning Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims 1
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims 1
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010019196 Head injury Diseases 0.000 claims 1
- 208000013016 Hypoglycemia Diseases 0.000 claims 1
- 206010021135 Hypovitaminosis Diseases 0.000 claims 1
- 206010061216 Infarction Diseases 0.000 claims 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- JXDYKVIHCLTXOP-UHFFFAOYSA-N Pseudoisatin Natural products C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 claims 1
- 230000003444 anaesthetic effect Effects 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 239000000890 drug combination Substances 0.000 claims 1
- 230000000142 dyskinetic effect Effects 0.000 claims 1
- 238000002635 electroconvulsive therapy Methods 0.000 claims 1
- 230000002218 hypoglycaemic effect Effects 0.000 claims 1
- 230000007574 infarction Effects 0.000 claims 1
- 230000035987 intoxication Effects 0.000 claims 1
- 231100000566 intoxication Toxicity 0.000 claims 1
- 229910052744 lithium Inorganic materials 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
- 208000030401 vitamin deficiency disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36208002P | 2002-03-07 | 2002-03-07 | |
| US10/167,491 US6825229B2 (en) | 2002-03-07 | 2002-06-13 | Methods for Alzheimer's Disease treatment and cognitive enhancement |
| PCT/US2003/007101 WO2003075850A2 (en) | 2002-03-07 | 2003-03-07 | Methods for alzheimer's disease treatment and cognitive enhancement |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005527512A JP2005527512A (ja) | 2005-09-15 |
| JP2005527512A5 true JP2005527512A5 (https=) | 2006-06-15 |
Family
ID=27807411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003574126A Withdrawn JP2005527512A (ja) | 2002-03-07 | 2003-03-07 | アルツハイマー病の治療および認知増強のための方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US6825229B2 (https=) |
| EP (2) | EP1490050B1 (https=) |
| JP (1) | JP2005527512A (https=) |
| AU (1) | AU2003220096A1 (https=) |
| CA (1) | CA2477973A1 (https=) |
| ES (1) | ES2639578T3 (https=) |
| WO (1) | WO2003075850A2 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6825229B2 (en) | 2002-03-07 | 2004-11-30 | Blanchette Rockefeller Neurosciences Institute | Methods for Alzheimer's Disease treatment and cognitive enhancement |
| US20080004332A1 (en) * | 2002-03-07 | 2008-01-03 | Alkon Daniel L | Methods for alzheimer's disease treatment and cognitive enhancement |
| US20070037871A1 (en) * | 2002-07-02 | 2007-02-15 | Blanchette Rockefeller Neurosciences Instiute | Pkc activation as a means for enhancing sappalpha secretion and improving cognition using bryostatin type compounds |
| US20050065205A1 (en) * | 2002-03-07 | 2005-03-24 | Daniel Alkon | Methods for Alzheimer's disease treatment and cognitive enhance |
| CA2490494A1 (en) * | 2002-07-02 | 2004-01-15 | Blanchette Rockefeller Neurosciences Institute | Pkc activation as a means for enhancing sapp.alpha. secretion and improving cognition using bryostatin type compounds |
| TW201206425A (en) | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Treatment of depressive disorders |
| WO2006094673A2 (en) * | 2005-03-08 | 2006-09-14 | Ludwig-Maximilians-Universität München | Synergistic mixtures of c6- to c12-alkanedi0ls and tropolone (derivatives) |
| US20070054890A1 (en) * | 2005-07-29 | 2007-03-08 | Alkon Daniel L | Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning |
| WO2007044094A1 (en) * | 2005-10-11 | 2007-04-19 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb) |
| US20080025961A1 (en) * | 2006-07-28 | 2008-01-31 | Alkon Daniel L | Methods of stimulating cellular growth, synaptic remodeling and consolidation of long-term memory |
| US20170319541A9 (en) * | 2006-07-28 | 2017-11-09 | Blanchette Rockefeller Neuroscience Institute | Methods of stimulating cellular growth, synaptic remodeling and consolidation of long-term memory |
| CA2659835A1 (en) * | 2006-08-04 | 2008-02-07 | Toyama Chemical Co., Ltd. | Protein kinase c activity enhancer containing alkyl ether derivative or salt thereof |
| EP3332797A3 (en) * | 2007-02-09 | 2018-08-01 | Blanchette Rockefeller Neurosciences Institute | Therapeutic effects of bryostatins, bryologs and other related substances on head trauma-induced memory impairment and brain injury |
| KR101075288B1 (ko) * | 2007-03-09 | 2011-10-19 | 콸콤 인코포레이티드 | 직교 변조 회전 트레이닝 시퀀스 |
| US9994585B2 (en) | 2007-12-31 | 2018-06-12 | Aphios Corporation | Transplantation therapies |
| WO2009099563A2 (en) * | 2008-02-05 | 2009-08-13 | Blanchette Rockefeller Neurosciences Institute | Combination of a nmda receptor channel blocker and a pkc activator for treatment of alzheimer's disease |
| EP2283023A2 (en) | 2008-04-16 | 2011-02-16 | University of Utah Research Foundation | Bryostatin analogues and methods of making and using thereof |
| EP2669386A1 (en) | 2008-07-28 | 2013-12-04 | Blanchette Rockefeller Neurosciences Institute | Stimulus-elicited genomic profile markers of alzheimer's disease |
| US20110023152A1 (en) * | 2008-12-04 | 2011-01-27 | Sigma-Aldrich Co. | Genome editing of cognition related genes in animals |
| US20140038186A1 (en) * | 2010-02-22 | 2014-02-06 | Tapan Kumar Khan | Alzheimer's disease-specific alterations of protein kinase c epsilon (pkc-epsilon) protein levels |
| US20120027687A1 (en) | 2010-07-08 | 2012-02-02 | Alkon Daniel L | Fatty acid protein kinase c activators and anticoagulant for the treatment of stroke |
| EP2605773A1 (en) * | 2010-08-19 | 2013-06-26 | Blanchette Rockefeller Neurosciences, Institute | Treatment of cognitive disorders associated with abnormal dendritic spines using pkc activators |
| CA2855932A1 (en) | 2011-11-13 | 2013-05-16 | Blanchette Rockefeller Neurosciences Institute | Pkc activators and combinations thereof |
| US9034347B2 (en) | 2011-12-19 | 2015-05-19 | Arphios Corporation | Drug delivery system and method for the treatment of neuro-degenerative disease |
| CN105228614A (zh) | 2012-11-28 | 2016-01-06 | 阿菲欧斯公司 | 用于治疗神经退化疾病和其它疾病的组合治疗剂和方法 |
| JP2016516201A (ja) * | 2013-03-15 | 2016-06-02 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | 神経保護性ｐｋｃ活性化因子を特定する方法 |
| US20180217163A1 (en) * | 2015-05-11 | 2018-08-02 | Daniel L. Alkon | Treatment of neurodegenerative conditions using pkc activators after determining the presence of the apoe4 allele |
| WO2017053659A1 (en) | 2015-09-23 | 2017-03-30 | Khan Tapan K | Methods for survival and rejuvenation of dermal fibroblasts using pkc activators |
| US20180311209A1 (en) | 2015-10-08 | 2018-11-01 | Cognitive Research Enterprises, Inc. | Dosing regimens of pkc activators |
| US20190125721A1 (en) * | 2016-05-04 | 2019-05-02 | Neurotrope Bioscience, Inc. | Methods and compositions for treatment of rett syndrome |
| EP3793543A1 (en) * | 2018-05-18 | 2021-03-24 | Neurotrope Bioscience, Inc. | Methods and compositions for treatment of alzheimer's disease |
| US12297244B2 (en) | 2019-06-05 | 2025-05-13 | Rensselaer Polytechnic Institute | Systems and methods for inhibiting γ-secretase production of amyloid-β peptides |
| WO2022132856A1 (en) * | 2020-12-16 | 2022-06-23 | Synaptogenix, Inc. | Treatment of amyotrophic lateral sclerosis using pkc activators |
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| US4560774A (en) | 1982-11-17 | 1985-12-24 | Arizona State University | Macrocyclic lactones |
| FI840260A7 (fi) | 1983-01-27 | 1984-07-28 | Ciba Geigy Ag | Pyrrolidinonijohdannaiset ja menetelmä niiden valmistamiseksi. |
| US4611066A (en) | 1984-08-10 | 1986-09-09 | Arizona State University | Bryostatins 4 to 8 |
| US5891906A (en) | 1986-06-11 | 1999-04-06 | Procyon Pharmaceuticals, Inc. | Polyacetate-derived phorboids having anti-inflammatory and other uses |
| US5891870A (en) | 1986-06-11 | 1999-04-06 | Procyon Pharmaceuticals, Inc. | Protein kinase C modulators Q |
| US6080784A (en) * | 1986-06-11 | 2000-06-27 | Procyon Pharmaceuticals, Inc. | Protein kinase C modulators N |
| US5962498A (en) | 1986-06-11 | 1999-10-05 | Procyon Pharmaceuticals, Inc. | Protein kinase C modulators. C. indolactam structural-types with anti-inflammatory activity |
| US5955501A (en) | 1986-06-11 | 1999-09-21 | Procyon Pharmaceuticals, Inc. | Protein kinase C modulators O |
| US6043270A (en) * | 1986-06-11 | 2000-03-28 | Procyon Pharmaceuticals, Inc. | Protein kinase C modulators V |
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| JP4568464B2 (ja) | 2001-11-07 | 2010-10-27 | 雪印乳業株式会社 | 記憶障害予防治療剤 |
| US20050065205A1 (en) | 2002-03-07 | 2005-03-24 | Daniel Alkon | Methods for Alzheimer's disease treatment and cognitive enhance |
| US6821979B2 (en) | 2002-03-07 | 2004-11-23 | Blanchette Rockefeller Neurosciences Institute | Synergistic enhancement of cognitive ability |
| US6825229B2 (en) * | 2002-03-07 | 2004-11-30 | Blanchette Rockefeller Neurosciences Institute | Methods for Alzheimer's Disease treatment and cognitive enhancement |
| CA2490494A1 (en) | 2002-07-02 | 2004-01-15 | Blanchette Rockefeller Neurosciences Institute | Pkc activation as a means for enhancing sapp.alpha. secretion and improving cognition using bryostatin type compounds |
| US20040229292A1 (en) | 2002-11-26 | 2004-11-18 | Sebastiano Cavallaro | Use of FGF-18 in the diagnosis and treatment of memory disorders |
| US7803400B2 (en) | 2002-12-03 | 2010-09-28 | Blanchette Rockefeller Neurosciences Institute | Artificial low-density lipoprotein carriers for transport of substances across the blood-brain barrier |
| EA008864B1 (ru) | 2003-09-30 | 2007-08-31 | Нью Ривер Фармасьютикалз Инк. | Фармацевтические композиции для предотвращения передозировки или неправильного употребления лекарственных средств |
| TW201206425A (en) | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Treatment of depressive disorders |
| US20070054890A1 (en) | 2005-07-29 | 2007-03-08 | Alkon Daniel L | Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning |
| WO2007044094A1 (en) | 2005-10-11 | 2007-04-19 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb) |
| US20080025961A1 (en) | 2006-07-28 | 2008-01-31 | Alkon Daniel L | Methods of stimulating cellular growth, synaptic remodeling and consolidation of long-term memory |
| EP3332797A3 (en) | 2007-02-09 | 2018-08-01 | Blanchette Rockefeller Neurosciences Institute | Therapeutic effects of bryostatins, bryologs and other related substances on head trauma-induced memory impairment and brain injury |
| JP5987867B2 (ja) | 2014-07-10 | 2016-09-07 | コニカミノルタ株式会社 | シート搬送装置および画像形成システム |
-
2002
- 2002-06-13 US US10/167,491 patent/US6825229B2/en not_active Expired - Lifetime
-
2003
- 2003-03-07 CA CA002477973A patent/CA2477973A1/en not_active Abandoned
- 2003-03-07 WO PCT/US2003/007101 patent/WO2003075850A2/en not_active Ceased
- 2003-03-07 EP EP03716386.2A patent/EP1490050B1/en not_active Expired - Lifetime
- 2003-03-07 EP EP10000734.3A patent/EP2172246B1/en not_active Expired - Lifetime
- 2003-03-07 ES ES10000734.3T patent/ES2639578T3/es not_active Expired - Lifetime
- 2003-03-07 JP JP2003574126A patent/JP2005527512A/ja not_active Withdrawn
- 2003-03-07 AU AU2003220096A patent/AU2003220096A1/en not_active Abandoned
-
2004
- 2004-09-03 US US10/933,536 patent/US20050037984A1/en not_active Abandoned
-
2013
- 2013-03-27 US US13/851,161 patent/US9539235B2/en not_active Expired - Fee Related
-
2015
- 2015-11-02 US US14/929,731 patent/US9446020B2/en not_active Expired - Fee Related
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