BRPI0407832A - inibidor de pten ou abridor dos canais maxi-k - Google Patents
inibidor de pten ou abridor dos canais maxi-kInfo
- Publication number
- BRPI0407832A BRPI0407832A BRPI0407832-2A BRPI0407832A BRPI0407832A BR PI0407832 A BRPI0407832 A BR PI0407832A BR PI0407832 A BRPI0407832 A BR PI0407832A BR PI0407832 A BRPI0407832 A BR PI0407832A
- Authority
- BR
- Brazil
- Prior art keywords
- maxi
- medicine
- pten
- opener
- channel opener
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"INIBIDOR DE PTEN OU ABRIDOR DOS CANAIS MAXI-K". A presente invenção refere-se a um novo abridor do PTEN ou um novo abridor de um canal K¬ +¬ ativado por Ca¬ 2+¬ de grande condutância (canal Maxi-K) que compreende como um ingrediente ativo um composto de tetrazolilalcóxi-dihidrocarboestirila da fórmula (1), em que R é cicloalquila, A é um alquileno inferior, e a ligação entre as posições 3 e 4 do núcleo de carboestirila é ligação única ou uma ligação dupla, ou um sal deste, que é útil como um medicamento para a promoção da sobrevivência de células normais, células cerebrais, células cardíacas, e pele, e ainda para a inibição da sepse Gram negativa e migração celular e invasão celular devido à inibição do PTEN e é ainda útil como um medicamento para o tratamento de distúrbios neuronais, por exemplo, um anticonvulsivo, um agente neuroprotetor, um medicamento para o tratamento de edema cerebral regional e enfraquecimento motor neurológico, distúrbios cognitivos, lesão cerebral traumática, doença de Parkinson, epilepsia, enxaqueca e doença de Alzheimer, etc.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44943503P | 2003-02-25 | 2003-02-25 | |
US44958903P | 2003-02-26 | 2003-02-26 | |
PCT/JP2004/002146 WO2004075897A1 (en) | 2003-02-25 | 2004-02-24 | Pten inhibitor or maxi-k channels opener |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0407832A true BRPI0407832A (pt) | 2006-02-14 |
Family
ID=32930512
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0407832-2A BRPI0407832A (pt) | 2003-02-25 | 2004-02-24 | inibidor de pten ou abridor dos canais maxi-k |
Country Status (20)
Country | Link |
---|---|
US (3) | US7825130B2 (pt) |
EP (1) | EP1599205B1 (pt) |
JP (3) | JP4590397B2 (pt) |
KR (1) | KR101031163B1 (pt) |
CN (2) | CN1780623B (pt) |
AR (1) | AR043379A1 (pt) |
AT (1) | ATE345800T1 (pt) |
AU (1) | AU2004216340B9 (pt) |
BR (1) | BRPI0407832A (pt) |
CA (1) | CA2515590C (pt) |
CY (1) | CY1106294T1 (pt) |
DE (1) | DE602004003348T2 (pt) |
DK (1) | DK1599205T3 (pt) |
ES (1) | ES2276282T3 (pt) |
HK (2) | HK1148225A1 (pt) |
MX (1) | MXPA05008996A (pt) |
MY (1) | MY136863A (pt) |
PT (1) | PT1599205E (pt) |
TW (1) | TWI323660B (pt) |
WO (1) | WO2004075897A1 (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI323660B (en) * | 2003-02-25 | 2010-04-21 | Otsuka Pharma Co Ltd | Pten inhibitor or maxi-k channels opener |
TW200848041A (en) | 2007-03-30 | 2008-12-16 | Otsuka Pharma Co Ltd | A medicament for treating schizophrenia comprising cilostazol |
DK2157973T3 (en) * | 2007-05-22 | 2015-08-17 | Univ Juntendo | DRUG COMPREHENSIVE A carbostyril derivative donepezil AND TREATMENT Alzheimer's disease |
AR067746A1 (es) * | 2007-08-02 | 2009-10-21 | Otsuka Pharma Co Ltd | Un medicamento para tratar glaucoma que comprende como elemento activo compuesto de ciclodextrina - clatrato de cilostazol |
US9259438B2 (en) | 2008-01-17 | 2016-02-16 | Kui Liu | Methods for in vitro maturation of ovarian follicles |
AR070816A1 (es) * | 2008-03-14 | 2010-05-05 | Otsuka Pharma Co Ltd | Farmaco de combinacion para tratar trastornos vasculares |
WO2009117387A2 (en) * | 2008-03-17 | 2009-09-24 | The Trustees Of Columbia University In The City Of New York | Methods to treat neurodegenerative conditions or diseases by targeting components of a pten signaling pathway |
AU2009255973B2 (en) * | 2008-06-06 | 2013-08-15 | Children's Medical Center Corporation | Promoting axon regeneration in the adult CNS through control of protein translation |
CA2777628C (en) * | 2009-10-16 | 2019-12-03 | The University Of British Columbia | Inhibitors of phosphatase and tensin homolog (pten) compositions, uses and methods |
EP2322163A1 (en) * | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
WO2013067125A1 (en) | 2011-11-01 | 2013-05-10 | Children's Medical Center Corporation | Co-activation of mtor and stat3 pathways to promote neuronal survival and regeneration |
CA2876371A1 (en) | 2012-06-15 | 2013-12-19 | Foundation For Biomedical Research And Innovation | Prophylactic and/or therapeutic agent for mild cognitive impairment |
JP2016040542A (ja) * | 2014-08-13 | 2016-03-24 | 学校法人金沢医科大学 | 認知症治療薬または認知症治療薬候補物質のスクリーニング方法 |
JP2017070404A (ja) * | 2015-10-06 | 2017-04-13 | アンディ チャオ | トイレ床面の清潔な芳香パッド |
CN109310688B (zh) | 2016-05-19 | 2023-09-01 | 国立研究开发法人国立循环器病研究中心 | 用于预防和/或治疗痴呆症的药物 |
WO2021230131A1 (ja) * | 2020-05-11 | 2021-11-18 | 株式会社島津製作所 | 軽度認知障害治療剤 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5535019A (en) * | 1978-09-01 | 1980-03-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
JPS5649378A (en) * | 1979-08-25 | 1981-05-02 | Otsuka Pharmaceut Co Ltd | Tetrazolylalkoxycarbostyril derivative |
JPH0653666B2 (ja) | 1990-10-22 | 1994-07-20 | 大塚製薬株式会社 | ヒトの糖尿病性知覚障害および末梢神経障害の治療剤 |
JPH0614444A (ja) * | 1992-06-25 | 1994-01-21 | Central Japan Railway Co | 電力ケーブル接続部の固定装置 |
WO1994014444A1 (en) * | 1992-12-24 | 1994-07-07 | Otsuka Pharmaceutical Co., Ltd. | Psoriasis remedy |
JPH06239745A (ja) * | 1992-12-24 | 1994-08-30 | Otsuka Pharmaceut Co Ltd | 乾癬治療剤 |
JPH0776584A (ja) | 1993-09-07 | 1995-03-20 | Otsuka Pharmaceut Co Ltd | 内皮細胞障害抑制剤 |
JP3944257B2 (ja) | 1995-12-07 | 2007-07-11 | 大塚製薬株式会社 | 肝実質細胞増殖因子産生増加剤 |
US6322524B1 (en) * | 1997-08-28 | 2001-11-27 | Visco Technologies, Inc. | Dual riser/single capillary viscometer |
US6019735A (en) * | 1997-08-28 | 2000-02-01 | Visco Technologies, Inc. | Viscosity measuring apparatus and method of use |
US6428488B1 (en) * | 1997-08-28 | 2002-08-06 | Kenneth Kensey | Dual riser/dual capillary viscometer for newtonian and non-newtonian fluids |
US6322525B1 (en) * | 1997-08-28 | 2001-11-27 | Visco Technologies, Inc. | Method of analyzing data from a circulating blood viscometer for determining absolute and effective blood viscosity |
BR9908716A (pt) * | 1998-05-01 | 2000-11-21 | Neal R Cutler | Tratamento de disfunção sexual em certos grupos de pacientes |
US6187790B1 (en) * | 1999-03-04 | 2001-02-13 | Neal R. Cutler | Use of cilostazol for treatment of sexual dysfunction |
US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
US6267985B1 (en) * | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
US6257985B1 (en) * | 1999-10-01 | 2001-07-10 | Rexnord Corporation | Global shaft coupling |
US6484565B2 (en) * | 1999-11-12 | 2002-11-26 | Drexel University | Single riser/single capillary viscometer using mass detection or column height detection |
JP4159224B2 (ja) | 2000-02-29 | 2008-10-01 | 三洋電機株式会社 | 食器洗浄機 |
US6458804B1 (en) * | 2001-01-26 | 2002-10-01 | R.T. Alamo Venturesi, Llc | Methods for the treatment of central nervous system disorders in certain patient groups |
US6743806B2 (en) * | 2002-10-23 | 2004-06-01 | Otsuka Pharmaceutical Company, Limited | Active oxygen scavenger |
TWI323660B (en) * | 2003-02-25 | 2010-04-21 | Otsuka Pharma Co Ltd | Pten inhibitor or maxi-k channels opener |
-
2004
- 2004-02-11 TW TW093103143A patent/TWI323660B/zh not_active IP Right Cessation
- 2004-02-17 MY MYPI20040511A patent/MY136863A/en unknown
- 2004-02-24 US US10/546,632 patent/US7825130B2/en not_active Expired - Fee Related
- 2004-02-24 CN CN2004800111403A patent/CN1780623B/zh not_active Expired - Fee Related
- 2004-02-24 ES ES04713984T patent/ES2276282T3/es not_active Expired - Lifetime
- 2004-02-24 DK DK04713984T patent/DK1599205T3/da active
- 2004-02-24 DE DE602004003348T patent/DE602004003348T2/de not_active Expired - Lifetime
- 2004-02-24 EP EP04713984A patent/EP1599205B1/en not_active Expired - Lifetime
- 2004-02-24 AU AU2004216340A patent/AU2004216340B9/en not_active Ceased
- 2004-02-24 CN CN201010130082.3A patent/CN101829116B/zh not_active Expired - Fee Related
- 2004-02-24 AT AT04713984T patent/ATE345800T1/de active
- 2004-02-24 BR BRPI0407832-2A patent/BRPI0407832A/pt not_active IP Right Cessation
- 2004-02-24 CA CA2515590A patent/CA2515590C/en not_active Expired - Fee Related
- 2004-02-24 WO PCT/JP2004/002146 patent/WO2004075897A1/en active IP Right Grant
- 2004-02-24 MX MXPA05008996A patent/MXPA05008996A/es active IP Right Grant
- 2004-02-24 KR KR1020057015646A patent/KR101031163B1/ko active IP Right Grant
- 2004-02-24 JP JP2006502683A patent/JP4590397B2/ja not_active Expired - Fee Related
- 2004-02-24 PT PT04713984T patent/PT1599205E/pt unknown
- 2004-02-24 AR ARP040100573A patent/AR043379A1/es unknown
-
2006
- 2006-11-02 HK HK11102481.9A patent/HK1148225A1/zh not_active IP Right Cessation
- 2006-11-02 HK HK06112087.3A patent/HK1091409A1/xx not_active IP Right Cessation
- 2006-12-19 CY CY20061101814T patent/CY1106294T1/el unknown
-
2009
- 2009-12-30 US US12/650,275 patent/US8329731B2/en not_active Expired - Fee Related
-
2010
- 2010-08-12 JP JP2010180661A patent/JP5208172B2/ja not_active Expired - Lifetime
-
2012
- 2012-11-07 US US13/671,448 patent/US8653104B2/en not_active Expired - Fee Related
-
2013
- 2013-01-10 JP JP2013002314A patent/JP5566482B2/ja not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07F | Notification of approval that there is no relation to art. 229 of lpi (pipeline patents) [chapter 7.6 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2450 DE 19-12-2017 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |