PT854874E - Compostos de lactona macrociclica e seu processo de producao - Google Patents

Compostos de lactona macrociclica e seu processo de producao

Info

Publication number
PT854874E
PT854874E PT95932876T PT95932876T PT854874E PT 854874 E PT854874 E PT 854874E PT 95932876 T PT95932876 T PT 95932876T PT 95932876 T PT95932876 T PT 95932876T PT 854874 E PT854874 E PT 854874E
Authority
PT
Portugal
Prior art keywords
production process
lactone compounds
macrocylic lactone
macrocylic
compound
Prior art date
Application number
PT95932876T
Other languages
English (en)
Inventor
H Nishida
Y Yamauchi
T Inagaki
Y Kojima
N Kojima
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PT854874E publication Critical patent/PT854874E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT95932876T 1994-11-10 1995-10-13 Compostos de lactona macrociclica e seu processo de producao PT854874E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9401896 1994-11-10
PCT/IB1995/000870 WO1996015131A1 (en) 1994-11-10 1995-10-13 Macrocyclic lactone compounds and their production process

Publications (1)

Publication Number Publication Date
PT854874E true PT854874E (pt) 2003-07-31

Family

ID=1341416

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95932876T PT854874E (pt) 1994-11-10 1995-10-13 Compostos de lactona macrociclica e seu processo de producao

Country Status (12)

Country Link
US (2) US6001998A (pt)
EP (1) EP0854874B1 (pt)
JP (1) JP3061863B2 (pt)
AT (1) ATE239024T1 (pt)
CA (1) CA2204739C (pt)
DE (1) DE69530616T2 (pt)
DK (1) DK0854874T3 (pt)
ES (1) ES2194054T3 (pt)
FI (1) FI971995A0 (pt)
MX (1) MX9703484A (pt)
PT (1) PT854874E (pt)
WO (1) WO1996015131A1 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69530616T2 (de) * 1994-11-10 2004-04-01 Pfizer Inc. Macrocyklische lactonverbindungen und verfahren zu ihrer herstellung
US20040235889A1 (en) * 2001-05-02 2004-11-25 Miao-Kun Sun Carbonic anhydrase activator for enhancing learning and memory
US6551591B1 (en) 2001-09-07 2003-04-22 Essential Therapeutics, Inc. Antibiotics from microbispora
US20050065205A1 (en) * 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
US20080004332A1 (en) * 2002-03-07 2008-01-03 Alkon Daniel L Methods for alzheimer's disease treatment and cognitive enhancement
US6825229B2 (en) 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
CA2557582A1 (en) * 2004-02-17 2006-03-09 Thomas E. Johnson Methods, compositions, and apparatuses for forming macrocyclic compounds
TW201207390A (en) * 2004-05-18 2012-02-16 Brni Neurosciences Inst Method for screening agent for antidepressant activity
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
CA2598805A1 (en) * 2005-02-24 2006-08-31 Biocern, Inc. Sperm cell separation methods and compositions
WO2008028081A2 (en) * 2006-08-30 2008-03-06 Biocern, Inc. Sperm cell separation methods and compositions containing aptamers or nucleic acid sequences for use therein
WO2006119211A2 (en) * 2005-05-02 2006-11-09 Genaera Corporation Methods and compositions for treating ocular disorders
CA2617003A1 (en) * 2005-07-29 2007-02-08 Blanchette Rockefeller Neurosciences Institute Use of a pkc activator, alone or combined with a pkc inhibitor to enhance long term memory
JP2009544753A (ja) 2006-07-28 2009-12-17 ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート 細胞成長、シナプスリモデリング及び長期記憶の固定を刺激する方法
WO2008033956A2 (en) * 2006-09-13 2008-03-20 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
US8088789B2 (en) * 2006-09-13 2012-01-03 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
US10695327B2 (en) 2006-09-13 2020-06-30 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
CA2674773A1 (en) * 2007-02-09 2008-08-21 Blanchette Rockefeller Neurosciences Institute Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury
ES2528033T3 (es) 2007-02-09 2015-02-03 Blanchette Rockefeller Neurosciences Institute Efectos terapéuticos de las briostatinas sobre la alteración de la memoria inducida por isquemia/accidente vascular cerebral y lesiones cerebrales
CA2760292A1 (en) * 2009-05-01 2010-11-04 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
JP5833007B2 (ja) * 2009-08-31 2015-12-16 ドクター・レディーズ・ラボラトリーズ・リミテッド ステロイドを含む局所製剤
US20120027687A1 (en) 2010-07-08 2012-02-02 Alkon Daniel L Fatty acid protein kinase c activators and anticoagulant for the treatment of stroke
WO2012024630A1 (en) 2010-08-19 2012-02-23 Blanchette Rockefeller Neurosciences Institute Treatment of cognitive disorders associated with abnormal dendritic spines using pkc activators
EP3967299A1 (en) 2011-11-13 2022-03-16 Cognitive Research Enterprises, Inc. Pkc activators and combinations thereof
CA2985625A1 (en) 2015-05-11 2016-11-17 Alkon, Daniel L. Treatment of neurodegenerative conditions using pkc activators after determining the presence of the apoe4 allele
RU2629653C1 (ru) * 2016-03-21 2017-08-30 Федеральное государственное бюджетное образовательное учреждение высшего образования "Юго-Западный государственный университет " (ЮЗГУ) Мостовой измеритель параметров двухполюсников
CN107827803A (zh) * 2017-11-28 2018-03-23 绍兴厚普生物科技有限责任公司 一种从发酵液中提取l‑羟脯氨酸的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6903238A (pt) * 1968-03-04 1969-09-08
US5091389A (en) * 1991-04-23 1992-02-25 Merck & Co., Inc. Lipophilic macrolide useful as an immunosuppressant
US5674732A (en) * 1992-04-27 1997-10-07 Pfizer Inc. Rapamycin producer
CA2106034A1 (en) * 1992-09-24 1994-03-25 Ralph J. Russo 21-norrapamycin
DE69530616T2 (de) * 1994-11-10 2004-04-01 Pfizer Inc. Macrocyklische lactonverbindungen und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
JPH11507907A (ja) 1999-07-13
FI971995A (fi) 1997-05-09
US6187568B1 (en) 2001-02-13
WO1996015131A1 (en) 1996-05-23
ATE239024T1 (de) 2003-05-15
DK0854874T3 (da) 2003-06-02
JP3061863B2 (ja) 2000-07-10
MX9703484A (es) 1997-08-30
CA2204739C (en) 2000-04-04
FI971995A0 (fi) 1997-05-09
EP0854874A1 (en) 1998-07-29
US6001998A (en) 1999-12-14
DE69530616T2 (de) 2004-04-01
DE69530616D1 (de) 2003-06-05
EP0854874B1 (en) 2003-05-02
ES2194054T3 (es) 2003-11-16

Similar Documents

Publication Publication Date Title
PT854874E (pt) Compostos de lactona macrociclica e seu processo de producao
EA199800288A1 (ru) Производные 5-o-дезозаминил-6-o-метилэритронолида а, способ их получения и их применение для получения биологически активных продуктов
CA2291931A1 (en) Isochroman compounds and their production process
EA199901016A1 (ru) 9-оксим-производные эритромицина
EA199800768A1 (ru) Новые производные эритромицина, способ их получения и их применение в качестве медикаментов
ZA979553B (en) Bacterial strains and use thereof in fermentation processes for 2-keto-L-gulonic acid production.
EA200100416A1 (ru) 13-членные азалиды и их применение в качестве антибиотических агентов
MY145819A (en) Process and intermediates useful in the preparation of pharmaceutical compounds as fulvestrant
EP1589018A4 (en) PROCESS FOR PRODUCING A DERIVATIVE OF HEXAHYDROFURANOL, INTERMEDIATE THEREOF AND PROCESS FOR PRODUCING THE SAME
PT736029E (pt) Sulfamatos de pseudofructopiranose anticonvulsivos
EP1211259A4 (en) ANTIBIOTIC CAPRAZAMYCINS AND METHOD FOR THE PRODUCTION THEREOF
DE3672361D1 (de) Ein neues ansamycin-antibiotikum, ein mikrobielles verfahren zu seiner herstellung und seine verwendung als arzneimittel.
HUP9801083A2 (hu) Eljárás (1S,4R)- vagy (1R,4S)-4-[(2-amino-6-klór-9H-purin)-9-il]-2-ciklopentén-1-metanol előállítására
CA2223360A1 (en) Cyclic peptide compounds and their production process
ATE123034T1 (de) Cephalosporinzwischenverbindungen, verfahren zu ihrer herstellung sowie zur herstellung ihrer endprodukte.
IS3815A (is) Afleiður fjölhydroxyfimmhringa-efna, framleiðsla þeirra og notkun sem lyfja
DE60130916D1 (de) Neue beta-lactamverbindungen und verfahren zu deren herstellung
Berova et al. Malonofungin: An antifungal aminomalonic acid from Phaeoramularia fusimaculans
AU4442993A (en) Novel substances and microorganisms which produce them
BG103704A (en) New compounds
DE69302267D1 (de) Actinoplanes als erzeuger von rapamycin
Bringmann A first biosynthetic proposal for the in vivo formation of naturally occurring diazepam-like 1, 4-benzodiazepines
KR960041369A (ko) 프라바스타닌 나트륨의 제조방법
KR960037685A (ko) 암모니오세팔로스포린 계열 항생제 및 그의 제조방법
BG108151A (en) Caloporoside derivatives, methods for the production thereof and their use