ATE239024T1 - Macrocyklische lactonverbindungen und verfahren zu ihrer herstellung - Google Patents

Macrocyklische lactonverbindungen und verfahren zu ihrer herstellung

Info

Publication number
ATE239024T1
ATE239024T1 AT95932876T AT95932876T ATE239024T1 AT E239024 T1 ATE239024 T1 AT E239024T1 AT 95932876 T AT95932876 T AT 95932876T AT 95932876 T AT95932876 T AT 95932876T AT E239024 T1 ATE239024 T1 AT E239024T1
Authority
AT
Austria
Prior art keywords
macrocyclic lactone
production
lactone compounds
compound
lactone compound
Prior art date
Application number
AT95932876T
Other languages
English (en)
Inventor
H Nishida
Y Yamauchi
T Inagaki
Y Kojima
N Kojima
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE239024T1 publication Critical patent/ATE239024T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Polyesters Or Polycarbonates (AREA)
AT95932876T 1994-11-10 1995-10-13 Macrocyklische lactonverbindungen und verfahren zu ihrer herstellung ATE239024T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9401896 1994-11-10
PCT/IB1995/000870 WO1996015131A1 (en) 1994-11-10 1995-10-13 Macrocyclic lactone compounds and their production process

Publications (1)

Publication Number Publication Date
ATE239024T1 true ATE239024T1 (de) 2003-05-15

Family

ID=1341416

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95932876T ATE239024T1 (de) 1994-11-10 1995-10-13 Macrocyklische lactonverbindungen und verfahren zu ihrer herstellung

Country Status (12)

Country Link
US (2) US6001998A (de)
EP (1) EP0854874B1 (de)
JP (1) JP3061863B2 (de)
AT (1) ATE239024T1 (de)
CA (1) CA2204739C (de)
DE (1) DE69530616T2 (de)
DK (1) DK0854874T3 (de)
ES (1) ES2194054T3 (de)
FI (1) FI971995A0 (de)
MX (1) MX9703484A (de)
PT (1) PT854874E (de)
WO (1) WO1996015131A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2204739C (en) * 1994-11-10 2000-04-04 Hiroyuki Nishida Macrocyclic lactone compounds and their production process
DE60229371D1 (de) * 2001-05-02 2008-11-27 Brni Neurosciences Inst Kohlensäureanhydrase-aktivatoren zur verbesserung der lern- und gedächtnisleistung
US6551591B1 (en) 2001-09-07 2003-04-22 Essential Therapeutics, Inc. Antibiotics from microbispora
US20080004332A1 (en) * 2002-03-07 2008-01-03 Alkon Daniel L Methods for alzheimer's disease treatment and cognitive enhancement
US20050065205A1 (en) * 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
US6825229B2 (en) 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
RU2428422C2 (ru) * 2004-02-17 2011-09-10 Томас И. ДЖОНСОН Способы, композиции и устройства для получения макроциклических соединений
TW200538181A (en) * 2004-05-18 2005-12-01 Brni Neurosciences Inst Treatment of depressive disorders
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
CA2598805A1 (en) * 2005-02-24 2006-08-31 Biocern, Inc. Sperm cell separation methods and compositions
WO2006119211A2 (en) * 2005-05-02 2006-11-09 Genaera Corporation Methods and compositions for treating ocular disorders
US20070054890A1 (en) * 2005-07-29 2007-03-08 Alkon Daniel L Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning
JP2009544753A (ja) 2006-07-28 2009-12-17 ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート 細胞成長、シナプスリモデリング及び長期記憶の固定を刺激する方法
AU2007289164A1 (en) * 2006-08-30 2008-03-06 Biocern, Inc. Sperm cell separation methods and compositions containing aptamers or nucleic acid sequences for use therein
US10695327B2 (en) 2006-09-13 2020-06-30 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
EP2431036B1 (de) * 2006-09-13 2017-04-12 Elixir Medical Corporation Makrocyclische Lactonverbindungen und Verfahren zu deren Verwendung
US8088789B2 (en) 2006-09-13 2012-01-03 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
WO2008100450A2 (en) 2007-02-09 2008-08-21 Blanchette Rockefeller Neurosciences Institute Therapeutic effects of bryostatins, bryologs, and other related substances on ischemia/stroke-induced memory impairment and brain injury
EP2959914A1 (de) 2007-02-09 2015-12-30 Blanchette Rockefeller Neurosciences, Institute Therapeutische wirkungen von bryologen auf durch kopftraumata herbeigeführte gedächtnisstörungen und hirnverletzungen
JP5726171B2 (ja) * 2009-05-01 2015-05-27 グリコミメティックス インコーポレイテッド Ｅ−セレクチンおよびｃｘｃｒ４ケモカイン受容体のヘテロ二官能性阻害剤
DK2473161T3 (en) * 2009-08-31 2017-09-11 Dr Reddys Laboratories Ltd TOPICAL FORMULATIONS INCLUDING A STEROID
WO2012006510A1 (en) 2010-07-08 2012-01-12 Alkon Daniel L Fatty acid protein kinase c activators and anticoagulant for the treatment of stroke
EP2605773A1 (de) 2010-08-19 2013-06-26 Blanchette Rockefeller Neurosciences, Institute Behandlung von kognitiven störungen im zusammenhang mit abnormalen dendritischen spikes anhand von pkc-aktivatoren
JP6422778B2 (ja) 2011-11-13 2018-11-14 ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート Ｐｋｃアクチベーターおよびその組合せ
EP3294290A1 (de) 2015-05-11 2018-03-21 Alkon, Daniel, L. Behandlung neurodegenerativen erkrankungen mittels pkc-aktivatoren nach bestimmung des vorhandenseins des apoe4-allels
RU2629653C1 (ru) * 2016-03-21 2017-08-30 Федеральное государственное бюджетное образовательное учреждение высшего образования "Юго-Западный государственный университет " (ЮЗГУ) Мостовой измеритель параметров двухполюсников
CN107827803A (zh) * 2017-11-28 2018-03-23 绍兴厚普生物科技有限责任公司 一种从发酵液中提取l‑羟脯氨酸的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1910715A1 (de) * 1968-03-04 1969-10-09 Stanley Drug Products Inc Antimikrobielle Faktoren und deren Verwendung
US5091389A (en) * 1991-04-23 1992-02-25 Merck & Co., Inc. Lipophilic macrolide useful as an immunosuppressant
US5674732A (en) * 1992-04-27 1997-10-07 Pfizer Inc. Rapamycin producer
CA2106034A1 (en) * 1992-09-24 1994-03-25 Ralph J. Russo 21-norrapamycin
CA2204739C (en) * 1994-11-10 2000-04-04 Hiroyuki Nishida Macrocyclic lactone compounds and their production process

Also Published As

Publication number Publication date
US6187568B1 (en) 2001-02-13
US6001998A (en) 1999-12-14
FI971995A (fi) 1997-05-09
JPH11507907A (ja) 1999-07-13
DE69530616T2 (de) 2004-04-01
CA2204739C (en) 2000-04-04
FI971995A0 (fi) 1997-05-09
WO1996015131A1 (en) 1996-05-23
DE69530616D1 (de) 2003-06-05
PT854874E (pt) 2003-07-31
EP0854874B1 (de) 2003-05-02
DK0854874T3 (da) 2003-06-02
MX9703484A (es) 1997-08-30
EP0854874A1 (de) 1998-07-29
ES2194054T3 (es) 2003-11-16
JP3061863B2 (ja) 2000-07-10

Similar Documents

Publication Publication Date Title
ATE239024T1 (de) Macrocyklische lactonverbindungen und verfahren zu ihrer herstellung
ATE121091T1 (de) Phospholipase a2-inhibitor, mikroorganismen, die diesen inhibitor erzeugen und mehrere verfahren zu seiner herstellung.
ATE231850T1 (de) Isochroman verbindungen und verfahren zu deren produktion
DE69623960T2 (de) Zwischenprodukte und verfahren zur herstellung von camptothecin-derivate (cpt-11) und verwandte verbindungen
MY140677A (en) Modified amino acids, pharmaceuticals containing these compounds and method for their production
IL175350A0 (en) Method for the production of statins
MX9804046A (es) 6-0-metil eritromicina d y proceso para hacerla.
ATE430160T1 (de) Lipopeptid-stereoisomere, verfahren zu ihrer herstellung und nützliche zwischenprodukte
MY145819A (en) Process and intermediates useful in the preparation of pharmaceutical compounds as fulvestrant
ATA170384A (de) Verfahren zur herstellung von neuen 2-oxoazetidin-derivate
CA2019799A1 (en) Fucosidase inhibitor
DE3672361D1 (de) Ein neues ansamycin-antibiotikum, ein mikrobielles verfahren zu seiner herstellung und seine verwendung als arzneimittel.
PL301862A1 (en) Novel 17,20-epoxy derivatives of pregnane, method of obtaining them and their application in obtaining cortisone derivatives and intermediate products
DE59709792D1 (de) Ringannelierte dihydropyrane, verfahren zur herstellung sowie deren verwendung
CA2223360A1 (en) Cyclic peptide compounds and their production process
ATE299851T1 (de) Verfahren zur herstellung von zwischenprodukten
DE69521199D1 (de) Verbessertes verfahren zur herstellung von carbapenem zwischenprodukten
BG103704A (en) New compounds
CA2257095A1 (en) Process for purifying sterically hindered 4-amino piperidines
DE50101634D1 (de) VERFAHREN ZUR HERSTELLUNG VON IMIDAZO [1,2-c] [2,3]BENZODIAZEPINEN UND ZWISCHENPRODUKTE BEI DEREN HERSTELLUNG
ATE218561T1 (de) Terpenoide lactonverbindungen und verfahren zu ihrer herstellung
DE3480792D1 (de) 2-amino-1,9-dihydro-6h-purin-6-one-7-oxyde, die pharmazeutisch vertraeglichen salze und ein verfahren zu ihrer herstellung.
DE60008748D1 (de) Fluorinierte diole und verfahren zu ihrer herstellung

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0854874

Country of ref document: EP

REN Ceased due to non-payment of the annual fee