FI971995A - Makrosykliset laktoniyhdisteet ja niiden tuotantomenetelmä - Google Patents

Makrosykliset laktoniyhdisteet ja niiden tuotantomenetelmä Download PDF

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Publication number
FI971995A
FI971995A FI971995A FI971995A FI971995A FI 971995 A FI971995 A FI 971995A FI 971995 A FI971995 A FI 971995A FI 971995 A FI971995 A FI 971995A FI 971995 A FI971995 A FI 971995A
Authority
FI
Finland
Prior art keywords
macrocyclic lactone
preparation process
lactone compounds
compound
lactone compound
Prior art date
Application number
FI971995A
Other languages
English (en)
Swedish (sv)
Other versions
FI971995A0 (fi
Inventor
Hiroyuki Nishida
Yuji Yamauchi
Taisuke Inagaki
Yasuhiro Kojima
Nakao Kojima
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI971995A publication Critical patent/FI971995A/fi
Publication of FI971995A0 publication Critical patent/FI971995A0/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
FI971995A 1994-11-10 1997-05-09 Makrosykliset laktoniyhdisteet ja niiden tuotantomenetelmä FI971995A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9401896 1994-11-10
PCT/IB1995/000870 WO1996015131A1 (en) 1994-11-10 1995-10-13 Macrocyclic lactone compounds and their production process

Publications (2)

Publication Number Publication Date
FI971995A true FI971995A (fi) 1997-05-09
FI971995A0 FI971995A0 (fi) 1997-05-09

Family

ID=1341416

Family Applications (1)

Application Number Title Priority Date Filing Date
FI971995A FI971995A0 (fi) 1994-11-10 1997-05-09 Makrosykliset laktoniyhdisteet ja niiden tuotantomenetelmä

Country Status (12)

Country Link
US (2) US6001998A (fi)
EP (1) EP0854874B1 (fi)
JP (1) JP3061863B2 (fi)
AT (1) ATE239024T1 (fi)
CA (1) CA2204739C (fi)
DE (1) DE69530616T2 (fi)
DK (1) DK0854874T3 (fi)
ES (1) ES2194054T3 (fi)
FI (1) FI971995A0 (fi)
MX (1) MX9703484A (fi)
PT (1) PT854874E (fi)
WO (1) WO1996015131A1 (fi)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3061863B2 (ja) * 1994-11-10 2000-07-10 ファイザー製薬株式会社 大環状ラクトン化合物及びその製法
DE60229371D1 (de) * 2001-05-02 2008-11-27 Brni Neurosciences Inst Kohlensäureanhydrase-aktivatoren zur verbesserung der lern- und gedächtnisleistung
US6551591B1 (en) 2001-09-07 2003-04-22 Essential Therapeutics, Inc. Antibiotics from microbispora
US6825229B2 (en) 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
US20080004332A1 (en) * 2002-03-07 2008-01-03 Alkon Daniel L Methods for alzheimer's disease treatment and cognitive enhancement
US20050065205A1 (en) * 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
JP2008504225A (ja) * 2004-02-17 2008-02-14 ジョンソン，トーマス，イー． 大環状化合物を形成するための方法、組成物および装置
TW201207390A (en) 2004-05-18 2012-02-16 Brni Neurosciences Inst Method for screening agent for antidepressant activity
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
WO2008028081A2 (en) * 2006-08-30 2008-03-06 Biocern, Inc. Sperm cell separation methods and compositions containing aptamers or nucleic acid sequences for use therein
CA2598805A1 (en) * 2005-02-24 2006-08-31 Biocern, Inc. Sperm cell separation methods and compositions
WO2006119211A2 (en) * 2005-05-02 2006-11-09 Genaera Corporation Methods and compositions for treating ocular disorders
KR101347100B1 (ko) * 2005-07-29 2014-01-03 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 단독의 또는 ｐｋｃ 억제제와 배합된 ｐｋｃ 활성화제의 장기 기억 향상을 위한 용도
CA2659242C (en) 2006-07-28 2015-08-11 Blanchette Rockefeller Neurosciences Institute Methods of stimulating cellular growth, synaptic remodeling and consolidation of long-term memory
US8088789B2 (en) 2006-09-13 2012-01-03 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
US10695327B2 (en) 2006-09-13 2020-06-30 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
WO2008033956A2 (en) * 2006-09-13 2008-03-20 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
JP5872138B2 (ja) 2007-02-09 2016-03-01 ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート 虚血／卒中誘導性の記憶障害および脳障害におけるブリオスタチン、ブリオログ、および他の関連物質の治療効果
EP3332797A3 (en) 2007-02-09 2018-08-01 Blanchette Rockefeller Neurosciences Institute Therapeutic effects of bryostatins, bryologs and other related substances on head trauma-induced memory impairment and brain injury
WO2010126888A1 (en) * 2009-05-01 2010-11-04 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
WO2011026076A2 (en) * 2009-08-31 2011-03-03 Dr. Reddy's Laboratories Ltd. Topical formulations comprising a steroid
JP6446624B2 (ja) 2010-07-08 2019-01-09 アルコン、ダニエル・エル． 脳卒中の治療法におけるｐｋｃ活性化因子および抗凝血剤
EP2605773A1 (en) 2010-08-19 2013-06-26 Blanchette Rockefeller Neurosciences, Institute Treatment of cognitive disorders associated with abnormal dendritic spines using pkc activators
CA2855932A1 (en) 2011-11-13 2013-05-16 Blanchette Rockefeller Neurosciences Institute Pkc activators and combinations thereof
JP2018521113A (ja) 2015-05-11 2018-08-02 アルコン、ダニエル・エル． ＡｐｏＥ４対立遺伝子の存在を決定した後のＰＫＣ活性化因子を使用した神経変性状態の治療
RU2629653C1 (ru) * 2016-03-21 2017-08-30 Федеральное государственное бюджетное образовательное учреждение высшего образования "Юго-Западный государственный университет " (ЮЗГУ) Мостовой измеритель параметров двухполюсников
CN107827803A (zh) * 2017-11-28 2018-03-23 绍兴厚普生物科技有限责任公司 一种从发酵液中提取l‑羟脯氨酸的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1910715A1 (de) * 1968-03-04 1969-10-09 Stanley Drug Products Inc Antimikrobielle Faktoren und deren Verwendung
US5091389A (en) * 1991-04-23 1992-02-25 Merck & Co., Inc. Lipophilic macrolide useful as an immunosuppressant
US5674732A (en) * 1992-04-27 1997-10-07 Pfizer Inc. Rapamycin producer
CA2106034A1 (en) * 1992-09-24 1994-03-25 Ralph J. Russo 21-norrapamycin
JP3061863B2 (ja) * 1994-11-10 2000-07-10 ファイザー製薬株式会社 大環状ラクトン化合物及びその製法

Also Published As

Publication number Publication date
WO1996015131A1 (en) 1996-05-23
US6187568B1 (en) 2001-02-13
EP0854874B1 (en) 2003-05-02
JP3061863B2 (ja) 2000-07-10
ES2194054T3 (es) 2003-11-16
CA2204739C (en) 2000-04-04
PT854874E (pt) 2003-07-31
DE69530616T2 (de) 2004-04-01
DE69530616D1 (de) 2003-06-05
US6001998A (en) 1999-12-14
JPH11507907A (ja) 1999-07-13
MX9703484A (es) 1997-08-30
ATE239024T1 (de) 2003-05-15
DK0854874T3 (da) 2003-06-02
EP0854874A1 (en) 1998-07-29
FI971995A0 (fi) 1997-05-09

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