DK0854874T3 - Makrocykliske lactonforbindelser og fremgangsmåde til fremstilling af disse - Google Patents

Makrocykliske lactonforbindelser og fremgangsmåde til fremstilling af disse

Info

Publication number
DK0854874T3
DK0854874T3 DK95932876T DK95932876T DK0854874T3 DK 0854874 T3 DK0854874 T3 DK 0854874T3 DK 95932876 T DK95932876 T DK 95932876T DK 95932876 T DK95932876 T DK 95932876T DK 0854874 T3 DK0854874 T3 DK 0854874T3
Authority
DK
Denmark
Prior art keywords
macrocyclic lactone
processes
preparation
lactone compounds
compound
Prior art date
Application number
DK95932876T
Other languages
English (en)
Inventor
Pharm Inc Nagoya Plan H-Pfizer
Phar Inc Nagoyaplant Y-Pfizer
Phar Inc Nagoya Plant T-Pfizer
Phar Inc Nagoya Plant Y-Pfizer
Pharm Inc Nagoya Plan N-Pfizer
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK0854874T3 publication Critical patent/DK0854874T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrane Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
DK95932876T 1994-11-10 1995-10-13 Makrocykliske lactonforbindelser og fremgangsmåde til fremstilling af disse DK0854874T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9401896 1994-11-10
PCT/IB1995/000870 WO1996015131A1 (en) 1994-11-10 1995-10-13 Macrocyclic lactone compounds and their production process

Publications (1)

Publication Number Publication Date
DK0854874T3 true DK0854874T3 (da) 2003-06-02

Family

ID=1341416

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95932876T DK0854874T3 (da) 1994-11-10 1995-10-13 Makrocykliske lactonforbindelser og fremgangsmåde til fremstilling af disse

Country Status (12)

Country Link
US (2) US6001998A (da)
EP (1) EP0854874B1 (da)
JP (1) JP3061863B2 (da)
AT (1) ATE239024T1 (da)
CA (1) CA2204739C (da)
DE (1) DE69530616T2 (da)
DK (1) DK0854874T3 (da)
ES (1) ES2194054T3 (da)
FI (1) FI971995A0 (da)
MX (1) MX9703484A (da)
PT (1) PT854874E (da)
WO (1) WO1996015131A1 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69530616T2 (de) * 1994-11-10 2004-04-01 Pfizer Inc. Macrocyklische lactonverbindungen und verfahren zu ihrer herstellung
CA2744115A1 (en) * 2001-05-02 2002-11-07 Blanchette Rockefeller Neurosciences Institute Carbonic anhydrase activators for enhancing learning and memory
US6551591B1 (en) 2001-09-07 2003-04-22 Essential Therapeutics, Inc. Antibiotics from microbispora
US20050065205A1 (en) * 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
US20080004332A1 (en) * 2002-03-07 2008-01-03 Alkon Daniel L Methods for alzheimer's disease treatment and cognitive enhancement
US6825229B2 (en) 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
EP1716153B1 (en) * 2004-02-17 2013-10-09 Thomas E. Johnson Methods, compositions, and apparatuses for forming macrocyclic compounds
TW201207390A (en) 2004-05-18 2012-02-16 Brni Neurosciences Inst Method for screening agent for antidepressant activity
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
WO2006091717A1 (en) * 2005-02-24 2006-08-31 Biocern, Inc. Sperm cell separation methods and compositions
WO2006119211A2 (en) * 2005-05-02 2006-11-09 Genaera Corporation Methods and compositions for treating ocular disorders
CA2617003A1 (en) * 2005-07-29 2007-02-08 Blanchette Rockefeller Neurosciences Institute Use of a pkc activator, alone or combined with a pkc inhibitor to enhance long term memory
CN103961347A (zh) 2006-07-28 2014-08-06 布朗歇特洛克菲勒神经科学研究所 刺激细胞生长、突触重塑和巩固长期记忆的方法
RU2475539C2 (ru) * 2006-08-30 2013-02-20 Байосерн, Инк. Способы разделения сперматозоидов и применяемые для этого композиции, содержащие аптамеры или последовательности нуклеиновых кислот
WO2008033956A2 (en) 2006-09-13 2008-03-20 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
US8088789B2 (en) 2006-09-13 2012-01-03 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
US10695327B2 (en) 2006-09-13 2020-06-30 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
KR20090120480A (ko) 2007-02-09 2009-11-24 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 허혈/뇌졸중-유도된 기억 장애 및 뇌 손상에 대한 브리오스타틴, 브리오로그 및 기타 관련된 물질의 치료학적 효과
EP2121000B1 (en) 2007-02-09 2015-09-23 Blanchette Rockefeller Neurosciences, Institute Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury
JP5726171B2 (ja) * 2009-05-01 2015-05-27 グリコミメティックス インコーポレイテッド Ｅ−セレクチンおよびｃｘｃｒ４ケモカイン受容体のヘテロ二官能性阻害剤
EP3141246A1 (en) * 2009-08-31 2017-03-15 Dr. Reddy's Laboratories Ltd. Topical formulations comprising a steroid
US20120020948A1 (en) 2010-07-08 2012-01-26 Alkon Daniel L Dag-type and indirect protein kinase c activators and anticoagulant for the treatment of stroke
JP6062362B2 (ja) 2010-08-19 2017-01-18 ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート Ｐｋｃ活性化剤を使用した、異常な樹状突起棘に関連した認知障害の治療
WO2013071282A1 (en) 2011-11-13 2013-05-16 Blanchette Rockefeller Neurosciences Institute Pkc activators and combinations thereof
US20180217163A1 (en) 2015-05-11 2018-08-02 Daniel L. Alkon Treatment of neurodegenerative conditions using pkc activators after determining the presence of the apoe4 allele
RU2629653C1 (ru) * 2016-03-21 2017-08-30 Федеральное государственное бюджетное образовательное учреждение высшего образования "Юго-Западный государственный университет " (ЮЗГУ) Мостовой измеритель параметров двухполюсников
CN107827803A (zh) * 2017-11-28 2018-03-23 绍兴厚普生物科技有限责任公司 一种从发酵液中提取l‑羟脯氨酸的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1910715A1 (de) * 1968-03-04 1969-10-09 Stanley Drug Products Inc Antimikrobielle Faktoren und deren Verwendung
US5091389A (en) * 1991-04-23 1992-02-25 Merck & Co., Inc. Lipophilic macrolide useful as an immunosuppressant
US5674732A (en) * 1992-04-27 1997-10-07 Pfizer Inc. Rapamycin producer
CA2106034A1 (en) * 1992-09-24 1994-03-25 Ralph J. Russo 21-norrapamycin
DE69530616T2 (de) * 1994-11-10 2004-04-01 Pfizer Inc. Macrocyklische lactonverbindungen und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
DE69530616T2 (de) 2004-04-01
DE69530616D1 (de) 2003-06-05
ATE239024T1 (de) 2003-05-15
US6001998A (en) 1999-12-14
CA2204739C (en) 2000-04-04
JP3061863B2 (ja) 2000-07-10
ES2194054T3 (es) 2003-11-16
JPH11507907A (ja) 1999-07-13
US6187568B1 (en) 2001-02-13
WO1996015131A1 (en) 1996-05-23
PT854874E (pt) 2003-07-31
EP0854874A1 (en) 1998-07-29
FI971995A (fi) 1997-05-09
MX9703484A (es) 1997-08-30
EP0854874B1 (en) 2003-05-02
FI971995A0 (fi) 1997-05-09

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