ES2061963T3 - Briostatinas inmunomoduladoras. - Google Patents
Briostatinas inmunomoduladoras.Info
- Publication number
- ES2061963T3 ES2061963T3 ES89300174T ES89300174T ES2061963T3 ES 2061963 T3 ES2061963 T3 ES 2061963T3 ES 89300174 T ES89300174 T ES 89300174T ES 89300174 T ES89300174 T ES 89300174T ES 2061963 T3 ES2061963 T3 ES 2061963T3
- Authority
- ES
- Spain
- Prior art keywords
- ctl
- bryostatin
- ril
- triggering
- bryostatins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
BAJAS CONCENTRACIONES DE LOS ACTIVADORES DE PROTEINA QUINASA C, BRIOTATINAS 1 Y 2, SIMERGIZADAS CON BSF - 1 SON UTILES PARA INICIAR DIFERENCIACION (EXPRESION DE ENCIMA DE GRANULOS) Y DESARROLLO DE CTL EN CELULAS - T NATIVAS DE NODOS LINFATICOS EN REPOSO. LA BRIOSTATINA AUMENTA MUCHO LA EFICACIA DE RIL - 2 PARA INICIAR EL DESARROLLO DE CTL PREPARADO IN VIVO DURANTE LA INCUBACION IN VITRO, PROPORCIONANDO ASI EVIDENCIA DEL USO DE CONCENTRACIONES MAS BAJAS DE RIL - 2 EN EL RECHAZO DE TUMORES IN VIVO. AMBAS BRIOSTATINAS 1 Y 2, INICIAN CITOTOXICIDAD DE CLONES CTL FRENTE A CELULAS DIANA QUE NO LLEVAN AG E INHIBEN LA CITOTOXICIDAD DE CTL FRENTE A CELULAS DIANA AG ESPECIFICAS. LAS BRIOSTATINAS 1 Y 2 SE SIMERGIZAN CON IONOFOROS DE CA2+ PARA INICIAR LA EXOCITOSIS DE GRANULOS CITOLITICOS DE CTL A CONCENTRACIONES MUY BAJAS. A CAUSA DE LA FALTA DE ACTIVIDAD PROMOTORA DE TUMORES DE LAS BRIOSTATINAS, SON UTILES COMO FARMACOS INMUNOMODULADORES Y COMO POTENCIADORES DE RIL - 2 EN INMUNOTERAPIA DE ADOPCION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14491288A | 1988-01-13 | 1988-01-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2061963T3 true ES2061963T3 (es) | 1994-12-16 |
Family
ID=22510713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89300174T Expired - Lifetime ES2061963T3 (es) | 1988-01-13 | 1989-01-10 | Briostatinas inmunomoduladoras. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0324574B1 (es) |
JP (1) | JP2973322B2 (es) |
AT (1) | ATE97321T1 (es) |
DE (1) | DE68910704T2 (es) |
ES (1) | ES2061963T3 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5681860A (en) * | 1993-09-21 | 1997-10-28 | The Trustees Of Columbia University In The City Of New York | Method of increasing expression of HLA, cell surface and TAA antigens of cells using 3-(N-acetylamino)-5-(N-decyl-N-methylamino)-benzyl alcohol |
EP0969869A2 (en) * | 1996-07-26 | 2000-01-12 | Susan P. Perrine | Compositions comprising an inducing agent and an anti-viral agent for the treatment of blood, viral and cellular disorders |
US6197743B1 (en) | 1996-07-26 | 2001-03-06 | The Trustees Of Boston University | Compositions and methods for the treatment of viral disorders |
WO1999040883A2 (en) | 1998-02-11 | 1999-08-19 | Faller Douglas V | Compositions and methods for the treatment of cystic fibrosis |
US7256286B2 (en) | 1999-11-30 | 2007-08-14 | The Board Of Trustees Of The Leland Stanford Junior University | Bryostatin analogues, synthetic methods and uses |
US6825229B2 (en) | 2002-03-07 | 2004-11-30 | Blanchette Rockefeller Neurosciences Institute | Methods for Alzheimer's Disease treatment and cognitive enhancement |
US20050065205A1 (en) | 2002-03-07 | 2005-03-24 | Daniel Alkon | Methods for Alzheimer's disease treatment and cognitive enhance |
TW201206425A (en) | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Treatment of depressive disorders |
CA2617003A1 (en) | 2005-07-29 | 2007-02-08 | Blanchette Rockefeller Neurosciences Institute | Use of a pkc activator, alone or combined with a pkc inhibitor to enhance long term memory |
EP2959914A1 (en) | 2007-02-09 | 2015-12-30 | Blanchette Rockefeller Neurosciences, Institute | Therapeutic effects of bryologs on head trauma-induced memory impairment and brain injury |
US20110086869A1 (en) | 2009-09-24 | 2011-04-14 | The Trustees Of Boston University | Methods for treating viral disorders |
CN102802412A (zh) | 2009-12-08 | 2012-11-28 | 海玛奎斯特医药公司 | 用于治疗红细胞病症的方法及低剂量方案 |
US20110245154A1 (en) | 2010-03-11 | 2011-10-06 | Hemaquest Pharmaceuticals, Inc. | Methods and Compositions for Treating Viral or Virally-Induced Conditions |
US20180030095A1 (en) | 2015-02-13 | 2018-02-01 | George Robert Pettit | Silstatin compounds |
WO2019094709A1 (en) | 2017-11-09 | 2019-05-16 | Pettit George R | Betulastatin compounds |
EP3976198A4 (en) | 2019-05-31 | 2023-07-19 | Viracta Subsidiary, Inc. | METHODS OF TREATMENT OF VIRAL ASSOCIATED CANCER WITH HISTONE DEACETYLASE INHIBITORS |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4560774A (en) * | 1982-11-17 | 1985-12-24 | Arizona State University | Macrocyclic lactones |
EP0149551A3 (en) * | 1984-01-16 | 1987-09-23 | Genentech, Inc. | Gamma interferon-interleukin-2 synergistic compositions and processes therefor |
DE3704389A1 (de) * | 1987-02-12 | 1988-08-25 | Blutspendedienst Dt Rote Kreuz | Verfahren zur herstellung von lymphokinen durch induktion lymphoider zellen |
-
1989
- 1989-01-10 JP JP1002172A patent/JP2973322B2/ja not_active Expired - Fee Related
- 1989-01-10 EP EP89300174A patent/EP0324574B1/en not_active Expired - Lifetime
- 1989-01-10 AT AT89300174T patent/ATE97321T1/de not_active IP Right Cessation
- 1989-01-10 DE DE89300174T patent/DE68910704T2/de not_active Expired - Fee Related
- 1989-01-10 ES ES89300174T patent/ES2061963T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE68910704T2 (de) | 1994-04-07 |
EP0324574B1 (en) | 1993-11-18 |
JPH01308228A (ja) | 1989-12-12 |
EP0324574A2 (en) | 1989-07-19 |
EP0324574A3 (en) | 1990-12-05 |
DE68910704D1 (de) | 1993-12-23 |
JP2973322B2 (ja) | 1999-11-08 |
ATE97321T1 (de) | 1993-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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