JP2005526833A5 - - Google Patents

Info

Publication number

JP2005526833A5

JP2005526833A5 JP2003585728A JP2003585728A JP2005526833A5 JP 2005526833 A5 JP2005526833 A5 JP 2005526833A5 JP 2003585728 A JP2003585728 A JP 2003585728A JP 2003585728 A JP2003585728 A JP 2003585728A JP 2005526833 A5 JP2005526833 A5 JP 2005526833A5

Authority

JP

Japan

Prior art keywords

dihydroxyvitamin

composition

hydroxyl

hydrogen

vitamin

Prior art date

2003-04-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000000203 mixture Substances 0.000 claims 20
• 125000003342 alkenyl group Chemical group 0.000 claims 10
• 229910052739 hydrogen Inorganic materials 0.000 claims 10
• 239000001257 hydrogen Substances 0.000 claims 10
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 10
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
• 125000000217 alkyl group Chemical group 0.000 claims 8
• 238000010521 absorption reaction Methods 0.000 claims 6
• GMRQFYUYWCNGIN-ZVUFCXRFSA-N 1,25-dihydroxy vitamin D3 Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-ZVUFCXRFSA-N 0.000 claims 4
• 201000002980 Hyperparathyroidism Diseases 0.000 claims 4
• 206010047626 Vitamin D Deficiency Diseases 0.000 claims 4
• 125000002252 acyl group Chemical group 0.000 claims 4
• 125000000753 cycloalkyl group Chemical group 0.000 claims 4
• 125000004991 fluoroalkenyl group Chemical group 0.000 claims 4
• 125000003709 fluoroalkyl group Chemical group 0.000 claims 4
• 238000007911 parenteral administration Methods 0.000 claims 4
• 208000011580 syndromic disease Diseases 0.000 claims 4
• GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 claims 3
• NEETXMRNUNEBRH-GOTXBORWSA-N (1r,3s,5z)-5-[(2e)-2-[(1r,3as,7ar)-1-[(2r,5s)-5,6-dimethylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CC[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C NEETXMRNUNEBRH-GOTXBORWSA-N 0.000 claims 2
• ZGLHBRQAEXKACO-XJRQOBMKSA-N 1alpha,25-dihydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C ZGLHBRQAEXKACO-XJRQOBMKSA-N 0.000 claims 2
• HVAVRRBYXYEBNC-RKULPTJNSA-N 24-hydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/C(C)(O)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C HVAVRRBYXYEBNC-RKULPTJNSA-N 0.000 claims 2
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
• 229930003316 Vitamin D Natural products 0.000 claims 2
• QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 2
• 230000032683 aging Effects 0.000 claims 2
• 229910052799 carbon Inorganic materials 0.000 claims 2
• 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 2
• 238000011260 co-administration Methods 0.000 claims 2
• 230000007812 deficiency Effects 0.000 claims 2
• HKXBNHCUPKIYDM-CGMHZMFXSA-N doxercalciferol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C HKXBNHCUPKIYDM-CGMHZMFXSA-N 0.000 claims 2
• 150000002431 hydrogen Chemical class 0.000 claims 2
• 238000001990 intravenous administration Methods 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 239000002694 phosphate binding agent Substances 0.000 claims 2
• 208000024891 symptom Diseases 0.000 claims 2
• 239000011710 vitamin D Substances 0.000 claims 2
• 235000019166 vitamin D Nutrition 0.000 claims 2
• 150000003710 vitamin D derivatives Chemical class 0.000 claims 2
• MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims 2
• 229940046008 vitamin d Drugs 0.000 claims 2
• 239000011612 calcitriol Substances 0.000 claims 1