JP2006519854A5 - - Google Patents

Info

Publication number

JP2006519854A5

JP2006519854A5 JP2006508652A JP2006508652A JP2006519854A5 JP 2006519854 A5 JP2006519854 A5 JP 2006519854A5 JP 2006508652 A JP2006508652 A JP 2006508652A JP 2006508652 A JP2006508652 A JP 2006508652A JP 2006519854 A5 JP2006519854 A5 JP 2006519854A5

Authority

JP

Japan

Prior art keywords

vitamin

compound

group

administered

hydrogen atom

Prior art date

2004-02-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 238000000034 method Methods 0.000 claims 40
• 239000011710 vitamin D Substances 0.000 claims 27
• 229940046008 vitamin d Drugs 0.000 claims 27
• 229930003316 Vitamin D Natural products 0.000 claims 25
• QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 25
• 235000019166 vitamin D Nutrition 0.000 claims 25
• -1 vitamin D compound Chemical class 0.000 claims 25
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 8
• 125000003342 alkenyl group Chemical group 0.000 claims 5
• 125000000217 alkyl group Chemical group 0.000 claims 5
• 125000002252 acyl group Chemical group 0.000 claims 3
• 239000011230 binding agent Substances 0.000 claims 3
• 208000020832 chronic kidney disease Diseases 0.000 claims 3
• 239000002552 dosage form Substances 0.000 claims 3
• 125000003709 fluoroalkyl group Chemical group 0.000 claims 3
• 239000002694 phosphate binding agent Substances 0.000 claims 3
• ODZFJAXAEXQSKL-USTMCHFFSA-N 1,24(S)-dihydroxyvitamin D2 Chemical compound C([C@@H]([C@]1(CCC2)C)[C@H](C)/C=C/[C@@](C)(O)C(C)C)CC1\C2=C\C=C1\C[C@@H](O)C[C@H](O)C1=C ODZFJAXAEXQSKL-USTMCHFFSA-N 0.000 claims 2
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical group [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
• 102000003982 Parathyroid hormone Human genes 0.000 claims 2
• 108090000445 Parathyroid hormone Proteins 0.000 claims 2
• 238000010521 absorption reaction Methods 0.000 claims 2
• 229910052791 calcium Inorganic materials 0.000 claims 2
• 239000011575 calcium Substances 0.000 claims 2
• 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 2
• 125000000753 cycloalkyl group Chemical group 0.000 claims 2
• HKXBNHCUPKIYDM-CGMHZMFXSA-N doxercalciferol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C HKXBNHCUPKIYDM-CGMHZMFXSA-N 0.000 claims 2
• 125000004991 fluoroalkenyl group Chemical group 0.000 claims 2
• 239000000199 parathyroid hormone Substances 0.000 claims 2
• 229960001319 parathyroid hormone Drugs 0.000 claims 2
• 230000003442 weekly effect Effects 0.000 claims 2
• NEETXMRNUNEBRH-GOTXBORWSA-N (1r,3s,5z)-5-[(2e)-2-[(1r,3as,7ar)-1-[(2r,5s)-5,6-dimethylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CC[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C NEETXMRNUNEBRH-GOTXBORWSA-N 0.000 claims 1
• ZGLHBRQAEXKACO-XJRQOBMKSA-N 1alpha,25-dihydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C ZGLHBRQAEXKACO-XJRQOBMKSA-N 0.000 claims 1
• HVAVRRBYXYEBNC-RKULPTJNSA-N 24-hydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/C(C)(O)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C HVAVRRBYXYEBNC-RKULPTJNSA-N 0.000 claims 1
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
• 201000002980 Hyperparathyroidism Diseases 0.000 claims 1
• 125000003118 aryl group Chemical group 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 claims 1
• 150000001721 carbon Chemical group 0.000 claims 1
• 229910052799 carbon Inorganic materials 0.000 claims 1
• 125000004122 cyclic group Chemical group 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 238000010253 intravenous injection Methods 0.000 claims 1
• MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims 1