JP2006519854A - ビタミンｄ２及びｄ４化合物により上皮小体機能亢進症を治療しかつ予防する方法 - Google Patents
ビタミンｄ２及びｄ４化合物により上皮小体機能亢進症を治療しかつ予防する方法 Download PDFInfo
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- JP2006519854A JP2006519854A JP2006508652A JP2006508652A JP2006519854A JP 2006519854 A JP2006519854 A JP 2006519854A JP 2006508652 A JP2006508652 A JP 2006508652A JP 2006508652 A JP2006508652 A JP 2006508652A JP 2006519854 A JP2006519854 A JP 2006519854A
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Landscapes
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/385,327 US20040043971A1 (en) | 1995-04-03 | 2003-03-10 | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
| PCT/US2004/003059 WO2004080467A2 (en) | 2003-03-10 | 2004-02-04 | Method of treating and preventing hyperparathyroidism with vitamin d2 or d4 compounds |
Publications (2)
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| EP (1) | EP1601364A2 (https=) |
| JP (1) | JP2006519854A (https=) |
| CN (1) | CN1758916A (https=) |
| AU (1) | AU2004220622A1 (https=) |
| BR (1) | BRPI0408198A (https=) |
| CA (1) | CA2517160A1 (https=) |
| WO (1) | WO2004080467A2 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010525079A (ja) * | 2007-04-25 | 2010-07-22 | シトクロマ インコーポレイテッド | ビタミンｄ療法のための方法および化合物 |
| JP2010525078A (ja) * | 2007-04-25 | 2010-07-22 | シトクロマ インコーポレイテッド | ビタミンｄ化合物およびワックス状担体を含有する制御放出性経口組成物 |
| JP2014098034A (ja) * | 2007-04-25 | 2014-05-29 | Proventiv Therapeutics Llc | 慢性腎臓病における続発性副甲状腺機能亢進症の安全かつ効果的な治療および予防方法 |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
| US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| CA2387693A1 (en) * | 1999-09-20 | 2001-03-29 | Eli Lilly And Company | Method for monitoring treatment with a parathyroid hormone |
| BR0214679A (pt) * | 2001-12-03 | 2004-12-14 | Novacea Inc | Composições farmacêuticas compreendendo compostos a base de vitamina d ativa |
| US20050026877A1 (en) * | 2002-12-03 | 2005-02-03 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| US20050020546A1 (en) * | 2003-06-11 | 2005-01-27 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| US20050148557A1 (en) * | 2003-07-29 | 2005-07-07 | Jin Tian | Use of Vitamin Ds to treat kidney disease |
| MXPA06002257A (es) * | 2003-08-26 | 2006-05-17 | Shire Holdings Ag | Farmaceutica que comprende compuestos de lantano. |
| US7381428B2 (en) | 2003-08-26 | 2008-06-03 | Shire International Licensing B.V. | Stabilized lanthanum carbonate compositions |
| US20050239756A1 (en) * | 2004-04-23 | 2005-10-27 | Bone Care International, Inc. | Methods of treating various vitamin D metabolism conditions with 1alpha-hydroxyvitamin D2 |
| WO2007047327A2 (en) * | 2005-10-12 | 2007-04-26 | Proventiv Therapeutics, Llc | Methods and articles for treating 25-hydroxyvitamin d insufficiency and deficiency |
| EP3066923B1 (en) * | 2006-01-30 | 2025-11-05 | Panion & BF Biotech Inc. | Method of treating chronic kidney disease |
| SI3095447T1 (sl) * | 2006-02-03 | 2022-02-28 | Opko Renal, Llc | Zdravljenje pomanjkanja vitamina D s 25-hidroksivitaminom D2 in 25-hidroksivitaminom D3 |
| HUE037309T2 (hu) | 2006-06-21 | 2018-08-28 | Opko Ireland Global Holdings Ltd | Terápia D-vitamin telítési szer alkalmazásával és D-vitamin hormon helyettesítõ szer |
| EP1932807A1 (en) * | 2006-12-14 | 2008-06-18 | Novartis AG | Inorganic compounds |
| DK2148684T3 (da) * | 2007-04-25 | 2013-04-22 | Cytochroma Inc | Fremgangsmåde til behandling af vitamin D-insufficiens og -deficiens |
| US20110039809A1 (en) * | 2008-02-13 | 2011-02-17 | Neil Robert Buck | Combined use of 25-hydroxy-vitamin d3 and vitamin d3 for improving bone mineral density and for treating osteoporisis |
| CN106214683A (zh) * | 2008-02-13 | 2016-12-14 | 帝斯曼知识产权资产管理有限公司 | 维生素d和25‑羟基维生素d3的组合 |
| ES2599761T5 (en) * | 2008-02-13 | 2025-06-18 | Dsm Ip Assets Bv | Use of 25-hydroxy-vitamin d3 and vitamin d to affect human muscle physiology |
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| EP2334292B1 (en) * | 2008-10-17 | 2019-05-08 | Fresenius Medical Care Holdings, Inc. | Method of determining a phosphorus binder dosage for a dialysis patient |
| PT2552484T (pt) | 2010-03-29 | 2020-04-03 | Opko Ireland Global Holdings Ltd | Métodos e composições para redução dos níveis de parafróides |
| EP2601532B1 (en) | 2010-08-06 | 2016-01-27 | Mycartis N.V. | Perlecan as a biomarker for renal dysfunction |
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| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| US10369161B2 (en) | 2014-12-30 | 2019-08-06 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-NOR-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat primary hyperparathyroidism |
| US9539264B2 (en) | 2014-12-30 | 2017-01-10 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism in patients previously treated with calcimimetics |
| MY198547A (en) | 2016-03-28 | 2023-09-04 | Opko Ireland Global Holdings Ltd | Methods of vitamin d treatment |
| CN106723065A (zh) * | 2017-01-12 | 2017-05-31 | 浙江格蕾斯生物科技有限公司 | 一种维生素d和硼复合营养补充剂 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5602116A (en) * | 1988-08-02 | 1997-02-11 | Bone Care International, Inc. | Method for treating and preventing secondary hyperparathyroidism |
| US5869473A (en) * | 1988-08-02 | 1999-02-09 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| US6376479B1 (en) * | 1995-04-03 | 2002-04-23 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US515135A (en) * | 1894-02-20 | Railway-switch | ||
| US2383446A (en) * | 1941-06-04 | 1945-08-28 | Du Pont | Antirachitic materials and processes for their production |
| US3697559A (en) * | 1971-02-25 | 1972-10-10 | Wisconsin Alumni Res Found | 1,25-dihydroxycholecalciferol |
| US3741996A (en) * | 1971-12-02 | 1973-06-26 | Wisconsin Alumni Res Found | 1{60 -hydroxycholecalciferol |
| US4670190A (en) * | 1973-01-10 | 1987-06-02 | Hesse Robert H | 1-α-hydroxy vitamin D compounds and process for preparing same |
| US3907843A (en) * | 1974-06-14 | 1975-09-23 | Wisconsin Alumni Res Found | 1{60 -Hydroxyergocalciferol and processes for preparing same |
| US4181721A (en) * | 1975-10-27 | 1980-01-01 | Schering Aktiengesellschaft | Depot preparations in an oily, unsaturated solution for intramuscular injection |
| US4202829A (en) * | 1978-01-05 | 1980-05-13 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
| US4260549A (en) * | 1979-05-21 | 1981-04-07 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
| US4195027A (en) * | 1978-01-16 | 1980-03-25 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
| US4160803A (en) * | 1978-03-23 | 1979-07-10 | Corning Glass Works | Self packaged test kit |
| US4225596A (en) * | 1978-10-13 | 1980-09-30 | Wisconsin Alumni Research Foundation | Method for treating calcium imbalance and improving calcium absorption in mammals |
| JPS5626820A (en) * | 1979-08-10 | 1981-03-16 | Chugai Pharmaceut Co Ltd | Immunosuppressing agent |
| US4234495A (en) * | 1979-09-10 | 1980-11-18 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxyvitamin D compounds from 1α-hydroxy-3,5-cyclovitamin D compounds |
| EP0028484B1 (en) * | 1979-10-23 | 1985-08-14 | Teijin Limited | Process for the preparation of active-type vitamin d3 compounds and of the cholesta-5,7-diene precursors, and products so obtained |
| US4362710A (en) * | 1980-07-04 | 1982-12-07 | Nissan Gosei Kogyo Co., Ltd. | Feeds for baby pigs, process for preparing the same and method of breeding baby pigs |
| JPS57149224A (en) * | 1981-03-13 | 1982-09-14 | Chugai Pharmaceut Co Ltd | Tumor-suppressing agent |
| US4652405A (en) * | 1981-08-28 | 1987-03-24 | Hoffman-La Roche Inc. | Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol |
| US4508651A (en) * | 1983-03-21 | 1985-04-02 | Hoffmann-La Roche Inc. | Synthesis of 1α,25-dihydroxyergocalciferol |
| US4689180A (en) * | 1984-01-30 | 1987-08-25 | Wisconsin Alumni Research Foundation | 1α,25-dihydroxy-22Z-dehydroxyvitamin D compound |
| US4717566A (en) * | 1984-03-19 | 1988-01-05 | Alza Corporation | Dosage system and method of using same |
| US4588716A (en) * | 1984-05-04 | 1986-05-13 | Wisconsin Alumni Research Foundation | Method for treating metabolic bone disease in mammals |
| US4554106A (en) * | 1984-11-01 | 1985-11-19 | Wisconsin Alumni Research Foundation | Method for preparing 1α-hydroxyvitamin D compounds |
| US4555364A (en) * | 1984-11-01 | 1985-11-26 | Wisconsin Alumni Research Foundation | Method for preparing 1-hydroxyvitamin D compounds |
| CA1332841C (en) * | 1984-11-27 | 1994-11-01 | Noboru Kubodera | Vitamin d derivatives and process for producing the same |
| US4717721A (en) * | 1985-05-30 | 1988-01-05 | Howard W. Bremer | Sidechain homo-vitamin D compounds with preferential anti-cancer activity |
| US4650665A (en) * | 1985-02-08 | 1987-03-17 | Ethicon, Inc. | Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition |
| US4661294A (en) * | 1985-03-18 | 1987-04-28 | The General Hospital Corporation | Biologically active 1-thio derivatives of vitamin D |
| IL78342A (en) * | 1985-04-04 | 1991-06-10 | Gen Hospital Corp | Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof |
| US4749710A (en) * | 1985-05-01 | 1988-06-07 | Hoffmann-La Roche Inc. | Immunosuppressive agents |
| CA1317546C (en) * | 1985-07-01 | 1993-05-11 | Werner Meier | Pharmaceutical preparations containing mixtures of hydroxy derivatives of vitamin d |
| US4866048A (en) * | 1985-08-02 | 1989-09-12 | Leo Pharmaceutical Products Ltd. | Novel vitamin D analogues |
| US5554386A (en) * | 1986-07-03 | 1996-09-10 | Advanced Magnetics, Inc. | Delivery of therapeutic agents to receptors using polysaccharides |
| US5527524A (en) * | 1986-08-18 | 1996-06-18 | The Dow Chemical Company | Dense star polymer conjugates |
| US5338532A (en) * | 1986-08-18 | 1994-08-16 | The Dow Chemical Company | Starburst conjugates |
| US4833125A (en) * | 1986-12-05 | 1989-05-23 | The General Hospital Corporation | Method of increasing bone mass |
| US4898855A (en) * | 1987-09-14 | 1990-02-06 | Hoffman-La Roche Inc. | Deuterated analogs of 1,25-dihydroxycholecalciferol |
| US4902481A (en) * | 1987-12-11 | 1990-02-20 | Millipore Corporation | Multi-well filtration test apparatus |
| KR0144358B1 (ko) * | 1988-04-21 | 1998-07-15 | 피. 라이달 크리스텐슨 | 비타민 d 동족체 |
| US5250523A (en) * | 1988-04-29 | 1993-10-05 | Wisconsin Alumni Research Foundation | Side chain unsaturated 1α-hydroxyvitanim D homologs |
| US5232836A (en) * | 1988-05-04 | 1993-08-03 | Ire-Medgenix S.A. | Vitamin D derivatives: therapeutic applications and applications to assays of metabolites of vitamin D |
| US5104864A (en) * | 1988-08-02 | 1992-04-14 | Bone Care International, Inc. | Method for treating and preventing loss of bone mass |
| EP0373687B1 (en) * | 1988-12-12 | 1993-06-02 | Duphar International Research B.V | Method for the photochemical conversion of tachysterol compounds into previtamin d compounds and of trans-vitamin d compounds into cis-vitamin d compounds |
| US4897388A (en) * | 1988-12-20 | 1990-01-30 | Geriatric Research Institute, Inc. | Method of treating Alzheimer's disease |
| US5098899A (en) * | 1989-03-06 | 1992-03-24 | Trustees Of Boston University | Method for therapeutically treating psoriatic arthritis using vitamin D analogues and metabolites |
| CA1333616C (en) * | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
| US5372996A (en) * | 1989-03-10 | 1994-12-13 | Endorecherche, Inc. | Method of treatment of androgen-related diseases |
| US4948789A (en) * | 1989-03-28 | 1990-08-14 | Chugai Seiyaku Kabushiki Kaisha | Suppression of parathyroid hormone synthesis and secretion |
| JP2645130B2 (ja) * | 1989-03-31 | 1997-08-25 | 日清製粉株式会社 | ステロイド誘導体 |
| GB2229921B (en) * | 1989-04-05 | 1992-12-16 | Chugai Pharmaceutical Co Ltd | Treatment for hyperparathyroidism with use of vitamin d derivatives |
| GB8915770D0 (en) * | 1989-07-10 | 1989-08-31 | Leo Pharm Prod Ltd | Chemical compounds |
| US5219528A (en) * | 1989-07-28 | 1993-06-15 | Pierce Chemical Company | Apparatus for rapid immunoassays |
| US5562910A (en) * | 1989-09-25 | 1996-10-08 | University Of Utah Research Foundation | Vaccine compositions and method for enhancing an immune response |
| CA2066716A1 (en) * | 1989-09-25 | 1991-03-26 | Raymond A. Daynes | Use of steroid hormones in compositions for inducing t cell lymphokine production |
| US5518725A (en) * | 1989-09-25 | 1996-05-21 | University Of Utah Research Foundation | Vaccine compositions and method for induction of mucosal immune response via systemic vaccination |
| US5260290A (en) * | 1990-02-14 | 1993-11-09 | Wisconsin Alumni Research Foundation | Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives |
| GB9007236D0 (en) * | 1990-03-30 | 1990-05-30 | Leo Pharm Prod Ltd | Chemical compounds |
| US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| EP0454204B1 (en) * | 1990-04-27 | 1995-06-28 | Duphar International Research B.V | Method for the photochemical isomeration of organic compounds under the influence of a photosensitizer |
| US5141719A (en) * | 1990-07-18 | 1992-08-25 | Bio-Rad Laboratories, Inc. | Multi-sample filtration plate assembly |
| US5756783A (en) * | 1990-09-21 | 1998-05-26 | Bone Care International, Inc. | 1α-Hydroxy-24-EPI-vitamin D4 |
| WO1992005130A1 (en) * | 1990-09-21 | 1992-04-02 | Lunar Corporation | NOVEL 1α-HYDROXY VITAMIN D4 AND NOVEL INTERMEDIATES AND ANALOGUES |
| US5786348A (en) * | 1991-01-08 | 1998-07-28 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2 |
| DK0503630T3 (da) * | 1991-03-13 | 1996-01-29 | Kuraray Co | Cyclohexantriolderivater |
| US5264184A (en) * | 1991-03-19 | 1993-11-23 | Minnesota Mining And Manufacturing Company | Device and a method for separating liquid samples |
| US5417923A (en) * | 1991-04-24 | 1995-05-23 | Pfizer Inc. | Assay tray assembly |
| DK0521550T3 (da) * | 1991-07-05 | 1996-11-04 | Duphar Int Res | Vitamin D forbindelse, fremgangsmåde til fremstilling af denne forbindelse og mellemprodukt derfor |
| US5205989A (en) * | 1991-09-18 | 1993-04-27 | Minnesota Mining And Manufacturing Company | Multi-well filtration apparatus |
| ATE188482T1 (de) * | 1992-02-27 | 2000-01-15 | Duphar Int Res | Verfahren zur herstellung 9-beta,10-alpha-5,7- dien-steroiden |
| US6113946A (en) * | 1992-04-03 | 2000-09-05 | The Regents Of The University Of California | Self-assembling polynucleotide delivery system comprising dendrimer polycations |
| US5795882A (en) * | 1992-06-22 | 1998-08-18 | Bone Care International, Inc. | Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations |
| DK0600079T3 (da) * | 1992-06-22 | 2002-04-15 | Bone Care Int Inc | Oral 1alpha-hydroxyprævitamin D |
| US5753638A (en) * | 1992-10-07 | 1998-05-19 | Hoffmann-La Roche Inc. | Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs |
| GB9223061D0 (en) * | 1992-11-04 | 1992-12-16 | Leo Pharm Prod Ltd | Chemical compounds |
| US5366965A (en) * | 1993-01-29 | 1994-11-22 | Boehringer Mannheim Gmbh | Regimen for treatment or prophylaxis of osteoporosis |
| US5350745A (en) * | 1993-01-29 | 1994-09-27 | Lunar Corporation | Treatment of myocardial failure |
| US5449668A (en) * | 1993-06-04 | 1995-09-12 | Duphar International Research B.V. | Vitamin D compounds and method of preparing these compounds |
| US5763429A (en) * | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
| US5597575A (en) * | 1994-06-06 | 1997-01-28 | Breitbarth; Richard | Composition for stimulating and inducing hair growth |
| US5665387A (en) * | 1994-09-01 | 1997-09-09 | K.U. Leuven Research & Development | Methods and compositions for primary and secondary prevention of autoimmune diabetes |
| US5559107A (en) * | 1994-10-20 | 1996-09-24 | Gates; Stephen | Regulation of immune response |
| US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
| US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
| US5739271A (en) * | 1995-06-07 | 1998-04-14 | Gen-Probe Incorporated | Thiocationic lipids |
| US5696103A (en) * | 1995-11-17 | 1997-12-09 | Syntex (U.S.A.) Inc. | Method for treating osteoporosis |
| US5691328A (en) * | 1996-02-02 | 1997-11-25 | Clarion Pharmaceuticals Inc. | Phosphoethanolamine conjugates of vitamin D compounds |
| US5716946A (en) * | 1996-02-13 | 1998-02-10 | Wisconsin Alumni Research Foundation | Multiple sclerosis treatment |
| JP2000509014A (ja) * | 1996-03-11 | 2000-07-18 | フォーカル，インコーポレイテッド | 放射性核種および放射性医薬品のポリマー送達 |
| US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
| TW367247B (en) * | 1998-02-03 | 1999-08-21 | Otsuka Pharma Co Ltd | Storage container for Vitamin D solution and transfusion container |
| WO1999049870A1 (en) * | 1998-03-27 | 1999-10-07 | Oregon Health Sciences University | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
| US5972917A (en) * | 1998-05-29 | 1999-10-26 | Bone Care Int Inc | 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof |
| NZ524657A (en) * | 2000-09-08 | 2004-12-24 | Wisconsin Alumni Res Found | 1 alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications |
| CA2438208A1 (en) * | 2001-02-07 | 2002-08-15 | Durect Corporation | Devices and methods for management of bone density |
| CA2440387A1 (en) * | 2001-03-23 | 2002-10-03 | Durect Corporation | Delivery of drugs from sustained release devices implanted in myocardial tissue or in the pericardial space |
-
2003
- 2003-03-10 US US10/385,327 patent/US20040043971A1/en not_active Abandoned
-
2004
- 2004-02-04 JP JP2006508652A patent/JP2006519854A/ja active Pending
- 2004-02-04 EP EP04708146A patent/EP1601364A2/en not_active Withdrawn
- 2004-02-04 WO PCT/US2004/003059 patent/WO2004080467A2/en not_active Ceased
- 2004-02-04 BR BRPI0408198-6A patent/BRPI0408198A/pt not_active IP Right Cessation
- 2004-02-04 CA CA002517160A patent/CA2517160A1/en not_active Abandoned
- 2004-02-04 AU AU2004220622A patent/AU2004220622A1/en not_active Abandoned
- 2004-02-04 CN CNA2004800066681A patent/CN1758916A/zh active Pending
-
2009
- 2009-05-06 US US12/436,173 patent/US20100087404A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5602116A (en) * | 1988-08-02 | 1997-02-11 | Bone Care International, Inc. | Method for treating and preventing secondary hyperparathyroidism |
| US5869473A (en) * | 1988-08-02 | 1999-02-09 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| US6376479B1 (en) * | 1995-04-03 | 2002-04-23 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010525079A (ja) * | 2007-04-25 | 2010-07-22 | シトクロマ インコーポレイテッド | ビタミンｄ療法のための方法および化合物 |
| JP2010525078A (ja) * | 2007-04-25 | 2010-07-22 | シトクロマ インコーポレイテッド | ビタミンｄ化合物およびワックス状担体を含有する制御放出性経口組成物 |
| JP2014098034A (ja) * | 2007-04-25 | 2014-05-29 | Proventiv Therapeutics Llc | 慢性腎臓病における続発性副甲状腺機能亢進症の安全かつ効果的な治療および予防方法 |
| JP2017075183A (ja) * | 2007-04-25 | 2017-04-20 | プロヴェンティヴ セラピュティックス リミテッド ライアビリティ カンパニー | 慢性腎臓病における続発性副甲状腺機能亢進症の安全かつ効果的な治療および予防方法 |
| JP2019196402A (ja) * | 2007-04-25 | 2019-11-14 | オプコ リーナル リミテッド ライアビリティ カンパニー | 慢性腎臓病における続発性副甲状腺機能亢進症の安全かつ効果的な治療および予防方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004220622A1 (en) | 2004-09-23 |
| US20100087404A1 (en) | 2010-04-08 |
| EP1601364A2 (en) | 2005-12-07 |
| BRPI0408198A (pt) | 2006-03-21 |
| WO2004080467A2 (en) | 2004-09-23 |
| WO2004080467A3 (en) | 2005-01-20 |
| US20040043971A1 (en) | 2004-03-04 |
| CN1758916A (zh) | 2006-04-12 |
| CA2517160A1 (en) | 2004-09-23 |
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