JP2001513487A5 - - Google Patents
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- Publication number
- JP2001513487A5 JP2001513487A5 JP2000506830A JP2000506830A JP2001513487A5 JP 2001513487 A5 JP2001513487 A5 JP 2001513487A5 JP 2000506830 A JP2000506830 A JP 2000506830A JP 2000506830 A JP2000506830 A JP 2000506830A JP 2001513487 A5 JP2001513487 A5 JP 2001513487A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- drug
- use according
- arachidonic acid
- zinc cation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 24
- 239000000203 mixture Substances 0.000 description 24
- 239000003814 drug Substances 0.000 description 20
- 229940079593 drug Drugs 0.000 description 18
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 16
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 15
- 229940006486 zinc cation Drugs 0.000 description 15
- 229940114079 arachidonic acid Drugs 0.000 description 12
- 235000021342 arachidonic acid Nutrition 0.000 description 12
- 229960002885 histidine Drugs 0.000 description 8
- 150000001450 anions Chemical class 0.000 description 6
- 239000002775 capsule Substances 0.000 description 6
- 206010012601 diabetes mellitus Diseases 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 241000124008 Mammalia Species 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- -1 zinc cations Chemical class 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/909,240 | 1997-08-11 | ||
| US08/909,240 US5834032A (en) | 1997-08-11 | 1997-08-11 | Compositions and methods for treating diabetes |
| PCT/US1998/016321 WO1999007224A1 (en) | 1997-08-11 | 1998-08-06 | Compositions and methods for treating diabetes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001513487A JP2001513487A (ja) | 2001-09-04 |
| JP2001513487A5 true JP2001513487A5 (https=) | 2006-01-05 |
Family
ID=25426873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000506830A Pending JP2001513487A (ja) | 1997-08-11 | 1998-08-06 | 糖尿病治療用組成物及び治療方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5834032A (https=) |
| JP (1) | JP2001513487A (https=) |
| KR (1) | KR100533618B1 (https=) |
| CN (1) | CN1216635C (https=) |
| AU (1) | AU8693098A (https=) |
| WO (1) | WO1999007224A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5750336A (en) * | 1994-02-10 | 1998-05-12 | The Salk Institute For Biological Studies | Assays for the identification of compounds which inhibit activation of cAMP and mitogen responsive genes |
| EP1115389B1 (en) * | 1998-09-25 | 2014-03-12 | PhilERA New Zealand Limited | Fructosamine oxidase: antagonists and inhibitors |
| JP2001220348A (ja) * | 1999-11-30 | 2001-08-14 | Japan Science & Technology Corp | 亜鉛（ｉｉ）有機錯体からなる血糖降下剤 |
| CN100553636C (zh) | 2000-08-04 | 2009-10-28 | Dmi生物科学公司 | 二酮基哌嗪和包含它们的组合物的使用方法 |
| JP4161031B2 (ja) * | 2000-10-31 | 2008-10-08 | 独立行政法人産業技術総合研究所 | 亜鉛含有リン酸カルシウム微粒子含有懸濁液または粒子溶媒混合系及び亜鉛欠乏症治療剤 |
| JP2003040784A (ja) * | 2001-01-31 | 2003-02-13 | Japan Science & Technology Corp | 血糖降下剤 |
| WO2004030522A2 (en) * | 2002-10-02 | 2004-04-15 | Dmi Biosciences, Inc. | Diagnosis and monitoring of diseases |
| US6989025B2 (en) * | 2002-10-04 | 2006-01-24 | Boston Scientific Scimed, Inc. | Extruded tubing with discontinuous striping |
| WO2004064742A2 (en) * | 2003-01-17 | 2004-08-05 | Uab Research Foundation | Methods and compositions for p2x receptor calcium entry channels and other calcium entry mechanisms |
| DE602004011275T2 (de) * | 2003-01-31 | 2009-01-15 | Moon K. Northridge Song | Zusammensetzungen und Verfahren zur Behandlung von Fettleibigkeit |
| EP2517718B1 (en) | 2003-05-15 | 2016-03-02 | Ampio Pharmaceuticals, Inc. | Treatment of T-cell mediated diseases |
| US20080249028A1 (en) * | 2005-03-09 | 2008-10-09 | Roger Williams Hospital | Thyrotropin-Releasing Hormone Analogs and Method of Use |
| US20060280787A1 (en) * | 2005-06-14 | 2006-12-14 | Baxter International Inc. | Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof |
| CN101674842A (zh) * | 2007-03-02 | 2010-03-17 | 普瑞芬医药有限公司 | 治疗阿尔茨海默氏病和痴呆的组合物和方法 |
| JP5856843B2 (ja) | 2008-05-27 | 2016-02-10 | アンピオ ファーマシューティカルズ，インコーポレイテッド | ジケトピペラジンを用いた医薬組成物 |
| EP2613786A4 (en) | 2010-09-07 | 2013-10-23 | Dmi Acquisition Corp | TREATMENT OF DISEASES |
| MY172699A (en) | 2011-10-10 | 2019-12-10 | Ampio Pharmaceuticals Inc | Implantable medical devices with increased immune tolerance, and methods for making and implanting |
| EA028343B1 (ru) | 2011-10-10 | 2017-11-30 | Ампио Фармасьютикалз, Инк. | Лечение дегенеративного заболевания сустава |
| EP2771007B1 (en) | 2011-10-28 | 2018-04-04 | Ampio Pharmaceuticals, Inc. | Treatment of rhinitis |
| BR112015020469A2 (pt) | 2013-03-15 | 2020-01-28 | Ampio Pharmaceuticals Inc | Usos de da-dkp, composição e método para fornecimento de células-tronco a umindivíduo |
| SG11201610280PA (en) * | 2014-06-20 | 2017-01-27 | Suntory Holdings Ltd | Carbohydrate metabolism-ameliorating agent |
| RU2736513C2 (ru) | 2014-08-18 | 2020-11-17 | Ампио Фармасьютикалз, Инк. | Лечение патологических состояний суставов |
| EP3310375A4 (en) | 2015-06-22 | 2019-02-20 | Ampio Pharmaceuticals, Inc. | USE OF LOW-MOLECULAR FRACTIONS OF HUMAN SERUMALBUMINE IN THE TREATMENT OF ILLNESSES |
| CN105748564A (zh) * | 2015-12-21 | 2016-07-13 | 天津中津药业股份有限公司 | 一种治疗糖尿病的药物组合物 |
| JP7005050B2 (ja) * | 2017-10-20 | 2022-01-21 | ノブメタファーマ カンパニー リミテッド | 亜鉛塩、シクロ－ヒスプロおよび抗糖尿薬物を有効成分として含有する糖尿病の予防または治療用薬学的組成物 |
| KR102163445B1 (ko) * | 2017-11-20 | 2020-10-07 | 주식회사 노브메타파마 | Chp(사이클로-히스프로)를 포함하는 골 손실 질환의 예방, 개선 또는 치료용 조성물 |
| US20210177932A1 (en) * | 2017-12-11 | 2021-06-17 | United States Government As Represented By The Department Of Veterans Affairs | Compositions and methods for prevention and treatment of immune deficiency and inflammation |
| KR20190074746A (ko) * | 2017-12-20 | 2019-06-28 | 주식회사 노브메타파마 | 시클로-히스프로를 유효성분으로 포함하는 당뇨병 예방 또는 치료용 약제학적 제제 |
| US20200345728A1 (en) * | 2019-04-30 | 2020-11-05 | Novmetapharma Co., Ltd. | Compositions and methods for treatment of atherosclerosis |
| KR102115353B1 (ko) * | 2019-05-17 | 2020-05-26 | 주식회사 노브메타파마 | Chp(사이클로-히스프로) 및 부갑상선 호르몬을 포함하는 골 손실 질환의 예방, 개선 또는 치료용 조성물 |
| WO2021126231A1 (en) * | 2019-12-20 | 2021-06-24 | Vector Vitale Ip Llc | Composition and method for the treatment of type i diabetes |
| KR20230025709A (ko) | 2020-06-17 | 2023-02-22 | 주식회사 노브메타파마 | 바이러스 감염을 치료하기 위한 조성물 및 방법 |
| CA3188423A1 (en) | 2020-09-04 | 2022-03-10 | Francois-Pierre Martin | Compositions and methods for providing health benefits in an animal |
| KR20240032221A (ko) * | 2022-08-31 | 2024-03-12 | 주식회사 노브메타파마 | 아연염 및 사이클로-히스프로를 유효성분으로 포함하는 호흡기 질환의 예방, 개선 또는 치료용 조성물 |
| KR20250066976A (ko) | 2023-11-07 | 2025-05-14 | 주식회사 노브메타파마 | 아연염 및 사이클로-히스프로를 유효성분으로 포함하는 당뇨병성 신증의 예방, 개선 또는 치료용 조성물 |
| JP2025084032A (ja) | 2023-11-21 | 2025-06-02 | ノブメタファーマ カンパニー リミテッド | グルコン酸亜鉛塩およびシクロ－ヒスプロを有効成分として含む肥満および糖尿病の予防、改善または治療用組成物 |
-
1997
- 1997-08-11 US US08/909,240 patent/US5834032A/en not_active Expired - Lifetime
-
1998
- 1998-08-06 JP JP2000506830A patent/JP2001513487A/ja active Pending
- 1998-08-06 CN CN988079313A patent/CN1216635C/zh not_active Expired - Fee Related
- 1998-08-06 AU AU86930/98A patent/AU8693098A/en not_active Abandoned
- 1998-08-06 KR KR10-2000-7001386A patent/KR100533618B1/ko not_active Expired - Lifetime
- 1998-08-06 WO PCT/US1998/016321 patent/WO1999007224A1/en not_active Ceased
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