CN1216635C - 治疗糖尿病的组合物与方法 - Google Patents

治疗糖尿病的组合物与方法 Download PDF

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Publication number
CN1216635C
CN1216635C CN988079313A CN98807931A CN1216635C CN 1216635 C CN1216635 C CN 1216635C CN 988079313 A CN988079313 A CN 988079313A CN 98807931 A CN98807931 A CN 98807931A CN 1216635 C CN1216635 C CN 1216635C
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CN
China
Prior art keywords
compositions
zinc
arachidonic acid
histidine
diabetes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN988079313A
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English (en)
Chinese (zh)
Other versions
CN1265560A (zh
Inventor
穆恩·K·桑
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Wenbao Medicine Co ltd
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Wenbao Medicine Co ltd
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Publication date
Application filed by Wenbao Medicine Co ltd filed Critical Wenbao Medicine Co ltd
Publication of CN1265560A publication Critical patent/CN1265560A/zh
Application granted granted Critical
Publication of CN1216635C publication Critical patent/CN1216635C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/315—Zinc compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN988079313A 1997-08-11 1998-08-06 治疗糖尿病的组合物与方法 Expired - Fee Related CN1216635C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/909,240 US5834032A (en) 1997-08-11 1997-08-11 Compositions and methods for treating diabetes
US08/909,240 1997-08-11

Publications (2)

Publication Number Publication Date
CN1265560A CN1265560A (zh) 2000-09-06
CN1216635C true CN1216635C (zh) 2005-08-31

Family

ID=25426873

Family Applications (1)

Application Number Title Priority Date Filing Date
CN988079313A Expired - Fee Related CN1216635C (zh) 1997-08-11 1998-08-06 治疗糖尿病的组合物与方法

Country Status (6)

Country Link
US (1) US5834032A (https=)
JP (1) JP2001513487A (https=)
KR (1) KR100533618B1 (https=)
CN (1) CN1216635C (https=)
AU (1) AU8693098A (https=)
WO (1) WO1999007224A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111246859A (zh) * 2017-10-20 2020-06-05 诺麦塔制药有限公司 含有锌盐、环二肽-组氨酸脯氨酸及作为有效成分的抗糖尿药物的糖尿病预防或治疗用药学组合物

Families Citing this family (35)

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US5750336A (en) * 1994-02-10 1998-05-12 The Salk Institute For Biological Studies Assays for the identification of compounds which inhibit activation of cAMP and mitogen responsive genes
EP1115389B1 (en) * 1998-09-25 2014-03-12 PhilERA New Zealand Limited Fructosamine oxidase: antagonists and inhibitors
JP2001220348A (ja) * 1999-11-30 2001-08-14 Japan Science & Technology Corp 亜鉛（ｉｉ）有機錯体からなる血糖降下剤
WO2002011676A2 (en) 2000-08-04 2002-02-14 Dmi Biosciences, Inc. Method of using diketopiperazines and composition containing them
JP4161031B2 (ja) * 2000-10-31 2008-10-08 独立行政法人産業技術総合研究所 亜鉛含有リン酸カルシウム微粒子含有懸濁液または粒子溶媒混合系及び亜鉛欠乏症治療剤
JP2003040784A (ja) * 2001-01-31 2003-02-13 Japan Science & Technology Corp 血糖降下剤
NZ539735A (en) * 2002-10-02 2009-07-31 Dmi Biosciences Inc Diagnosis and monitoring of diseases using markers, such as diketopiperazines
US6989025B2 (en) * 2002-10-04 2006-01-24 Boston Scientific Scimed, Inc. Extruded tubing with discontinuous striping
WO2004064742A2 (en) * 2003-01-17 2004-08-05 Uab Research Foundation Methods and compositions for p2x receptor calcium entry channels and other calcium entry mechanisms
EP1442741B1 (en) * 2003-01-31 2008-01-16 United States Government as represented by the Department of Veterans Affaires, At the Office of General Counsel - PSG IV (024) Compositions and methods for treating obesity
EP1622633B1 (en) 2003-05-15 2016-02-24 Ampio Pharmaceuticals, Inc. Treatment of t-cell mediated diseases
JP2008538547A (ja) * 2005-03-09 2008-10-30 ロジャー・ウィリアムズ・ホスピタル 甲状腺刺激ホルモン放出ホルモン類縁体及び使用方法
US20060280787A1 (en) * 2005-06-14 2006-12-14 Baxter International Inc. Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof
KR101530050B1 (ko) * 2007-03-02 2015-06-22 주식회사 노브메타파마 알츠하이머 질환 및 치매를 치료하기 위한 조성물 및 방법
EP2300011A4 (en) 2008-05-27 2012-06-20 Dmi Life Sciences Inc THERAPEUTIC PROCESSES AND COMPOUNDS
CA2810844C (en) 2010-09-07 2017-03-21 Dmi Acquisition Corp. Diketopiperazine compositions for the treatment of metabolic syndrome and related conditions
SG10201608087WA (en) 2011-10-10 2016-11-29 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
EP3721884A1 (en) 2011-10-10 2020-10-14 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease with da-dkp (= aspartyl-alanyl diketopiperazine)
CN103841974A (zh) 2011-10-28 2014-06-04 安皮奥制药股份有限公司 鼻炎的治疗
CA2906864A1 (en) 2013-03-15 2014-09-18 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
US20170143701A1 (en) * 2014-06-20 2017-05-25 Suntory Holdings Limited Carbohydrate metabolism-ameliorating agent
CA2958080A1 (en) 2014-08-18 2016-02-25 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
CN105748564A (zh) * 2015-12-21 2016-07-13 天津中津药业股份有限公司 一种治疗糖尿病的药物组合物
JP6944221B2 (ja) * 2017-11-20 2021-10-06 ノブメタファーマ カンパニー リミテッド Ｃｈｐ（シクロ−ヒスプロ）を含む骨損失疾患の予防、改善または治療用組成物
US20210177932A1 (en) * 2017-12-11 2021-06-17 United States Government As Represented By The Department Of Veterans Affairs Compositions and methods for prevention and treatment of immune deficiency and inflammation
KR20190074746A (ko) * 2017-12-20 2019-06-28 주식회사 노브메타파마 시클로-히스프로를 유효성분으로 포함하는 당뇨병 예방 또는 치료용 약제학적 제제
US20200345728A1 (en) * 2019-04-30 2020-11-05 Novmetapharma Co., Ltd. Compositions and methods for treatment of atherosclerosis
KR102115353B1 (ko) * 2019-05-17 2020-05-26 주식회사 노브메타파마 Chp(사이클로-히스프로) 및 부갑상선 호르몬을 포함하는 골 손실 질환의 예방, 개선 또는 치료용 조성물
CA3162366C (en) * 2019-12-20 2023-03-14 Peter Novak Composition and method for the treatment of type i diabetes
KR20230025709A (ko) * 2020-06-17 2023-02-22 주식회사 노브메타파마 바이러스 감염을 치료하기 위한 조성물 및 방법
CN115884769A (zh) 2020-09-04 2023-03-31 雀巢产品有限公司 用于向动物提供健康益处的组合物和方法
KR20240032221A (ko) * 2022-08-31 2024-03-12 주식회사 노브메타파마 아연염 및 사이클로-히스프로를 유효성분으로 포함하는 호흡기 질환의 예방, 개선 또는 치료용 조성물
KR20250066976A (ko) 2023-11-07 2025-05-14 주식회사 노브메타파마 아연염 및 사이클로-히스프로를 유효성분으로 포함하는 당뇨병성 신증의 예방, 개선 또는 치료용 조성물
JP2025084032A (ja) 2023-11-21 2025-06-02 ノブメタファーマ カンパニー リミテッド グルコン酸亜鉛塩およびシクロ－ヒスプロを有効成分として含む肥満および糖尿病の予防、改善または治療用組成物

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111246859A (zh) * 2017-10-20 2020-06-05 诺麦塔制药有限公司 含有锌盐、环二肽-组氨酸脯氨酸及作为有效成分的抗糖尿药物的糖尿病预防或治疗用药学组合物
CN111246859B (zh) * 2017-10-20 2022-05-03 诺麦塔制药有限公司 含有锌盐、环二肽-组氨酸脯氨酸及作为有效成分的抗糖尿药物的糖尿病预防或治疗用药学组合物

Also Published As

Publication number Publication date
HK1031174A1 (en) 2001-06-08
KR100533618B1 (ko) 2005-12-06
US5834032A (en) 1998-11-10
WO1999007224A1 (en) 1999-02-18
KR20010022786A (ko) 2001-03-26
AU8693098A (en) 1999-03-01
JP2001513487A (ja) 2001-09-04
CN1265560A (zh) 2000-09-06

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