JP2005526727A - ｐＨ感受性カチオン脂質、それを含有するリポソーム及びナノカプセル - Google Patents
ｐＨ感受性カチオン脂質、それを含有するリポソーム及びナノカプセル Download PDFInfo
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- JP2005526727A JP2005526727A JP2003569178A JP2003569178A JP2005526727A JP 2005526727 A JP2005526727 A JP 2005526727A JP 2003569178 A JP2003569178 A JP 2003569178A JP 2003569178 A JP2003569178 A JP 2003569178A JP 2005526727 A JP2005526727 A JP 2005526727A
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- Prior art keywords
- liposome
- lipid
- active substance
- acid
- liposomes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 125000005647 linker group Chemical group 0.000 claims abstract description 4
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- 239000013543 active substance Substances 0.000 claims description 47
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- 238000000034 method Methods 0.000 claims description 22
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- BLCJBICVQSYOIF-UHFFFAOYSA-N 2,2-diaminobutanoic acid Chemical compound CCC(N)(N)C(O)=O BLCJBICVQSYOIF-UHFFFAOYSA-N 0.000 claims description 2
- PECYZEOJVXMISF-UHFFFAOYSA-N 3-aminoalanine Chemical compound [NH3+]CC(N)C([O-])=O PECYZEOJVXMISF-UHFFFAOYSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
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- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
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- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10207177A DE10207177A1 (de) | 2002-02-19 | 2002-02-19 | Fakultativ kationische Lipide |
| PCT/EP2003/001661 WO2003070220A1 (de) | 2002-02-19 | 2003-02-19 | Ph sensitiv kationische lipide, lipsomen und nanokapseln, die diese umfassen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005526727A true JP2005526727A (ja) | 2005-09-08 |
| JP2005526727A5 JP2005526727A5 (https=) | 2006-04-06 |
Family
ID=27674784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569178A Abandoned JP2005526727A (ja) | 2002-02-19 | 2003-02-19 | ｐＨ感受性カチオン脂質、それを含有するリポソーム及びナノカプセル |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8192753B2 (https=) |
| EP (1) | EP1480621A1 (https=) |
| JP (1) | JP2005526727A (https=) |
| AU (1) | AU2003210303A1 (https=) |
| DE (1) | DE10207177A1 (https=) |
| WO (1) | WO2003070220A1 (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009518297A (ja) * | 2005-12-01 | 2009-05-07 | プロネイ・セラピューティクス・インコーポレイテッド | 両性リポソーム製剤 |
| JP2009532056A (ja) * | 2006-04-06 | 2009-09-10 | ポリプラス トランスフェクション エスアー | 遺伝子サイレンシングに活性なオリゴヌクレオチドの形質導入用組成物およびその生物学適用と治療適用 |
| WO2010104128A1 (ja) * | 2009-03-11 | 2010-09-16 | 株式会社バイオナノシータ | ｐＨ応答性リポソーム |
| US9795566B2 (en) | 2014-07-17 | 2017-10-24 | Fujifilm Corporation | Imidazole compound and liposome containing same |
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| WO2003093449A2 (en) * | 2002-05-06 | 2003-11-13 | Nucleonics, Inc. | Methods for delivery of nucleic acids |
| EP1706149A2 (en) * | 2004-01-15 | 2006-10-04 | Alza Corporation | Liposome composition for delivery of therapeutic agents |
| KR20080082956A (ko) | 2005-09-15 | 2008-09-12 | 노보솜 아게 | 양쪽성 리포솜의 개선 또는 양쪽성 리포솜에 관련된 개선 |
| US20080088046A1 (en) * | 2006-10-13 | 2008-04-17 | Steffen Panzner | Amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome |
| US8101741B2 (en) | 2005-11-02 | 2012-01-24 | Protiva Biotherapeutics, Inc. | Modified siRNA molecules and uses thereof |
| RU2451022C2 (ru) * | 2005-12-15 | 2012-05-20 | Сантр Насьональ Де Ля Решерш Сьентифик (Снрс) | Катионные олигонуклеотиды, автоматизированные способы их получения и их применение |
| JP5424885B2 (ja) | 2006-10-13 | 2014-02-26 | マリーナ バイオテック，インコーポレイテッド | 両性リポソームにおけるまたは両性リポソームに関する改善、両性リポソームを処方する方法および両性リポソームに充填する方法 |
| WO2008074487A2 (en) * | 2006-12-19 | 2008-06-26 | Novosom Ag | Lipids and lipid assemblies comprising transfection enhancer elements |
| WO2009082817A1 (en) | 2007-12-27 | 2009-07-09 | Protiva Biotherapeutics, Inc. | Silencing of polo-like kinase expression using interfering rna |
| FR2926818B1 (fr) * | 2008-01-30 | 2012-04-06 | Centre Nat Rech Scient | siRNA CATIONIQUES, SYNTHESE ET UTILISATION POUR L'ARN INTERFERENCE |
| JP2011516094A (ja) | 2008-04-15 | 2011-05-26 | プロチバ バイオセラピューティクス インコーポレイティッド | 干渉ｒｎａを用いたｃｓｎ５遺伝子発現のサイレンシング方法 |
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| HUE026646T2 (en) | 2010-07-06 | 2016-07-28 | Glaxosmithkline Biologicals Sa | Preferred liposomes containing lipids of PKA value for delivery of RNA |
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| WO2013032643A2 (en) * | 2011-08-31 | 2013-03-07 | Dicerna Pharmaceuticals, Inc. | Lipids capable of conformational change and their use in formulations to deliver therapeutic agents to cells |
| AU2012340086A1 (en) | 2011-11-17 | 2014-05-29 | The Regents Of The University Of California | Therapeutic RNA switches compositions and methods of use |
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| BR112015010220A2 (pt) | 2012-11-05 | 2017-12-05 | Pronai Therapeutics Inc | métodos de utilização de biomarcadores para tratamento de câncer |
| BR112017006679A2 (pt) | 2014-10-02 | 2017-12-26 | Protiva Biotherapeutics Inc | moléculas, composição, partícula, composição farmacêutica, métodos para silenciar a expressão de um gene, usos de uma partícula, métodos para melhorar um ou mais sintomas, métodos para tratar uma infecção, usos de uma composição, método para inibir a replicação do vírus da hepatite d |
| US20180245074A1 (en) | 2015-06-04 | 2018-08-30 | Protiva Biotherapeutics, Inc. | Treating hepatitis b virus infection using crispr |
| CN108350455A (zh) | 2015-07-29 | 2018-07-31 | 阿布特斯生物制药公司 | 用于使b型肝炎病毒基因表达沉默的组合物和方法 |
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| JPH11217328A (ja) * | 1998-01-28 | 1999-08-10 | Nissin Food Prod Co Ltd | 抗ｈｉｖ活性を発現する脂質集合体 |
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| US7112337B2 (en) * | 1999-04-23 | 2006-09-26 | Alza Corporation | Liposome composition for delivery of nucleic acid |
| WO2001026625A2 (en) * | 1999-10-08 | 2001-04-19 | Alza Corp | Neutral-cationic lipid for nucleic acid and drug delivery |
| DE10109898A1 (de) * | 2001-02-21 | 2002-09-05 | Novosom Gmbh | Lipide mit veränderlicher Ladung |
| DE10109897A1 (de) * | 2001-02-21 | 2002-11-07 | Novosom Ag | Fakultativ kationische Liposomen und Verwendung dieser |
-
2002
- 2002-02-19 DE DE10207177A patent/DE10207177A1/de not_active Ceased
-
2003
- 2003-02-19 US US10/505,107 patent/US8192753B2/en active Active
- 2003-02-19 EP EP03742540A patent/EP1480621A1/de not_active Ceased
- 2003-02-19 AU AU2003210303A patent/AU2003210303A1/en not_active Abandoned
- 2003-02-19 WO PCT/EP2003/001661 patent/WO2003070220A1/de not_active Ceased
- 2003-02-19 JP JP2003569178A patent/JP2005526727A/ja not_active Abandoned
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009518297A (ja) * | 2005-12-01 | 2009-05-07 | プロネイ・セラピューティクス・インコーポレイテッド | 両性リポソーム製剤 |
| JP2009532056A (ja) * | 2006-04-06 | 2009-09-10 | ポリプラス トランスフェクション エスアー | 遺伝子サイレンシングに活性なオリゴヌクレオチドの形質導入用組成物およびその生物学適用と治療適用 |
| KR101414392B1 (ko) | 2006-04-06 | 2014-07-18 | 뽈리쁠뤼스-트랑스펙씨옹 | 유전자 침묵에 유효한 올리고뉴클레오티드의 형질감염용 조성물 및 이의 생물학적 및 치료적 용도 |
| WO2010104128A1 (ja) * | 2009-03-11 | 2010-09-16 | 株式会社バイオナノシータ | ｐＨ応答性リポソーム |
| JP2010209012A (ja) * | 2009-03-11 | 2010-09-24 | Ichimaru Pharcos Co Ltd | ｐＨ応答性リポソーム |
| US8871252B2 (en) | 2009-03-11 | 2014-10-28 | Nanotheta Co, Ltd. | pH-responsive liposome |
| US9795566B2 (en) | 2014-07-17 | 2017-10-24 | Fujifilm Corporation | Imidazole compound and liposome containing same |
Also Published As
| Publication number | Publication date |
|---|---|
| US8192753B2 (en) | 2012-06-05 |
| WO2003070220A1 (de) | 2003-08-28 |
| EP1480621A1 (de) | 2004-12-01 |
| DE10207177A1 (de) | 2003-09-04 |
| AU2003210303A1 (en) | 2003-09-09 |
| US20060002991A1 (en) | 2006-01-05 |
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