JP2005526153A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005526153A5 JP2005526153A5 JP2003578430A JP2003578430A JP2005526153A5 JP 2005526153 A5 JP2005526153 A5 JP 2005526153A5 JP 2003578430 A JP2003578430 A JP 2003578430A JP 2003578430 A JP2003578430 A JP 2003578430A JP 2005526153 A5 JP2005526153 A5 JP 2005526153A5
- Authority
- JP
- Japan
- Prior art keywords
- saccharide
- capsular saccharide
- modified
- sugar
- capsular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000001720 carbohydrates Chemical class 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 22
- 235000000346 sugar Nutrition 0.000 claims description 14
- 125000006239 protecting group Chemical group 0.000 claims description 13
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 12
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 11
- PFKFTWBEEFSNDU-UHFFFAOYSA-N 1,1'-Carbonyldiimidazole Substances C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 claims description 10
- 239000003153 chemical reaction reagent Substances 0.000 claims description 10
- 150000004676 glycans Chemical class 0.000 claims description 9
- 229920001282 polysaccharide Polymers 0.000 claims description 9
- 239000005017 polysaccharide Substances 0.000 claims description 9
- 230000001588 bifunctional effect Effects 0.000 claims description 8
- 239000000010 aprotic solvent Substances 0.000 claims description 6
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 claims description 6
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims description 4
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical group CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 claims description 3
- -1 amino compound Chemical class 0.000 claims description 3
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 claims description 3
- GUVUOGQBMYCBQP-UHFFFAOYSA-N dmpu Chemical compound CN1CCCN(C)C1=O GUVUOGQBMYCBQP-UHFFFAOYSA-N 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 125000003277 amino group Chemical group 0.000 claims description 2
- VRAVWQUXPCWGSU-UHFFFAOYSA-N bis(1h-1,2,4-triazol-5-yl)methanone Chemical compound N1=CNN=C1C(=O)C=1N=CNN=1 VRAVWQUXPCWGSU-UHFFFAOYSA-N 0.000 claims description 2
- XYCAAOUPBWVNPF-UHFFFAOYSA-N bis(2h-benzotriazol-4-yl)methanone Chemical compound C=1C=CC=2NN=NC=2C=1C(=O)C1=CC=CC2=C1N=NN2 XYCAAOUPBWVNPF-UHFFFAOYSA-N 0.000 claims description 2
- ROORDVPLFPIABK-UHFFFAOYSA-N diphenyl carbonate Chemical compound C=1C=CC=CC=1OC(=O)OC1=CC=CC=C1 ROORDVPLFPIABK-UHFFFAOYSA-N 0.000 claims description 2
- 150000008163 sugars Chemical class 0.000 claims description 2
- UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 claims description 2
- 241000588650 Neisseria meningitidis Species 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 229920001542 oligosaccharide Polymers 0.000 claims 7
- 150000002482 oligosaccharides Chemical class 0.000 claims 7
- 150000002772 monosaccharides Chemical group 0.000 claims 5
- 231100000699 Bacterial toxin Toxicity 0.000 claims 3
- 230000001580 bacterial effect Effects 0.000 claims 3
- 239000000688 bacterial toxin Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000004513 sizing Methods 0.000 claims 3
- 241000921898 Neisseria meningitidis serogroup A Species 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 1
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010027202 Meningitis bacterial Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical group O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 230000005875 antibody response Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 201000009904 bacterial meningitis Diseases 0.000 claims 1
- 229960003983 diphtheria toxoid Drugs 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 239000012646 vaccine adjuvant Substances 0.000 claims 1
- 229940124931 vaccine adjuvant Drugs 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000003431 cross linking reagent Substances 0.000 description 2
- XVDBWWRIXBMVJV-UHFFFAOYSA-N n-[bis(dimethylamino)phosphanyl]-n-methylmethanamine Chemical compound CN(C)P(N(C)C)N(C)C XVDBWWRIXBMVJV-UHFFFAOYSA-N 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical compound OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0207117A GB0207117D0 (en) | 2002-03-26 | 2002-03-26 | Modified saccharides having improved stability in water |
| GB0220195A GB0220195D0 (en) | 2002-08-30 | 2002-08-30 | Modified saccharides having improved stability in water |
| GB0229494A GB0229494D0 (en) | 2002-12-18 | 2002-12-18 | Modified saccharides having improved stability in water |
| GB0230163A GB0230163D0 (en) | 2002-12-24 | 2002-12-24 | Modified saccharides having improved stability in water |
| PCT/IB2003/001436 WO2003080678A1 (en) | 2002-03-26 | 2003-03-26 | Modified saccharides having improved stability in water |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010044780A Division JP5361767B2 (ja) | 2002-03-26 | 2010-03-01 | 水中において改善された安定性を持つ修飾糖 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005526153A JP2005526153A (ja) | 2005-09-02 |
| JP2005526153A5 true JP2005526153A5 (https=) | 2010-04-15 |
Family
ID=28457825
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003578430A Ceased JP2005526153A (ja) | 2002-03-26 | 2003-03-26 | 水中において改善された安定性を持つ修飾糖 |
| JP2010044780A Expired - Fee Related JP5361767B2 (ja) | 2002-03-26 | 2010-03-01 | 水中において改善された安定性を持つ修飾糖 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010044780A Expired - Fee Related JP5361767B2 (ja) | 2002-03-26 | 2010-03-01 | 水中において改善された安定性を持つ修飾糖 |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP1490409B1 (https=) |
| JP (2) | JP2005526153A (https=) |
| AT (1) | ATE419278T1 (https=) |
| BR (1) | BR0308768A (https=) |
| CA (1) | CA2480389C (https=) |
| CY (2) | CY1108911T1 (https=) |
| DE (1) | DE60325565D1 (https=) |
| DK (2) | DK1490409T3 (https=) |
| ES (2) | ES2616180T3 (https=) |
| HU (1) | HUE030532T2 (https=) |
| MX (1) | MXPA04009339A (https=) |
| NZ (1) | NZ535968A (https=) |
| PT (2) | PT1777236T (https=) |
| WO (1) | WO2003080678A1 (https=) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| MXPA04011249A (es) | 2002-05-14 | 2005-06-06 | Chiron Srl | Vacunas mucosales con adyuvante de quitosano y antigenos meningococicos. |
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
| HUE031886T2 (en) | 2002-10-11 | 2017-08-28 | Glaxosmithkline Biologicals Sa | Polypeptide vaccines for extensive protection against hypervirulent meningococcal lines |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| EP2172213B1 (en) | 2003-01-30 | 2013-04-03 | Novartis AG | Injectable vaccines against multiple meningococcal serogroups |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| NZ546430A (en) | 2003-10-02 | 2009-04-30 | Novartis Vaccines & Diagnostic | Liquid vaccines for multiple meningococcal serogroups |
| GB0406013D0 (en) | 2004-03-17 | 2004-04-21 | Chiron Srl | Analysis of saccharide vaccines without interference |
| NZ550533A (en) | 2004-04-30 | 2010-02-26 | Novartis Vaccines & Diagnostic | Meningococcal conjugate vaccination comprising N. meningitidis and diphtheria toxin |
| GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
| GB0409745D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
| BRPI0511442A (pt) * | 2004-05-20 | 2007-12-26 | Chiron Srl | análise de eluatos por cromatografia lìquida |
| GB0411387D0 (en) | 2004-05-21 | 2004-06-23 | Chiron Srl | Analysis of saccharide length |
| KR20070101207A (ko) * | 2004-08-30 | 2007-10-16 | 사노피 파스퇴르 인크 | 다가 수막구균 유도체화된 다당류-단백질 접합체 및 백신 |
| MX2007003292A (es) * | 2004-09-21 | 2007-09-07 | Sanofi Pasteur Inc | Conjugados y vacuna con proteinas de polisacarido derivadas meningococales multivalentes. |
| MX2007013881A (es) * | 2005-05-06 | 2008-10-22 | Novartis Vaccines & Diagnostic | Inmunogenos para vacunas de meningitides-a. |
| PE20110072A1 (es) * | 2005-06-27 | 2011-02-04 | Glaxosmithkline Biolog Sa | Composicion inmunogenica |
| GB0513071D0 (en) * | 2005-06-27 | 2005-08-03 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| CA2620416A1 (en) * | 2005-08-24 | 2007-03-01 | Novartis Vaccines And Diagnostics S.R.L. | Zwitterionization of capsular saccharides |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| GB0605757D0 (en) | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
| PL2004225T3 (pl) | 2006-03-22 | 2012-09-28 | Novartis Ag | Schematy immunizacji koniugatami meningokokowymi |
| GB0612854D0 (en) | 2006-06-28 | 2006-08-09 | Novartis Ag | Saccharide analysis |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| AU2014200640B2 (en) * | 2007-01-11 | 2016-06-16 | Glaxosmithkline Biologicals Sa | Modified saccharides |
| ES2555786T3 (es) | 2007-06-04 | 2016-01-08 | Glaxosmithkline Biologicals Sa | Formulación de vacunas contra la meningitis |
| GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| BR122016015627A2 (pt) | 2007-10-19 | 2018-10-30 | Novartis Ag | kit, composição antigênica liofilizada e método para preparação de uma composição imunogênica |
| CN102356089B (zh) | 2008-02-21 | 2014-02-19 | 诺华股份有限公司 | 脑膜炎球菌fHBP多肽 |
| GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| GB0822633D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
| WO2010070453A2 (en) | 2008-12-17 | 2010-06-24 | Novartis Ag | Meningococcal vaccines including hemoglobin receptor |
| EP3017826A1 (en) | 2009-03-24 | 2016-05-11 | Novartis AG | Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates |
| EP2411048B1 (en) | 2009-03-24 | 2020-05-06 | GlaxoSmithKline Biologicals SA | Adjuvanting meningococcal factor h binding protein |
| SA110310528B1 (ar) | 2009-06-22 | 2014-07-02 | Wyeth Llc | التركيبات المولدة للمناعة لأنتيجينات ستافيلوكوكس أوريس |
| SG10201406432RA (en) | 2009-06-22 | 2014-11-27 | Wyeth Llc | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
| CN102596240B (zh) | 2009-08-27 | 2015-02-04 | 诺华股份有限公司 | 包括脑膜炎球菌fHBP序列的杂交多肽 |
| CN102724988B (zh) | 2009-09-30 | 2014-09-10 | 诺华股份有限公司 | 脑膜炎球菌fHBP多肽的表达 |
| CA2779816A1 (en) | 2009-10-27 | 2011-05-05 | Novartis Ag | Modified meningococcal fhbp polypeptides |
| AU2011268507B2 (en) | 2010-06-25 | 2014-08-14 | Novartis Ag | Combinations of meningococcal factor H binding proteins |
| CN107913396B (zh) | 2010-08-23 | 2022-03-08 | 惠氏有限责任公司 | 脑膜炎萘瑟氏菌rLP2086抗原的稳定制剂 |
| EP2612148B1 (en) | 2010-09-04 | 2019-06-12 | GlaxoSmithKline Biologicals SA | Bactericidal antibody assays to assess immunogenicity and potency of meningococcal capsular saccharide vaccines |
| AU2011300409B2 (en) | 2010-09-10 | 2015-03-26 | Wyeth Llc | Non-lipidated variants of Neisseria meningitidis ORF2086 antigens |
| WO2012117377A1 (en) | 2011-03-02 | 2012-09-07 | Novartis Ag | Combination vaccines with lower doses of antigen and/or adjuvant |
| EP2729178A1 (en) | 2011-07-08 | 2014-05-14 | Novartis AG | Tyrosine ligation process |
| RU2636350C2 (ru) | 2011-11-07 | 2017-11-22 | Новартис Аг | МОЛЕКУЛА, СОДЕРЖАЩАЯ SPR0096 и SPR2021 |
| JP2015505309A (ja) | 2011-12-29 | 2015-02-19 | ノバルティス アーゲー | 髄膜炎菌ｈ因子結合タンパク質のアジュバントされた組み合わせ |
| EP2822584A1 (en) | 2012-03-08 | 2015-01-14 | Novartis AG | Combination vaccines with tlr4 agonists |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| MY198910A (en) | 2012-03-09 | 2023-10-02 | Pfizer | Neisseria meningitidis compositions and methods thereof |
| JP6324961B2 (ja) | 2012-09-06 | 2018-05-16 | ノバルティス アーゲー | 血清群ｂ髄膜炎菌とｄ／ｔ／ｐとの組み合わせワクチン |
| US20150320852A1 (en) | 2012-12-18 | 2015-11-12 | Glaxosmithkline Biologicals Sa | Conjugates for protecting against diphtheria and/or tetanus |
| GB201300707D0 (en) | 2013-01-15 | 2013-02-27 | Novartis Ag | Compounds and processes |
| WO2014136064A2 (en) | 2013-03-08 | 2014-09-12 | Pfizer Inc. | Immunogenic fusion polypeptides |
| AU2014286990A1 (en) | 2013-07-11 | 2016-02-11 | Novartis Ag | Lysine-specific chemoenzymatic protein modifications using microbial transglutaminase |
| RU2662968C2 (ru) | 2013-09-08 | 2018-07-31 | Пфайзер Инк. | Иммуногенная композиция против neisseria meningitidis (варианты) |
| KR20160127104A (ko) | 2014-02-28 | 2016-11-02 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 변형된 수막구균 fhbp 폴리펩티드 |
| US10407703B2 (en) * | 2014-04-17 | 2019-09-10 | Medizinische Hochschule Hannover | Means and methods for producing Neisseria meningitidis capsular polysaccharides of low dispersity |
| WO2016132294A1 (en) | 2015-02-19 | 2016-08-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| US12109259B2 (en) | 2016-09-02 | 2024-10-08 | Glaxosmithkline Biologicals Sa | Vaccines for Neisseria gonorrhoeae |
| BR112019003992A2 (pt) | 2016-09-02 | 2019-05-28 | Sanofi Pasteur Inc | vacina contra neisseria meningitidis |
| AU2018215585B2 (en) | 2017-01-31 | 2022-03-17 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| WO2021059181A1 (en) | 2019-09-27 | 2021-04-01 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| GB202208093D0 (en) | 2022-06-01 | 2022-07-13 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| GB202208089D0 (en) | 2022-06-01 | 2022-07-13 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB733459A (en) * | 1952-05-21 | 1955-07-13 | Wander A G A | Process for preparing stimulating agents for clinical use from bacterial polysaccharides |
| DE2748132A1 (de) * | 1977-10-27 | 1979-05-03 | Behringwerke Ag | Stabilisator fuer polysaccharid |
| US4882317A (en) * | 1984-05-10 | 1989-11-21 | Merck & Co., Inc. | Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency |
| US4727136A (en) * | 1985-10-01 | 1988-02-23 | Canadian Patents And Development Ltd. | Modified meningococcal group B polysaccharide for conjugate vaccine |
| HU9201966D0 (en) * | 1989-12-14 | 1992-10-28 | Ca Nat Research Council | An improved vaccine of meningococcus-polysaccharide conjunction |
| FR2682388B1 (fr) * | 1991-10-10 | 1995-06-09 | Pasteur Merieux Serums Vacc | Procede de preparation d'un oligoside par depolymerisation d'un polyoside issu d'un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal. |
| ES2166097T5 (es) * | 1996-08-27 | 2007-03-16 | Novartis Vaccines And Diagnostics, Inc. | Glicoconjugados de neisseria meningitidis de serogrupo b y procedimientos para usarlos. |
| EP0977764A4 (en) * | 1997-03-26 | 2001-04-11 | Brigham & Womens Hospital | PROCESS FOR PRODUCING SACCHARIDE FRAGMENTS |
| KR100757630B1 (ko) * | 1997-12-23 | 2007-09-10 | 박스터 헬쓰케어 에스.에이. | 신규한 추출 및 단리 방법으로 수득되는 세균성 캡슐형 다당류 |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
-
2003
- 2003-03-26 ES ES06076853.8T patent/ES2616180T3/es not_active Expired - Lifetime
- 2003-03-26 EP EP03712543A patent/EP1490409B1/en not_active Expired - Lifetime
- 2003-03-26 DK DK03712543T patent/DK1490409T3/da active
- 2003-03-26 BR BR0308768-9A patent/BR0308768A/pt not_active IP Right Cessation
- 2003-03-26 EP EP06076853.8A patent/EP1777236B8/en not_active Expired - Lifetime
- 2003-03-26 DK DK06076853.8T patent/DK1777236T3/en active
- 2003-03-26 ES ES03712543T patent/ES2318117T3/es not_active Expired - Lifetime
- 2003-03-26 PT PT60768538T patent/PT1777236T/pt unknown
- 2003-03-26 MX MXPA04009339A patent/MXPA04009339A/es active IP Right Grant
- 2003-03-26 WO PCT/IB2003/001436 patent/WO2003080678A1/en not_active Ceased
- 2003-03-26 PT PT03712543T patent/PT1490409E/pt unknown
- 2003-03-26 NZ NZ535968A patent/NZ535968A/en not_active IP Right Cessation
- 2003-03-26 AT AT03712543T patent/ATE419278T1/de active
- 2003-03-26 JP JP2003578430A patent/JP2005526153A/ja not_active Ceased
- 2003-03-26 CA CA2480389A patent/CA2480389C/en not_active Expired - Fee Related
- 2003-03-26 HU HUE06076853A patent/HUE030532T2/en unknown
- 2003-03-26 DE DE60325565T patent/DE60325565D1/de not_active Expired - Lifetime
-
2009
- 2009-03-23 CY CY20091100322T patent/CY1108911T1/el unknown
-
2010
- 2010-03-01 JP JP2010044780A patent/JP5361767B2/ja not_active Expired - Fee Related
-
2017
- 2017-01-25 CY CY20171100115T patent/CY1118584T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005526153A5 (https=) | ||
| CA2480389A1 (en) | Modified saccharides having improved stability in water | |
| JP2010132925A5 (https=) | ||
| JP2006511465A5 (https=) | ||
| CA2497167A1 (en) | Modified saccharides, conjugates thereof, and their manufacture | |
| JP2020533438A5 (https=) | ||
| JP2008540398A5 (https=) | ||
| KR20200014921A (ko) | 면역원성과 항원항체 결합성이 개선된 2가 또는 다가 접합체 다당류를 가진 다가 접합체 백신 | |
| RU2758090C2 (ru) | Новые конъюгаты полисахарида с белком и способ их получения | |
| Lipinski et al. | A structurally diversified linker enhances the immune response to a small carbohydrate hapten | |
| CN107224577B (zh) | 一种基于3型肺炎链球菌荚膜多糖的寡糖缀合物及其制备方法与应用 | |
| US5952454A (en) | Linking compounds useful for coupling carbohydrates to amine-containing carriers | |
| US20140234364A1 (en) | Total synthesis and immunological evaluation of saccharide moieties of the lipopolysaccharide from neisseria meningitidis | |
| CN1205217C (zh) | 核糖－核糖醇－磷酸之寡糖衍生物及含有它们的疫苗 | |
| EP2986986B1 (en) | Oligosaccharide conjugates and methods of use | |
| RU2338753C2 (ru) | Модифицированные сахариды, имеющие улучшенную стабильность в воде | |
| US12234302B2 (en) | Chitosan derivatives and methods for preparing the same | |
| JP6784841B2 (ja) | ヘモフィルス属インフルエンザ菌ｂ型に対するワクチンとしての安定した加水分解耐性合成ポリリボシルリビトールホスフェート誘導体 | |
| Ogawa et al. | Synthesis of a functionalized hexasaccharide precursor of a glycoconjugate vaccine against cholera | |
| Ogawa et al. | Synthesis of the dodecasaccharide fragment representing the O-polysaccharide of Vibrio cholerae O: 1, serotype Ogawa, bearing an aglycon offering flexibility for chemical linking to proteins | |
| US10772946B2 (en) | Immunogenic compositions against S. aureus | |
| Kovác | Studies toward a rationally designed conjugate vaccine for cholera using synthetic carbohydrate antigens | |
| JP4071415B2 (ja) | シアル酸分岐シクロデキストリン誘導体 | |
| HK40008295A (en) | Stable hydrolysis-resistant synthetic polyribosylribitolphosphate derivatives as vaccines against haemophilus influenzae type b | |
| JPS60149597A (ja) | Ｎ‐グリコシル化ウレア類、カルバメート類及びチオカルバメート類 |