JP2005526153A5 - - Google Patents
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- Publication number
- JP2005526153A5 JP2005526153A5 JP2003578430A JP2003578430A JP2005526153A5 JP 2005526153 A5 JP2005526153 A5 JP 2005526153A5 JP 2003578430 A JP2003578430 A JP 2003578430A JP 2003578430 A JP2003578430 A JP 2003578430A JP 2005526153 A5 JP2005526153 A5 JP 2005526153A5
- Authority
- JP
- Japan
- Prior art keywords
- saccharide
- capsular saccharide
- modified
- sugar
- capsular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000001720 carbohydrates Chemical class 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 22
- 235000000346 sugar Nutrition 0.000 claims description 14
- 125000006239 protecting group Chemical group 0.000 claims description 13
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 12
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 11
- PFKFTWBEEFSNDU-UHFFFAOYSA-N 1,1'-Carbonyldiimidazole Substances C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 claims description 10
- 239000003153 chemical reaction reagent Substances 0.000 claims description 10
- 150000004676 glycans Chemical class 0.000 claims description 9
- 229920001282 polysaccharide Polymers 0.000 claims description 9
- 239000005017 polysaccharide Substances 0.000 claims description 9
- 230000001588 bifunctional effect Effects 0.000 claims description 8
- 239000000010 aprotic solvent Substances 0.000 claims description 6
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 claims description 6
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims description 4
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical group CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 claims description 3
- -1 amino compound Chemical class 0.000 claims description 3
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 claims description 3
- GUVUOGQBMYCBQP-UHFFFAOYSA-N dmpu Chemical compound CN1CCCN(C)C1=O GUVUOGQBMYCBQP-UHFFFAOYSA-N 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 125000003277 amino group Chemical group 0.000 claims description 2
- VRAVWQUXPCWGSU-UHFFFAOYSA-N bis(1h-1,2,4-triazol-5-yl)methanone Chemical compound N1=CNN=C1C(=O)C=1N=CNN=1 VRAVWQUXPCWGSU-UHFFFAOYSA-N 0.000 claims description 2
- XYCAAOUPBWVNPF-UHFFFAOYSA-N bis(2h-benzotriazol-4-yl)methanone Chemical compound C=1C=CC=2NN=NC=2C=1C(=O)C1=CC=CC2=C1N=NN2 XYCAAOUPBWVNPF-UHFFFAOYSA-N 0.000 claims description 2
- ROORDVPLFPIABK-UHFFFAOYSA-N diphenyl carbonate Chemical compound C=1C=CC=CC=1OC(=O)OC1=CC=CC=C1 ROORDVPLFPIABK-UHFFFAOYSA-N 0.000 claims description 2
- 150000008163 sugars Chemical class 0.000 claims description 2
- UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 claims description 2
- 241000588650 Neisseria meningitidis Species 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 229920001542 oligosaccharide Polymers 0.000 claims 7
- 150000002482 oligosaccharides Chemical class 0.000 claims 7
- 150000002772 monosaccharides Chemical group 0.000 claims 5
- 231100000699 Bacterial toxin Toxicity 0.000 claims 3
- 230000001580 bacterial effect Effects 0.000 claims 3
- 239000000688 bacterial toxin Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000004513 sizing Methods 0.000 claims 3
- 241000921898 Neisseria meningitidis serogroup A Species 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 1
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010027202 Meningitis bacterial Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical group O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 230000005875 antibody response Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 201000009904 bacterial meningitis Diseases 0.000 claims 1
- 229960003983 diphtheria toxoid Drugs 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 239000012646 vaccine adjuvant Substances 0.000 claims 1
- 229940124931 vaccine adjuvant Drugs 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000003431 cross linking reagent Substances 0.000 description 2
- XVDBWWRIXBMVJV-UHFFFAOYSA-N n-[bis(dimethylamino)phosphanyl]-n-methylmethanamine Chemical compound CN(C)P(N(C)C)N(C)C XVDBWWRIXBMVJV-UHFFFAOYSA-N 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical compound OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0207117A GB0207117D0 (en) | 2002-03-26 | 2002-03-26 | Modified saccharides having improved stability in water |
| GB0220195A GB0220195D0 (en) | 2002-08-30 | 2002-08-30 | Modified saccharides having improved stability in water |
| GB0229494A GB0229494D0 (en) | 2002-12-18 | 2002-12-18 | Modified saccharides having improved stability in water |
| GB0230163A GB0230163D0 (en) | 2002-12-24 | 2002-12-24 | Modified saccharides having improved stability in water |
| PCT/IB2003/001436 WO2003080678A1 (en) | 2002-03-26 | 2003-03-26 | Modified saccharides having improved stability in water |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010044780A Division JP5361767B2 (ja) | 2002-03-26 | 2010-03-01 | 水中において改善された安定性を持つ修飾糖 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005526153A JP2005526153A (ja) | 2005-09-02 |
| JP2005526153A5 true JP2005526153A5 (https=) | 2010-04-15 |
Family
ID=28457825
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003578430A Ceased JP2005526153A (ja) | 2002-03-26 | 2003-03-26 | 水中において改善された安定性を持つ修飾糖 |
| JP2010044780A Expired - Fee Related JP5361767B2 (ja) | 2002-03-26 | 2010-03-01 | 水中において改善された安定性を持つ修飾糖 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010044780A Expired - Fee Related JP5361767B2 (ja) | 2002-03-26 | 2010-03-01 | 水中において改善された安定性を持つ修飾糖 |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP1490409B1 (https=) |
| JP (2) | JP2005526153A (https=) |
| AT (1) | ATE419278T1 (https=) |
| BR (1) | BR0308768A (https=) |
| CA (1) | CA2480389C (https=) |
| CY (2) | CY1108911T1 (https=) |
| DE (1) | DE60325565D1 (https=) |
| DK (2) | DK1777236T3 (https=) |
| ES (2) | ES2616180T3 (https=) |
| HU (1) | HUE030532T2 (https=) |
| MX (1) | MXPA04009339A (https=) |
| NZ (1) | NZ535968A (https=) |
| PT (2) | PT1777236T (https=) |
| WO (1) | WO2003080678A1 (https=) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| MXPA04011249A (es) | 2002-05-14 | 2005-06-06 | Chiron Srl | Vacunas mucosales con adyuvante de quitosano y antigenos meningococicos. |
| GB0220198D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
| HUE031886T2 (en) | 2002-10-11 | 2017-08-28 | Glaxosmithkline Biologicals Sa | Polypeptide vaccines for extensive protection against hypervirulent meningococcal lines |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| ES2461350T3 (es) * | 2003-01-30 | 2014-05-19 | Novartis Ag | Vacunas inyectables contra múltiples serogrupos de meningococos |
| CN103357002A (zh) | 2003-10-02 | 2013-10-23 | 诺华疫苗和诊断有限公司 | 多种脑膜炎球菌血清群的液体疫苗 |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| GB0406013D0 (en) | 2004-03-17 | 2004-04-21 | Chiron Srl | Analysis of saccharide vaccines without interference |
| GB0409745D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
| GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
| ATE512670T1 (de) | 2004-04-30 | 2011-07-15 | Novartis Vaccines & Diagnostic | Meningokokken-konjugat-impfung |
| EP1747457B1 (en) * | 2004-05-20 | 2011-11-30 | Novartis AG | Analysis of liquid chromatography eluates |
| GB0411387D0 (en) | 2004-05-21 | 2004-06-23 | Chiron Srl | Analysis of saccharide length |
| EP1784214A4 (en) * | 2004-08-30 | 2009-09-23 | Sanofi Pasteur Inc | POLYSACCHARIDE / PROTEIN CONJUGATES MULTIVALENT MENINGOCOCCUS DERIVATIVE AND VACCINE |
| JP2008513541A (ja) * | 2004-09-21 | 2008-05-01 | サノフィ パストゥール インコーポレイテッド | 多価髄膜炎菌誘導体化多糖−タンパク質複合体およびワクチン |
| ES2533248T3 (es) * | 2005-05-06 | 2015-04-08 | Novartis Ag | Inmunógenos para vacunas contra Meningitidis A |
| US8398983B2 (en) | 2005-06-27 | 2013-03-19 | Glaxosmithkline Biologicals, S.A. | Immunogenic composition |
| GB0513071D0 (en) * | 2005-06-27 | 2005-08-03 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| AU2006283302B2 (en) * | 2005-08-24 | 2012-11-15 | Novartis Vaccines And Diagnostics Srl | Zwitterionization of capsular saccharides |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| PL2004225T3 (pl) | 2006-03-22 | 2012-09-28 | Novartis Ag | Schematy immunizacji koniugatami meningokokowymi |
| GB0605757D0 (en) | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
| GB0612854D0 (en) | 2006-06-28 | 2006-08-09 | Novartis Ag | Saccharide analysis |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| AU2014200640B2 (en) * | 2007-01-11 | 2016-06-16 | Glaxosmithkline Biologicals Sa | Modified saccharides |
| CA2688268A1 (en) | 2007-06-04 | 2008-12-11 | Novartis Ag | Formulation of meningitis vaccines |
| GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| WO2009050586A1 (en) | 2007-10-19 | 2009-04-23 | Novartis Ag | Meningococcal vaccine formulations |
| CN102356089B (zh) | 2008-02-21 | 2014-02-19 | 诺华股份有限公司 | 脑膜炎球菌fHBP多肽 |
| GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| GB0822633D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
| JP2012512240A (ja) | 2008-12-17 | 2012-05-31 | ノバルティス アーゲー | ヘモグロビン受容体を含む髄膜炎菌ワクチン |
| HUE049695T2 (hu) | 2009-03-24 | 2020-10-28 | Glaxosmithkline Biologicals Sa | Adjuváló H meningococcus faktort kötõ fehérje |
| EP3017826A1 (en) | 2009-03-24 | 2016-05-11 | Novartis AG | Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates |
| BRPI1011753B8 (pt) | 2009-06-22 | 2021-05-25 | Wyeth Llc | conjugados imunogênicos de polissacarídeo capsular de staphylococcus aureus de sorotipos 5 e 8, seu uso e composições que os compreendem |
| HUE036372T2 (hu) | 2009-06-22 | 2018-07-30 | Wyeth Llc | Staphylococcus aureus antigének immunogén készítményei |
| US20110076300A1 (en) | 2009-08-27 | 2011-03-31 | Mariagrazia Pizza | Hybrid Polypeptides Including Meningococcal fHBP Sequences |
| CN102724988B (zh) | 2009-09-30 | 2014-09-10 | 诺华股份有限公司 | 脑膜炎球菌fHBP多肽的表达 |
| CA2779816A1 (en) | 2009-10-27 | 2011-05-05 | Novartis Ag | Modified meningococcal fhbp polypeptides |
| CA2803239A1 (en) | 2010-06-25 | 2011-12-29 | Novartis Ag | Combinations of meningococcal factor h binding proteins |
| KR101594228B1 (ko) | 2010-08-23 | 2016-02-15 | 와이어쓰 엘엘씨 | 네이세리아 메닌기티디스 ｒＬＰ２０８６ 항원의 안정한 제제 |
| ES2744471T3 (es) | 2010-09-04 | 2020-02-25 | Glaxosmithkline Biologicals Sa | Ensayos de anticuerpos bactericidas para evaluar la inmunogenia y la potencia de vacunas de sacárido capsular meningocócico |
| NZ607224A (en) | 2010-09-10 | 2014-11-28 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
| WO2012117377A1 (en) | 2011-03-02 | 2012-09-07 | Novartis Ag | Combination vaccines with lower doses of antigen and/or adjuvant |
| WO2013009564A1 (en) | 2011-07-08 | 2013-01-17 | Novartis Ag | Tyrosine ligation process |
| EP2776069A1 (en) | 2011-11-07 | 2014-09-17 | Novartis AG | Carrier molecule comprising a spr0096 and a spr2021 antigen |
| EP2797624A1 (en) | 2011-12-29 | 2014-11-05 | Novartis AG | Adjuvanted combinations of meningococcal factor h binding proteins |
| CN104159603A (zh) | 2012-03-08 | 2014-11-19 | 诺华股份有限公司 | 带有tlr4激动剂的联合疫苗 |
| MX359256B (es) | 2012-03-09 | 2018-09-19 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| US9526776B2 (en) | 2012-09-06 | 2016-12-27 | Glaxosmithkline Biologicals Sa | Combination vaccines with serogroup B meningococcus and D/T/P |
| EP2934574A1 (en) | 2012-12-18 | 2015-10-28 | GlaxoSmithKline Biologicals SA | Conjugates for protecting against diphtheria and/or tetanus |
| GB201300707D0 (en) | 2013-01-15 | 2013-02-27 | Novartis Ag | Compounds and processes |
| US9802987B2 (en) | 2013-03-08 | 2017-10-31 | Pfizer Inc. | Immunogenic fusion polypeptides |
| EP3019515B1 (en) | 2013-07-11 | 2019-08-21 | Novartis AG | Lysine-specific chemoenzymatic protein modifications using microbial transglutaminase |
| RU2662968C2 (ru) | 2013-09-08 | 2018-07-31 | Пфайзер Инк. | Иммуногенная композиция против neisseria meningitidis (варианты) |
| JP6786394B2 (ja) | 2014-02-28 | 2020-11-18 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 改変髄膜炎菌ｆＨｂｐポリペプチド |
| US10407703B2 (en) * | 2014-04-17 | 2019-09-10 | Medizinische Hochschule Hannover | Means and methods for producing Neisseria meningitidis capsular polysaccharides of low dispersity |
| AU2016221318B2 (en) | 2015-02-19 | 2020-06-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| US12161707B2 (en) | 2016-09-02 | 2024-12-10 | Glaxosmithkline Biologicals Sa | Vaccines for Neisseria gonorrhoeae |
| KR102906912B1 (ko) | 2016-09-02 | 2026-01-05 | 사노피 파스퇴르 인크 | 네이세리아 메닌기티디스 백신 |
| AU2018215585B2 (en) | 2017-01-31 | 2022-03-17 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| EP4034157A1 (en) | 2019-09-27 | 2022-08-03 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| GB202208093D0 (en) | 2022-06-01 | 2022-07-13 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| GB202208089D0 (en) | 2022-06-01 | 2022-07-13 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB733459A (en) * | 1952-05-21 | 1955-07-13 | Wander A G A | Process for preparing stimulating agents for clinical use from bacterial polysaccharides |
| DE2748132A1 (de) * | 1977-10-27 | 1979-05-03 | Behringwerke Ag | Stabilisator fuer polysaccharid |
| US4882317A (en) * | 1984-05-10 | 1989-11-21 | Merck & Co., Inc. | Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency |
| US4727136A (en) * | 1985-10-01 | 1988-02-23 | Canadian Patents And Development Ltd. | Modified meningococcal group B polysaccharide for conjugate vaccine |
| DE69019164T2 (de) * | 1989-12-14 | 1995-09-07 | National Research Council Of Canada, Ottawa, Ontario | Verbessertes meningokokkale polysaccharidkonjugatvakzin. |
| FR2682388B1 (fr) * | 1991-10-10 | 1995-06-09 | Pasteur Merieux Serums Vacc | Procede de preparation d'un oligoside par depolymerisation d'un polyoside issu d'un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal. |
| ES2166097T5 (es) * | 1996-08-27 | 2007-03-16 | Novartis Vaccines And Diagnostics, Inc. | Glicoconjugados de neisseria meningitidis de serogrupo b y procedimientos para usarlos. |
| WO1998042718A1 (en) * | 1997-03-26 | 1998-10-01 | The Brigham And Women's Hospital, Inc. | Method for generating saccharide fragments |
| WO1999032653A1 (en) * | 1997-12-23 | 1999-07-01 | North American Vaccine, Inc. | Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugates vaccines |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
-
2003
- 2003-03-26 PT PT60768538T patent/PT1777236T/pt unknown
- 2003-03-26 DK DK06076853.8T patent/DK1777236T3/en active
- 2003-03-26 JP JP2003578430A patent/JP2005526153A/ja not_active Ceased
- 2003-03-26 BR BR0308768-9A patent/BR0308768A/pt not_active IP Right Cessation
- 2003-03-26 EP EP03712543A patent/EP1490409B1/en not_active Expired - Lifetime
- 2003-03-26 CA CA2480389A patent/CA2480389C/en not_active Expired - Fee Related
- 2003-03-26 PT PT03712543T patent/PT1490409E/pt unknown
- 2003-03-26 DE DE60325565T patent/DE60325565D1/de not_active Expired - Lifetime
- 2003-03-26 MX MXPA04009339A patent/MXPA04009339A/es active IP Right Grant
- 2003-03-26 DK DK03712543T patent/DK1490409T3/da active
- 2003-03-26 ES ES06076853.8T patent/ES2616180T3/es not_active Expired - Lifetime
- 2003-03-26 HU HUE06076853A patent/HUE030532T2/en unknown
- 2003-03-26 AT AT03712543T patent/ATE419278T1/de active
- 2003-03-26 ES ES03712543T patent/ES2318117T3/es not_active Expired - Lifetime
- 2003-03-26 WO PCT/IB2003/001436 patent/WO2003080678A1/en not_active Ceased
- 2003-03-26 NZ NZ535968A patent/NZ535968A/en not_active IP Right Cessation
- 2003-03-26 EP EP06076853.8A patent/EP1777236B8/en not_active Expired - Lifetime
-
2009
- 2009-03-23 CY CY20091100322T patent/CY1108911T1/el unknown
-
2010
- 2010-03-01 JP JP2010044780A patent/JP5361767B2/ja not_active Expired - Fee Related
-
2017
- 2017-01-25 CY CY20171100115T patent/CY1118584T1/el unknown
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