JP2005526102A - Ｃ型肝炎ウイルスｒｎａ依存性ｒｎａポリメラーゼのピラノンおよびピランジオン阻害剤 - Google Patents
Ｃ型肝炎ウイルスｒｎａ依存性ｒｎａポリメラーゼのピラノンおよびピランジオン阻害剤 Download PDFInfo
- Publication number
- JP2005526102A JP2005526102A JP2003580314A JP2003580314A JP2005526102A JP 2005526102 A JP2005526102 A JP 2005526102A JP 2003580314 A JP2003580314 A JP 2003580314A JP 2003580314 A JP2003580314 A JP 2003580314A JP 2005526102 A JP2005526102 A JP 2005526102A
- Authority
- JP
- Japan
- Prior art keywords
- nhc
- group
- compound
- heteroaryl
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 *C(*(*)CC(*)(O1)I)C1=* Chemical compound *C(*(*)CC(*)(O1)I)C1=* 0.000 description 1
- BQLCHUYXEJEZEH-UHFFFAOYSA-N O=C(CC(CCC#Cc(cc1)cc2c1[s]cn2)(C1CCCC1)O1)CC1=O Chemical compound O=C(CC(CCC#Cc(cc1)cc2c1[s]cn2)(C1CCCC1)O1)CC1=O BQLCHUYXEJEZEH-UHFFFAOYSA-N 0.000 description 1
- GFJMIHXTGRAGSG-UHFFFAOYSA-N Oc1cc(C#CCCC(CC(C2)=O)(C3CCCC3)OC2=O)ccc1 Chemical compound Oc1cc(C#CCCC(CC(C2)=O)(C3CCCC3)OC2=O)ccc1 GFJMIHXTGRAGSG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Enzymes And Modification Thereof (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36938102P | 2002-04-01 | 2002-04-01 | |
| PCT/IB2003/001206 WO2003082848A1 (en) | 2002-04-01 | 2003-03-21 | Pyranon and pyrandion inhibitors of hepatitis c virus rna-dependent rna polymerase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005526102A true JP2005526102A (ja) | 2005-09-02 |
| JP2005526102A5 JP2005526102A5 (https=) | 2006-05-11 |
Family
ID=28675577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003580314A Abandoned JP2005526102A (ja) | 2002-04-01 | 2003-03-21 | Ｃ型肝炎ウイルスｒｎａ依存性ｒｎａポリメラーゼのピラノンおよびピランジオン阻害剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6878727B2 (https=) |
| EP (1) | EP1490350B1 (https=) |
| JP (1) | JP2005526102A (https=) |
| AT (1) | ATE337309T1 (https=) |
| AU (1) | AU2003215826A1 (https=) |
| BR (1) | BR0308856A (https=) |
| CA (1) | CA2480583C (https=) |
| DE (1) | DE60307804T2 (https=) |
| ES (1) | ES2268394T3 (https=) |
| MX (1) | MXPA04009672A (https=) |
| WO (1) | WO2003082848A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008047694A1 (fr) * | 2006-10-13 | 2008-04-24 | Aska Pharmaceutical Co., Ltd. | Procédé de fabrication d'un composé benzothiazole |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DOP2003000641A (es) * | 2002-05-10 | 2003-11-15 | Pfizer | Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan |
| US7148226B2 (en) * | 2003-02-21 | 2006-12-12 | Agouron Pharmaceuticals, Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
| CN102911161A (zh) | 2004-02-20 | 2013-02-06 | 贝林格尔.英格海姆国际有限公司 | 病毒聚合酶抑制剂 |
| WO2006050035A1 (en) | 2004-10-29 | 2006-05-11 | Schering Corporation | Substituted 5-oxo pyrazoles and [1,2,4]triazoles as antiviral agents |
| EP1881828A4 (en) * | 2005-05-20 | 2009-06-03 | Valeant Res & Dev | TREATMENT OF HEPATITIS C (HCV) USING SUB-THERAPEUTIC DOSES OF RIBAVIRIN |
| US7816348B2 (en) * | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| EP2142215B1 (en) | 2007-05-04 | 2012-03-07 | Vertex Pharmceuticals Incorporated | Combination therapy for the treatment of hcv infection |
| WO2009018656A1 (en) * | 2007-08-03 | 2009-02-12 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| CA2693997C (en) * | 2007-08-03 | 2013-01-15 | Pierre L. Beaulieu | Viral polymerase inhibitors |
| CN101903351B (zh) * | 2007-12-19 | 2014-09-10 | 贝林格尔.英格海姆国际有限公司 | 病毒聚合酶抑制剂 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1140049A (en) * | 1977-12-22 | 1983-01-25 | Dke J.E. Helgstran | Pharmaceutical preparations from derivatives of hydroxycarbonylphosphonic acid |
| US6174868B1 (en) * | 1992-09-10 | 2001-01-16 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of hepatitis C virus-associated diseases |
| US5846964A (en) * | 1993-07-19 | 1998-12-08 | Tokyo Tanabe Company Limited | Hepatitis C virus proliferation inhibitor |
| IL129871A (en) * | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
| US6340690B1 (en) * | 1999-02-22 | 2002-01-22 | Bio-Chem Pharma Inc. | Antiviral methods using [1,8]naphthyridine derivatives |
| AR034127A1 (es) * | 2000-07-21 | 2004-02-04 | Schering Corp | Imidazolidinonas como inhibidores de ns3-serina proteasa del virus de hepatitis c, composicion farmaceutica, un metodo para su preparacion, y el uso de las mismas para la manufactura de un medicamento |
-
2003
- 2003-03-21 MX MXPA04009672A patent/MXPA04009672A/es active IP Right Grant
- 2003-03-21 WO PCT/IB2003/001206 patent/WO2003082848A1/en not_active Ceased
- 2003-03-21 DE DE60307804T patent/DE60307804T2/de not_active Expired - Fee Related
- 2003-03-21 CA CA002480583A patent/CA2480583C/en not_active Expired - Fee Related
- 2003-03-21 AU AU2003215826A patent/AU2003215826A1/en not_active Abandoned
- 2003-03-21 EP EP03745205A patent/EP1490350B1/en not_active Expired - Lifetime
- 2003-03-21 JP JP2003580314A patent/JP2005526102A/ja not_active Abandoned
- 2003-03-21 ES ES03745205T patent/ES2268394T3/es not_active Expired - Lifetime
- 2003-03-21 AT AT03745205T patent/ATE337309T1/de not_active IP Right Cessation
- 2003-03-21 BR BR0308856-1A patent/BR0308856A/pt not_active IP Right Cessation
- 2003-03-31 US US10/403,537 patent/US6878727B2/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008047694A1 (fr) * | 2006-10-13 | 2008-04-24 | Aska Pharmaceutical Co., Ltd. | Procédé de fabrication d'un composé benzothiazole |
| JP5244604B2 (ja) * | 2006-10-13 | 2013-07-24 | あすか製薬株式会社 | ベンゾチアゾール化合物の製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US6878727B2 (en) | 2005-04-12 |
| US20030195239A1 (en) | 2003-10-16 |
| CA2480583C (en) | 2008-07-15 |
| AU2003215826A1 (en) | 2003-10-13 |
| DE60307804D1 (de) | 2006-10-05 |
| MXPA04009672A (es) | 2004-11-12 |
| EP1490350B1 (en) | 2006-08-23 |
| DE60307804T2 (de) | 2007-01-18 |
| EP1490350A1 (en) | 2004-12-29 |
| ATE337309T1 (de) | 2006-09-15 |
| BR0308856A (pt) | 2005-02-22 |
| CA2480583A1 (en) | 2003-10-09 |
| WO2003082848A1 (en) | 2003-10-09 |
| ES2268394T3 (es) | 2007-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060315 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060315 |
|
| A762 | Written abandonment of application |
Free format text: JAPANESE INTERMEDIATE CODE: A762 Effective date: 20081226 |