JP2005524461A5 - - Google Patents
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- JP2005524461A5 JP2005524461A5 JP2004502795A JP2004502795A JP2005524461A5 JP 2005524461 A5 JP2005524461 A5 JP 2005524461A5 JP 2004502795 A JP2004502795 A JP 2004502795A JP 2004502795 A JP2004502795 A JP 2004502795A JP 2005524461 A5 JP2005524461 A5 JP 2005524461A5
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- JP
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- Prior art keywords
- disease
- sensitizer
- cancer
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 20
- 201000010099 disease Diseases 0.000 claims 14
- 238000002595 magnetic resonance imaging Methods 0.000 claims 12
- 238000000034 method Methods 0.000 claims 10
- 239000003504 photosensitizing agent Substances 0.000 claims 8
- 208000035475 disorder Diseases 0.000 claims 6
- 238000002428 photodynamic therapy Methods 0.000 claims 6
- 238000003384 imaging method Methods 0.000 claims 5
- 230000036284 oxygen consumption Effects 0.000 claims 5
- 230000005855 radiation Effects 0.000 claims 5
- 230000001225 therapeutic effect Effects 0.000 claims 5
- 230000003211 malignant effect Effects 0.000 claims 4
- 239000008280 blood Substances 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 230000005670 electromagnetic radiation Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 108010013121 palladium-bacteriopheophorbide Proteins 0.000 claims 3
- 230000001235 sensitizing effect Effects 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 2
- 230000005284 excitation Effects 0.000 claims 2
- 230000005865 ionizing radiation Effects 0.000 claims 2
- 239000003642 reactive oxygen metabolite Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 108010003118 Bacteriochlorophylls Proteins 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- VSEIDZLLWQQJGK-CHOZPQDDSA-N CCC1=C(C)C2=N\C\1=C/C1=C(C)C(C(O)=O)=C(N1)\C(CC(=O)N[C@@H](CC(O)=O)C(O)=O)=C1/N=C(/C=C3\N/C(=C\2)C(C=C)=C3C)[C@@H](C)[C@@H]1CCC(O)=O Chemical compound CCC1=C(C)C2=N\C\1=C/C1=C(C)C(C(O)=O)=C(N1)\C(CC(=O)N[C@@H](CC(O)=O)C(O)=O)=C1/N=C(/C=C3\N/C(=C\2)C(C=C)=C3C)[C@@H](C)[C@@H]1CCC(O)=O VSEIDZLLWQQJGK-CHOZPQDDSA-N 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- LYPFDBRUNKHDGX-SOGSVHMOSA-N N1C2=CC=C1\C(=C1\C=CC(=N1)\C(=C1\C=C/C(/N1)=C(/C1=N/C(/CC1)=C2/C1=CC(O)=CC=C1)C1=CC(O)=CC=C1)\C1=CC(O)=CC=C1)C1=CC(O)=CC=C1 Chemical compound N1C2=CC=C1\C(=C1\C=CC(=N1)\C(=C1\C=C/C(/N1)=C(/C1=N/C(/CC1)=C2/C1=CC(O)=CC=C1)C1=CC(O)=CC=C1)\C1=CC(O)=CC=C1)C1=CC(O)=CC=C1 LYPFDBRUNKHDGX-SOGSVHMOSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 208000009621 actinic keratosis Diseases 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- BHPNXACHQYJJJS-UHFFFAOYSA-N bacteriochlorin Chemical compound N1C(C=C2N=C(C=C3NC(=C4)C=C3)CC2)=CC=C1C=C1CCC4=N1 BHPNXACHQYJJJS-UHFFFAOYSA-N 0.000 claims 1
- DSJXIQQMORJERS-AGGZHOMASA-M bacteriochlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC([C@H](CC)[C@H]3C)=[N+]4C3=CC3=C(C(C)=O)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 DSJXIQQMORJERS-AGGZHOMASA-M 0.000 claims 1
- 206010061691 benign mesothelioma Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 229930002875 chlorophyll Natural products 0.000 claims 1
- 235000019804 chlorophyll Nutrition 0.000 claims 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical group C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000007106 menorrhagia Diseases 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- WIQKYZYFTAEWBF-UHFFFAOYSA-L motexafin lutetium hydrate Chemical compound O.[Lu+3].CC([O-])=O.CC([O-])=O.C1=C([N-]2)C(CC)=C(CC)C2=CC(C(=C2C)CCCO)=NC2=CN=C2C=C(OCCOCCOCCOC)C(OCCOCCOCCOC)=CC2=NC=C2C(C)=C(CCCO)C1=N2 WIQKYZYFTAEWBF-UHFFFAOYSA-L 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 238000006213 oxygenation reaction Methods 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 229950010924 talaporfin Drugs 0.000 claims 1
- 229960002197 temoporfin Drugs 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- ZQFGRJWRSLZCSQ-ZSFNYQMMSA-N verteporfin Chemical compound C=1C([C@@]2([C@H](C(=O)OC)C(=CC=C22)C(=O)OC)C)=NC2=CC(C(=C2C=C)C)=NC2=CC(C(=C2CCC(O)=O)C)=NC2=CC2=NC=1C(C)=C2CCC(=O)OC ZQFGRJWRSLZCSQ-ZSFNYQMMSA-N 0.000 claims 1
- 229960003895 verteporfin Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37840902P | 2002-05-08 | 2002-05-08 | |
| PCT/IL2003/000371 WO2003094695A2 (en) | 2002-05-08 | 2003-05-08 | Sensitized online bold-mri imaging method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005524461A JP2005524461A (ja) | 2005-08-18 |
| JP2005524461A5 true JP2005524461A5 (https=) | 2006-06-15 |
Family
ID=29420397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004502795A Pending JP2005524461A (ja) | 2002-05-08 | 2003-05-08 | 増感オンラインｂｏｌｄ−ｍｒｉイメージング法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7715901B2 (https=) |
| EP (2) | EP1509129A4 (https=) |
| JP (1) | JP2005524461A (https=) |
| AU (1) | AU2003230164B2 (https=) |
| BR (1) | BR0304716A (https=) |
| CA (1) | CA2485224A1 (https=) |
| IL (1) | IL164999A (https=) |
| NO (1) | NO20040042L (https=) |
| RU (1) | RU2343829C2 (https=) |
| WO (1) | WO2003094695A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4721144B2 (ja) * | 2004-02-24 | 2011-07-13 | 学校法人早稲田大学 | 測定方法および測定装置 |
| DK1753457T3 (en) | 2004-06-07 | 2016-12-05 | Yeda Res & Dev | Cationic bakterieklorofylderivater and uses |
| US8315450B2 (en) * | 2004-11-24 | 2012-11-20 | Wisconsin Alumni Research Foundation | Method and system for display of medical image data |
| KR20070112194A (ko) * | 2005-02-17 | 2007-11-22 | 라이트 사이언시즈 온콜로지, 인코포레이티드 | 죽상동맥경화증의 예방치료를 위한 광반응성 시스템과 방법 |
| CN101184527B (zh) * | 2005-05-26 | 2012-05-09 | 皇家飞利浦电子股份有限公司 | 并入功能性成像信息的放射治疗方案设备 |
| JP5139441B2 (ja) * | 2006-11-30 | 2013-02-06 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 血管構造の可視化 |
| JP4966640B2 (ja) * | 2006-12-18 | 2012-07-04 | 学校法人慶應義塾 | 光線力学的治療装置およびその使用方法 |
| CA2716940C (en) * | 2008-02-29 | 2016-01-19 | The Regents Of The University Of Michigan | Systems and methods for imaging changes in tissue |
| WO2010043997A1 (en) * | 2008-10-13 | 2010-04-22 | Koninklijke Philips Electronics N.V. | Flow insensitive magnetization preparation pulse for t2* contrast |
| US8571634B2 (en) * | 2010-07-23 | 2013-10-29 | David R. Hubbard | Method to diagnose and measure vascular drainage insufficiency in the central nervous system |
| EP2425873A1 (fr) | 2010-09-07 | 2012-03-07 | Steba Maor SA | Modélisation de l'action d'une fibre optique dans un traitement par therapie photodynamique, et assistance à la planification d'un tel traitement |
| FI20115306L (fi) | 2011-03-31 | 2012-10-01 | Valkee Oy | Valon annostelulaite |
| US20120278380A1 (en) * | 2011-04-29 | 2012-11-01 | Joseph Curran | Outdoor Tracker System with Visual Communication Devices |
| EP2745240A2 (en) * | 2011-09-29 | 2014-06-25 | Koninklijke Philips N.V. | Distortion reduced signal detection |
| US9480402B2 (en) | 2011-11-11 | 2016-11-01 | Washington University | System and method for task-less mapping of brain activity |
| US11633505B2 (en) | 2012-12-11 | 2023-04-25 | National University Corporation Kumamoto University | Nuclear magnetic resonance diagnostic agent, and method for detecting or diagnosing state of cell, tissue or organ in subject using same |
| CN103927732B (zh) * | 2013-01-11 | 2016-03-30 | 上海联影医疗科技有限公司 | 一种胸壁线的检测方法 |
| US9125606B2 (en) * | 2013-03-13 | 2015-09-08 | Koninklijke Philips N.V. | Device and method for determining the blood oxygen saturation of a subject |
| US10426388B2 (en) | 2014-01-31 | 2019-10-01 | The General Hospital Corporation | Prediction of tumor recurrence by measuring oxygen saturation |
| WO2020210813A1 (en) * | 2019-04-11 | 2020-10-15 | The General Hospital Corporation | Generating imaging-based neurological state biomarkers and estimating cerebrospinal fluid (csf) dynamics based on coupled neural and csf oscillations during sleep |
| US11443429B2 (en) | 2019-05-30 | 2022-09-13 | Washington University | Atlas registration for resting state network mapping in patients with brain tumors |
| CN111035612B (zh) * | 2019-12-31 | 2020-12-18 | 华中科技大学 | 一种活性氧响应性凝胶贮库及其制备方法与应用 |
| CN116376033B (zh) * | 2023-03-03 | 2024-01-16 | 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） | 一种活性氧响应的自激活骨架聚合物及其制备方法和应用 |
| US12429544B2 (en) * | 2023-03-17 | 2025-09-30 | Texas Tech University System | Method and device for detecting subclinical hypoxemia using whole blood T2P |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5171749A (en) * | 1987-01-20 | 1992-12-15 | University Of British Columbia | Wavelength-specific cytotoxic agents |
| US5190966A (en) * | 1988-07-06 | 1993-03-02 | Health Research, Inc. | Purified hematoporphyrin dimers and trimers useful in photodynamic therapy |
| US5177073A (en) * | 1988-09-30 | 1993-01-05 | Baylor Research Institute | Therapeutic compositions derived from photoactive compounds |
| US5298502A (en) * | 1988-12-12 | 1994-03-29 | Fmc Corporation | Method and composition for photodynamic treatment and detection of tumors |
| US5162509A (en) * | 1989-03-06 | 1992-11-10 | Board Of Regents, The University Of Texas System | Process for preparing expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles |
| US5159065A (en) * | 1989-12-21 | 1992-10-27 | Board Of Regents, The University Of Texas System | Sapphyrins, derivatives and syntheses |
| US5214036A (en) * | 1990-03-08 | 1993-05-25 | University Of British Columbia | Benzoporphyrin derivatives for photodynamic therapy |
| US5189029A (en) * | 1990-04-23 | 1993-02-23 | Bo-Dekk Ventures, Ltd. | Indacene compounds and methods for using the same |
| US5166197A (en) * | 1990-07-17 | 1992-11-24 | Kenney Malcolm E | Phthalocyanine photosensitizers for photodynamic therapy |
| US6196226B1 (en) * | 1990-08-10 | 2001-03-06 | University Of Washington | Methods and apparatus for optically imaging neuronal tissue and activity |
| US5244671A (en) * | 1991-01-29 | 1993-09-14 | Cytopharm, Inc. | Derivatives of porphycene for photodynamic therapy of cancer |
| US5179120A (en) * | 1991-06-28 | 1993-01-12 | Cytopharm, Inc. | Porphycene compounds for photodynamic therapy |
| US5277913A (en) * | 1991-09-09 | 1994-01-11 | Thompson David H | Liposomal delivery system with photoactivatable triggered release |
| US5261874A (en) * | 1991-09-16 | 1993-11-16 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Extra-corporeal blood access, sensing, and radiation methods and apparatuses |
| US5888997A (en) * | 1994-04-14 | 1999-03-30 | Pharmacyclics, Inc. | Radiation sensitization using texaphyrins |
| US5807881A (en) * | 1992-05-27 | 1998-09-15 | Quadra Logic Technologies, Inc. | Method for selectively reducing activated leukocyte cell population |
| IL102645A (en) | 1992-07-26 | 1998-02-22 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them |
| US6147195A (en) | 1993-07-26 | 2000-11-14 | Yeda Research And Development Co., Ltd. | Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them |
| IL116126A0 (en) | 1995-11-24 | 1996-01-31 | Yeda Res & Dev | Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them |
| US6022959A (en) * | 1996-08-20 | 2000-02-08 | Pharmacyclics, Inc. | Nucleic acids internally-derivatized with a texaphyrin metal complex and uses thereof |
| US6493570B1 (en) * | 1998-11-02 | 2002-12-10 | Photogen, Inc. | Method for improved imaging and photodynamic therapy |
| GB9700396D0 (en) * | 1997-01-10 | 1997-02-26 | Photocure As | Photochemotherapeutic compositions |
| JP2002510537A (ja) * | 1998-04-08 | 2002-04-09 | ザ ジェネラル ホスピタル コーポレーション | 薬理検査用ｍｒｉ（ｐｈｍｒｉ） |
| US6364845B1 (en) * | 1998-09-17 | 2002-04-02 | University Of Rochester | Methods for diagnosing visuospatial disorientation or assessing visuospatial orientation capacity |
| EP1137411B1 (en) * | 1998-12-09 | 2006-12-06 | YEDA RESEARCH AND DEVELOPMENT Co. LTD. | Palladium-substituted bacteriochlorophyll derivatives and use thereof |
| US6162242A (en) * | 1999-01-21 | 2000-12-19 | Peyman; Gholam A. | Selective photodynamic treatment |
| RU2169922C1 (ru) * | 1999-02-12 | 2001-06-27 | Трушин Алексей Иванович | Способ диагностики областей пролиферации и устройство для его осуществления |
| US7108982B1 (en) * | 1999-02-19 | 2006-09-19 | University Of Iowa Research Foundation | Diagnostics and the therapeutics for macular degeneration |
| WO2001037717A2 (en) * | 1999-11-26 | 2001-05-31 | Applied Spectral Imaging Ltd. | System and method for functional brain mapping |
| IL133253A0 (en) | 1999-12-01 | 2001-04-30 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them |
| RU2169590C1 (ru) * | 2000-03-17 | 2001-06-27 | Закрытое акционерное общество "БИОСПЕК"-"BIOSPEC"JSC | Спектральное устройство для контроля и мониторинга процесса фотодинамической терапии |
| WO2002003872A2 (en) * | 2000-07-11 | 2002-01-17 | Johns Hopkins University | Application of photochemotherapy for the treatment of cardiac arrhythmias |
| US6567684B1 (en) * | 2000-11-08 | 2003-05-20 | Regents Of The University Of Michigan | Imaging system, computer, program product and method for detecting changes in rates of water diffusion in a tissue using magnetic resonance imaging (MRI) |
| ATE539681T1 (de) * | 2001-01-30 | 2012-01-15 | R Christopher Decharms | Methoden für die physiologische überwachung, schulung und regulierung |
| EP1381311A4 (en) * | 2001-02-23 | 2005-04-27 | Allos Therapeutics Inc | METHODS AND REAGENTS FOR THE ACQUISITION OF SIGNALS AND IMAGES OF MAGNETIC RESONANCE IMAGING |
-
2003
- 2003-05-08 AU AU2003230164A patent/AU2003230164B2/en not_active Ceased
- 2003-05-08 EP EP03723008A patent/EP1509129A4/en not_active Ceased
- 2003-05-08 WO PCT/IL2003/000371 patent/WO2003094695A2/en not_active Ceased
- 2003-05-08 US US10/513,656 patent/US7715901B2/en not_active Expired - Fee Related
- 2003-05-08 CA CA002485224A patent/CA2485224A1/en not_active Abandoned
- 2003-05-08 JP JP2004502795A patent/JP2005524461A/ja active Pending
- 2003-05-08 BR BR0304716-4A patent/BR0304716A/pt not_active IP Right Cessation
- 2003-05-08 EP EP11172478A patent/EP2401962A1/en not_active Withdrawn
- 2003-05-08 RU RU2004135823/14A patent/RU2343829C2/ru not_active IP Right Cessation
-
2004
- 2004-01-06 NO NO20040042A patent/NO20040042L/no not_active Application Discontinuation
- 2004-11-03 IL IL164999A patent/IL164999A/en not_active IP Right Cessation
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