AU2003230164B2 - Sensitized online BOLD-MRI imaging method - Google Patents

Sensitized online BOLD-MRI imaging method Download PDF

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Publication number
AU2003230164B2
AU2003230164B2 AU2003230164A AU2003230164A AU2003230164B2 AU 2003230164 B2 AU2003230164 B2 AU 2003230164B2 AU 2003230164 A AU2003230164 A AU 2003230164A AU 2003230164 A AU2003230164 A AU 2003230164A AU 2003230164 B2 AU2003230164 B2 AU 2003230164B2
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AU
Australia
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bold
sensitizer
disease
photosensitizer
pdt
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AU2003230164A
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AU2003230164A1 (en
Inventor
Assaf Gilead
Shimon Gross
Michal Neeman
Yoram Salomon
Avigdor Scherz
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Yeda Research and Development Co Ltd
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Yeda Research and Development Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4806—Functional imaging of brain activation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Radiation-Therapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2003230164A 2002-05-08 2003-05-08 Sensitized online BOLD-MRI imaging method Ceased AU2003230164B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37840902P 2002-05-08 2002-05-08
US60/378,409 2002-05-08
PCT/IL2003/000371 WO2003094695A2 (en) 2002-05-08 2003-05-08 Sensitized online bold-mri imaging method

Publications (2)

Publication Number Publication Date
AU2003230164A1 AU2003230164A1 (en) 2003-11-11
AU2003230164B2 true AU2003230164B2 (en) 2008-05-01

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003230164A Ceased AU2003230164B2 (en) 2002-05-08 2003-05-08 Sensitized online BOLD-MRI imaging method

Country Status (10)

Country Link
US (1) US7715901B2 (https=)
EP (2) EP1509129A4 (https=)
JP (1) JP2005524461A (https=)
AU (1) AU2003230164B2 (https=)
BR (1) BR0304716A (https=)
CA (1) CA2485224A1 (https=)
IL (1) IL164999A (https=)
NO (1) NO20040042L (https=)
RU (1) RU2343829C2 (https=)
WO (1) WO2003094695A2 (https=)

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KR20070112194A (ko) * 2005-02-17 2007-11-22 라이트 사이언시즈 온콜로지, 인코포레이티드 죽상동맥경화증의 예방치료를 위한 광반응성 시스템과 방법
CN101184527B (zh) * 2005-05-26 2012-05-09 皇家飞利浦电子股份有限公司 并入功能性成像信息的放射治疗方案设备
JP5139441B2 (ja) * 2006-11-30 2013-02-06 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 血管構造の可視化
JP4966640B2 (ja) * 2006-12-18 2012-07-04 学校法人慶應義塾 光線力学的治療装置およびその使用方法
CA2716940C (en) * 2008-02-29 2016-01-19 The Regents Of The University Of Michigan Systems and methods for imaging changes in tissue
WO2010043997A1 (en) * 2008-10-13 2010-04-22 Koninklijke Philips Electronics N.V. Flow insensitive magnetization preparation pulse for t2* contrast
US8571634B2 (en) * 2010-07-23 2013-10-29 David R. Hubbard Method to diagnose and measure vascular drainage insufficiency in the central nervous system
EP2425873A1 (fr) 2010-09-07 2012-03-07 Steba Maor SA Modélisation de l'action d'une fibre optique dans un traitement par therapie photodynamique, et assistance à la planification d'un tel traitement
FI20115306L (fi) 2011-03-31 2012-10-01 Valkee Oy Valon annostelulaite
US20120278380A1 (en) * 2011-04-29 2012-11-01 Joseph Curran Outdoor Tracker System with Visual Communication Devices
EP2745240A2 (en) * 2011-09-29 2014-06-25 Koninklijke Philips N.V. Distortion reduced signal detection
US9480402B2 (en) 2011-11-11 2016-11-01 Washington University System and method for task-less mapping of brain activity
US11633505B2 (en) 2012-12-11 2023-04-25 National University Corporation Kumamoto University Nuclear magnetic resonance diagnostic agent, and method for detecting or diagnosing state of cell, tissue or organ in subject using same
CN103927732B (zh) * 2013-01-11 2016-03-30 上海联影医疗科技有限公司 一种胸壁线的检测方法
US9125606B2 (en) * 2013-03-13 2015-09-08 Koninklijke Philips N.V. Device and method for determining the blood oxygen saturation of a subject
US10426388B2 (en) 2014-01-31 2019-10-01 The General Hospital Corporation Prediction of tumor recurrence by measuring oxygen saturation
WO2020210813A1 (en) * 2019-04-11 2020-10-15 The General Hospital Corporation Generating imaging-based neurological state biomarkers and estimating cerebrospinal fluid (csf) dynamics based on coupled neural and csf oscillations during sleep
US11443429B2 (en) 2019-05-30 2022-09-13 Washington University Atlas registration for resting state network mapping in patients with brain tumors
CN111035612B (zh) * 2019-12-31 2020-12-18 华中科技大学 一种活性氧响应性凝胶贮库及其制备方法与应用
CN116376033B (zh) * 2023-03-03 2024-01-16 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） 一种活性氧响应的自激活骨架聚合物及其制备方法和应用
US12429544B2 (en) * 2023-03-17 2025-09-30 Texas Tech University System Method and device for detecting subclinical hypoxemia using whole blood T2P

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Also Published As

Publication number Publication date
EP1509129A2 (en) 2005-03-02
BR0304716A (pt) 2004-07-13
US20060135868A1 (en) 2006-06-22
EP1509129A4 (en) 2009-03-25
EP2401962A1 (en) 2012-01-04
RU2004135823A (ru) 2005-05-10
RU2343829C2 (ru) 2009-01-20
NO20040042L (no) 2004-03-05
WO2003094695A2 (en) 2003-11-20
AU2003230164A1 (en) 2003-11-11
JP2005524461A (ja) 2005-08-18
IL164999A0 (en) 2005-12-18
IL164999A (en) 2010-12-30
CA2485224A1 (en) 2003-11-20
WO2003094695A3 (en) 2004-03-18
US7715901B2 (en) 2010-05-11

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FGA Letters patent sealed or granted (standard patent)
TH Corrigenda

Free format text: IN VOL 18, NO 2, PAGE(S) 613 UNDER THE HEADING APPLICATIONS OPI NAME INDEX UNDER THE NAME YEDA RESEARCH AND DEVELOPMENT CO. LTD., APPLICATION NO. 2003230164, UNDER INID (43) CORRECT THE DATE TO 24 NOVEMBER 2003

MK14 Patent ceased section 143(a) (annual fees not paid) or expired