|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
CH668554A5
(de)
|
1984-04-09 |
1989-01-13 |
Sandoz Ag |
Liposomen welche polypeptide mit interleukin-2-aktivitaet enthalten sowie verfahren zu ihrer herstellung.
|
|
EP0169146A3
(en)
|
1984-07-20 |
1988-07-20 |
Merck & Co. Inc. |
Monoclonal antibodies directed against the cellular receptor of human rhinovirus
|
|
US4698420A
(en)
*
|
1985-02-25 |
1987-10-06 |
Xoma Corporation |
Antibody hybrid molecules and process for their preparation
|
|
US5077195A
(en)
*
|
1985-03-01 |
1991-12-31 |
Board Of Reagents, The University Of Texas System |
Polypeptides complementary to peptides or proteins having an amino acid sequence or nucleotide coding sequence at least partially known and methods of design therefor
|
|
US4975282A
(en)
|
1985-06-26 |
1990-12-04 |
The Liposome Company, Inc. |
Multilamellar liposomes having improved trapping efficiencies
|
|
DE3682257D1
(de)
|
1985-11-22 |
1991-12-05 |
Takeda Chemical Industries Ltd |
Liposomzusammensetzung.
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4946778A
(en)
*
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5869620A
(en)
*
|
1986-09-02 |
1999-02-09 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
ATE87659T1
(de)
|
1986-09-02 |
1993-04-15 |
Enzon Lab Inc |
Bindungsmolekuele mit einzelpolypeptidkette.
|
|
US6121424A
(en)
*
|
1991-11-25 |
2000-09-19 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
US5260203A
(en)
*
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
JP2666345B2
(ja)
|
1987-04-16 |
1997-10-22 |
武田薬品工業株式会社 |
リポソーム製剤およびその製造法
|
|
US5284931A
(en)
*
|
1987-05-04 |
1994-02-08 |
Dana Farber Cancer Institute |
Intercellular adhesion molecules, and their binding ligands
|
|
US5565550A
(en)
*
|
1987-05-04 |
1996-10-15 |
Dana Farber Cancer Institute |
Antibodies to ICAM-2, and fragments thereof
|
|
ATE128727T1
(de)
|
1987-05-04 |
1995-10-15 |
Dana Farber Cancer Inst Inc |
Interzellulare adhäsions-moleküle und deren bindungsliganden.
|
|
US5273876A
(en)
|
1987-06-26 |
1993-12-28 |
Syntro Corporation |
Recombinant human cytomegalovirus containing foreign gene
|
|
US5223409A
(en)
*
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
EP0967277A3
(en)
|
1988-09-06 |
2003-10-15 |
Xoma Corporation |
Production of chimeric mouse-human antibodies with specificity to human tumor antigens
|
|
ES2201052T3
(es)
|
1988-09-28 |
2004-03-16 |
Dana Farber Cancer Institute |
Moleculas de adhesion intercelular y sus ligandos de union.
|
|
IL162181A
(en)
|
1988-12-28 |
2006-04-10 |
Pdl Biopharma Inc |
A method of producing humanized immunoglubulin, and polynucleotides encoding the same
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
WO1990009441A1
(en)
|
1989-02-01 |
1990-08-23 |
The General Hospital Corporation |
Herpes simplex virus type i expression vector
|
|
US5665577A
(en)
|
1989-02-06 |
1997-09-09 |
Dana-Farber Cancer Institute |
Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
|
|
EP0387701B1
(en)
|
1989-03-09 |
1992-08-12 |
Boehringer Ingelheim Pharmaceuticals Inc. |
Use of intercellular adhesion molecules, and their binding ligands in the treatment of asthma
|
|
US5081584A
(en)
*
|
1989-03-13 |
1992-01-14 |
United States Of America |
Computer-assisted design of anti-peptides based on the amino acid sequence of a target peptide
|
|
EP0404003A3
(en)
|
1989-06-19 |
1991-10-16 |
Xoma Corporation |
Chimeric mouse-human km10 antibody with specificity to a human tumor cell antigen
|
|
US5324510A
(en)
*
|
1989-09-01 |
1994-06-28 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Use of antibodies to intercellular adhesion molecule-1 (ICAM-1) in the treatment of asthma
|
|
AU6663990A
(en)
|
1989-11-13 |
1991-05-16 |
Green Cross Corporation, The |
Chimeric mouse-human antibodies with specificity to hiv antigens
|
|
WO1991007493A1
(en)
|
1989-11-13 |
1991-05-30 |
Xoma Corporation |
Chimeric mouse human antibodies with specificity to hiv antigens
|
|
CA2044590A1
(en)
|
1989-11-13 |
1991-05-14 |
Marc D. Better |
Chimeric mouse-human a10 antibody with specificity to a human tumor cell antigen
|
|
US5264618A
(en)
|
1990-04-19 |
1993-11-23 |
Vical, Inc. |
Cationic lipids for intracellular delivery of biologically active molecules
|
|
GB9009549D0
(en)
*
|
1990-04-27 |
1990-06-20 |
Celltech Ltd |
Recombinant antibody and method
|
|
GB9009548D0
(en)
|
1990-04-27 |
1990-06-20 |
Celltech Ltd |
Chimeric antibody and method
|
|
EP0459577A3
(en)
*
|
1990-06-01 |
1992-08-05 |
Merck & Co. Inc. |
Microbially expressed portions of a monoclonal antibody block rhinovirus attachment to cell receptors
|
|
US5723286A
(en)
*
|
1990-06-20 |
1998-03-03 |
Affymax Technologies N.V. |
Peptide library and screening systems
|
|
EP1285967A3
(en)
|
1990-09-21 |
2005-03-02 |
Chiron Corporation |
Human retroviral packaging cell line
|
|
US5582996A
(en)
*
|
1990-12-04 |
1996-12-10 |
The Wistar Institute Of Anatomy & Biology |
Bifunctional antibodies and method of preparing same
|
|
DE69131908T3
(de)
|
1991-02-19 |
2008-04-03 |
Oxford Biomedica (Uk) Ltd. |
Viruspartikel mit veraendertem wirtspektrum
|
|
GB9105383D0
(en)
|
1991-03-14 |
1991-05-01 |
Immunology Ltd |
An immunotherapeutic for cervical cancer
|
|
US5223396A
(en)
*
|
1991-05-03 |
1993-06-29 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Method for detecting organ transplant rejection
|
|
EP1400536A1
(en)
*
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Method for making humanized antibodies
|
|
ES2136092T3
(es)
*
|
1991-09-23 |
1999-11-16 |
Medical Res Council |
Procedimientos para la produccion de anticuerpos humanizados.
|
|
AU665025B2
(en)
|
1991-09-23 |
1995-12-14 |
Cambridge Antibody Technology Limited |
Production of chimeric antibodies - a combinatorial approach
|
|
US5716805A
(en)
*
|
1991-10-25 |
1998-02-10 |
Immunex Corporation |
Methods of preparing soluble, oligomeric proteins
|
|
DE69232137T2
(de)
|
1991-11-25 |
2002-05-29 |
Enzon Inc |
Multivalente antigen-bindende proteine
|
|
US5932448A
(en)
|
1991-11-29 |
1999-08-03 |
Protein Design Labs., Inc. |
Bispecific antibody heterodimers
|
|
EP1291360A1
(en)
*
|
1991-12-13 |
2003-03-12 |
Xoma Corporation |
Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
|
|
HU215180B
(hu)
*
|
1992-01-23 |
1998-10-28 |
Merck Patent Gmbh. |
Eljárás monomer és dimer antitest-fragment fúziós fehérjék előállítására
|
|
US6129914A
(en)
*
|
1992-03-27 |
2000-10-10 |
Protein Design Labs, Inc. |
Bispecific antibody effective to treat B-cell lymphoma and cell line
|
|
AU3972893A
(en)
|
1992-04-03 |
1993-11-08 |
Baylor College Of Medicine |
Gene therapy using the intestine
|
|
US6329507B1
(en)
*
|
1992-08-21 |
2001-12-11 |
The Dow Chemical Company |
Dimer and multimer forms of single chain polypeptides
|
|
US5639641A
(en)
*
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
US5832448A
(en)
*
|
1996-10-16 |
1998-11-03 |
Health Hero Network |
Multiple patient monitoring system for proactive health management
|
|
WO1994012520A1
(en)
*
|
1992-11-20 |
1994-06-09 |
Enzon, Inc. |
Linker for linked fusion polypeptides
|
|
WO1994012629A1
(en)
|
1992-12-02 |
1994-06-09 |
Baylor College Of Medicine |
Episomal vectors for gene therapy
|
|
ATE199392T1
(de)
|
1992-12-04 |
2001-03-15 |
Medical Res Council |
Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
|
|
US6307026B1
(en)
*
|
1992-12-10 |
2001-10-23 |
Celltech Limited |
Humanized antibodies directed against A33 antigen
|
|
FR2702160B1
(fr)
|
1993-03-02 |
1995-06-02 |
Biovecteurs As |
Vecteurs particulaires synthétiques et procédé de préparation.
|
|
US5491074A
(en)
*
|
1993-04-01 |
1996-02-13 |
Affymax Technologies Nv |
Association peptides
|
|
DE9390311U1
(de)
*
|
1993-05-18 |
1996-05-09 |
I.D.M. Immuno-Designed Molecules, Paris |
Neue Makrophagen mit Eignung als Wirkstoffe von pharmazeutischen Zusammensetzungen
|
|
EP0728202A4
(en)
|
1993-11-12 |
1997-04-23 |
Univ Case Western Reserve |
EPISOMIC EXPRESSION VECTOR FOR HUMAN GENE THERAPY
|
|
US5928944A
(en)
|
1994-02-04 |
1999-07-27 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method of adenoviral-medicated cell transfection
|
|
US5731172A
(en)
|
1994-03-09 |
1998-03-24 |
Sumitomo Pharmaceuticals Company, Ltd. |
Recombinant adenovirus and process for producing the same
|
|
GB9409768D0
(en)
*
|
1994-05-16 |
1994-07-06 |
Medical Res Council |
Trimerising polypeptides
|
|
US5604090A
(en)
|
1994-06-06 |
1997-02-18 |
Fred Hutchinson Cancer Research Center |
Method for increasing transduction of cells by adeno-associated virus vectors
|
|
US5763733A
(en)
*
|
1994-10-13 |
1998-06-09 |
Enzon, Inc. |
Antigen-binding fusion proteins
|
|
US5693508A
(en)
|
1994-11-08 |
1997-12-02 |
Chang; Lung-Ji |
Retroviral expression vectors containing MoMLV/CMV-IE/HIV-TAR chimeric long terminal repeats
|
|
US5573925A
(en)
*
|
1994-11-28 |
1996-11-12 |
The Wistar Institute Of Anatomy And Biology |
P53 proteins with altered tetramerization domains
|
|
US5721340A
(en)
*
|
1994-11-28 |
1998-02-24 |
The Wistar Institute Of Anatomy & Biology |
p53 proteins with altered tetramerization domains
|
|
US5632448A
(en)
*
|
1995-01-25 |
1997-05-27 |
Ransburg Corporation |
Rotary powder applicator
|
|
US5731168A
(en)
*
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
JP3770333B2
(ja)
|
1995-03-15 |
2006-04-26 |
大日本住友製薬株式会社 |
組換えdnaウイルスおよびその製造方法
|
|
CA2222055A1
(en)
*
|
1995-05-23 |
1996-11-28 |
Morphosys Gesellschaft Fur Proteinoptimierung Mbh |
Multimeric proteins
|
|
US6110456A
(en)
|
1995-06-07 |
2000-08-29 |
Yale University |
Oral delivery or adeno-associated viral vectors
|
|
JP2783276B2
(ja)
*
|
1995-07-04 |
1998-08-06 |
日本電気株式会社 |
半導体装置の製造方法
|
|
US5942433A
(en)
|
1995-07-31 |
1999-08-24 |
The United States Of America As Represented By The Department Of Health And Human Services |
Extension of a protein-protein interaction surface to inactivate the function of a cellular protein
|
|
US6013516A
(en)
|
1995-10-06 |
2000-01-11 |
The Salk Institute For Biological Studies |
Vector and method of use for nucleic acid delivery to non-dividing cells
|
|
JP2000504934A
(ja)
|
1995-12-22 |
2000-04-25 |
バクスター バイオテク テクノロジー エス.アー.アール.エル. |
結合ドメインを含むグロビン
|
|
WO1997035616A1
(en)
*
|
1996-03-25 |
1997-10-02 |
Pacific Northwest Cancer Foundation |
Monoclonal antibodies specific for the extracellular domain of prostate specific membrane antigen
|
|
US5861397A
(en)
|
1996-10-03 |
1999-01-19 |
Vical Incorporated |
Piperazine based cytofectins
|
|
US6096291A
(en)
|
1996-12-27 |
2000-08-01 |
Biovector Therapeutics, S.A. |
Mucosal administration of substances to mammals
|
|
EP2338915A3
(en)
*
|
1997-04-07 |
2011-10-12 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
ES2245052T3
(es)
|
1997-12-01 |
2005-12-16 |
Fang Fang |
Anticuerpos de recombinacion multivalentes destinados para el tratamiento de infecciones debidas al rinovirus humano (hrv).
|
|
JPH11228446A
(ja)
*
|
1998-02-16 |
1999-08-24 |
Mitsubishi Chemical Corp |
抗マラリア剤
|
|
US20020165153A1
(en)
|
1998-04-06 |
2002-11-07 |
Peter Angel |
Transcription factors and their use
|
|
US5965712A
(en)
*
|
1998-06-19 |
1999-10-12 |
Virginia Commonwealth University |
LZ-CD23 chimera for inhibition of IgE-mediated allergic disease
|
|
DK1121382T3
(da)
*
|
1998-10-16 |
2006-11-13 |
Biogen Idec Inc |
Interferon-beta-fusionsproteiner og deres anvendelser
|
|
US20030035798A1
(en)
*
|
2000-08-16 |
2003-02-20 |
Fang Fang |
Humanized antibodies
|
|
JP2002531466A
(ja)
*
|
1998-12-01 |
2002-09-24 |
プロテイン デザイン ラブス, インコーポレイテッド |
γ−インターフェロンに対するヒト化抗体
|
|
WO2001000814A2
(en)
|
1999-06-25 |
2001-01-04 |
Universität Zürich |
Hetero-associating coiled-coil peptides and screenign method therefor
|
|
NZ517774A
(en)
|
1999-09-17 |
2005-01-28 |
Gtc Biotherapeutics Inc |
A method of making a fusion protein such as an immunoglobulin heavy or light chain subunit fused to an enzyme or toxin subunit
|
|
AUPQ425699A0
(en)
*
|
1999-11-25 |
1999-12-23 |
University Of Newcastle Research Associates Limited, The |
A method of treating a malignancy in a subject and a pharmaceutical composition for use in same
|
|
WO2001042451A2
(en)
*
|
1999-12-08 |
2001-06-14 |
Genset |
FULL-LENGTH HUMAN cDNAs ENCODING POTENTIALLY SECRETED PROTEINS
|
|
AU2001257445B2
(en)
|
2000-04-28 |
2006-11-02 |
Planet Biotechnology, Inc. |
Immunoadhesin for the prevention of rhinovirus infection
|
|
WO2003062370A2
(en)
*
|
2001-07-19 |
2003-07-31 |
Perlan Therapeutics, Inc. |
Multimeric proteins and methods of making and using same
|
|
JP4236000B2
(ja)
|
2003-09-25 |
2009-03-11 |
元気株式会社 |
3次元画像処理装置、3次元画像処理方法及びプログラム
|