JP2005514413A5 - - Google Patents
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- Publication number
- JP2005514413A5 JP2005514413A5 JP2003557583A JP2003557583A JP2005514413A5 JP 2005514413 A5 JP2005514413 A5 JP 2005514413A5 JP 2003557583 A JP2003557583 A JP 2003557583A JP 2003557583 A JP2003557583 A JP 2003557583A JP 2005514413 A5 JP2005514413 A5 JP 2005514413A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkoxy
- lower alkyl
- hydrogen
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 50
- 125000003545 alkoxy group Chemical group 0.000 claims description 49
- 229910052739 hydrogen Inorganic materials 0.000 claims description 35
- 239000001257 hydrogen Substances 0.000 claims description 35
- 229910052736 halogen Inorganic materials 0.000 claims description 33
- 150000002367 halogens Chemical class 0.000 claims description 33
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 32
- 125000004475 heteroaralkyl group Chemical group 0.000 claims description 32
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 31
- 125000003118 aryl group Chemical group 0.000 claims description 30
- 125000001072 heteroaryl group Chemical group 0.000 claims description 28
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 28
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 26
- 125000001424 substituent group Chemical group 0.000 claims description 23
- 125000005415 substituted alkoxy group Chemical group 0.000 claims description 17
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 6
- 150000002431 hydrogen Chemical class 0.000 claims 31
- 125000004104 aryloxy group Chemical group 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 8
- YMWUJEATGCHHMB-UHFFFAOYSA-N methylene dichloride Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 7
- 125000005055 alkyl alkoxy group Chemical group 0.000 claims 5
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 125000004429 atoms Chemical group 0.000 claims 2
- 125000005842 heteroatoms Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 6
- 125000002541 furyl group Chemical group 0.000 description 4
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 3
- 125000000524 functional group Chemical group 0.000 description 2
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 description 2
- 125000002883 imidazolyl group Chemical group 0.000 description 2
- 125000003226 pyrazolyl group Chemical group 0.000 description 2
- 125000004076 pyridyl group Chemical group 0.000 description 2
- 125000000714 pyrimidinyl group Chemical group 0.000 description 2
- 125000000168 pyrrolyl group Chemical group 0.000 description 2
- 125000003107 substituted aryl group Chemical group 0.000 description 2
- 125000000335 thiazolyl group Chemical group 0.000 description 2
- 125000001544 thienyl group Chemical group 0.000 description 2
- 125000004306 triazinyl group Chemical group 0.000 description 2
- 238000004617 QSAR study Methods 0.000 description 1
- -1 alkyl imine Chemical class 0.000 description 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 1
- 125000005518 carboxamido group Chemical group 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000006575 electron-withdrawing group Chemical group 0.000 description 1
- 230000002209 hydrophobic Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34466001P | 2001-12-26 | 2001-12-26 | |
| US37164902P | 2002-04-10 | 2002-04-10 | |
| PCT/US2002/041481 WO2003057225A2 (en) | 2001-12-26 | 2002-12-24 | Phosphate transport inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010008273A Division JP2010132674A (ja) | 2001-12-26 | 2010-01-18 | リン酸塩輸送インヒビター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005514413A JP2005514413A (ja) | 2005-05-19 |
| JP2005514413A5 true JP2005514413A5 (US07094801-20060822-C00072.png) | 2010-03-04 |
| JP4610900B2 JP4610900B2 (ja) | 2011-01-12 |
Family
ID=26994039
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003557583A Expired - Fee Related JP4610900B2 (ja) | 2001-12-26 | 2002-12-24 | リン酸塩輸送インヒビター |
| JP2010008273A Withdrawn JP2010132674A (ja) | 2001-12-26 | 2010-01-18 | リン酸塩輸送インヒビター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010008273A Withdrawn JP2010132674A (ja) | 2001-12-26 | 2010-01-18 | リン酸塩輸送インヒビター |
Country Status (7)
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7119120B2 (en) * | 2001-12-26 | 2006-10-10 | Genzyme Corporation | Phosphate transport inhibitors |
| US7119112B2 (en) * | 2002-02-28 | 2006-10-10 | Icagen, Inc. | Sulfonamides as potassium channel blockers |
| US20040161474A1 (en) * | 2002-05-24 | 2004-08-19 | Moerck Rudi E. | Rare earth metal compounds methods of making, and methods of using the same |
| US20060083791A1 (en) | 2002-05-24 | 2006-04-20 | Moerck Rudi E | Rare earth metal compounds methods of making, and methods of using the same |
| NZ538513A (en) * | 2002-09-05 | 2007-02-23 | Neurosearch As | Diarylurea derivatives and their use as chloride channel blockers |
| EP1398029A1 (en) * | 2002-09-10 | 2004-03-17 | LION Bioscience AG | NR3B1 nuclear receptor binding 3-substituted pyrazole derivatives |
| US7491718B2 (en) * | 2002-10-08 | 2009-02-17 | Abbott Laboratories | Sulfonamides having antiangiogenic and anticancer activity |
| US7220406B2 (en) | 2002-10-22 | 2007-05-22 | Genzyme Corporation | Method for promoting bone formation |
| DE10257357A1 (de) | 2002-12-09 | 2004-06-24 | Bayer Ag | Fluorhaltige Benzaldehyde |
| EP1753421B1 (en) * | 2004-04-20 | 2012-08-01 | Amgen Inc. | Arylsulfonamides and uses as hydroxysteroid dehydrogenase |
| WO2006044657A2 (en) * | 2004-10-15 | 2006-04-27 | Altairnano, Inc. | Phosphate binder with reduced pill burden |
| WO2006077901A1 (ja) * | 2005-01-20 | 2006-07-27 | Shionogi & Co., Ltd. | Ctgf発現阻害剤 |
| US20080069860A1 (en) * | 2005-08-17 | 2008-03-20 | Allison Wren | Hyperphosphatemia in domestic animals: compositions and methods of treatment |
| EP1928349A4 (en) * | 2005-08-17 | 2008-10-01 | Altairnano Inc | COMPOSITIONS AND METHODS FOR TREATING CHRONIC RENAL FAILURE AND OTHER CONDITIONS IN DOMESTIC ANIMALS |
| DE102005044156A1 (de) * | 2005-09-15 | 2007-03-29 | Riemser Arzneimittel Ag | Substituierte Acetophenonderivate |
| GB0526252D0 (en) * | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| GB0526255D0 (en) * | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| JP2009542653A (ja) * | 2006-07-05 | 2009-12-03 | ジェンザイム コーポレーション | リン酸塩過剰血症のための鉄（ｉｉ）含有治療剤 |
| US8119693B2 (en) * | 2007-05-08 | 2012-02-21 | Sanford-Burnham Medical Research Institute | Tissue non-specific alkaline phosphatase inhibitors and uses thereof for treating vascular calcification |
| US7776877B2 (en) * | 2007-06-22 | 2010-08-17 | Chemocentryx, Inc. | N-(2-(hetaryl)aryl) arylsulfonamides and N-(2-(hetaryl) hetaryl arylsulfonamides |
| CN102137669A (zh) * | 2008-06-03 | 2011-07-27 | 弗雷森纽斯医疗护理德国有限责任公司 | 包含γ分泌酶调节剂的药物组合物 |
| ES2714453T3 (es) * | 2008-06-09 | 2019-05-28 | Univ Muenchen Ludwig Maximilians | Fármacos para inhibir la agregación de proteínas implicadas en enfermedades relacionadas con enfermedades neurodegenerativas y/o agregación de proteínas |
| WO2010005922A1 (en) * | 2008-07-07 | 2010-01-14 | Fasgen, Inc. | Novel compounds, pharmaceutical compositions containing same, methods of use for same, and methods for preparing same |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| KR101766619B1 (ko) | 2008-12-31 | 2017-08-08 | 알데릭스, 인코포레이티드 | 체액 저류 또는 염 과부하와 연관된 장애 및 위장관 장애의 치료 시에 ｎｈｅ-매개된 역수송을 억제하는 화합물 및 방법 |
| JP5783910B2 (ja) | 2009-01-26 | 2015-09-24 | シトクロマ インコーポレイテッド | 小分子を用いるリン酸管理 |
| AU2010303270A1 (en) | 2009-10-09 | 2012-05-03 | Zafgen Corporation | Sulphone compounds for use in the treatment of obesity |
| RU2566757C2 (ru) * | 2010-03-05 | 2015-10-27 | Дуофос | Арилфторфосфатные ингибиторы кишечного апикального мембранного натрий/фосфатного котранспорта |
| US8961917B2 (en) | 2010-05-12 | 2015-02-24 | Spectrum Pharmaceuticals, Inc. | Lanthanum carbonate hydroxide, lanthanum oxycarbonate and methods of their manufacture and use |
| JP5823514B2 (ja) * | 2010-07-07 | 2015-11-25 | アーデリクス，インコーポレーテッド | リン酸輸送を阻害する化合物及び方法 |
| JP5827328B2 (ja) * | 2010-07-07 | 2015-12-02 | アーデリクス，インコーポレーテッド | リン酸輸送を阻害する化合物及び方法 |
| JP5827326B2 (ja) * | 2010-07-07 | 2015-12-02 | アーデリクス，インコーポレーテッド | リン酸輸送を阻害する化合物及び方法 |
| JP5827327B2 (ja) | 2010-07-07 | 2015-12-02 | アーデリクス，インコーポレーテッド | リン酸輸送を阻害する化合物及び方法 |
| KR20130043207A (ko) | 2010-07-22 | 2013-04-29 | 자프겐 인크. | 트리시클릭 화합물 및 이의 제조 및 사용 방법 |
| JP6058557B2 (ja) | 2011-01-26 | 2017-01-11 | ザフゲン，インコーポレイテッド | テトラゾール化合物ならびにその作製方法および使用方法 |
| BR112013028534A2 (pt) | 2011-05-06 | 2016-09-06 | Zafgen Inc | compostos tricíclicos parcialmente saturados e métodos para produção e utilização dos mesmos |
| BR112013028666A2 (pt) | 2011-05-06 | 2017-08-08 | Zafgen Inc | compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo |
| BR112013028665A2 (pt) | 2011-05-06 | 2016-09-06 | Zafgen Inc | compostos de sulfonamida tricíclicos e métodos para fazer e usar os mesmos |
| JP6035347B2 (ja) | 2012-01-18 | 2016-11-30 | ザフゲン，インコーポレイテッド | 三環式スルホンアミド化合物ならびにその作製および使用方法 |
| EP2804856B1 (en) | 2012-01-18 | 2017-03-15 | Zafgen, Inc. | Tricyclic sulfone compounds and methods of making and using same |
| KR102138390B1 (ko) | 2012-08-21 | 2020-07-27 | 알데릭스, 인코포레이티드 | 체액 저류 또는 염 과부하와 연관된 장애 및 위장관 장애의 치료에서 ｎｈｅ-매개된 역수송 저해를 위한 화합물 및 방법 |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| CA2890342A1 (en) | 2012-11-05 | 2014-05-08 | Zafgen, Inc. | Tricyclic compounds and methods of making and using same |
| EP2925737B1 (en) | 2012-11-05 | 2017-06-14 | Zafgen, Inc. | Tricyclic compounds for use in the treatment and/or control of obesity |
| CN104918615B (zh) | 2012-11-05 | 2018-10-12 | 扎夫根股份有限公司 | 治疗肝病的方法 |
| EP2983667B1 (en) | 2013-04-12 | 2019-03-20 | Ardelyx, Inc. | Nhe3-binding compounds and methods for inhibiting phosphate transport |
| CN103467452B (zh) * | 2013-09-11 | 2015-11-18 | 陕西理工学院 | 一种苯甲酰胺类化合物及其应用 |
| CN106008360B (zh) * | 2016-08-11 | 2018-10-16 | 华南农业大学 | 一种对氨基苯磺酰咪唑及其制备方法 |
| JOP20190080A1 (ar) | 2016-10-14 | 2019-04-11 | Bayer Pharma AG | مركبات مشتقة من 6-(1h-بيرازول-1-يل) بيريميدين-4- أمين مستبدل واستخداماتها |
| JP7120549B2 (ja) * | 2016-12-15 | 2022-08-17 | 小野薬品工業株式会社 | Ｔｒｅｋ（ｔｗｉｋ関連ｋチャネル）チャネルのアクチベータ |
| AU2018206479B2 (en) | 2017-01-09 | 2022-07-14 | Ardelyx, Inc. | Inhibitors of NHE-mediated antiport |
| WO2018129552A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds useful for treating gastrointestinal tract disorders |
| WO2019028343A1 (en) * | 2017-08-03 | 2019-02-07 | Georgetown University | SMALL MOLECULE INHIBITORS OF SLC25A1 |
| EP3740482A1 (en) | 2018-01-17 | 2020-11-25 | Migal Galilee Research Institute Ltd. | New methionine metabolic pathway inhibitors |
| EP3740466B1 (en) | 2018-01-17 | 2024-03-06 | Migal Galilee Research Institute Ltd. | New methionine metabolic pathway inhibitors |
| WO2019179436A1 (zh) * | 2018-03-20 | 2019-09-26 | 成都海创药业有限公司 | 一种酰胺类化合物及其在治疗癌症中的用途 |
| EP3802514B1 (en) | 2018-06-01 | 2022-08-03 | Promega Corporation | Inhibitors of oplophorus luciferase-derived bioluminescent complexes |
| SG11202110406SA (en) | 2019-04-11 | 2021-10-28 | Angion Biomedica Corp | Solid forms of (e)-3-[2-(2-thienyl)vinyl]-1h-pyrazole |
| US20220323389A1 (en) * | 2019-08-26 | 2022-10-13 | Georgetown University | Treating non-alcoholic fatty liver disease and inflammatory steatohepatitis with slc25a1 inhibitors |
| WO2023219127A1 (ja) * | 2022-05-11 | 2023-11-16 | 中外製薬株式会社 | 嚢胞性疾患を治療または予防するための医薬組成物 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2140441C (en) * | 1992-07-28 | 2006-11-21 | Garry Fenton | Inhibitors of c-amp phosphodiesterase and tnf |
| EP0619116A3 (en) * | 1993-04-05 | 1994-11-23 | Hoechst Japan | Use of synthetic retinoids for osteopathy. |
| US5496545A (en) | 1993-08-11 | 1996-03-05 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5667775A (en) | 1993-08-11 | 1997-09-16 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| CA2155662A1 (en) | 1993-12-27 | 1995-07-06 | Fumihiro Ozaki | Anthranilic acid derivative |
| AU706262B2 (en) * | 1995-10-23 | 1999-06-10 | Osteoscreen, Inc. | Compositions and methods for treating bone deficit conditions |
| TW523506B (en) | 1996-12-18 | 2003-03-11 | Ono Pharmaceutical Co | Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients |
| US6255298B1 (en) * | 1997-08-06 | 2001-07-03 | Smithkline Beecham Corporation | Macrophage scavenger receptor antagonists for use in the treatment of cardiovascular diseases |
| HUP0102782A3 (en) * | 1998-06-19 | 2002-12-28 | Smithkline Beecham Corp | Salycilanilide as inhibitors of transcription factor nf-kb |
| JP3972163B2 (ja) * | 1999-06-18 | 2007-09-05 | 株式会社大塚製薬工場 | ホスホン酸ジエステル誘導体 |
| AR030911A1 (es) | 1999-07-20 | 2003-09-03 | Smithkline Beecham Corp | Uso de n-aril-2-sulfonamidobenzamidas para la manufactura de un medicamento para el tratamiento de la insuficiencia renal cronica y composiciones farmaceuticas |
| US20030212074A1 (en) | 2000-05-02 | 2003-11-13 | Dimitri Gaitanopoulos | Phosphate transport inhibitors |
| KR20020093983A (ko) | 2000-05-12 | 2002-12-16 | 스미스클라인 비참 코포레이션 | 포스페이트 수송 억제제 |
| WO2002028353A2 (en) * | 2000-10-05 | 2002-04-11 | Smithkline Beecham Corporation | Phosphate transport inhibitors |
| DE10121003A1 (de) * | 2001-04-28 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| US7119120B2 (en) * | 2001-12-26 | 2006-10-10 | Genzyme Corporation | Phosphate transport inhibitors |
-
2002
- 2002-12-20 US US10/327,627 patent/US7119120B2/en not_active Expired - Lifetime
- 2002-12-24 AT AT02806234T patent/ATE362360T1/de not_active IP Right Cessation
- 2002-12-24 AT AT06077276T patent/ATE464905T1/de not_active IP Right Cessation
- 2002-12-24 WO PCT/US2002/041481 patent/WO2003057225A2/en active IP Right Grant
- 2002-12-24 JP JP2003557583A patent/JP4610900B2/ja not_active Expired - Fee Related
- 2002-12-24 EP EP06077276A patent/EP1815860B1/en not_active Expired - Lifetime
- 2002-12-24 DE DE60236117T patent/DE60236117D1/de not_active Expired - Lifetime
- 2002-12-24 AU AU2002367396A patent/AU2002367396A1/en not_active Abandoned
- 2002-12-24 DE DE60220188T patent/DE60220188T2/de not_active Expired - Lifetime
- 2002-12-24 EP EP02806234A patent/EP1465638B1/en not_active Expired - Lifetime
-
2006
- 2006-07-19 US US11/489,286 patent/US20070021509A1/en not_active Abandoned
-
2010
- 2010-01-18 JP JP2010008273A patent/JP2010132674A/ja not_active Withdrawn
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