DE60236117D1 - Phosphattransporthemmer - Google Patents

Phosphattransporthemmer

Info

Publication number
DE60236117D1
DE60236117D1 DE60236117T DE60236117T DE60236117D1 DE 60236117 D1 DE60236117 D1 DE 60236117D1 DE 60236117 T DE60236117 T DE 60236117T DE 60236117 T DE60236117 T DE 60236117T DE 60236117 D1 DE60236117 D1 DE 60236117D1
Authority
DE
Germany
Prior art keywords
phosphate transport
transport inhibitor
lower alkyl
substituted
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60236117T
Other languages
English (en)
Inventor
Stephen Randall Holmes-Farley
Cecilia M Bastos
Andrew T Papoulis
Thomas H Jozefiak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Application granted granted Critical
Publication of DE60236117D1 publication Critical patent/DE60236117D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/38—Silver; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
DE60236117T 2001-12-26 2002-12-24 Phosphattransporthemmer Expired - Lifetime DE60236117D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34466001P 2001-12-26 2001-12-26
US37164902P 2002-04-10 2002-04-10

Publications (1)

Publication Number Publication Date
DE60236117D1 true DE60236117D1 (de) 2010-06-02

Family

ID=26994039

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60236117T Expired - Lifetime DE60236117D1 (de) 2001-12-26 2002-12-24 Phosphattransporthemmer
DE60220188T Expired - Lifetime DE60220188T2 (de) 2001-12-26 2002-12-24 Hemmer des phosphattransports

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60220188T Expired - Lifetime DE60220188T2 (de) 2001-12-26 2002-12-24 Hemmer des phosphattransports

Country Status (7)

Country Link
US (2) US7119120B2 (de)
EP (2) EP1815860B1 (de)
JP (2) JP4610900B2 (de)
AT (2) ATE362360T1 (de)
AU (1) AU2002367396A1 (de)
DE (2) DE60236117D1 (de)
WO (1) WO2003057225A2 (de)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7119120B2 (en) * 2001-12-26 2006-10-10 Genzyme Corporation Phosphate transport inhibitors
US7119112B2 (en) * 2002-02-28 2006-10-10 Icagen, Inc. Sulfonamides as potassium channel blockers
US20040161474A1 (en) * 2002-05-24 2004-08-19 Moerck Rudi E. Rare earth metal compounds methods of making, and methods of using the same
US20060083791A1 (en) 2002-05-24 2006-04-20 Moerck Rudi E Rare earth metal compounds methods of making, and methods of using the same
CN100497302C (zh) * 2002-09-05 2009-06-10 神经研究公司 二芳基脲衍生物和它们作为氯通道阻滞剂的用途
EP1398029A1 (de) * 2002-09-10 2004-03-17 LION Bioscience AG 3-substituierte Pyrazol-Derivate,die an den NR3B1 Rezeptor binden
US7491718B2 (en) * 2002-10-08 2009-02-17 Abbott Laboratories Sulfonamides having antiangiogenic and anticancer activity
WO2004037274A1 (en) * 2002-10-22 2004-05-06 Genzyme Corporation Amine polymers for promoting bone formation
DE10257357A1 (de) * 2002-12-09 2004-06-24 Bayer Ag Fluorhaltige Benzaldehyde
JP2007533749A (ja) * 2004-04-20 2007-11-22 アムゲン インコーポレイティッド アリールスルホンアミドおよびそれに関連する使用方法
EP1809305A4 (de) * 2004-10-15 2009-12-30 Altairnano Inc Phosphatbindemittel mit verringerter tablettenlast
JPWO2006077901A1 (ja) * 2005-01-20 2008-06-19 塩野義製薬株式会社 Ｃｔｇｆ発現阻害剤
US20080058250A1 (en) * 2005-08-17 2008-03-06 Allison Wren Treatment of chronic renal failure and other conditions in domestic animals: compositions and methods
AU2006279364A1 (en) * 2005-08-17 2007-02-22 Altairnano, Inc. Hyperphosphatemia in domestic animals: compositions and methods of treatment
DE102005044156A1 (de) * 2005-09-15 2007-03-29 Riemser Arzneimittel Ag Substituierte Acetophenonderivate
GB0526252D0 (en) * 2005-12-22 2006-02-01 Novartis Ag Organic compounds
GB0526255D0 (en) * 2005-12-22 2006-02-01 Novartis Ag Organic compounds
WO2008005217A2 (en) * 2006-07-05 2008-01-10 Genzyme Corporation Iron(ii)-containing treatments for hyperphosphatemia
JP5671336B2 (ja) * 2007-05-08 2015-02-18 バーナム インスティテュート フォー メディカル リサーチ 組織非特異的アルカリホスファターゼ阻害因子および血管石灰化を処置するためのそれらの使用
US7776877B2 (en) 2007-06-22 2010-08-17 Chemocentryx, Inc. N-(2-(hetaryl)aryl) arylsulfonamides and N-(2-(hetaryl) hetaryl arylsulfonamides
EP2307019A1 (de) * 2008-06-03 2011-04-13 Fresenius Medical Care Deutschland GmbH Pharmazeutische zusammensetzungen mit gammasekretasemodulatoren
PL2307381T3 (pl) * 2008-06-09 2021-07-05 Ludwig-Maximilians-Universität München Nowe leki do hamowania agregacji białek związanych z chorobami związanymi z agregacją białka i/lub chorobami neurodegeneracyjnymi
MX2011000051A (es) * 2008-07-07 2011-07-28 Fasgen Inc Nuevos compuestos, composiciones farmaceuticas que contienen los mismos, metodos para usar los mismos, y metodos para preparar los mismos.
KR20170091783A (ko) 2008-12-31 2017-08-09 알데릭스, 인코포레이티드 체액 저류 또는 염 과부하와 연관된 장애 및 위장관 장애의 치료 시에 ｎｈｅ-매개된 역수송을 억제하는 화합물 및 방법
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
JP5783910B2 (ja) 2009-01-26 2015-09-24 シトクロマ インコーポレイテッド 小分子を用いるリン酸管理
KR20120083905A (ko) 2009-10-09 2012-07-26 자프겐 코포레이션 비만의 치료에 사용하기 위한 설폰 화합물
JP5819865B2 (ja) * 2010-03-05 2015-11-24 デュオフォス 小腸刷子縁膜ナトリウム／リン酸塩共−輸送のアリールフルオロホスフェート阻害剤
US8961917B2 (en) 2010-05-12 2015-02-24 Spectrum Pharmaceuticals, Inc. Lanthanum carbonate hydroxide, lanthanum oxycarbonate and methods of their manufacture and use
WO2012006477A1 (en) 2010-07-07 2012-01-12 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
EP2590656B1 (de) 2010-07-07 2017-11-15 Ardelyx, Inc. Verbindungen und verfahren zur hemmung eines phosphattransports
WO2012006474A2 (en) 2010-07-07 2012-01-12 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
EP2590655B1 (de) * 2010-07-07 2015-06-24 Ardelyx, Inc. Verbindungen und verfahren zur hemmung eines phosphattransports
CN103249735B (zh) 2010-07-22 2016-04-06 扎夫根股份有限公司 三环化合物及其制备和使用方法
EP2668169B1 (de) 2011-01-26 2017-11-15 Zafgen, Inc. Tetrazolverbindungen sowie verfahren zu ihrer herstellung und verwendung
EP2705036B1 (de) 2011-05-06 2015-08-12 Zafgen Inc. Tricyclische sulfonamidverbindungen sowie verfahren zu ihrer herstellung und verwendung
EA025526B1 (ru) 2011-05-06 2017-01-30 Зафджен Инк. Частично насыщенные трициклические соединения и способы их получения и применения
KR20140040739A (ko) 2011-05-06 2014-04-03 자프겐 인크. 삼환식 피라졸 설폰아마이드 화합물 그리고 그의 제조방법 및 그를 이용하는 방법
US9440943B2 (en) 2012-01-18 2016-09-13 Zafgen, Inc. Tricyclic sulfone compounds and methods of making and using same
JP6035347B2 (ja) 2012-01-18 2016-11-30 ザフゲン，インコーポレイテッド 三環式スルホンアミド化合物ならびにその作製および使用方法
RU2015107019A (ru) 2012-08-21 2016-10-10 Эрделикс Инк. Соединения и способы для ингибирования nhe-опосредованного антипорта в лечении расстройств, ассоциированных с задержкой жидкости или солевой перегрузкой и заболеваний желудочно-кишечного тракта
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
WO2014071363A1 (en) 2012-11-05 2014-05-08 Zafgen, Inc. Tricyclic compounds and methods of making and using same
CA2890343A1 (en) 2012-11-05 2014-05-08 Zafgen, Inc. Tricyclic compounds useful in the treatment of liver disorders
KR20150080614A (ko) 2012-11-05 2015-07-09 자프겐 인크. 비만의 치료 및/또는 제어에서 사용하기 위한 트리시클릭 화합물
EP3988120A1 (de) 2013-04-12 2022-04-27 Ardelyx, Inc. Nhe3-bindende verbindungen und verfahren zur phosphattransporthemmung
CN103467452B (zh) * 2013-09-11 2015-11-18 陕西理工学院 一种苯甲酰胺类化合物及其应用
CN106008360B (zh) * 2016-08-11 2018-10-16 华南农业大学 一种对氨基苯磺酰咪唑及其制备方法
JOP20190080A1 (ar) 2016-10-14 2019-04-11 Bayer Pharma AG مركبات مشتقة من 6-(1h-بيرازول-1-يل) بيريميدين-4- أمين مستبدل واستخداماتها
JP7120549B2 (ja) * 2016-12-15 2022-08-17 小野薬品工業株式会社 Ｔｒｅｋ（ｔｗｉｋ関連ｋチャネル）チャネルのアクチベータ
MA47203A (fr) 2017-01-09 2019-11-13 Ardelyx Inc Inhibiteurs d'antiport à médiation par nhe
WO2018129552A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds useful for treating gastrointestinal tract disorders
US20200246285A1 (en) * 2017-08-03 2020-08-06 Georgetown University Small molecule inhibitors of slc25a1
CN111699182A (zh) 2018-01-17 2020-09-22 米加尔-加利里研究院有限公司 新型蛋氨酸代谢途径抑制剂
CN111630032A (zh) * 2018-01-17 2020-09-04 米加尔-加利里研究院有限公司 新型蛋氨酸代谢途径抑制剂
CN110305045A (zh) * 2018-03-20 2019-10-08 成都海创药业有限公司 一种酰胺类化合物及其在治疗癌症中的用途
WO2019232384A1 (en) * 2018-06-01 2019-12-05 Promega Corporation Inhibitors of oplophorus luciferase-derived bioluminescent complexes
SG11202110406SA (en) 2019-04-11 2021-10-28 Angion Biomedica Corp Solid forms of (e)-3-[2-(2-thienyl)vinyl]-1h-pyrazole
US20220323389A1 (en) * 2019-08-26 2022-10-13 Georgetown University Treating non-alcoholic fatty liver disease and inflammatory steatohepatitis with slc25a1 inhibitors
WO2023219127A1 (ja) * 2022-05-11 2023-11-16 中外製薬株式会社 嚢胞性疾患を治療または予防するための医薬組成物

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL106517A0 (en) * 1992-07-28 1994-08-26 Rhone Poulenc Rorer Ltd Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic or heteroatom containing linking group
EP0619116A3 (en) * 1993-04-05 1994-11-23 Hoechst Japan Use of synthetic retinoids for osteopathy.
US5667775A (en) 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5496545A (en) 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
EP0686625B1 (de) * 1993-12-27 1999-05-26 Eisai Co., Ltd. Anthranilsäure derivate
EA199800393A1 (ru) * 1995-10-23 1998-12-24 Займодженетикс, Инк. Композиции и способы их применение для лечения поражения костей
TW523506B (en) * 1996-12-18 2003-03-11 Ono Pharmaceutical Co Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients
EP1005347A4 (de) * 1997-08-06 2002-08-28 Smithkline Beecham Corp Antagonisten der rezeptoren der monozyten makrophagen zur verwendung im behandlung kardiovaskuläre erkrankungen
HUP0102782A3 (en) * 1998-06-19 2002-12-28 Smithkline Beecham Corp Salycilanilide as inhibitors of transcription factor nf-kb
JP3972163B2 (ja) * 1999-06-18 2007-09-05 株式会社大塚製薬工場 ホスホン酸ジエステル誘導体
AR030911A1 (es) 1999-07-20 2003-09-03 Smithkline Beecham Corp Uso de n-aril-2-sulfonamidobenzamidas para la manufactura de un medicamento para el tratamiento de la insuficiencia renal cronica y composiciones farmaceuticas
AU2001259354A1 (en) 2000-05-02 2001-11-12 Smith Kline Beecham Corporation Phosphate transport inhibitors
JP2003533477A (ja) 2000-05-12 2003-11-11 スミスクライン・ビーチャム・コーポレイション リン酸輸送阻害剤
AU2002213048A1 (en) * 2000-10-05 2002-04-15 Smith Kline Beecham Corporation Phosphate transport inhibitors
DE10121003A1 (de) * 2001-04-28 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
US7119120B2 (en) * 2001-12-26 2006-10-10 Genzyme Corporation Phosphate transport inhibitors

Also Published As

Publication number Publication date
EP1815860A2 (de) 2007-08-08
JP2010132674A (ja) 2010-06-17
JP4610900B2 (ja) 2011-01-12
ATE464905T1 (de) 2010-05-15
WO2003057225A3 (en) 2004-04-08
WO2003057225A2 (en) 2003-07-17
ATE362360T1 (de) 2007-06-15
EP1465638B1 (de) 2007-05-16
EP1465638A2 (de) 2004-10-13
US7119120B2 (en) 2006-10-10
AU2002367396A1 (en) 2003-07-24
US20070021509A1 (en) 2007-01-25
EP1815860A3 (de) 2007-11-21
US20040019113A1 (en) 2004-01-29
DE60220188T2 (de) 2008-01-24
JP2005514413A (ja) 2005-05-19
EP1815860B1 (de) 2010-04-21
DE60220188D1 (de) 2007-06-28

Similar Documents

Publication Publication Date Title
DE60236117D1 (de) Phosphattransporthemmer
IT1290823B1 (it) Idrossifeniltriazine
DE69221794T2 (de) 3-benzyliden-1-carbamoyl-2-pyrrolidon-analoga
ES2182234T3 (es) Inhibidores de metaloproteasa.
DK0771794T3 (da) Oxygenholdige heterocykliske forbindelser
EA200000048A1 (ru) ИНГИБИТОРЫ ФАКТОРА Ха, СОДЕРЖАЩИЕ ГРУППУ С НЕЙТРАЛЬНОЙ P1-СПЕЦИФИЧНОСТЬЮ
TR200100432T2 (tr) Hepatit C inhibitörü tri-peptidler
BR0010242A (pt) Composições quìmicas que atraem artrópodes
CO5261493A1 (es) Procedimiento y compuestos para la inhibicion de la mrp1
ATE172452T1 (de) Bicyclische stichstoff enthaltende derivate als prolyl-endopeptidase inhibitoren
DE69808099D1 (de) Substituierte 6-alkylphenanthridine
MY101917A (en) Biocidal mixture
DE60111228D1 (de) Heteropolycyclische inhibitoren
PT1197215E (pt) Composicoes antelminticas
DE60223227D1 (de) BenzoÄbÄthiophenderivate und Verfahren zu deren Herstellung
DK0844241T3 (da) Inhibitor af narkotisk analgetisk afhængighed/resistensudvikling
DK0668279T3 (da) 6-azaindol thromboxansytaseinhibitor
UA26459C2 (uk) Іhгібітор впливу амілоїдhих білків
DE602004020971D1 (de) Schlammbehandlung
EA199800931A1 (ru) Способ получения ингибиторов фосфодиэстеразы iv
DK0777471T3 (da) Inhibering af leukotrienbiosynese med urinstofderivater
WO2002033216A3 (en) Corrosion inhibitor-drag reducer combinations
ES2185154T3 (es) Metodo de uso de inhibidores de la ciclooxigenasa-2 en el tratamiento y prevencion de la demencia.
MXPA03005556A (es) Derivados de 1,1-dioxo-1,2-benzotiacina-3-carboxamidas, metodo para prepararlos y composiciones farmaceuticas que los contienen.
DE60108873D1 (de) Nicht-antibakterielle tetrazykline als anti-pilz medikamente

Legal Events

Date Code Title Description
8364 No opposition during term of opposition