JP2005514349A5 - - Google Patents
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- JP2005514349A5 JP2005514349A5 JP2003543571A JP2003543571A JP2005514349A5 JP 2005514349 A5 JP2005514349 A5 JP 2005514349A5 JP 2003543571 A JP2003543571 A JP 2003543571A JP 2003543571 A JP2003543571 A JP 2003543571A JP 2005514349 A5 JP2005514349 A5 JP 2005514349A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- polymer
- weight
- aromatic alcohol
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 89
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 53
- 229920000642 polymer Polymers 0.000 claims description 46
- 239000003795 chemical substances by application Substances 0.000 claims description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 229920000249 biocompatible polymer Polymers 0.000 claims description 5
- 238000000034 method Methods 0.000 description 52
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical group CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 30
- 239000002904 solvent Substances 0.000 description 27
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 16
- 239000004310 lactic acid Substances 0.000 description 15
- 235000014655 lactic acid Nutrition 0.000 description 15
- 229920001577 copolymer Polymers 0.000 description 13
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical group C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 12
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 11
- -1 polyhydroxycellulose Polymers 0.000 description 10
- 125000001072 heteroaryl group Chemical group 0.000 description 9
- 125000002947 alkylene group Chemical group 0.000 description 8
- 235000019445 benzyl alcohol Nutrition 0.000 description 6
- 229960002903 benzyl benzoate Drugs 0.000 description 6
- 150000002148 esters Chemical class 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 125000003118 aryl group Chemical group 0.000 description 5
- 125000005647 linker group Chemical group 0.000 description 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 4
- 239000005711 Benzoic acid Substances 0.000 description 4
- 229920002101 Chitin Polymers 0.000 description 4
- 229920001661 Chitosan Polymers 0.000 description 4
- 229920002732 Polyanhydride Polymers 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 229920000954 Polyglycolide Polymers 0.000 description 4
- 229920001710 Polyorthoester Polymers 0.000 description 4
- 125000005907 alkyl ester group Chemical group 0.000 description 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 4
- 235000010233 benzoic acid Nutrition 0.000 description 4
- 125000005842 heteroatom Chemical group 0.000 description 4
- 229920002674 hyaluronan Polymers 0.000 description 4
- 229960003160 hyaluronic acid Drugs 0.000 description 4
- 239000001630 malic acid Substances 0.000 description 4
- 235000011090 malic acid Nutrition 0.000 description 4
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
- 229920001308 poly(aminoacid) Polymers 0.000 description 4
- 229920000747 poly(lactic acid) Polymers 0.000 description 4
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 description 4
- 229920002627 poly(phosphazenes) Polymers 0.000 description 4
- 229920000768 polyamine Polymers 0.000 description 4
- 229920001610 polycaprolactone Polymers 0.000 description 4
- 229920000515 polycarbonate Polymers 0.000 description 4
- 239000004417 polycarbonate Substances 0.000 description 4
- 239000000622 polydioxanone Substances 0.000 description 4
- 229920006149 polyester-amide block copolymer Polymers 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 229920001855 polyketal Polymers 0.000 description 4
- 229920006324 polyoxymethylene Polymers 0.000 description 4
- 229920002635 polyurethane Polymers 0.000 description 4
- 239000004814 polyurethane Substances 0.000 description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
- 150000003890 succinate salts Chemical class 0.000 description 4
- 238000013268 sustained release Methods 0.000 description 4
- 239000012730 sustained-release form Substances 0.000 description 4
- 230000009974 thixotropic effect Effects 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 102000004895 Lipoproteins Human genes 0.000 description 2
- 108090001030 Lipoproteins Proteins 0.000 description 2
- 102000011931 Nucleoproteins Human genes 0.000 description 2
- 108010061100 Nucleoproteins Proteins 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000002491 angiogenic effect Effects 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 description 2
- 230000001028 anti-proliverative effect Effects 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 239000003080 antimitotic agent Substances 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 159000000032 aromatic acids Chemical class 0.000 description 2
- 150000008365 aromatic ketones Chemical class 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000004067 bulking agent Substances 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 229940127089 cytotoxic agent Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000003527 fibrinolytic agent Substances 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000003018 immunosuppressive agent Substances 0.000 description 2
- 229940125721 immunosuppressive agent Drugs 0.000 description 2
- 239000003589 local anesthetic agent Substances 0.000 description 2
- 229960005015 local anesthetics Drugs 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 239000003607 modifier Substances 0.000 description 2
- 229940023490 ophthalmic product Drugs 0.000 description 2
- 239000002357 osmotic agent Substances 0.000 description 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 2
- 102000040430 polynucleotide Human genes 0.000 description 2
- 108091033319 polynucleotide Proteins 0.000 description 2
- 239000002157 polynucleotide Substances 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 229920001897 terpolymer Polymers 0.000 description 2
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33630701P | 2001-11-14 | 2001-11-14 | |
| US60/336,307 | 2001-11-14 | ||
| PCT/US2002/036715 WO2003041684A2 (en) | 2001-11-14 | 2002-11-14 | Injectable depot compositions and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010085269A Division JP5325152B2 (ja) | 2001-11-14 | 2010-04-01 | 注入可能なデポー組成物およびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005514349A JP2005514349A (ja) | 2005-05-19 |
| JP2005514349A5 true JP2005514349A5 (enExample) | 2006-01-26 |
| JP5078217B2 JP5078217B2 (ja) | 2012-11-21 |
Family
ID=23315497
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003543571A Expired - Fee Related JP5078217B2 (ja) | 2001-11-14 | 2002-11-14 | 注入可能なデポー組成物およびそれらの使用 |
| JP2010085269A Expired - Fee Related JP5325152B2 (ja) | 2001-11-14 | 2010-04-01 | 注入可能なデポー組成物およびそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010085269A Expired - Fee Related JP5325152B2 (ja) | 2001-11-14 | 2010-04-01 | 注入可能なデポー組成物およびそれらの使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20030170289A1 (enExample) |
| EP (1) | EP1446100B1 (enExample) |
| JP (2) | JP5078217B2 (enExample) |
| KR (1) | KR20040058100A (enExample) |
| CN (2) | CN1972665A (enExample) |
| AT (1) | ATE507816T1 (enExample) |
| AU (1) | AU2009201086A1 (enExample) |
| BR (1) | BR0206984A (enExample) |
| CA (1) | CA2466632C (enExample) |
| DE (1) | DE60239952D1 (enExample) |
| IL (1) | IL162000A0 (enExample) |
| MX (1) | MXPA04004663A (enExample) |
| NO (1) | NO20033177L (enExample) |
| NZ (1) | NZ533435A (enExample) |
| WO (1) | WO2003041684A2 (enExample) |
| ZA (2) | ZA200306284B (enExample) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4724354B2 (ja) | 2001-02-23 | 2011-07-13 | ジェネンテック， インコーポレイテッド | 注射用の崩壊性ポリマー |
| NZ533436A (en) | 2001-11-14 | 2007-10-26 | Alza Corp | Catheter injectable depot compositons and uses thereof |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| AR039729A1 (es) * | 2002-06-25 | 2005-03-09 | Alza Corp | Formulaciones de deposito de corta duracion |
| IL166418A0 (en) * | 2002-07-31 | 2006-01-15 | Alza Corp | Injectable depot compositions and uses thereof |
| US8501215B2 (en) | 2002-07-31 | 2013-08-06 | Guohua Chen | Injectable multimodal polymer depot compositions and uses thereof |
| BR0315304A (pt) | 2002-11-06 | 2005-08-16 | Alza Corp | Formulações com depósito para liberação controlada |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| US20060177430A1 (en) * | 2002-12-20 | 2006-08-10 | Chakshu Research Inc | Treatment of ocular disorders with ophthalmic formulations containing methylsulfonylmethane as a transport enhancer |
| US20060166879A1 (en) * | 2002-12-20 | 2006-07-27 | Chakshu Research Inc | Treatment of conditions associated with the presence of macromolecular aggregates, particularly ophthalmic disorders |
| US20060172972A1 (en) * | 2002-12-20 | 2006-08-03 | Chakshu Research Inc | Formulation and method for administration of ophthalmologically active agents |
| WO2004057959A2 (en) | 2002-12-20 | 2004-07-15 | Generipharm, Inc. | Intracutaneous injection |
| NZ540885A (en) * | 2002-12-20 | 2009-02-28 | Chakshu Res Inc | Ophthalmic formulation for the prevention and treatment of ocular conditions |
| FR2850282B1 (fr) | 2003-01-27 | 2007-04-06 | Jerome Asius | Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation |
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| US11078262B2 (en) | 2007-04-30 | 2021-08-03 | Allergan, Inc. | High viscosity macromolecular compositions for treating ocular conditions |
| JP5599705B2 (ja) | 2007-05-18 | 2014-10-01 | デュレクト コーポレーション | 改良されたデポー製剤 |
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| US9272044B2 (en) | 2010-06-08 | 2016-03-01 | Indivior Uk Limited | Injectable flowable composition buprenorphine |
| US20120046225A1 (en) | 2010-07-19 | 2012-02-23 | The Regents Of The University Of Colorado, A Body Corporate | Stable glucagon formulations for the treatment of hypoglycemia |
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| CN105853348B (zh) | 2011-03-10 | 2019-08-30 | Xeris药物公司 | 肠胃外注射用稳定溶液 |
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| US9125805B2 (en) | 2012-06-27 | 2015-09-08 | Xeris Pharmaceuticals, Inc. | Stable formulations for parenteral injection of small molecule drugs |
| US9018162B2 (en) | 2013-02-06 | 2015-04-28 | Xeris Pharmaceuticals, Inc. | Methods for rapidly treating severe hypoglycemia |
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| CN109602692B (zh) | 2013-03-11 | 2022-11-04 | 度瑞公司 | 包含高粘度液体载体的可注射控制释放组合物 |
| CN105764491A (zh) | 2013-12-09 | 2016-07-13 | 度瑞公司 | 药物活性剂复合物、聚合物复合物，以及包括其的组合物和方法 |
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| AU2015341490C1 (en) | 2014-11-07 | 2021-03-11 | Indivior Uk Limited | Buprenorphine dosing regimens |
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| US9649364B2 (en) | 2015-09-25 | 2017-05-16 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic formulations in aprotic polar solvents |
| US11590205B2 (en) | 2015-09-25 | 2023-02-28 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents |
| MA53353A (fr) | 2016-05-16 | 2021-06-09 | Intarcia Therapeutics Inc | Polypeptides sélectifs pour le récepteur du glucagon et méthodes pour leur utilisation |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| KR20190104039A (ko) | 2017-01-03 | 2019-09-05 | 인타르시아 세라퓨틱스 인코포레이티드 | Glp-1 수용체 효능제의 연속적인 투여 및 약물의 동시-투여를 포함하는 방법 |
| US11752099B2 (en) * | 2017-03-27 | 2023-09-12 | W. L. Gore & Associates, Inc. | Injectable and biodegradable polymer formulations for controlled release of bioactive agents |
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| KR20220140711A (ko) | 2020-01-13 | 2022-10-18 | 듀렉트 코퍼레이션 | 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법 |
| KR20230145053A (ko) | 2021-01-12 | 2023-10-17 | 듀렉트 코퍼레이션 | 지속 방출 약물 전달 시스템 및 관련 방법 |
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-
2002
- 2002-11-14 KR KR10-2003-7009391A patent/KR20040058100A/ko not_active Ceased
- 2002-11-14 EP EP02793941A patent/EP1446100B1/en not_active Expired - Lifetime
- 2002-11-14 IL IL16200002A patent/IL162000A0/xx unknown
- 2002-11-14 WO PCT/US2002/036715 patent/WO2003041684A2/en not_active Ceased
- 2002-11-14 AT AT02793941T patent/ATE507816T1/de not_active IP Right Cessation
- 2002-11-14 BR BR0206984-9A patent/BR0206984A/pt not_active IP Right Cessation
- 2002-11-14 CA CA2466632A patent/CA2466632C/en not_active Expired - Fee Related
- 2002-11-14 CN CNA028267265A patent/CN1972665A/zh active Pending
- 2002-11-14 MX MXPA04004663A patent/MXPA04004663A/es unknown
- 2002-11-14 CN CNA028270282A patent/CN1703197A/zh active Pending
- 2002-11-14 NZ NZ533435A patent/NZ533435A/en unknown
- 2002-11-14 JP JP2003543571A patent/JP5078217B2/ja not_active Expired - Fee Related
- 2002-11-14 US US10/295,527 patent/US20030170289A1/en not_active Abandoned
- 2002-11-14 DE DE60239952T patent/DE60239952D1/de not_active Expired - Lifetime
-
2003
- 2003-07-11 NO NO20033177A patent/NO20033177L/no not_active Application Discontinuation
- 2003-08-13 ZA ZA200306284A patent/ZA200306284B/en unknown
- 2003-08-13 ZA ZA200306286A patent/ZA200306286B/en unknown
-
2009
- 2009-03-18 AU AU2009201086A patent/AU2009201086A1/en not_active Abandoned
-
2010
- 2010-04-01 JP JP2010085269A patent/JP5325152B2/ja not_active Expired - Fee Related
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