JP2005514030A5 - - Google Patents
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- Publication number
- JP2005514030A5 JP2005514030A5 JP2003558131A JP2003558131A JP2005514030A5 JP 2005514030 A5 JP2005514030 A5 JP 2005514030A5 JP 2003558131 A JP2003558131 A JP 2003558131A JP 2003558131 A JP2003558131 A JP 2003558131A JP 2005514030 A5 JP2005514030 A5 JP 2005514030A5
- Authority
- JP
- Japan
- Prior art keywords
- binding
- binding protein
- linker
- polypeptide
- polypeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34210301P | 2001-12-26 | 2001-12-26 | |
| PCT/US2002/038985 WO2003057829A2 (en) | 2001-12-26 | 2002-12-26 | Methods of generating multispecific, multivalent agents from vh and vl domains |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005514030A JP2005514030A (ja) | 2005-05-19 |
| JP2005514030A5 true JP2005514030A5 (https=) | 2006-02-23 |
Family
ID=23340336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003558131A Withdrawn JP2005514030A (ja) | 2001-12-26 | 2002-12-26 | Ｖｈおよびｖｌドメインから多重特異性多価薬剤を製造する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20030162709A1 (https=) |
| EP (1) | EP1468097A4 (https=) |
| JP (1) | JP2005514030A (https=) |
| KR (1) | KR20040091616A (https=) |
| AU (1) | AU2002364531A1 (https=) |
| BR (1) | BR0215403A (https=) |
| CA (1) | CA2471868A1 (https=) |
| IL (1) | IL162732A0 (https=) |
| MX (1) | MXPA04006327A (https=) |
| PL (1) | PL372144A1 (https=) |
| RU (1) | RU2004122702A (https=) |
| WO (1) | WO2003057829A2 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6962702B2 (en) * | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| CA2463616C (en) * | 2001-10-15 | 2011-07-12 | Immunomedics, Inc. | Affinity enhancement agents |
| US8435529B2 (en) | 2002-06-14 | 2013-05-07 | Immunomedics, Inc. | Combining radioimmunotherapy and antibody-drug conjugates for improved cancer therapy |
| US9770517B2 (en) | 2002-03-01 | 2017-09-26 | Immunomedics, Inc. | Anti-Trop-2 antibody-drug conjugates and uses thereof |
| CA2478047C (en) | 2002-03-01 | 2014-01-21 | Immunomedics, Inc. | Rs7 antibodies |
| US20040022726A1 (en) * | 2002-06-03 | 2004-02-05 | Goldenberg David M. | Methods and compositions for intravesical therapy of bladder cancer |
| MXPA05008222A (es) * | 2003-01-31 | 2005-10-05 | Immunomedics Inc | Metodos y composiciones para administrar agentes terapeuticos y de diagnostico. |
| WO2004094613A2 (en) * | 2003-04-22 | 2004-11-04 | Ibc Pharmaceuticals | Polyvalent protein complex |
| CN1326881C (zh) * | 2003-09-29 | 2007-07-18 | 中国人民解放军军事医学科学院基础医学研究所 | 一种三价双特异性抗体，其制备方法及用途 |
| US20060057062A1 (en) * | 2004-09-10 | 2006-03-16 | Trotter Dinko G | Compositions and methods useful in pretargeted imaging |
| ES2665422T3 (es) | 2005-03-03 | 2018-04-25 | Immunomedics Inc. | Anticuerpos L243 humanizados |
| RU2423381C2 (ru) | 2005-07-25 | 2011-07-10 | Трабьон Фармасьютикалз, Инк. | Снижение количества в-клеток с использованием cd37-специфических и cd20-специфических связывающих молекул |
| EP1928507B1 (en) * | 2005-09-09 | 2015-11-11 | Georgia State University Research Foundation, Inc. | Targeted contrast agents and methods for targeting contrast agents |
| JP5377965B2 (ja) | 2005-09-09 | 2013-12-25 | ジョージア ステート ユニバーシティ リサーチ ファウンデーション、インコーポレイテッド | 標的化された造影剤および造影剤を標的化するための方法 |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| CA2628221A1 (en) | 2005-10-31 | 2007-05-10 | Oncomed Pharmaceuticals, Inc. | Anti-frizzled receptor antibodies for treating cancer |
| NZ573646A (en) | 2006-06-12 | 2012-04-27 | Wyeth Llc | Single-chain multivalent binding proteins with effector function |
| US8481272B2 (en) | 2006-08-04 | 2013-07-09 | Georgia State University Research Foundation, Inc. | Enzyme sensors, methods for preparing and using such sensors, and methods of detecting protease activity |
| EP2097507B1 (en) | 2006-12-14 | 2015-05-06 | Georgia State University Research Foundation, Inc. | Analyte sensors and use thereof for detecting analyte activity |
| WO2009146099A2 (en) | 2008-04-02 | 2009-12-03 | Georgia State University Research Foundation, Inc. | Contrast agents, methods for preparing contrast agents, and methods of imaging |
| RU2531754C2 (ru) | 2008-04-11 | 2014-10-27 | ЭМЕРДЖЕНТ ПРОДАКТ ДИВЕЛОПМЕНТ СИЭТЛ,ЭлЭлСи,US | Связывающееся с cd37 иммунотерапевтическое средство и его комбинация с бифункциональным химиотерапевтическим средством |
| SG190568A1 (en) | 2008-09-26 | 2013-06-28 | Oncomed Pharm Inc | Frizzled-binding agents and uses thereof |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| CA2794674A1 (en) | 2010-04-01 | 2011-10-06 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| US9956304B2 (en) | 2012-06-05 | 2018-05-01 | Georgia State University Research Foundation, Inc. | Contrast agents, methods for preparing contrast agents, and methods of imaging |
| US9382329B2 (en) | 2012-08-14 | 2016-07-05 | Ibc Pharmaceuticals, Inc. | Disease therapy by inducing immune response to Trop-2 expressing cells |
| AU2013334790A1 (en) | 2012-10-23 | 2015-04-30 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using Wnt pathway-binding agents |
| AU2014212081A1 (en) | 2013-02-04 | 2015-08-13 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a Wnt pathway inhibitor |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| EP2930188A1 (en) * | 2014-04-13 | 2015-10-14 | Affimed Therapeutics AG | Trifunctional antigen-binding molecule |
| AU2016252771B2 (en) | 2015-04-22 | 2021-12-16 | Immunomedics, Inc. | Isolation, detection, diagnosis and/or characterization of circulating Trop-2-positive cancer cells |
| WO2017053469A2 (en) | 2015-09-21 | 2017-03-30 | Aptevo Research And Development Llc | Cd3 binding polypeptides |
| EP3156417A1 (en) | 2015-10-13 | 2017-04-19 | Affimed GmbH | Multivalent fv antibodies |
| US11571476B2 (en) | 2017-12-11 | 2023-02-07 | Taipei Medical University | Anti-tumor/anti-tumor associated fibroblast/anti-hapten trispecific antibodies and use thereof |
| TWI870708B (zh) * | 2017-12-12 | 2025-01-21 | 臺北醫學大學 | 多特異性抗體及其用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3382317D1 (de) * | 1982-03-15 | 1991-07-25 | Schering Corp | Hybride dns, damit hergestellte bindungszusammensetzung und verfahren dafuer. |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US6121424A (en) * | 1991-11-25 | 2000-09-19 | Enzon, Inc. | Multivalent antigen-binding proteins |
| FR2604092B1 (fr) * | 1986-09-19 | 1990-04-13 | Immunotech Sa | Immunoreactifs destines a cibler les cellules animales pour leur visualisation ou leur destruction in vivo |
| US5132405A (en) * | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6096289A (en) * | 1992-05-06 | 2000-08-01 | Immunomedics, Inc. | Intraoperative, intravascular, and endoscopic tumor and lesion detection, biopsy and therapy |
| US5844094A (en) * | 1992-09-25 | 1998-12-01 | Commonwealth Scientific And Industrial Research Organization | Target binding polypeptide |
| ES2156149T3 (es) * | 1992-12-04 | 2001-06-16 | Medical Res Council | Proteinas de union multivalente y multiespecificas, su fabricacion y su uso. |
| BR9606706A (pt) * | 1995-10-16 | 1999-04-06 | Unilever Nv | Análogo de fragmento de anticorpo biespecífico ou bivalente uso processo para produzir o mesmo |
| ATE267610T1 (de) * | 1996-03-20 | 2004-06-15 | Immunomedics Inc | Glykosylierte igg antikörper |
| WO1997038102A1 (en) * | 1996-04-04 | 1997-10-16 | Unilever Plc | Multivalent and multispecific antigen-binding protein |
| US6183744B1 (en) * | 1997-03-24 | 2001-02-06 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| US7074405B1 (en) * | 1998-06-22 | 2006-07-11 | Immunomedics, Inc. | Use of bi-specific antibodies for pre-targeting diagnosis and therapy |
-
2002
- 2002-12-26 WO PCT/US2002/038985 patent/WO2003057829A2/en not_active Ceased
- 2002-12-26 US US10/328,190 patent/US20030162709A1/en not_active Abandoned
- 2002-12-26 JP JP2003558131A patent/JP2005514030A/ja not_active Withdrawn
- 2002-12-26 AU AU2002364531A patent/AU2002364531A1/en not_active Abandoned
- 2002-12-26 CA CA002471868A patent/CA2471868A1/en not_active Abandoned
- 2002-12-26 BR BR0215403-0A patent/BR0215403A/pt not_active IP Right Cessation
- 2002-12-26 RU RU2004122702/13A patent/RU2004122702A/ru not_active Application Discontinuation
- 2002-12-26 IL IL16273202A patent/IL162732A0/xx unknown
- 2002-12-26 PL PL02372144A patent/PL372144A1/xx not_active Application Discontinuation
- 2002-12-26 EP EP02799908A patent/EP1468097A4/en not_active Withdrawn
- 2002-12-26 KR KR10-2004-7010211A patent/KR20040091616A/ko not_active Withdrawn
- 2002-12-26 MX MXPA04006327A patent/MXPA04006327A/es not_active Application Discontinuation
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