JP2005514030A5 - - Google Patents
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- Publication number
- JP2005514030A5 JP2005514030A5 JP2003558131A JP2003558131A JP2005514030A5 JP 2005514030 A5 JP2005514030 A5 JP 2005514030A5 JP 2003558131 A JP2003558131 A JP 2003558131A JP 2003558131 A JP2003558131 A JP 2003558131A JP 2005514030 A5 JP2005514030 A5 JP 2005514030A5
- Authority
- JP
- Japan
- Prior art keywords
- binding
- binding protein
- linker
- polypeptide
- polypeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34210301P | 2001-12-26 | 2001-12-26 | |
| PCT/US2002/038985 WO2003057829A2 (en) | 2001-12-26 | 2002-12-26 | Methods of generating multispecific, multivalent agents from vh and vl domains |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005514030A JP2005514030A (ja) | 2005-05-19 |
| JP2005514030A5 true JP2005514030A5 (https=) | 2006-02-23 |
Family
ID=23340336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003558131A Withdrawn JP2005514030A (ja) | 2001-12-26 | 2002-12-26 | Ｖｈおよびｖｌドメインから多重特異性多価薬剤を製造する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20030162709A1 (https=) |
| EP (1) | EP1468097A4 (https=) |
| JP (1) | JP2005514030A (https=) |
| KR (1) | KR20040091616A (https=) |
| AU (1) | AU2002364531A1 (https=) |
| BR (1) | BR0215403A (https=) |
| CA (1) | CA2471868A1 (https=) |
| IL (1) | IL162732A0 (https=) |
| MX (1) | MXPA04006327A (https=) |
| PL (1) | PL372144A1 (https=) |
| RU (1) | RU2004122702A (https=) |
| WO (1) | WO2003057829A2 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6962702B2 (en) * | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| KR101027889B1 (ko) * | 2001-10-15 | 2011-04-07 | 아이비씨 파마슈티컬스, 인코퍼레이티드 | 친화력 증강제 |
| US8435529B2 (en) | 2002-06-14 | 2013-05-07 | Immunomedics, Inc. | Combining radioimmunotherapy and antibody-drug conjugates for improved cancer therapy |
| US9770517B2 (en) | 2002-03-01 | 2017-09-26 | Immunomedics, Inc. | Anti-Trop-2 antibody-drug conjugates and uses thereof |
| WO2003074566A2 (en) * | 2002-03-01 | 2003-09-12 | Immunomedics, Inc. | Rs7 antibodies |
| US20040022726A1 (en) * | 2002-06-03 | 2004-02-05 | Goldenberg David M. | Methods and compositions for intravesical therapy of bladder cancer |
| CN1767860A (zh) * | 2003-01-31 | 2006-05-03 | 免疫医疗公司 | 施用治疗和诊断剂的方法和组合物 |
| US20050003403A1 (en) * | 2003-04-22 | 2005-01-06 | Rossi Edmund A. | Polyvalent protein complex |
| CN1326881C (zh) * | 2003-09-29 | 2007-07-18 | 中国人民解放军军事医学科学院基础医学研究所 | 一种三价双特异性抗体，其制备方法及用途 |
| US20060057062A1 (en) * | 2004-09-10 | 2006-03-16 | Trotter Dinko G | Compositions and methods useful in pretargeted imaging |
| ES2665422T3 (es) | 2005-03-03 | 2018-04-25 | Immunomedics Inc. | Anticuerpos L243 humanizados |
| US9339559B2 (en) | 2005-09-09 | 2016-05-17 | Georgia State University Research Foundation, Inc. | Targeted contrast agents and methods for targeting contrast agents |
| HRP20140338T1 (hr) | 2005-07-25 | 2014-06-20 | Emergent Product Development Seattle, Llc | Smanjenje broja b-stanica upotrebom molekula koje se specifiäśno vežu na cd37 i cd20 |
| CA2621763C (en) * | 2005-09-09 | 2021-04-06 | Georgia State University Research Foundation, Inc. | Targeted contrast agents and methods for targeting contrast agents |
| DK2500360T3 (en) | 2005-10-31 | 2015-10-26 | Oncomed Pharm Inc | Compositions and methods for the diagnosis and treatment of cancer |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| WO2007146968A2 (en) | 2006-06-12 | 2007-12-21 | Trubion Pharmaceuticals, Inc. | Single-chain multivalent binding proteins with effector function |
| WO2008019123A2 (en) | 2006-08-04 | 2008-02-14 | Georgia State University Research Foundation, Inc. | Enzyme sensors, methods for preparing and using such sensors, and methods of detecting protease activity |
| EP2097507B1 (en) | 2006-12-14 | 2015-05-06 | Georgia State University Research Foundation, Inc. | Analyte sensors and use thereof for detecting analyte activity |
| EP2257316B1 (en) | 2008-04-02 | 2018-11-07 | Georgia State University Research Foundation, Inc. | Contrast agents, methods for preparing contrast agents, and methods of imaging |
| EP2365003A1 (en) | 2008-04-11 | 2011-09-14 | Emergent Product Development Seattle, LLC | CD37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof |
| CN103002911B (zh) | 2008-09-26 | 2015-08-26 | 昂考梅德药品有限公司 | 卷曲蛋白结合药剂及其应用 |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| CA2794674A1 (en) | 2010-04-01 | 2011-10-06 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| WO2013184786A2 (en) * | 2012-06-05 | 2013-12-12 | Georgia State University Research Foundation, Inc. | Contrast agents, methods for preparing contrast agents, and methods of imaging |
| US9382329B2 (en) | 2012-08-14 | 2016-07-05 | Ibc Pharmaceuticals, Inc. | Disease therapy by inducing immune response to Trop-2 expressing cells |
| WO2014066328A1 (en) | 2012-10-23 | 2014-05-01 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using wnt pathway-binding agents |
| JP2016510411A (ja) | 2013-02-04 | 2016-04-07 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Ｗｎｔ経路インヒビターによる処置の方法およびモニタリング |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| EP2930188A1 (en) * | 2014-04-13 | 2015-10-14 | Affimed Therapeutics AG | Trifunctional antigen-binding molecule |
| WO2016172427A1 (en) | 2015-04-22 | 2016-10-27 | Immunomedics, Inc. | Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells |
| EP3352760B1 (en) | 2015-09-21 | 2026-03-11 | Aptevo Research and Development LLC | Cd3 binding polypeptides |
| EP3156417A1 (en) * | 2015-10-13 | 2017-04-19 | Affimed GmbH | Multivalent fv antibodies |
| US11571476B2 (en) | 2017-12-11 | 2023-02-07 | Taipei Medical University | Anti-tumor/anti-tumor associated fibroblast/anti-hapten trispecific antibodies and use thereof |
| TWI870708B (zh) * | 2017-12-12 | 2025-01-21 | 臺北醫學大學 | 多特異性抗體及其用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3382317D1 (de) * | 1982-03-15 | 1991-07-25 | Schering Corp | Hybride dns, damit hergestellte bindungszusammensetzung und verfahren dafuer. |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US6121424A (en) * | 1991-11-25 | 2000-09-19 | Enzon, Inc. | Multivalent antigen-binding proteins |
| FR2604092B1 (fr) * | 1986-09-19 | 1990-04-13 | Immunotech Sa | Immunoreactifs destines a cibler les cellules animales pour leur visualisation ou leur destruction in vivo |
| US5132405A (en) * | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6096289A (en) * | 1992-05-06 | 2000-08-01 | Immunomedics, Inc. | Intraoperative, intravascular, and endoscopic tumor and lesion detection, biopsy and therapy |
| SG41929A1 (en) * | 1992-09-25 | 1997-08-15 | Commw Scient Ind Res Org | Target binding polypeptide |
| ATE199392T1 (de) * | 1992-12-04 | 2001-03-15 | Medical Res Council | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| US5989830A (en) * | 1995-10-16 | 1999-11-23 | Unilever Patent Holdings Bv | Bifunctional or bivalent antibody fragment analogue |
| EP0888125B1 (en) * | 1996-03-20 | 2004-05-26 | Immunomedics, Inc. | GLYCOSYLATED IgG ANTIBODIES |
| ES2225961T3 (es) * | 1996-04-04 | 2005-03-16 | Unilever N.V. | Proteina de union a antigeno multivalente y multiespecifica. |
| US6183744B1 (en) * | 1997-03-24 | 2001-02-06 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| WO1999066951A2 (en) * | 1998-06-22 | 1999-12-29 | Immunomedics, Inc. | Use of bi-specific antibodies for pre-targeting diagnosis and therapy |
-
2002
- 2002-12-26 EP EP02799908A patent/EP1468097A4/en not_active Withdrawn
- 2002-12-26 BR BR0215403-0A patent/BR0215403A/pt not_active IP Right Cessation
- 2002-12-26 JP JP2003558131A patent/JP2005514030A/ja not_active Withdrawn
- 2002-12-26 KR KR10-2004-7010211A patent/KR20040091616A/ko not_active Withdrawn
- 2002-12-26 US US10/328,190 patent/US20030162709A1/en not_active Abandoned
- 2002-12-26 PL PL02372144A patent/PL372144A1/xx not_active Application Discontinuation
- 2002-12-26 CA CA002471868A patent/CA2471868A1/en not_active Abandoned
- 2002-12-26 IL IL16273202A patent/IL162732A0/xx unknown
- 2002-12-26 WO PCT/US2002/038985 patent/WO2003057829A2/en not_active Ceased
- 2002-12-26 MX MXPA04006327A patent/MXPA04006327A/es not_active Application Discontinuation
- 2002-12-26 AU AU2002364531A patent/AU2002364531A1/en not_active Abandoned
- 2002-12-26 RU RU2004122702/13A patent/RU2004122702A/ru not_active Application Discontinuation
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