JP2002544237A5 - - Google Patents
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- Publication number
- JP2002544237A5 JP2002544237A5 JP2000617917A JP2000617917A JP2002544237A5 JP 2002544237 A5 JP2002544237 A5 JP 2002544237A5 JP 2000617917 A JP2000617917 A JP 2000617917A JP 2000617917 A JP2000617917 A JP 2000617917A JP 2002544237 A5 JP2002544237 A5 JP 2002544237A5
- Authority
- JP
- Japan
- Prior art keywords
- spa
- variant
- polypeptide
- fab
- amino acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010088160 Staphylococcal Protein A Proteins 0.000 description 72
- 229920001184 polypeptide Polymers 0.000 description 32
- 102000004196 processed proteins & peptides Human genes 0.000 description 32
- 108090000765 processed proteins & peptides Proteins 0.000 description 32
- 150000001413 amino acids Chemical class 0.000 description 20
- 239000008194 pharmaceutical composition Substances 0.000 description 15
- 125000003275 alpha amino acid group Chemical group 0.000 description 8
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 210000004698 lymphocyte Anatomy 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 241000724791 Filamentous phage Species 0.000 description 4
- 239000000203 mixture Substances 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 208000032839 leukemia Diseases 0.000 description 2
- 238000001243 protein synthesis Methods 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 206010043778 thyroiditis Diseases 0.000 description 2
- 230000014616 translation Effects 0.000 description 2
- 241001515965 unidentified phage Species 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 210000000207 lymphocyte subset Anatomy 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13438699P | 1999-05-15 | 1999-05-15 | |
| US60/134,386 | 1999-05-15 | ||
| PCT/US2000/013402 WO2000069457A1 (en) | 1999-05-15 | 2000-05-15 | Protein a based binding domains with desirable activities |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002544237A JP2002544237A (ja) | 2002-12-24 |
| JP2002544237A5 true JP2002544237A5 (https=) | 2007-07-12 |
Family
ID=22463140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000617917A Pending JP2002544237A (ja) | 1999-05-15 | 2000-05-15 | 望ましい活性を有するプロテインａに基づく結合ドメイン |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060205016A1 (https=) |
| EP (2) | EP1181052A4 (https=) |
| JP (1) | JP2002544237A (https=) |
| AU (1) | AU777005B2 (https=) |
| CA (1) | CA2374013A1 (https=) |
| WO (1) | WO2000069457A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7425331B2 (en) | 2002-04-10 | 2008-09-16 | Protalex, Inc. | Protein A methods of use |
| US7211258B2 (en) | 2002-04-10 | 2007-05-01 | Protalex, Inc. | Protein A compositions and methods of use |
| EP2066419B1 (en) | 2006-09-29 | 2015-11-11 | GE Healthcare Bio-Sciences AB | Chromatography ligand comprising domain c from staphyloccocus aureus protein a for antibody isolation |
| WO2008067547A2 (en) * | 2006-11-30 | 2008-06-05 | Research Development Foundation | Improved immunoglobulin libraries |
| EP2099932A4 (en) | 2006-12-06 | 2009-11-18 | Repligen Corp | NUCLEIC ACIDS ENCODING THE RECOMBINANT PROTEIN A |
| US8592555B2 (en) * | 2008-08-11 | 2013-11-26 | Emd Millipore Corporation | Immunoglobulin-binding proteins with improved specificity |
| CN102165312B (zh) * | 2008-09-25 | 2015-04-22 | Jsr株式会社 | 亲合层析用填充剂 |
| SG195555A1 (en) * | 2008-12-24 | 2013-12-30 | Emd Millipore Corp | Caustic stable chromatography ligands |
| WO2010110288A1 (ja) * | 2009-03-24 | 2010-09-30 | 株式会社カネカ | 免疫グロブリンに親和性を有するタンパク質および免疫グロブリン結合性アフィニティーリガンド |
| ES2784957T3 (es) * | 2009-04-03 | 2020-10-02 | Univ Chicago | Composiciones y métodos relacionados con variantes de la proteína A (SPA) |
| JP6002128B2 (ja) | 2010-07-02 | 2016-10-05 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | プロテインＡ（ＳｐＡ）変種に関連する組成物および方法 |
| SG186552A1 (en) | 2011-06-08 | 2013-01-30 | Emd Millipore Corp | Chromatography matrices including novel staphylococcus aureus protein a based ligands |
| BR112014003315A2 (pt) * | 2011-08-15 | 2017-03-01 | Univ Chicago | composições e métodos relacionados a anticorpos para a proteína a estafilocócica |
| US20160074497A1 (en) * | 2013-05-03 | 2016-03-17 | The University Of Chicago | Staphylococcus live cell vaccines |
| GB201506868D0 (en) * | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method for protein purification |
| MX2021013833A (es) | 2019-05-14 | 2022-03-17 | Univ Chicago | Metodos y composiciones que comprenden variantes de la proteina a de estafilococos (spa). |
| WO2021051136A1 (en) | 2019-09-13 | 2021-03-18 | The University Of Chicago | Methods and compositions for treating staphylococcal infections |
| WO2025036605A1 (en) * | 2023-08-14 | 2025-02-20 | Cytiva Bioprocess R&D Ab | Vh3 binding separation matrix and methods for using the same |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8300693L (sv) * | 1983-02-09 | 1984-08-10 | Sven Lofdahl | Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US4879378A (en) | 1989-03-30 | 1989-11-07 | Union Carbide Chemicals And Plastics Company Inc. | Polysiloxanes with pendant sterically hindered phenol moiety connected to the silicon atom via a carbonylyoxy-containing link |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5198531A (en) | 1991-06-14 | 1993-03-30 | Research Diagnostic Antibodies | Polymeric resin for peptide synthesis |
| US5240680A (en) | 1991-12-19 | 1993-08-31 | Chiron Corporation | Automated apparatus for use in peptide synthesis |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5891438A (en) * | 1992-10-30 | 1999-04-06 | The Regents Of The University Of California | Method for stimulating production of variable region gene family restricted antibodies through B-cell superantigen vaccination |
| SE9400088D0 (sv) * | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| CA2245835A1 (en) | 1995-06-14 | 1997-01-03 | The Regents Of The University Of California | Novel high affinity human antibodies to tumor antigens |
| US6031071A (en) | 1996-01-24 | 2000-02-29 | Biophage, Inc. | Methods of generating novel peptides |
| AU2429397A (en) * | 1996-03-29 | 1997-10-22 | David S. Terman | Polymerized staphylococcal protein a for treatment of diseases |
| US6013763A (en) * | 1996-06-04 | 2000-01-11 | Genentech, Inc. | Peptide variants of protein A |
-
2000
- 2000-05-15 JP JP2000617917A patent/JP2002544237A/ja active Pending
- 2000-05-15 EP EP00932472A patent/EP1181052A4/en not_active Withdrawn
- 2000-05-15 WO PCT/US2000/013402 patent/WO2000069457A1/en not_active Ceased
- 2000-05-15 EP EP08015536A patent/EP2017343A3/en not_active Withdrawn
- 2000-05-15 AU AU50191/00A patent/AU777005B2/en not_active Ceased
- 2000-05-15 CA CA002374013A patent/CA2374013A1/en not_active Abandoned
-
2006
- 2006-02-16 US US11/357,443 patent/US20060205016A1/en not_active Abandoned
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