JP2005512595A5 - - Google Patents
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- Publication number
- JP2005512595A5 JP2005512595A5 JP2003556516A JP2003556516A JP2005512595A5 JP 2005512595 A5 JP2005512595 A5 JP 2005512595A5 JP 2003556516 A JP2003556516 A JP 2003556516A JP 2003556516 A JP2003556516 A JP 2003556516A JP 2005512595 A5 JP2005512595 A5 JP 2005512595A5
- Authority
- JP
- Japan
- Prior art keywords
- isolated mutant
- product
- bacillus
- eubacterium
- mutant eubacterium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000186394 Eubacterium Species 0.000 claims 37
- 241000894006 Bacteria Species 0.000 claims 16
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 238000006467 substitution reaction Methods 0.000 claims 10
- 102000004190 Enzymes Human genes 0.000 claims 8
- 108090000790 Enzymes Proteins 0.000 claims 8
- 229940088598 enzyme Drugs 0.000 claims 8
- 150000001413 amino acids Chemical class 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 241000194108 Bacillus licheniformis Species 0.000 claims 3
- 244000063299 Bacillus subtilis Species 0.000 claims 3
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 3
- 108010064250 RNA polymerase beta subunit Proteins 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000004382 Amylase Substances 0.000 claims 2
- 108010065511 Amylases Proteins 0.000 claims 2
- 102000013142 Amylases Human genes 0.000 claims 2
- 241000193830 Bacillus <bacterium> Species 0.000 claims 2
- 241000193744 Bacillus amyloliquefaciens Species 0.000 claims 2
- 241001328122 Bacillus clausii Species 0.000 claims 2
- 241000193422 Bacillus lentus Species 0.000 claims 2
- 102100032487 Beta-mannosidase Human genes 0.000 claims 2
- 241000193385 Geobacillus stearothermophilus Species 0.000 claims 2
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 claims 2
- 102000004195 Isomerases Human genes 0.000 claims 2
- 108090000769 Isomerases Proteins 0.000 claims 2
- 102000003960 Ligases Human genes 0.000 claims 2
- 108090000364 Ligases Proteins 0.000 claims 2
- 102000004317 Lyases Human genes 0.000 claims 2
- 108090000856 Lyases Proteins 0.000 claims 2
- 102000004316 Oxidoreductases Human genes 0.000 claims 2
- 108090000854 Oxidoreductases Proteins 0.000 claims 2
- 108700043532 RpoB Proteins 0.000 claims 2
- 102000004357 Transferases Human genes 0.000 claims 2
- 108090000992 Transferases Proteins 0.000 claims 2
- 235000019418 amylase Nutrition 0.000 claims 2
- 108010055059 beta-Mannosidase Proteins 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 235000014633 carbohydrates Nutrition 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- 108010011619 6-Phytase Proteins 0.000 claims 1
- 102000004400 Aminopeptidases Human genes 0.000 claims 1
- 108090000915 Aminopeptidases Proteins 0.000 claims 1
- 102000044503 Antimicrobial Peptides Human genes 0.000 claims 1
- 108700042778 Antimicrobial Peptides Proteins 0.000 claims 1
- 241000193752 Bacillus circulans Species 0.000 claims 1
- 241000193749 Bacillus coagulans Species 0.000 claims 1
- 241000194107 Bacillus megaterium Species 0.000 claims 1
- 241000194110 Bacillus sp. (in: Bacteria) Species 0.000 claims 1
- 241000193388 Bacillus thuringiensis Species 0.000 claims 1
- 241000193764 Brevibacillus brevis Species 0.000 claims 1
- 108010006303 Carboxypeptidases Proteins 0.000 claims 1
- 102000005367 Carboxypeptidases Human genes 0.000 claims 1
- 102000016938 Catalase Human genes 0.000 claims 1
- 108010053835 Catalase Proteins 0.000 claims 1
- 108010031396 Catechol oxidase Proteins 0.000 claims 1
- 102000030523 Catechol oxidase Human genes 0.000 claims 1
- 108010059892 Cellulase Proteins 0.000 claims 1
- 108010022172 Chitinases Proteins 0.000 claims 1
- 102000012286 Chitinases Human genes 0.000 claims 1
- 241000833010 Claudius Species 0.000 claims 1
- 241001112695 Clostridiales Species 0.000 claims 1
- 108010025880 Cyclomaltodextrin glucanotransferase Proteins 0.000 claims 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims 1
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims 1
- 108010053770 Deoxyribonucleases Proteins 0.000 claims 1
- 102000016911 Deoxyribonucleases Human genes 0.000 claims 1
- 101710121765 Endo-1,4-beta-xylanase Proteins 0.000 claims 1
- 108090000371 Esterases Proteins 0.000 claims 1
- 108010093031 Galactosidases Proteins 0.000 claims 1
- 102000002464 Galactosidases Human genes 0.000 claims 1
- 102100022624 Glucoamylase Human genes 0.000 claims 1
- 108010015776 Glucose oxidase Proteins 0.000 claims 1
- 239000004366 Glucose oxidase Substances 0.000 claims 1
- 102000004366 Glucosidases Human genes 0.000 claims 1
- 108010056771 Glucosidases Proteins 0.000 claims 1
- -1 Haloperoxidase Proteins 0.000 claims 1
- 102000004157 Hydrolases Human genes 0.000 claims 1
- 108090000604 Hydrolases Proteins 0.000 claims 1
- 108010029541 Laccase Proteins 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 102000004882 Lipase Human genes 0.000 claims 1
- 239000004367 Lipase Substances 0.000 claims 1
- 102000001696 Mannosidases Human genes 0.000 claims 1
- 108010054377 Mannosidases Proteins 0.000 claims 1
- 241000194109 Paenibacillus lautus Species 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 102000003992 Peroxidases Human genes 0.000 claims 1
- 108010059820 Polygalacturonase Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 108010083644 Ribonucleases Proteins 0.000 claims 1
- 102000006382 Ribonucleases Human genes 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 108060008539 Transglutaminase Proteins 0.000 claims 1
- 108060008724 Tyrosinase Proteins 0.000 claims 1
- 102000003425 Tyrosinase Human genes 0.000 claims 1
- 229940054340 bacillus coagulans Drugs 0.000 claims 1
- 229940097012 bacillus thuringiensis Drugs 0.000 claims 1
- 108010051210 beta-Fructofuranosidase Proteins 0.000 claims 1
- 108010005774 beta-Galactosidase Proteins 0.000 claims 1
- 102000005936 beta-Galactosidase Human genes 0.000 claims 1
- 108010089934 carbohydrase Proteins 0.000 claims 1
- 229940106157 cellulase Drugs 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 108010005400 cutinase Proteins 0.000 claims 1
- 108010093305 exopolygalacturonase Proteins 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 229940116332 glucose oxidase Drugs 0.000 claims 1
- 235000019420 glucose oxidase Nutrition 0.000 claims 1
- 108010002430 hemicellulase Proteins 0.000 claims 1
- 229940059442 hemicellulase Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 239000001573 invertase Substances 0.000 claims 1
- 235000011073 invertase Nutrition 0.000 claims 1
- 235000019421 lipase Nutrition 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000037353 metabolic pathway Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 108040007629 peroxidase activity proteins Proteins 0.000 claims 1
- 229940085127 phytase Drugs 0.000 claims 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 102000003601 transglutaminase Human genes 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101972 | 2001-12-29 | ||
| DKPA200101972 | 2001-12-29 | ||
| DKPA200200274 | 2002-02-21 | ||
| DKPA200200274 | 2002-02-21 | ||
| PCT/DK2002/000886 WO2003055996A1 (en) | 2001-12-29 | 2002-12-20 | Eubacterial rna-polymerase mutants with altered product production |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011046487A Division JP2011155977A (ja) | 2001-12-29 | 2011-03-03 | 変更された生成物生産性を有するユーバクテリアｒｎａ−ポリメラーゼ変異体 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2005512595A JP2005512595A (ja) | 2005-05-12 |
| JP2005512595A6 JP2005512595A6 (ja) | 2005-08-04 |
| JP2005512595A5 true JP2005512595A5 (enExample) | 2006-03-02 |
| JP4741186B2 JP4741186B2 (ja) | 2011-08-03 |
Family
ID=26069122
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003556516A Expired - Fee Related JP4741186B2 (ja) | 2001-12-29 | 2002-12-20 | 変更された生成物生産性を有するユーバクテリアｒｎａ−ポリメラーゼ変異体 |
| JP2011046487A Ceased JP2011155977A (ja) | 2001-12-29 | 2011-03-03 | 変更された生成物生産性を有するユーバクテリアｒｎａ−ポリメラーゼ変異体 |
| JP2013241836A Expired - Fee Related JP5876460B2 (ja) | 2001-12-29 | 2013-11-22 | 変更された生成物生産性を有するユーバクテリアｒｎａ−ポリメラーゼ変異体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011046487A Ceased JP2011155977A (ja) | 2001-12-29 | 2011-03-03 | 変更された生成物生産性を有するユーバクテリアｒｎａ−ポリメラーゼ変異体 |
| JP2013241836A Expired - Fee Related JP5876460B2 (ja) | 2001-12-29 | 2013-11-22 | 変更された生成物生産性を有するユーバクテリアｒｎａ−ポリメラーゼ変異体 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US20050095669A1 (enExample) |
| EP (1) | EP1461426B1 (enExample) |
| JP (3) | JP4741186B2 (enExample) |
| CN (2) | CN1610740B (enExample) |
| AT (1) | ATE383419T1 (enExample) |
| AU (1) | AU2002351750A1 (enExample) |
| DE (1) | DE60224579T2 (enExample) |
| DK (1) | DK1461426T3 (enExample) |
| WO (1) | WO2003055996A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4997420B2 (ja) * | 2006-03-28 | 2012-08-08 | 花王株式会社 | 変異微生物 |
| JP6139139B2 (ja) * | 2012-01-11 | 2017-05-31 | 国立大学法人 岡山大学 | 変異型ＲＮＡポリメラーゼβ−サブユニット遺伝子 |
| KR101594156B1 (ko) * | 2013-06-25 | 2016-02-15 | 씨제이제일제당 주식회사 | Ｌ-라이신 생산능이 향상된 미생물 및 그를 이용하여 ｌ-라이신을 생산하는 방법 |
| WO2017075195A1 (en) | 2015-10-30 | 2017-05-04 | Danisco Us Inc | Enhanced protein expression and methods thereof |
| CN106244714B (zh) * | 2016-09-23 | 2019-09-24 | 山西大学 | 一种巨大芽孢杆菌特异性检测的基因芯片 |
| CN112840028B (zh) * | 2018-08-07 | 2024-01-16 | Cj第一制糖株式会社 | 包含变体RpoC编码序列的核酸分子 |
| CN111118091A (zh) * | 2018-10-31 | 2020-05-08 | 宁夏乙征生物工程有限公司 | 一种抗菌肽的生产方法 |
| US20230399672A1 (en) * | 2020-11-02 | 2023-12-14 | University Of Stuttgart | Genome-modified bacterial strains for large scale bioprocesses |
| CN112608911B (zh) * | 2020-12-18 | 2022-07-05 | 湖州中科工业生物技术中心 | 一种rna聚合酶突变体及其应用 |
| WO2023247514A1 (en) | 2022-06-22 | 2023-12-28 | Novozymes A/S | Recombinant mannanase expression |
| CN120041420B (zh) * | 2025-04-25 | 2025-10-03 | 天津科技大学 | 一种RNA聚合酶β亚单位突变体及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6762040B2 (en) * | 2000-05-24 | 2004-07-13 | Novozymes A/S | Method for increasing gene copy number in a host cell and resulting host cell |
| EP1239040A3 (de) * | 2001-02-16 | 2003-01-08 | Degussa AG | Mutationen im rpoB-Gen L-Lysin produzierender Corynebacterium glutamicum-Stämme und Verfahren zur Herstellung von L-Lysin |
-
2002
- 2002-12-20 DK DK02787465T patent/DK1461426T3/da active
- 2002-12-20 AT AT02787465T patent/ATE383419T1/de not_active IP Right Cessation
- 2002-12-20 JP JP2003556516A patent/JP4741186B2/ja not_active Expired - Fee Related
- 2002-12-20 CN CN02826472XA patent/CN1610740B/zh not_active Expired - Lifetime
- 2002-12-20 AU AU2002351750A patent/AU2002351750A1/en not_active Abandoned
- 2002-12-20 CN CN201010155784.7A patent/CN101851599B/zh not_active Expired - Lifetime
- 2002-12-20 US US10/498,302 patent/US20050095669A1/en not_active Abandoned
- 2002-12-20 EP EP02787465A patent/EP1461426B1/en not_active Expired - Lifetime
- 2002-12-20 DE DE60224579T patent/DE60224579T2/de not_active Expired - Lifetime
- 2002-12-20 WO PCT/DK2002/000886 patent/WO2003055996A1/en not_active Ceased
-
2009
- 2009-08-21 US US12/545,535 patent/US20090317865A1/en not_active Abandoned
-
2011
- 2011-03-03 JP JP2011046487A patent/JP2011155977A/ja not_active Ceased
-
2013
- 2013-01-22 US US13/747,032 patent/US20130122548A1/en not_active Abandoned
- 2013-11-22 JP JP2013241836A patent/JP5876460B2/ja not_active Expired - Fee Related
-
2015
- 2015-02-09 US US14/616,950 patent/US20150147783A1/en not_active Abandoned
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