JP2005511762A5 - - Google Patents
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- Publication number
- JP2005511762A5 JP2005511762A5 JP2003552222A JP2003552222A JP2005511762A5 JP 2005511762 A5 JP2005511762 A5 JP 2005511762A5 JP 2003552222 A JP2003552222 A JP 2003552222A JP 2003552222 A JP2003552222 A JP 2003552222A JP 2005511762 A5 JP2005511762 A5 JP 2005511762A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- alkyl
- substituted
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 77
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 25
- 239000000203 mixture Substances 0.000 claims 12
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 5
- -1 piperazino ring Chemical group 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 230000000843 anti-fungal effect Effects 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 4
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 4
- 125000005940 1,4-dioxanyl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 3
- ORPVFFVNUGRIMC-UHFFFAOYSA-N 5h-chrysen-6-one Chemical compound C12=CC=CC=C2C(=O)CC2=C1C=CC1=CC=CC=C21 ORPVFFVNUGRIMC-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 230000000845 anti-microbial effect Effects 0.000 claims 2
- 230000005907 cancer growth Effects 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000006413 ring segment Chemical group 0.000 claims 2
- 125000005505 thiomorpholino group Chemical group 0.000 claims 2
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
- QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 230000002682 anti-psoriatic effect Effects 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000000532 dioxanyl group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000013160 medical therapy Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 230000003381 solubilizing effect Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33269201P | 2001-11-14 | 2001-11-14 | |
| US60/332,692 | 2001-11-14 | ||
| PCT/US2002/036475 WO2003051289A2 (en) | 2001-11-14 | 2002-11-14 | Solubilized topoisomerase poison agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005511762A JP2005511762A (ja) | 2005-04-28 |
| JP2005511762A5 true JP2005511762A5 (https=) | 2005-12-22 |
| JP4789414B2 JP4789414B2 (ja) | 2011-10-12 |
Family
ID=23299415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003552222A Expired - Fee Related JP4789414B2 (ja) | 2001-11-14 | 2002-11-14 | 可溶化トポイソメラーゼ毒性剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6987109B2 (https=) |
| EP (1) | EP1453507B1 (https=) |
| JP (1) | JP4789414B2 (https=) |
| KR (1) | KR20040088466A (https=) |
| AT (1) | ATE424200T1 (https=) |
| AU (1) | AU2002365161B2 (https=) |
| CA (1) | CA2467279A1 (https=) |
| DE (1) | DE60231426D1 (https=) |
| MX (1) | MXPA04004607A (https=) |
| WO (1) | WO2003051289A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1453812B1 (en) * | 2001-11-14 | 2008-08-20 | Rutgers, The State University | Cytotoxic agents |
| MXPA04004607A (es) * | 2001-11-14 | 2004-09-10 | Univ Rutgers | Agentes de venenos de topoisomerasa solubilizados. |
| DE60235287D1 (de) * | 2001-11-14 | 2010-03-25 | Univ Rutgers | Löslich gemachte topoisomerase-gifte |
| AU2002364953A1 (en) * | 2001-11-14 | 2003-06-17 | Edmond J. Lavoie | Topoisomerase poison agents |
| AU2003268075A1 (en) * | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents |
| US6992088B2 (en) * | 2002-08-09 | 2006-01-31 | Rutgers, The State University Of New Jersey | Nitro and amino substituted heterocycles as topoisomerase I targeting agents |
| US6989387B2 (en) * | 2002-08-09 | 2006-01-24 | Rutgers, The State University Of New Jersey | Nitro and amino substituted topoisomerase agents |
| CA2510337C (en) * | 2002-11-12 | 2013-01-08 | Rutgers, The State University Of New Jersey | Topoisomerase-targeting agents |
| EP1646388A4 (en) | 2003-05-12 | 2007-04-18 | Purdue Research Foundation | CYTOTOXIC INDENO AND ISOINDOLOISOCHINOLONE |
| US7495100B2 (en) | 2004-05-07 | 2009-02-24 | Purdue Research Foundation | Synthesis of indenoisoquinolines |
| DK2403856T3 (da) | 2009-03-06 | 2013-04-08 | Univ Rutgers | Methylendioxybenzo[i]phenanthridinderivater anvendt til behandling af cancer |
| WO2010127363A1 (en) | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Toposiomerase inhibitors |
| CN102993094B (zh) * | 2011-09-08 | 2014-07-23 | 中国石油大学(北京) | 一种四氢喹啉衍生物的合成方法 |
| US11091498B2 (en) | 2016-04-04 | 2021-08-17 | Rutgers, The State University Of New Jersey | Topoisomerase poisons |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2981731A (en) * | 1961-04-25 | Acridine derivatives | ||
| US2985661A (en) * | 1956-02-06 | 1961-05-23 | American Cyanamid Co | Preparation of 2(omicron-aminophenyl)-benzimidazole |
| US2915523A (en) * | 1956-12-03 | 1959-12-01 | Parke Davis & Co | Benzacridine compounds |
| US3272707A (en) | 1964-07-17 | 1966-09-13 | Smith Kline French Lab | Pharmaceutical compositions and methods for their use |
| CH420044A (de) * | 1964-09-01 | 1967-03-15 | Ciba Geigy | Verwendung von neuen Azol-Derivaten als optische Aufheller für textile organische Materialien |
| US3267107A (en) * | 1964-09-17 | 1966-08-16 | American Home Prod | 3-(4'-5'-methylenedioxy-phenyl)-7, 8-dimethoxy-1, 2, 3, 4,-tetrahydroisoquinolines |
| US3849561A (en) * | 1964-10-20 | 1974-11-19 | S Naruto | Anti-peptic ulcer substance from corydalis tubers |
| US3272107A (en) * | 1965-04-23 | 1966-09-13 | Geo Space Corp | Radial vane shutter |
| DE1670684A1 (de) * | 1966-04-01 | 1970-12-03 | Hoechst Ag | Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten |
| US3542782A (en) * | 1967-03-15 | 1970-11-24 | Sandoz Ag | 5,6-dihydro-8h-isoquino(1,2-b)quinazolines |
| JPS4942700A (https=) * | 1972-08-25 | 1974-04-22 | ||
| US3912740A (en) * | 1974-02-28 | 1975-10-14 | Us Health | Method for the preparation of oxygenated benzo{8 c{9 phenanthridine compounds |
| PT73763B (fr) | 1981-10-01 | 1983-10-26 | Quatrum Empresa Nacional De Qu | Procede pour la preparation de nouveaux epoxides d'alkaloides benzofenantridiniques et de compositions pharmaceutiques qui les contiennent |
| US5153178A (en) * | 1982-05-14 | 1992-10-06 | Maroko Peter R | Compositions and method of treatment for improving circulatory performance |
| US4761417A (en) * | 1982-05-14 | 1988-08-02 | Maroko Peter R | Compounds, compositions and method of treatments for improving circulatory performance |
| IE55519B1 (en) | 1982-05-14 | 1990-10-10 | Maroko Peter R | Use of a protoberberine alkaloid and composition containing same |
| US4980344A (en) * | 1982-05-14 | 1990-12-25 | Maroko Peter R | Compositions for improving circulatory performance |
| US4749708A (en) * | 1982-05-14 | 1988-06-07 | Maroko Peter R | Composition for improving circulatory performance |
| JPS61130289A (ja) * | 1984-11-29 | 1986-06-18 | Ss Pharmaceut Co Ltd | １３−プロピルベルベリンの塩 |
| FR2595356B1 (fr) * | 1986-03-05 | 1991-05-24 | Pasteur Strasbourg Universite | Derives des nitro ou aminobenzyltetrahydroisoquinoleines, procedes d'obtention, compositions pharmaceutiques les contenant, proprietes pharmacologiques et applications |
| US5244903A (en) * | 1987-03-31 | 1993-09-14 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
| SU1530628A1 (ru) | 1987-11-20 | 1989-12-23 | Ленинградский Технологический Институт Им.Ленсовета | Тригидрохлорид 2-[2-фенил-5(6)-бензимидазолил]-N-(3-диметиламинопропил)-5(6)-бензимидазолкарбоксамида в качестве флуоресцентного красител дл исследовани ДНК |
| US5106863A (en) * | 1990-03-26 | 1992-04-21 | Ortho Pharmaceutical Corporation | Substituted imidazole and pyridine derivatives |
| US5135934A (en) * | 1990-07-06 | 1992-08-04 | Du Pont Merck Pharmaceutical Company | 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents |
| US5126351A (en) * | 1991-01-24 | 1992-06-30 | Glaxo Inc. | Antitumor compounds |
| US5223506A (en) * | 1991-06-04 | 1993-06-29 | Glaxo Inc. | Cyclic antitumor compounds |
| US5428040A (en) * | 1993-08-31 | 1995-06-27 | The Du Pont Merck Pharmaceutical Company | Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents |
| CA2150235A1 (en) * | 1993-09-28 | 1995-04-06 | Fumio Suzuki | A novel tetracyclic compound |
| US5807874A (en) * | 1995-05-17 | 1998-09-15 | Rutgers, The State University Of New Jersey | Trisbenzimidazoles useful as topoisomerase I inhibitors |
| NZ307959A (en) | 1995-05-17 | 1998-08-26 | Univ Rutgers | Substituted tribenzimidazole derivatives where the substituent can be aryl or heteroaryl and medicaments |
| US5767142A (en) * | 1996-03-20 | 1998-06-16 | Rutgers, The State University Of New Jersey | Trisbenzimidazoles useful as topoisomerase I inhibitors |
| ES2161442T3 (es) | 1996-02-12 | 2001-12-01 | Univ Rutgers | Analogos de coralina como inhibidores de topoisomerasa. |
| US5770617A (en) | 1996-03-20 | 1998-06-23 | Rutgers, The State University Of New Jersey | Terbenzimidazoles useful as antifungal agents |
| JP2001501197A (ja) * | 1996-09-23 | 2001-01-30 | ルトガーズ，ザ ステイト ユニバーシティ オブ ニュージャージー | 抗―腫瘍剤としての置換された複素環式化合物類 |
| US6140328A (en) * | 1997-12-12 | 2000-10-31 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
| CA2347100C (en) | 1998-10-14 | 2010-12-14 | Purdue Research Foundation | Novel indenoisoquinolines as antineoplastic agents |
| US6740650B2 (en) * | 1999-10-29 | 2004-05-25 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
| WO2001032631A2 (en) * | 1999-10-29 | 2001-05-10 | Rutgers, The State University Of New Jerey | Heterocyclic cytotoxic agents |
| DE60235287D1 (de) * | 2001-11-14 | 2010-03-25 | Univ Rutgers | Löslich gemachte topoisomerase-gifte |
| MXPA04004607A (es) * | 2001-11-14 | 2004-09-10 | Univ Rutgers | Agentes de venenos de topoisomerasa solubilizados. |
| AU2002364953A1 (en) * | 2001-11-14 | 2003-06-17 | Edmond J. Lavoie | Topoisomerase poison agents |
| EP1453812B1 (en) * | 2001-11-14 | 2008-08-20 | Rutgers, The State University | Cytotoxic agents |
| US6989387B2 (en) * | 2002-08-09 | 2006-01-24 | Rutgers, The State University Of New Jersey | Nitro and amino substituted topoisomerase agents |
| US6992088B2 (en) * | 2002-08-09 | 2006-01-31 | Rutgers, The State University Of New Jersey | Nitro and amino substituted heterocycles as topoisomerase I targeting agents |
| AU2003268075A1 (en) * | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents |
-
2002
- 2002-11-14 MX MXPA04004607A patent/MXPA04004607A/es active IP Right Grant
- 2002-11-14 AT AT02803313T patent/ATE424200T1/de not_active IP Right Cessation
- 2002-11-14 JP JP2003552222A patent/JP4789414B2/ja not_active Expired - Fee Related
- 2002-11-14 AU AU2002365161A patent/AU2002365161B2/en not_active Ceased
- 2002-11-14 KR KR10-2004-7007453A patent/KR20040088466A/ko not_active Withdrawn
- 2002-11-14 DE DE60231426T patent/DE60231426D1/de not_active Expired - Lifetime
- 2002-11-14 EP EP02803313A patent/EP1453507B1/en not_active Expired - Lifetime
- 2002-11-14 CA CA002467279A patent/CA2467279A1/en not_active Abandoned
- 2002-11-14 WO PCT/US2002/036475 patent/WO2003051289A2/en not_active Ceased
-
2004
- 2004-05-14 US US10/846,951 patent/US6987109B2/en not_active Expired - Lifetime
-
2005
- 2005-08-24 US US11/210,457 patent/US20060058306A1/en not_active Abandoned
-
2010
- 2010-05-28 US US12/789,750 patent/US20100240664A1/en not_active Abandoned
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