ES2161442T3 - Analogos de coralina como inhibidores de topoisomerasa. - Google Patents

Analogos de coralina como inhibidores de topoisomerasa.

Info

Publication number
ES2161442T3
ES2161442T3 ES97906466T ES97906466T ES2161442T3 ES 2161442 T3 ES2161442 T3 ES 2161442T3 ES 97906466 T ES97906466 T ES 97906466T ES 97906466 T ES97906466 T ES 97906466T ES 2161442 T3 ES2161442 T3 ES 2161442T3
Authority
ES
Spain
Prior art keywords
topoisomerasa
coraline
inhibitors
analogs
provides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97906466T
Other languages
English (en)
Inventor
Edmond J Lavoie
Darshan B Makhey
Leroy Fong Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Original Assignee
Rutgers State University of New Jersey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rutgers State University of New Jersey filed Critical Rutgers State University of New Jersey
Application granted granted Critical
Publication of ES2161442T3 publication Critical patent/ES2161442T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA DERIVADOS ALCALOIDES PROTOBERBERINA UTILES COMO AGENTES ANTICANCEROSOS Y METODOS DE USO DE LOS MISMOS. LA INVENCION TAMBIEN PROPORCIONA DERIVADOS PROTOBERBERINA UTILES COMO INHIBIDORES DE LA TOPOISOMERASA. LA INVENCION PROPORCIONA ADEMAS DERIVADOS DE LA CORALINA Y NITIDINA QUE SON AGENTES TERAPEUTICOS EFECTIVOS SELECTIVOS PARA LA TOPOISOMERASA I CONTRA LAS CELULAS CANCEROSAS RESISTENTES A CAMPTOTECINA Y SON ESPECIALMENTE EFICACES CONTRA LOS TUMORES DEL SNC.
ES97906466T 1996-02-12 1997-02-11 Analogos de coralina como inhibidores de topoisomerasa. Expired - Lifetime ES2161442T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1145296P 1996-02-12 1996-02-12
US3216196P 1996-10-01 1996-10-01

Publications (1)

Publication Number Publication Date
ES2161442T3 true ES2161442T3 (es) 2001-12-01

Family

ID=26682407

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97906466T Expired - Lifetime ES2161442T3 (es) 1996-02-12 1997-02-11 Analogos de coralina como inhibidores de topoisomerasa.

Country Status (18)

Country Link
EP (1) EP0888346B1 (es)
JP (1) JP2000504687A (es)
KR (1) KR19990082488A (es)
CN (1) CN1067070C (es)
AU (1) AU710070C (es)
BR (1) BR9707425A (es)
CA (1) CA2241551A1 (es)
CZ (1) CZ254498A3 (es)
DE (1) DE69705112T2 (es)
ES (1) ES2161442T3 (es)
HU (1) HUP9900413A3 (es)
IL (1) IL124803A0 (es)
NO (1) NO983669L (es)
NZ (1) NZ330705A (es)
PL (1) PL328402A1 (es)
PT (1) PT888346E (es)
TR (1) TR199801555T2 (es)
WO (1) WO1997029106A1 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW460464B (en) * 1996-11-25 2001-10-21 Nippon Kayaku Kk Novel phenanthridinium derivative having an anti-tumor activity and pharmaceutical composition containing the same
US6140328A (en) * 1997-12-12 2000-10-31 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
IL137351A0 (en) 1998-02-12 2001-07-24 Univ Rutgers Heterocyclic topoisomerase poisons
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
CN1093129C (zh) * 1999-08-19 2002-10-23 广州市海科生物技术有限公司 一种具有抗肿瘤生理活性的尖叶唐松草阿原碱及其提取方法
US6740650B2 (en) 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
SI1465625T1 (sl) 2001-11-14 2010-06-30 Univ Rutgers Solubilizirani topoizomerazni strupi
MXPA04004607A (es) 2001-11-14 2004-09-10 Univ Rutgers Agentes de venenos de topoisomerasa solubilizados.
EP1453506B1 (en) 2001-11-14 2008-04-02 Rutgers, The State University Topoisomerase poison agents
WO2004014862A1 (en) 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted heterocycles as topoisomerase i targeting agents
US6989387B2 (en) 2002-08-09 2006-01-24 Rutgers, The State University Of New Jersey Nitro and amino substituted topoisomerase agents
AU2003268075A1 (en) 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
CA2510337C (en) 2002-11-12 2013-01-08 Rutgers, The State University Of New Jersey Topoisomerase-targeting agents
AU2006275514B2 (en) 2005-07-29 2012-04-05 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
CN101641339B (zh) 2007-02-01 2013-07-17 雷斯韦洛吉克斯公司 用于预防和治疗心血管疾病的化合物
EP2014651A1 (en) * 2007-07-12 2009-01-14 Exonhit Therapeutics SA Compounds and methods for modulating Rho GTPases
KR101629356B1 (ko) 2008-06-26 2016-06-13 리스버로직스 코퍼레이션 퀴나졸리논 유도체의 제조방법
AU2010204106B2 (en) 2009-01-08 2014-05-08 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
US9562051B2 (en) 2009-03-06 2017-02-07 Rutgers, The State University Of New Jersey Methylenedioxybenzo [I] phenanthridine derivatives used to treat cancer
MX2021012876A (es) 2009-03-18 2022-06-23 Resverlogix Corp Nuevos agentes anti-inflamatorios.
ES2821018T3 (es) 2009-04-22 2021-04-23 Resverlogix Corp Nuevos agentes antiinflamatorios
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
US8188109B2 (en) * 2009-07-20 2012-05-29 Naxospharma S.R.L. Benzoquinolizinium salt derivatives as anticancer agents
CN102746292B (zh) * 2011-04-18 2015-03-18 中国医学科学院医药生物技术研究所 环化的小檗碱衍生物及其制备方法和用途
PT2773354T (pt) 2011-11-01 2019-07-17 Resverlogix Corp Formulações orais de libertação imediata para quinazolinonas substituídas
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
AU2013365926B9 (en) 2012-12-21 2019-01-17 Zenith Epigenetics Ltd. Novel heterocyclic compounds as bromodomain inhibitors
WO2014144097A1 (en) * 2013-03-15 2014-09-18 Georgetown University Antifungal drugs
KR102339228B1 (ko) 2013-08-23 2021-12-13 뉴파마, 인크. 특정 화학 물질, 조성물, 및 방법
US10947201B2 (en) 2015-02-17 2021-03-16 Neupharma, Inc. Certain chemical entities, compositions, and methods
US10111885B2 (en) 2015-03-13 2018-10-30 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases
CN105541714A (zh) * 2015-12-16 2016-05-04 浙江普洛康裕制药有限公司 一种罂粟碱及盐酸罂粟碱的制备方法
EP3442979A4 (en) 2016-04-04 2019-12-18 Rutgers, the State University of New Jersey topoisomerase poisons
CN109843858B (zh) 2016-08-15 2023-05-05 润新生物公司 某些化学实体、组合物及方法
CN110759963A (zh) * 2018-07-25 2020-02-07 中山大学 一种稠环类化合物及其制备方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5126351A (en) * 1991-01-24 1992-06-30 Glaxo Inc. Antitumor compounds
US5223506A (en) * 1991-06-04 1993-06-29 Glaxo Inc. Cyclic antitumor compounds

Also Published As

Publication number Publication date
PL328402A1 (en) 1999-01-18
AU2115597A (en) 1997-08-28
WO1997029106A1 (en) 1997-08-14
AU710070C (en) 2001-08-30
EP0888346A1 (en) 1999-01-07
AU710070B2 (en) 1999-09-16
PT888346E (pt) 2001-10-31
IL124803A0 (en) 1999-01-26
CZ254498A3 (cs) 1998-12-16
BR9707425A (pt) 1999-07-20
EP0888346B1 (en) 2001-06-06
JP2000504687A (ja) 2000-04-18
CN1211252A (zh) 1999-03-17
TR199801555T2 (xx) 1998-11-23
NO983669L (no) 1998-09-23
CA2241551A1 (en) 1997-08-14
HUP9900413A3 (en) 2002-02-28
NZ330705A (en) 2000-03-27
DE69705112D1 (en) 2001-07-12
DE69705112T2 (de) 2002-03-21
HUP9900413A2 (hu) 1999-05-28
CN1067070C (zh) 2001-06-13
KR19990082488A (ko) 1999-11-25
NO983669D0 (no) 1998-08-11

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