NO983669D0 - Coralyne analoger som topoisomeraseinhibitorer - Google Patents
Coralyne analoger som topoisomeraseinhibitorerInfo
- Publication number
- NO983669D0 NO983669D0 NO983669A NO983669A NO983669D0 NO 983669 D0 NO983669 D0 NO 983669D0 NO 983669 A NO983669 A NO 983669A NO 983669 A NO983669 A NO 983669A NO 983669 D0 NO983669 D0 NO 983669D0
- Authority
- NO
- Norway
- Prior art keywords
- coralyne
- analogues
- topoisomerase inhibitors
- topoisomerase
- inhibitors
- Prior art date
Links
- PDYBUYVOPAJLKP-UHFFFAOYSA-M 2,3,10,11-tetramethoxy-8-methylisoquinolino[2,1-b]isoquinolin-7-ium;chloride Chemical class [Cl-].C1=C(OC)C(OC)=CC2=CC3=C(C=C(C(OC)=C4)OC)C4=CC=[N+]3C(C)=C21 PDYBUYVOPAJLKP-UHFFFAOYSA-M 0.000 title 1
- 239000003534 dna topoisomerase inhibitor Substances 0.000 title 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1145296P | 1996-02-12 | 1996-02-12 | |
| US3216196P | 1996-10-01 | 1996-10-01 | |
| PCT/US1997/001676 WO1997029106A1 (en) | 1996-02-12 | 1997-02-11 | Coralyne analogs as topoisomerase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO983669D0 true NO983669D0 (no) | 1998-08-11 |
| NO983669L NO983669L (no) | 1998-09-23 |
Family
ID=26682407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO983669A NO983669L (no) | 1996-02-12 | 1998-08-11 | Coralyne analoger som topoisomeraseinhibitorer |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0888346B1 (no) |
| JP (1) | JP2000504687A (no) |
| KR (1) | KR19990082488A (no) |
| CN (1) | CN1067070C (no) |
| AU (1) | AU710070C (no) |
| BR (1) | BR9707425A (no) |
| CA (1) | CA2241551A1 (no) |
| CZ (1) | CZ254498A3 (no) |
| DE (1) | DE69705112T2 (no) |
| ES (1) | ES2161442T3 (no) |
| HU (1) | HUP9900413A3 (no) |
| IL (1) | IL124803A0 (no) |
| NO (1) | NO983669L (no) |
| NZ (1) | NZ330705A (no) |
| PL (1) | PL328402A1 (no) |
| PT (1) | PT888346E (no) |
| TR (1) | TR199801555T2 (no) |
| WO (1) | WO1997029106A1 (no) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW460464B (en) * | 1996-11-25 | 2001-10-21 | Nippon Kayaku Kk | Novel phenanthridinium derivative having an anti-tumor activity and pharmaceutical composition containing the same |
| US6140328A (en) * | 1997-12-12 | 2000-10-31 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
| IL137351A0 (en) | 1998-02-12 | 2001-07-24 | Univ Rutgers | Heterocyclic topoisomerase poisons |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| CN1093129C (zh) * | 1999-08-19 | 2002-10-23 | 广州市海科生物技术有限公司 | 一种具有抗肿瘤生理活性的尖叶唐松草阿原碱及其提取方法 |
| US6740650B2 (en) | 1999-10-29 | 2004-05-25 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
| MXPA04004607A (es) | 2001-11-14 | 2004-09-10 | Univ Rutgers | Agentes de venenos de topoisomerasa solubilizados. |
| EP1453506B1 (en) | 2001-11-14 | 2008-04-02 | Rutgers, The State University | Topoisomerase poison agents |
| EP1465625B1 (en) | 2001-11-14 | 2010-02-03 | Rutgers, The State University | Solubilized topoisomerase poisons |
| US6992089B2 (en) | 2002-08-09 | 2006-01-31 | Rutgers, The University Of New Jersey | Nitro and amino substituted topoisomerase agents |
| WO2004014918A1 (en) | 2002-08-09 | 2004-02-19 | Rutgers, The State University | Nitro and amino substituted topoisomerase agents |
| US6992088B2 (en) | 2002-08-09 | 2006-01-31 | Rutgers, The State University Of New Jersey | Nitro and amino substituted heterocycles as topoisomerase I targeting agents |
| EP1562593B1 (en) | 2002-11-12 | 2014-07-16 | Rutgers, The State University of New Jersey | Topoisomerase-targeting agents |
| AU2006275514B2 (en) | 2005-07-29 | 2012-04-05 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| CN101641339B (zh) | 2007-02-01 | 2013-07-17 | 雷斯韦洛吉克斯公司 | 用于预防和治疗心血管疾病的化合物 |
| EP2014651A1 (en) * | 2007-07-12 | 2009-01-14 | Exonhit Therapeutics SA | Compounds and methods for modulating Rho GTPases |
| PL2346837T3 (pl) | 2008-06-26 | 2015-07-31 | Resverlogix Corp | Sposoby wytwarzania pochodnych chinazolinonu |
| EP2382194B1 (en) | 2009-01-08 | 2014-03-12 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular disease |
| JP5773888B2 (ja) | 2009-03-06 | 2015-09-02 | ラットガーズ，ザ・ステート・ユニバーシティ・オブ・ニュージャージー | 癌治療に用いられるメチレンジオキシベンゾ［ｉ］フェナントリジン誘導体 |
| US9238640B2 (en) | 2009-03-18 | 2016-01-19 | Resverlogix Corp. | Anti-inflammatory agents |
| EP3431086B1 (en) | 2009-04-22 | 2020-06-17 | Resverlogix Corp. | Novel anti-inflammatory agents |
| WO2010127363A1 (en) | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Toposiomerase inhibitors |
| US8188109B2 (en) * | 2009-07-20 | 2012-05-29 | Naxospharma S.R.L. | Benzoquinolizinium salt derivatives as anticancer agents |
| CN102746292B (zh) * | 2011-04-18 | 2015-03-18 | 中国医学科学院医药生物技术研究所 | 环化的小檗碱衍生物及其制备方法和用途 |
| HUE044986T2 (hu) | 2011-11-01 | 2019-11-28 | Resverlogix Corp | Orális, azonnali felszabadulású készítmények szubsztituált kinazolinonokhoz |
| US9765039B2 (en) | 2012-11-21 | 2017-09-19 | Zenith Epigenetics Ltd. | Biaryl derivatives as bromodomain inhibitors |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| JP2016507496A (ja) | 2012-12-21 | 2016-03-10 | ゼニス・エピジェネティクス・コーポレイションＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｃｏｒｐ． | ブロモドメイン阻害剤としての新規複素環式化合物 |
| US9642846B2 (en) | 2013-03-15 | 2017-05-09 | Georgetown University | Antifungal drugs |
| EP3508204A1 (en) | 2013-08-23 | 2019-07-10 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| CN107613769A (zh) * | 2015-02-17 | 2018-01-19 | 润新生物公司 | 某些化学实体、组合物和方法 |
| JP6903585B2 (ja) | 2015-03-13 | 2021-07-14 | レスバーロジックス コーポレイション | 補体関連疾患の治療のための組成物および治療方法 |
| CN105541714A (zh) * | 2015-12-16 | 2016-05-04 | 浙江普洛康裕制药有限公司 | 一种罂粟碱及盐酸罂粟碱的制备方法 |
| US11091498B2 (en) | 2016-04-04 | 2021-08-17 | Rutgers, The State University Of New Jersey | Topoisomerase poisons |
| CN109843858B (zh) | 2016-08-15 | 2023-05-05 | 润新生物公司 | 某些化学实体、组合物及方法 |
| CN110759963A (zh) * | 2018-07-25 | 2020-02-07 | 中山大学 | 一种稠环类化合物及其制备方法和用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5126351A (en) * | 1991-01-24 | 1992-06-30 | Glaxo Inc. | Antitumor compounds |
| US5223506A (en) * | 1991-06-04 | 1993-06-29 | Glaxo Inc. | Cyclic antitumor compounds |
-
1997
- 1997-02-11 ES ES97906466T patent/ES2161442T3/es not_active Expired - Lifetime
- 1997-02-11 KR KR1019980706221A patent/KR19990082488A/ko not_active Withdrawn
- 1997-02-11 HU HU9900413A patent/HUP9900413A3/hu unknown
- 1997-02-11 JP JP9528606A patent/JP2000504687A/ja active Pending
- 1997-02-11 NZ NZ330705A patent/NZ330705A/en unknown
- 1997-02-11 PT PT97906466T patent/PT888346E/pt unknown
- 1997-02-11 WO PCT/US1997/001676 patent/WO1997029106A1/en not_active Application Discontinuation
- 1997-02-11 CZ CZ982544A patent/CZ254498A3/cs unknown
- 1997-02-11 PL PL97328402A patent/PL328402A1/xx unknown
- 1997-02-11 AU AU21155/97A patent/AU710070C/en not_active Ceased
- 1997-02-11 CN CN97192211A patent/CN1067070C/zh not_active Expired - Fee Related
- 1997-02-11 BR BR9707425A patent/BR9707425A/pt unknown
- 1997-02-11 EP EP97906466A patent/EP0888346B1/en not_active Expired - Lifetime
- 1997-02-11 TR TR1998/01555T patent/TR199801555T2/xx unknown
- 1997-02-11 CA CA002241551A patent/CA2241551A1/en not_active Abandoned
- 1997-02-11 DE DE69705112T patent/DE69705112T2/de not_active Expired - Fee Related
- 1997-02-11 IL IL12480397A patent/IL124803A0/xx unknown
-
1998
- 1998-08-11 NO NO983669A patent/NO983669L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ330705A (en) | 2000-03-27 |
| PL328402A1 (en) | 1999-01-18 |
| TR199801555T2 (xx) | 1998-11-23 |
| PT888346E (pt) | 2001-10-31 |
| JP2000504687A (ja) | 2000-04-18 |
| NO983669L (no) | 1998-09-23 |
| CA2241551A1 (en) | 1997-08-14 |
| DE69705112T2 (de) | 2002-03-21 |
| HUP9900413A2 (hu) | 1999-05-28 |
| WO1997029106A1 (en) | 1997-08-14 |
| AU2115597A (en) | 1997-08-28 |
| CN1067070C (zh) | 2001-06-13 |
| CZ254498A3 (cs) | 1998-12-16 |
| EP0888346B1 (en) | 2001-06-06 |
| AU710070C (en) | 2001-08-30 |
| DE69705112D1 (en) | 2001-07-12 |
| BR9707425A (pt) | 1999-07-20 |
| AU710070B2 (en) | 1999-09-16 |
| HUP9900413A3 (en) | 2002-02-28 |
| EP0888346A1 (en) | 1999-01-07 |
| KR19990082488A (ko) | 1999-11-25 |
| CN1211252A (zh) | 1999-03-17 |
| ES2161442T3 (es) | 2001-12-01 |
| IL124803A0 (en) | 1999-01-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |