JP2005511617A5 - - Google Patents
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- Publication number
- JP2005511617A5 JP2005511617A5 JP2003543547A JP2003543547A JP2005511617A5 JP 2005511617 A5 JP2005511617 A5 JP 2005511617A5 JP 2003543547 A JP2003543547 A JP 2003543547A JP 2003543547 A JP2003543547 A JP 2003543547A JP 2005511617 A5 JP2005511617 A5 JP 2005511617A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- substituted
- alkyl
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 83
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 22
- 239000000203 mixture Substances 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 11
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 5
- -1 piperazino ring Chemical group 0.000 claims 5
- 230000000843 anti-fungal effect Effects 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 4
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 4
- 125000005940 1,4-dioxanyl group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 230000000845 anti-microbial effect Effects 0.000 claims 2
- 230000005907 cancer growth Effects 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- 125000005505 thiomorpholino group Chemical group 0.000 claims 2
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
- QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 claims 1
- WKVSKVKDOPVICN-UHFFFAOYSA-N COC1=C2C(=C(C3=NC=C4C5=C(C(N(C4=C31)CCNC)=O)C=CC=C5)OC)OCO2 Chemical compound COC1=C2C(=C(C3=NC=C4C5=C(C(N(C4=C31)CCNC)=O)C=CC=C5)OC)OCO2 WKVSKVKDOPVICN-UHFFFAOYSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 230000002682 anti-psoriatic effect Effects 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- UVXCXZBZPFCAAJ-UHFFFAOYSA-N arc-111 Chemical compound C1=C2OCOC2=CC2=C(N(CCN(C)C)C(=O)C3=C4C=C(C(=C3)OC)OC)C4=CN=C21 UVXCXZBZPFCAAJ-UHFFFAOYSA-N 0.000 claims 1
- VQKWAUROYFTROF-UHFFFAOYSA-N arc-31 Chemical compound O=C1N(CCN(C)C)C2=C3C=C4OCOC4=CC3=NN=C2C2=C1C=C(OC)C(OC)=C2 VQKWAUROYFTROF-UHFFFAOYSA-N 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- LJDHPGBKAIDRDH-UHFFFAOYSA-N chembl177804 Chemical compound C12=CC(OC)=C(OC)C=C2C(=O)N(CCN(CC)CC)C(C2=C3)=C1C=NC2=CC1=C3OCO1 LJDHPGBKAIDRDH-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000000532 dioxanyl group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000013160 medical therapy Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 claims 1
- 230000003381 solubilizing effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33273401P | 2001-11-14 | 2001-11-14 | |
| PCT/US2002/036901 WO2003041660A2 (en) | 2001-11-14 | 2002-11-14 | Solubilized topoisomerase poisons |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010126977A Division JP5337104B2 (ja) | 2001-11-14 | 2010-06-02 | 可溶化トポイソメラーゼ毒 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005511617A JP2005511617A (ja) | 2005-04-28 |
| JP2005511617A5 true JP2005511617A5 (enExample) | 2006-01-19 |
| JP4628675B2 JP4628675B2 (ja) | 2011-02-09 |
Family
ID=23299632
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003543547A Expired - Fee Related JP4628675B2 (ja) | 2001-11-14 | 2002-11-14 | 可溶化トポイソメラーゼ毒 |
| JP2010126977A Expired - Fee Related JP5337104B2 (ja) | 2001-11-14 | 2010-06-02 | 可溶化トポイソメラーゼ毒 |
| JP2013120501A Pending JP2013166801A (ja) | 2001-11-14 | 2013-06-07 | 可溶化トポイソメラーゼ毒 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010126977A Expired - Fee Related JP5337104B2 (ja) | 2001-11-14 | 2010-06-02 | 可溶化トポイソメラーゼ毒 |
| JP2013120501A Pending JP2013166801A (ja) | 2001-11-14 | 2013-06-07 | 可溶化トポイソメラーゼ毒 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US7049315B2 (enExample) |
| EP (3) | EP1465625B1 (enExample) |
| JP (3) | JP4628675B2 (enExample) |
| KR (1) | KR20050044491A (enExample) |
| AT (1) | ATE456952T1 (enExample) |
| AU (1) | AU2002363658B2 (enExample) |
| CA (1) | CA2467774C (enExample) |
| CY (1) | CY1110631T1 (enExample) |
| DE (1) | DE60235287D1 (enExample) |
| DK (1) | DK1465625T3 (enExample) |
| ES (1) | ES2340473T3 (enExample) |
| MX (1) | MXPA04004606A (enExample) |
| PT (1) | PT1465625E (enExample) |
| SI (1) | SI1465625T1 (enExample) |
| WO (1) | WO2003041660A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4789414B2 (ja) | 2001-11-14 | 2011-10-12 | ラトガーズ，ザ ステイト ユニバーシティ | 可溶化トポイソメラーゼ毒性剤 |
| DE60225943T2 (de) | 2001-11-14 | 2009-01-29 | Rutgers, The State University | Topoisomerase-giftmittel |
| WO2003041653A2 (en) | 2001-11-14 | 2003-05-22 | Rutgers, The State University | Cytotoxic agents |
| CA2467774C (en) | 2001-11-14 | 2011-09-20 | Rutgers, The State University | Solubilized topoisomerase poisons |
| AU2003265406A1 (en) | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted topoisomerase agents |
| AU2003268075A1 (en) * | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents |
| US6992088B2 (en) * | 2002-08-09 | 2006-01-31 | Rutgers, The State University Of New Jersey | Nitro and amino substituted heterocycles as topoisomerase I targeting agents |
| JP4774212B2 (ja) | 2002-11-12 | 2011-09-14 | ラトガーズ、ザ・ステイト・ユニバーシテイ・オブ・ニユー・ジヤージー | トポイソメラーゼ−ターゲッティング剤 |
| WO2006010127A2 (en) * | 2004-07-09 | 2006-01-26 | Medisyn Technologies, Inc. | Therapeutic compound and treatments |
| EP2019592A4 (en) * | 2006-05-24 | 2009-12-30 | Reddys Lab Ltd Dr | 5 (S) - (2'-HYDROXYETHOXY) -20 (S) -CAMPTOTHECINE AND ITS PREPARATION AND ITS USE FOR THE TREATMENT OF CANCER |
| US8394818B2 (en) | 2008-10-17 | 2013-03-12 | Dana-Farber Cancer Institute, Inc. | Soluble mTOR complexes and modulators thereof |
| TW201038578A (en) * | 2009-01-30 | 2010-11-01 | Univ Rutgers | Methods to treat cancer |
| WO2010102219A1 (en) | 2009-03-06 | 2010-09-10 | Rutgers, The State University Of New Jersey | Methylenedioxybenzo [i] phenanthridine derivatives used to treat cancer |
| WO2010127360A1 (en) * | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Toposiomerase inhibitors |
| WO2010127363A1 (en) | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Toposiomerase inhibitors |
| WO2012015901A1 (en) * | 2010-07-28 | 2012-02-02 | Genzyme Corporation | Methods for treating gastric and pancreatic malignancies |
| WO2012015875A1 (en) * | 2010-07-28 | 2012-02-02 | Genzyme Corporation | Methods for treating hematological malignancies |
| US9879003B2 (en) | 2012-04-11 | 2018-01-30 | Dana-Farber Cancer Institute, Inc. | Host targeted inhibitors of dengue virus and other viruses |
| WO2014063054A1 (en) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof |
| WO2017176648A1 (en) | 2016-04-04 | 2017-10-12 | Rutgers, The State University Of New Jersey | Topoisomerase poisons |
| CN111925370B (zh) * | 2020-09-01 | 2023-07-21 | 湖北科苑生物药业有限公司 | 一种吡嗪并吡唑并萘啶类化合物及其制备方法与应用 |
| CN117337195A (zh) * | 2021-04-29 | 2024-01-02 | 上海汇连生物医药有限公司 | 抗体偶联药物的制备方法及应用 |
| CN114335101B (zh) * | 2021-12-28 | 2024-11-22 | 深圳市华星光电半导体显示技术有限公司 | 显示面板及其制备方法 |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2981731A (en) * | 1961-04-25 | Acridine derivatives | ||
| US2985681A (en) * | 1953-08-28 | 1961-05-23 | Knoll Ag | Phenylacetic acid and aminoalkyl esters thereof |
| US2985661A (en) * | 1956-02-06 | 1961-05-23 | American Cyanamid Co | Preparation of 2(omicron-aminophenyl)-benzimidazole |
| US2915523A (en) * | 1956-12-03 | 1959-12-01 | Parke Davis & Co | Benzacridine compounds |
| US3272707A (en) * | 1964-07-17 | 1966-09-13 | Smith Kline French Lab | Pharmaceutical compositions and methods for their use |
| CH420044A (de) * | 1964-09-01 | 1967-03-15 | Ciba Geigy | Verwendung von neuen Azol-Derivaten als optische Aufheller für textile organische Materialien |
| US3267107A (en) * | 1964-09-17 | 1966-08-16 | American Home Prod | 3-(4'-5'-methylenedioxy-phenyl)-7, 8-dimethoxy-1, 2, 3, 4,-tetrahydroisoquinolines |
| US3849561A (en) * | 1964-10-20 | 1974-11-19 | S Naruto | Anti-peptic ulcer substance from corydalis tubers |
| DE1670684A1 (de) * | 1966-04-01 | 1970-12-03 | Hoechst Ag | Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten |
| US3542782A (en) * | 1967-03-15 | 1970-11-24 | Sandoz Ag | 5,6-dihydro-8h-isoquino(1,2-b)quinazolines |
| JPS4942700A (enExample) * | 1972-08-25 | 1974-04-22 | ||
| US3912740A (en) * | 1974-02-28 | 1975-10-14 | Us Health | Method for the preparation of oxygenated benzo{8 c{9 phenanthridine compounds |
| PT73763B (fr) | 1981-10-01 | 1983-10-26 | Quatrum Empresa Nacional De Qu | Procede pour la preparation de nouveaux epoxides d'alkaloides benzofenantridiniques et de compositions pharmaceutiques qui les contiennent |
| US5153178A (en) * | 1982-05-14 | 1992-10-06 | Maroko Peter R | Compositions and method of treatment for improving circulatory performance |
| US4980344A (en) * | 1982-05-14 | 1990-12-25 | Maroko Peter R | Compositions for improving circulatory performance |
| IE55519B1 (en) | 1982-05-14 | 1990-10-10 | Maroko Peter R | Use of a protoberberine alkaloid and composition containing same |
| US4761417A (en) * | 1982-05-14 | 1988-08-02 | Maroko Peter R | Compounds, compositions and method of treatments for improving circulatory performance |
| US4749708A (en) * | 1982-05-14 | 1988-06-07 | Maroko Peter R | Composition for improving circulatory performance |
| US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| JPS61130289A (ja) * | 1984-11-29 | 1986-06-18 | Ss Pharmaceut Co Ltd | １３−プロピルベルベリンの塩 |
| FR2595356B1 (fr) * | 1986-03-05 | 1991-05-24 | Pasteur Strasbourg Universite | Derives des nitro ou aminobenzyltetrahydroisoquinoleines, procedes d'obtention, compositions pharmaceutiques les contenant, proprietes pharmacologiques et applications |
| US5244903A (en) * | 1987-03-31 | 1993-09-14 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
| US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| SU1530628A1 (ru) | 1987-11-20 | 1989-12-23 | Ленинградский Технологический Институт Им.Ленсовета | Тригидрохлорид 2-[2-фенил-5(6)-бензимидазолил]-N-(3-диметиламинопропил)-5(6)-бензимидазолкарбоксамида в качестве флуоресцентного красител дл исследовани ДНК |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| US5106863A (en) * | 1990-03-26 | 1992-04-21 | Ortho Pharmaceutical Corporation | Substituted imidazole and pyridine derivatives |
| US5135934A (en) * | 1990-07-06 | 1992-08-04 | Du Pont Merck Pharmaceutical Company | 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents |
| US5126351A (en) * | 1991-01-24 | 1992-06-30 | Glaxo Inc. | Antitumor compounds |
| DE4116593C1 (enExample) * | 1991-05-22 | 1993-01-07 | Fa. Hermann Heye, 3063 Obernkirchen, De | |
| US5223506A (en) * | 1991-06-04 | 1993-06-29 | Glaxo Inc. | Cyclic antitumor compounds |
| US5428040A (en) * | 1993-08-31 | 1995-06-27 | The Du Pont Merck Pharmaceutical Company | Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents |
| CA2150235A1 (en) | 1993-09-28 | 1995-04-06 | Fumio Suzuki | A novel tetracyclic compound |
| US5807874A (en) * | 1995-05-17 | 1998-09-15 | Rutgers, The State University Of New Jersey | Trisbenzimidazoles useful as topoisomerase I inhibitors |
| US5767142A (en) * | 1996-03-20 | 1998-06-16 | Rutgers, The State University Of New Jersey | Trisbenzimidazoles useful as topoisomerase I inhibitors |
| NZ307959A (en) | 1995-05-17 | 1998-08-26 | Univ Rutgers | Substituted tribenzimidazole derivatives where the substituent can be aryl or heteroaryl and medicaments |
| KR19990082488A (ko) | 1996-02-12 | 1999-11-25 | 루트거스, 더 스테이트 유니버시티 오브 뉴 저지 | 토포이소머라제 억제제로서의 코르알린 동족체 |
| US5770617A (en) * | 1996-03-20 | 1998-06-23 | Rutgers, The State University Of New Jersey | Terbenzimidazoles useful as antifungal agents |
| US5981541A (en) * | 1996-09-23 | 1999-11-09 | Rutgers, The State University Of New Jersey | Substituted heterocycles as anti-tumor agents |
| US6140328A (en) * | 1997-12-12 | 2000-10-31 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
| EP2050452A1 (en) | 1998-10-14 | 2009-04-22 | Purdue Research Foundation | indenoisoquinolines as topoisomerase inhibitors I useful as antineoplastic agents |
| US6740650B2 (en) * | 1999-10-29 | 2004-05-25 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
| CA2389312A1 (en) | 1999-10-29 | 2001-05-10 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
| JP2005515180A (ja) | 2001-11-13 | 2005-05-26 | ザ プロクター アンド ギャンブル カンパニー | 阻害物質で安定化させた酵素を含有する局所適用組成物 |
| JP4789414B2 (ja) * | 2001-11-14 | 2011-10-12 | ラトガーズ，ザ ステイト ユニバーシティ | 可溶化トポイソメラーゼ毒性剤 |
| DE60225943T2 (de) * | 2001-11-14 | 2009-01-29 | Rutgers, The State University | Topoisomerase-giftmittel |
| WO2003041653A2 (en) * | 2001-11-14 | 2003-05-22 | Rutgers, The State University | Cytotoxic agents |
| CA2467774C (en) * | 2001-11-14 | 2011-09-20 | Rutgers, The State University | Solubilized topoisomerase poisons |
| US7493607B2 (en) * | 2002-07-09 | 2009-02-17 | Bluerisc Inc. | Statically speculative compilation and execution |
| AU2003268075A1 (en) * | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents |
| AU2003265406A1 (en) * | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted topoisomerase agents |
| US6992088B2 (en) * | 2002-08-09 | 2006-01-31 | Rutgers, The State University Of New Jersey | Nitro and amino substituted heterocycles as topoisomerase I targeting agents |
| JP4774212B2 (ja) * | 2002-11-12 | 2011-09-14 | ラトガーズ、ザ・ステイト・ユニバーシテイ・オブ・ニユー・ジヤージー | トポイソメラーゼ−ターゲッティング剤 |
-
2002
- 2002-11-14 CA CA2467774A patent/CA2467774C/en not_active Expired - Fee Related
- 2002-11-14 AT AT02801198T patent/ATE456952T1/de active
- 2002-11-14 WO PCT/US2002/036901 patent/WO2003041660A2/en not_active Ceased
- 2002-11-14 EP EP02801198A patent/EP1465625B1/en not_active Expired - Lifetime
- 2002-11-14 SI SI200230896T patent/SI1465625T1/sl unknown
- 2002-11-14 KR KR1020047007448A patent/KR20050044491A/ko not_active Ceased
- 2002-11-14 PT PT02801198T patent/PT1465625E/pt unknown
- 2002-11-14 DK DK02801198.9T patent/DK1465625T3/da active
- 2002-11-14 ES ES02801198T patent/ES2340473T3/es not_active Expired - Lifetime
- 2002-11-14 MX MXPA04004606A patent/MXPA04004606A/es active IP Right Grant
- 2002-11-14 EP EP09015160A patent/EP2196205A1/en not_active Withdrawn
- 2002-11-14 AU AU2002363658A patent/AU2002363658B2/en not_active Ceased
- 2002-11-14 DE DE60235287T patent/DE60235287D1/de not_active Expired - Lifetime
- 2002-11-14 JP JP2003543547A patent/JP4628675B2/ja not_active Expired - Fee Related
- 2002-11-14 EP EP10011073A patent/EP2286812A1/en not_active Withdrawn
-
2004
- 2004-05-14 US US10/846,834 patent/US7049315B2/en not_active Expired - Lifetime
-
2005
- 2005-08-24 US US11/210,456 patent/US7517883B2/en not_active Expired - Fee Related
-
2009
- 2009-03-27 US US12/413,235 patent/US7781587B2/en not_active Expired - Fee Related
-
2010
- 2010-05-03 CY CY20101100388T patent/CY1110631T1/el unknown
- 2010-06-02 JP JP2010126977A patent/JP5337104B2/ja not_active Expired - Fee Related
- 2010-08-05 US US12/851,370 patent/US8389721B2/en not_active Expired - Fee Related
-
2013
- 2013-06-07 JP JP2013120501A patent/JP2013166801A/ja active Pending
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