MXPA04004606A - Venenos de topoisomerasa solubilizados. - Google Patents

Venenos de topoisomerasa solubilizados.

Info

Publication number
MXPA04004606A
MXPA04004606A MXPA04004606A MXPA04004606A MXPA04004606A MX PA04004606 A MXPA04004606 A MX PA04004606A MX PA04004606 A MXPA04004606 A MX PA04004606A MX PA04004606 A MXPA04004606 A MX PA04004606A MX PA04004606 A MXPA04004606 A MX PA04004606A
Authority
MX
Mexico
Prior art keywords
formula
compounds
topoisomerase poisons
solubilized
solubilized topoisomerase
Prior art date
Application number
MXPA04004606A
Other languages
English (en)
Inventor
F Liu Leroy
Original Assignee
Univ Rutgers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rutgers filed Critical Univ Rutgers
Publication of MXPA04004606A publication Critical patent/MXPA04004606A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Abstract

La presente invencion proporciona compuestos de la formula (I), en donde A, B, W, Y, Z Y R1 tienen cualquiera de los significados definidos en la descripcion y sus sales farmaceuticamente aceptables. La presente invencion proporciona tambien composiciones farmaceuticas que comprenden un compuesto de la formula I, procesos para la preparacion de compuestos de la formula I, intermediarios utiles para preparar compuestos de la formula I y metodos terapeuticos para el tratamiento del cancer usando los compuestos de la formula I.
MXPA04004606A 2001-11-14 2002-11-14 Venenos de topoisomerasa solubilizados. MXPA04004606A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33273401P 2001-11-14 2001-11-14
PCT/US2002/036901 WO2003041660A2 (en) 2001-11-14 2002-11-14 Solubilized topoisomerase poisons

Publications (1)

Publication Number Publication Date
MXPA04004606A true MXPA04004606A (es) 2004-09-10

Family

ID=23299632

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04004606A MXPA04004606A (es) 2001-11-14 2002-11-14 Venenos de topoisomerasa solubilizados.

Country Status (15)

Country Link
US (4) US7049315B2 (es)
EP (3) EP1465625B1 (es)
JP (3) JP4628675B2 (es)
KR (1) KR20050044491A (es)
AT (1) ATE456952T1 (es)
AU (1) AU2002363658B2 (es)
CA (1) CA2467774C (es)
CY (1) CY1110631T1 (es)
DE (1) DE60235287D1 (es)
DK (1) DK1465625T3 (es)
ES (1) ES2340473T3 (es)
MX (1) MXPA04004606A (es)
PT (1) PT1465625E (es)
SI (1) SI1465625T1 (es)
WO (1) WO2003041660A2 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003051289A2 (en) 2001-11-14 2003-06-26 Rutgers, The State University Solubilized topoisomerase poison agents
AU2002364953A1 (en) 2001-11-14 2003-06-17 Edmond J. Lavoie Topoisomerase poison agents
JP4628675B2 (ja) * 2001-11-14 2011-02-09 ラトガーズ，ザ ステイト ユニバーシティ 可溶化トポイソメラーゼ毒
ATE405568T1 (de) 2001-11-14 2008-09-15 Univ Rutgers Cytotoxische mittel
AU2003265406A1 (en) 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted topoisomerase agents
WO2004014906A2 (en) * 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
WO2004014862A1 (en) 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted heterocycles as topoisomerase i targeting agents
AU2003290818A1 (en) 2002-11-12 2004-06-03 Edmond J. Lavoie Topoisomerase-targeting agents
EP1778228A4 (en) 2004-07-09 2010-08-11 Medisyn Technologies Inc THERAPEUTIC CONNECTION AND TREATMENTS
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US8394818B2 (en) 2008-10-17 2013-03-12 Dana-Farber Cancer Institute, Inc. Soluble mTOR complexes and modulators thereof
TW201038578A (en) * 2009-01-30 2010-11-01 Univ Rutgers Methods to treat cancer
DK2403856T3 (da) 2009-03-06 2013-04-08 Univ Rutgers Methylendioxybenzo[i]phenanthridinderivater anvendt til behandling af cancer
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
WO2010127360A1 (en) * 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
WO2012015901A1 (en) * 2010-07-28 2012-02-02 Genzyme Corporation Methods for treating gastric and pancreatic malignancies
WO2012015875A1 (en) * 2010-07-28 2012-02-02 Genzyme Corporation Methods for treating hematological malignancies
WO2013154778A1 (en) 2012-04-11 2013-10-17 Dana-Farber Cancer Institute, Inc. Host targeted inhibitors of dengue virus and other viruses
WO2014063054A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
EP3442979A4 (en) 2016-04-04 2019-12-18 Rutgers, the State University of New Jersey topoisomerase poisons
CN111925370B (zh) * 2020-09-01 2023-07-21 湖北科苑生物药业有限公司 一种吡嗪并吡唑并萘啶类化合物及其制备方法与应用

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Also Published As

Publication number Publication date
US7781587B2 (en) 2010-08-24
PT1465625E (pt) 2010-03-09
SI1465625T1 (sl) 2010-06-30
WO2003041660A3 (en) 2003-10-16
WO2003041660A2 (en) 2003-05-22
ES2340473T3 (es) 2010-06-04
DK1465625T3 (da) 2010-05-31
JP2010184942A (ja) 2010-08-26
CY1110631T1 (el) 2015-04-29
EP1465625B1 (en) 2010-02-03
US20110136812A1 (en) 2011-06-09
AU2002363658B2 (en) 2008-09-11
CA2467774C (en) 2011-09-20
US20060052381A1 (en) 2006-03-09
JP2005511617A (ja) 2005-04-28
EP2286812A1 (en) 2011-02-23
JP2013166801A (ja) 2013-08-29
US7049315B2 (en) 2006-05-23
US8389721B2 (en) 2013-03-05
JP5337104B2 (ja) 2013-11-06
ATE456952T1 (de) 2010-02-15
CA2467774A1 (en) 2003-05-22
US20050009824A1 (en) 2005-01-13
JP4628675B2 (ja) 2011-02-09
US20090239871A1 (en) 2009-09-24
EP1465625A4 (en) 2005-06-08
US7517883B2 (en) 2009-04-14
KR20050044491A (ko) 2005-05-12
DE60235287D1 (de) 2010-03-25
EP2196205A1 (en) 2010-06-16
EP1465625A2 (en) 2004-10-13

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