JP2005511531A - 5’−アシルアミノ−1,1’−ビフェニル−4−カルボキサミド誘導体およびp38キナーゼ阻害剤としてのそれらの使用 - Google Patents
5’−アシルアミノ−1,1’−ビフェニル−4−カルボキサミド誘導体およびp38キナーゼ阻害剤としてのそれらの使用 Download PDFInfo
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- JP2005511531A JP2005511531A JP2003535775A JP2003535775A JP2005511531A JP 2005511531 A JP2005511531 A JP 2005511531A JP 2003535775 A JP2003535775 A JP 2003535775A JP 2003535775 A JP2003535775 A JP 2003535775A JP 2005511531 A JP2005511531 A JP 2005511531A
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- methyl
- biphenyl
- amino
- cyclopropylmethyl
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- 0 Cc(cc1)c(*)cc1N Chemical compound Cc(cc1)c(*)cc1N 0.000 description 2
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PCT/EP2002/011576 WO2003032971A1 (en) | 2001-10-17 | 2002-10-16 | 5’-acylamino-1,1’-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors |
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GB0124933D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
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2001
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-
2002
- 2002-10-16 EP EP02782931A patent/EP1435934A1/en not_active Withdrawn
- 2002-10-16 JP JP2003535775A patent/JP2005511531A/ja active Pending
- 2002-10-16 US US10/492,605 patent/US7432289B2/en not_active Expired - Fee Related
- 2002-10-16 AU AU2002346929A patent/AU2002346929A1/en not_active Abandoned
- 2002-10-16 WO PCT/EP2002/011576 patent/WO2003032971A1/en active Application Filing
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US9365557B2 (en) | 2008-12-19 | 2016-06-14 | Vertex Pharmaceuticals Incorporated | Substituted pyrazin-2-amines as inhibitors of ATR kinase |
US10961232B2 (en) | 2008-12-19 | 2021-03-30 | Vertex Pharmaceuticals Incorporated | Substituted pyrazines as ATR kinase inhibitors |
US9701674B2 (en) | 2008-12-19 | 2017-07-11 | Vertex Pharmaceuticals Incorporated | Substituted pyrazines as ATR kinase inhibitors |
US10479784B2 (en) | 2008-12-19 | 2019-11-19 | Vertex Pharmaceuticals Incorporated | Substituted pyrazin-2-amines as inhibitors of ATR kinase |
JP2013526540A (ja) * | 2010-05-12 | 2013-06-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | Atrキナーゼ阻害剤として有用な化合物 |
US9334244B2 (en) | 2010-05-12 | 2016-05-10 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
US9630956B2 (en) | 2010-05-12 | 2017-04-25 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
US10208027B2 (en) | 2011-09-30 | 2019-02-19 | Vertex Pharmaceuticals Incorporated | Processes for preparing ATR inhibitors |
US9862709B2 (en) | 2011-09-30 | 2018-01-09 | Vertex Pharmaceuticals Incorporated | Processes for making compounds useful as inhibitors of ATR kinase |
US10813929B2 (en) | 2011-09-30 | 2020-10-27 | Vertex Pharmaceuticals Incorporated | Treating cancer with ATR inhibitors |
US10822331B2 (en) | 2011-09-30 | 2020-11-03 | Vertex Pharmaceuticals Incorporated | Processes for preparing ATR inhibitors |
US10478430B2 (en) | 2012-04-05 | 2019-11-19 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase and combination therapies thereof |
US11110086B2 (en) | 2012-04-05 | 2021-09-07 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase and combination therapies thereof |
US9791456B2 (en) | 2012-10-04 | 2017-10-17 | Vertex Pharmaceuticals Incorporated | Method for measuring ATR inhibition mediated increases in DNA damage |
JP2017500333A (ja) * | 2013-12-20 | 2017-01-05 | バイエル・ファルマ・アクティエンゲゼルシャフト | グルコース輸送阻害剤 |
US11464774B2 (en) | 2015-09-30 | 2022-10-11 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors |
Also Published As
Publication number | Publication date |
---|---|
US7432289B2 (en) | 2008-10-07 |
AU2002346929A1 (en) | 2003-04-28 |
US20040242868A1 (en) | 2004-12-02 |
GB0124939D0 (en) | 2001-12-05 |
EP1435934A1 (en) | 2004-07-14 |
WO2003032971A1 (en) | 2003-04-24 |
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