JP2005511212A - ナノコンポジットを含む医療機器 - Google Patents
ナノコンポジットを含む医療機器 Download PDFInfo
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
- A61F2002/018—Filters implantable into blood vessels made from tubes or sheets of material, e.g. by etching or laser-cutting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
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- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
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- A61F2230/005—Rosette-shaped, e.g. star-shaped
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0067—Three-dimensional shapes conical
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- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/90—Stent for heart valve
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
【解決手段】 本発明はナノコンポジットを含む医療機器を提供する。本発明の医療機器の製造の際にナノコンポジットを用いることにより、該医療機器は、種々の都合の良い性質を実現し得る。本発明の医療機器の製造方法も提供される。本発明の医療機器は、その用途における特定の利点を提供することが予想されるように、本発明の医療機器が体に治療的に接触され、それにより、治療又は診断が行われる治療又は診断方法を包含する診療方法もまた提供される。
Description
の他の種の充填剤粒子を含むマトリックスからなり得る。
図1は、本発明に従う医療機器の遠位端の長手方向の断面図であり、
図2は、図1に示す機器の、2−2線に沿って横断した断面図である。
い周期的でまた連続的、継続的環境に耐える強い機械的強度を示し、そしてまた充分に可撓性である。該機器はまた望ましくは、長期間これら機器が体内に残留すると考えられるので、実質的に非トロンボゲン形成性であり得る。更に、特定の用途において、このような機器は望ましくは生分解性であり得る。
独により発揮される性質に加わる性質を示すように設計され得る。医療機器の1種又はそれより多くの部材を製造する際にナノコンポジット材料を用いることは、ナノコンポジットの特定の性質が、医療機器産業において特に好都合な方法にて利用されることを可能にする。
充填粒子としてセラミックナノ繊維を含むナノコンポジットを用いて、もう一つの方法として且つ都合良く、製造され得る。このようなナノコンポジットは通常の押出プロセスを使用して製造され得るので、シャフトの領域を更に選択的に補強するため、間欠押出及び/又は多層押出を使用してセラミックナノ繊維を選択的に含ませ得る。更に、都合が良いことに、セラミックナノ繊維は、所望により、回転又は逆転押出を用いることにより配向し得、この配向は、シャフトの増強されたトルク性能を提供し得る。このような配向が望まれない場合、よりランダムなセラミックナノ繊維の配向を得るため、超音波振動を前記押出プロセスに導入することができる。これらプロセス上の利点に加えて、このようなシャフト材は、所望の程度の強化を伴うシャフト材をカテーテルに提供するので、MRI用途においても有用であろう。
る。例えば、充填剤粒子がどのような形状であっても、20:1より大きいアスペクト比を有する充填剤粒子は、該充填剤粒子とマトリックス材料との間の前記の増大された分散及び/又は相互作用を促進し得るであろうと考えられる。幾つかの実施態様において、充填剤粒子は望ましくは、50:1と2500:1の間、典型的には200:1と2000:1の間、例えば、300:1と1500:1の間のアスペクト比を有するであろう。
ヒドロキシル基を有しており、そしてそれ故、例えばカルボン酸により更に官能化され得、これは次いで、更に官能化されて、マトリックス材料内の官能性基と相互作用し得る。加えて、アルミノシリケート又はマグネシオシリケートのような白土は、コポリマーの一成分が白土と適合性であり、そしてコポリマーの他成分がポリマーマトリックスと適合性である、ブロックコポリマー又はグラフトコポリマーにより官能化され得る。またモンモリロナイトのような白土は、アルキルアンモニウムにより官能化され得、その結果該白土は、例えば、ポリウレタンと相互作用することが可能である。
の範囲内であると考えられる。
Solubilization of Single Walled Carbon Nanotubes by Functionalization with Glucosamine)”、ナノレターズ(Nano Letters)、2(4)、第369〜373頁(2002年)、並びにバンジョパジャヤ(Bandyopadhyaya)等、“水溶液中の個々のカーボンナノチューブの安定化(Stabilization of Individual Carbon Nanotubes in Aqueous Solutions))”、ナノレターズ(Nano Letters)、2(1)、第25〜28頁(2002年)に記載されており、それぞれの開示全体が、本明細書中に参照として取り込まれている。
の適用前に、ナノ粒子を含む溶液に分散剤を含ませることが好都合であり又は望ましいことであり得る。
to Make Nanotubes Dissolve)”、化学及び工学ニュース(Chemical and Engineering News) 、80(28)、第38〜39頁;並びにスター(Star)等、“澱粉が結合されたカーボンナノチューブ(Starched carbon nanotubes) ”、アンゲバンテ ヒェミー−国際版(Angewante Chemie-International Edition)、41(14)、第2508頁(2002年)を参照;これらの開示全体は、本明細書中に参照として取り込まれている。
ポジット及び/又はナノ粒子を製造する多くの方法が知られており、そして、これらの何れも、本発明の医療機器に取り込むためナノコンポジット及びナノ粒子を製造するために用いることができる。多くのこのような方法が、例えば、“ナノコンポジッツ2001、プラスチックへの新たな価値の移送(Nanocomposites 2001,Delivering New Value to Plastics)”、管理者会議経営会(Executive Conference Management) 、6月25〜27日、2001年、シカゴ、イリノイ州、に開示及び記載されており、これらの開示全体が、本明細書中に参照として取り込まれている。
HDPE/POSSナノコンポジットによる内部シャフトカテーテル管状体の製造
1)二軸スクリュー押出混練によるHDPE/POSSナノコンポジットの製造
有機物により官能化されたPOSS[MS0830;カナダ国、ファウンテンヴァレイのハイブリッドプラスチックス(Hybrid Plastics) 社から市販品を入手可能なオクタメチル−POSS]を、高密度ポリエチレン[米国、テキサス州、ヒューストンのシェブロン−フィリップスケミカル社(Chevron-Phillips Chemical Company) から市販品を入手可能なHDPEマーレックス(Marlex)4903]と混練した。特に、HDPE対POSSの比率が4:1の供給材を、190℃及び200RPMの速度で作動している、逆転分散性二軸スクリュー混練機ZSE27[米国、ニュージャージー州、アレンデールのリーストリッツ社(Leistritz Company) から市販品を入手可能]に供給した。混練吐出量は、1時間当たり5ポンド(約2.27kg)であった。
HDPE/POSSナノコンポジット対プレクサー(Plexar)390無水物で変性されたポリエチレン[米国、テキサス州、ヒューストンのイクイスターケミカル社(Equistar Chemical Company) から市販品を入手可能]の4:1混合物を予備混合し、その後更に、マーレックス(Marlex)4903ポリエチレンにより3:1に希釈し、そして220℃で押し出して、寸法0.018インチ(約0.0457cm)×0.024インチ(約0.0610cm)の管状体にした。得られた内部シャフト管状体は、慣用の組み立て技術を使用して、ワイヤー、シングルオペレーターエクスチェンジカテーテル又はステントデリバリーシステムの全てに使用することができる。
ペバックス(Pebax) (登録商標)/POSSナノコンポジットによる外部シャフトカテーテル管状体の製造
1)二軸スクリュー押出混練によるペバックス(登録商標)/POSSナノコンポジットの製造
有機物により官能化されたPOSS[AM0265;ハイブリッドプラスチックス(Hybrid Plastics) 社から市販品を入手可能なアミノプロピルイソブチルPOSS]を、ペバックス(登録商標)7233[ペバックス(登録商標)は、ベルギー国、ブリュッセルのアトフィナ(Atofina) 社から市販品を入手可能なポリエーテルブロックアミドである]と混練した。特に、ペバックス(登録商標)対POSSの比率が4:1の供給材を、200℃及び100RPMの速度で作動している、リーストリッツ(Leistritz) 社製ZSE27逆転二軸スクリュー混練機に供給した。混練吐出量は、1時間当たり5ポンド(約2.27kg)であった。
ペバックス(登録商標)/POSSナノコンポジット対ペバックス(登録商標)7233の3:1希釈物を製造し、そして226℃で押し出して、寸法0.0306インチ(約0.0777cm)×0.0362インチ(約0.0919cm)の外部シャフトカテーテル管状体にした。
管状体押出プロセスの間、前記ナノコンポジットは、充填剤が充填された慣用のペバックス(登録商標)よりも更に安定であり得る。この方法により製造された管状体にEtO滅菌が行われるとき、POSSナノ充填剤は、このような滅菌処理が行われるとき充填剤が充填されていないペバックス医療機器又は医療部材において生じることが予想される弛緩に比較して、配向したペバックス(登録商標)鎖が有害な程度に弛緩することを低減又は実質的に阻止するであろう。
ペバックス(登録商標)/白土による外部シャフトカテーテル管状体の製造
ペバックス(登録商標)7233を95%、そして白土充填剤5%を含む、2099X83109C(登録商標)と称される、ペバックス(登録商標)/白土ナノコンポジット材料を、米国、ミネソタ州、ウィノナのRTP社から購入した。この材料を、押出温度226℃で押し出して、寸法0.0306インチ(約0.0777cm)×0.0362インチ(約0.0919cm)の、許容し得る外部シャフトカテーテル管状体にした。
ペバックス(登録商標)/モンモリロナイトナノコンポジットによる多層管状体の製造
72デュロメーターペバックス(登録商標)材料[例えば、アトケム(Atochem) 社から市販品を入手可能なペバックス(登録商標)7233]95%及びモンモリロナイト充填剤5%を含むペバックス(登録商標)/モンモリロナイトナノコンポジット材料を、上述の二軸スクリュー押出機により混練する。ナノコンポジット材料をその後、押出のために適する粘度を与えるのに充分な温度、例えば、約190℃ないし約215℃で、充填剤が充填されていないペバックス(登録商標)と共に共押出して、中間層としてペバックス(登録商標)/モンモリロナイトナノコンポジットを有し、そして内層及び外層として充填剤が充填されていないペバックス(登録商標)を有する、許容し得る3層管状体にする。前記3層管状体は、該管状体の目的とする用途に適した寸法を有する。前記管状体が、例えば、バルーンの形成において使用されるものであるとき、適する寸法は、内径約0.0176インチ(約0.0447cm)及び外径約0.342インチ(約0.869cm)であろう。
ペバックス(登録商標)/変性されたモンモリロナイトナノコンポジットによる1層管状体の製造
70デュロメーターペバックス(登録商標)材料(例えば、アトケム社から市販品を入手可能なペバックス(登録商標)7033)90%及び変性されたモンモリロナイト充填剤10%を含むペバックス(登録商標)/モンモリロナイトナノコンポジット材料を、上述の二軸スクリュー押出機により混練する。混練前に、上記本文中に記載のように、ポリエーテル及び/又はポリアミドと相互作用することが可能なブロックコモノマーを含む官能化剤によりモンモリロナイトを変性する。ナノコンポジット材料を、押出のために適する粘度を与えるのに充分な温度、即ち、約190℃ないし約215℃で押し出して、目的とする管状体の用途に適する寸法を有する許容し得る1層管状体にする。この管状体は、その後、バルーン、カテーテルの内部管腔、カテーテルの外部管腔などを形成するために使用することができる。前記管状体が、例えば、バルーンの形成において使用されるものであるとき、適する寸法は、内径約0.0176インチ(約0.0447cm)及び外径約0.342インチ(約0.869cm)であろう。
ナイロン12/変性されたモンモリロナイトナノコンポジットによる1層管状体の製造
ナイロン12[アトフィナ社からリルサン(Rilsan)(登録商標)の下に市販品を入手可能]を99%及び変性されたモンモリロナイト充填材1%を含むナイロン12/モンモリロナイトナノコンポジット材料を下記のように製造する。全ての材料を粉末として購入するか又は既知の方法により粉砕して粉末にする。モンモリロナイトは、上記本文中に記載されているように、ブロックポリアミド又はポリアミド基を有する何れかの材料を含む官能化剤により変性する。粉末状のナイロン12及び粉末状の官能化されたモンモリロナイトは、一緒に混合され、そして秤量供給装置(又は、何れかの他の許容し得る粉末供給機構)を通って押出プロセスに供給される。ナノコンポジット材料を、その後、押出のために適する粘度を与えるのに充分な温度、即ち、約210℃ないし約240℃、典型的には約220℃ないし約230℃で押し出して、目的とする管状体の用途に適する寸法を有する許容し得る1層管状体にする。このような用途は、例えば、バルーン、カテーテルの内
部管腔、カテーテルの外部管腔などの形成を包含し得る。このようなナノコンポジットを含む管状体は、バルーンの形成に特に有用であると考えられ、この用途のために適する管状体の寸法は、内径約0.0176インチ(約0.0447cm)及び外径約0.342インチ(約0.869cm)であろう。より特別には、前記バルーンは何れかの既知の方法により形成され、その後、何れかの既知の組み立て方法により、カテーテルシャフトに取り付けられ得る。
単壁カーボンナノチューブ結合層を含む、熱結合された多層カテーテルシャフトの製造
多層カテーテルシャフトは、以下のようなオーバー−ザ−ワイヤー直列押出プロセス(over-the-wire tandem extrusion process)を使用して、単壁のカーボンナノチューブ結合層を間に含む1層のペバックス(登録商標)と1層のプレキサー(Plexar)(登録商標)[米国、テキサス州、ヒューストンのイクイスターケミカル社(Equistar Chemical Company) ]から製造される。
プレキサー(登録商標)を220℃で、テフロン(登録商標)コートした銅のマンドレル上に押し出す。アラビアゴムと単壁カーボンナノチューブ(純粋1mL、アラビアゴム200mg及びカーボンナノチューブ30mg)の水溶液をその後、プレキサー(登録商標)のシャフト上に噴霧する。前記シャフトを120℃オーブンを通過させることにより、過剰な水を全て除去する。直列した第2の押出機が、温度226℃で、前記プレキサー(登録商標)カーボンナノチューブ上にペバックス(登録商標)の層を押し出す。得られた多層管状体は、境界層におけるカーボンナノチューブの埋設に起因する層間の向上した結合強度を示す。
ペバックス(登録商標)/白土ナノコンポジットの性能及び性質に対する異なる官能化剤の効果
ペバックス(登録商標)7233を95%及び白土5%を含む3つのナノコンポジットを製造した。より特別には、未変性白土を含む第1のこのようなナノコンポジット、ヒドロキシル末端基を有するブロックポリマーにより変性された白土を含む第2のこのようなナノコンポジット及びカルボキシル末端基を有するブロックポリマーにより変性された白土を含む第3のこのようなナノコンポジットを、上述のように、二軸スクリュー押出機により別々に混練した。この材料を押し出して管状体にし、そしてインストロン(Instron) で試験した。破断伸び(イプシロン)、弾性率(E)並びに極限強さ(シグマ)を測定した。結果を以下の表1に示す。
Claims (59)
- 医療機器であって、その少なくとも一部材が、
マトリックス材料、
少なくとも1種のナノ粒子状充填剤粒子(nanoparticulate filler particles)を含むナノコンポジット材料(nanocomposite material)から製造されている医療機器。 - 前記ナノコンポジット材料が、官能化剤(functinalizer) 、相溶化剤(compatibilizer)、分散剤又はそれらの組み合わせを更に含む、請求項1記載の医療機器。
- 前記医療機器が、経管腔医療機器(transluminal medical device) である、請求項1記載の医療機器。
- 前記少なくとも一部材が、多層経管腔医療機器の少なくとも1層からなる、請求項3記載の医療機器。
- 前記少なくとも一部材が、多管腔カテーテル(multilumen catheter) の内腔壁からなる、請求項4記載の医療機器。
- 前記少なくとも一部材が、多管腔カテーテル(multilumen catheter) の外腔壁からなる、請求項4記載の医療機器。
- 前記多層経管腔医療機器の少なくとも1層が、その長手軸に沿って厚さが徐々に薄くなっている、請求項4記載の医療機器。
- 前記医療機器の可撓性が、その長手軸に沿って変化している、請求項3記載の医療機器。
- 前記多層経管腔医療機器が、少なくとも1層のナノコンポジット層及び少なくとも1層の非ナノコンポジット層を含む、請求項4記載の医療機器。
- 前記多層経管腔医療機器が、少なくとも1層の非ナノコンポジット層により分離された少なくとも2層のナノコンポジット層を含む、請求項4記載の医療機器。
- 前記多層経管腔医療機器が、少なくとも第1ナノコンポジット層及び第2ナノコンポジット層を含み、該第1ナノコンポジット層及び該第2ナノコンポジット層は、異なるナノコンポジットから構成されている、請求項4記載の医療機器。
- 前記第1ナノコンポジット層及び前記第2ナノコンポジット層の少なくとも1層が少なくとも第1官能化剤を更に含み、且つその他の点では、同一のナノコンポジット材料から構成されている、請求項4記載の医療機器。
- 前記多層経管腔医療機器が少なくとも第1ナノコンポジット層及び第2ナノコンポジット層を含み、該第1ナノコンポジット層は少なくとも第1官能化剤を、該第2ナノコンポジット層は少なくとも第2官能化剤をそれぞれ更に含み、且つその他の点では、同一のナノコンポジット材料から構成されている、請求項4記載の医療機器。
- 前記少なくとも一部材が少なくとも2層からなる膨張性バルーンからなる、請求項1記載の医療機器。
- 少なくとも2層の各々が異なる官能化剤を含み、且つその他の点では、同一のナノコンポジット材料から構成されている、請求項14記載の医療機器。
- 前記マトリックス材料が熱硬化性材料からなる、請求項1記載の医療機器。
- 前記熱硬化性材料がニトリル・ブタジエン・エラストマー、シリコーン、エポキシ、イソシアネート、EPDM、エピクロロヒドリン、或いはそれらのコポリマー、ブロックコポリマー又はポリマーブレンドを含む、請求項16記載の医療機器。
- 前記マトリックス材料が熱可塑性材料からなる、請求項1記載の医療機器。
- 前記熱可塑性材料がポリオレフィン、ポリアミド、ポリエステル、ポリエーテル、ポリウレタン、ポリ尿素、ポリビニル、ポリアクリリック、フルオロポリマー、或いはそれらの何れかのコポリマー、ブロックコポリマー又はブレンドを含む、請求項18記載の医療機器。
- 前記熱可塑性材料がナイロンである、請求項19記載の医療機器。
- 前記ナイロンがナイロン12である、請求項20記載の医療機器。
- 前記熱可塑性材料がポリエーテルアミドブロックコポリマーである、請求項19記載の医療機器。
- 前記充填剤粒子が合成又は天然フィロシリケート、モノマー状シリケート、カーボン又はセラミックナノチューブ、ナノワイヤー又はナノ繊維、金属又は金属酸化物粉末、磁性又は常磁性粉末、感温性ポリマー、生分解性ポリマー、デンドリマー又はデンドリマー金属錯体、或いはそれらの組み合わせからなる、請求項1記載の医療機器。
- 前記充填剤粒子が1種又はそれより多くのフィロシリケートからなる、請求項23記載の医療機器。
- 前記充填剤粒子が1種又はそれより多くの白土からなる、請求項23記載の医療機器。
- 前記クレーの少なくとも1種がモンモリロナイトからなる、請求項25記載の医療機器。
- 前記充填剤粒子が、1種又はそれより多くの多面体オリゴマー状シルセキオキサン(silsequioxanes)からなる、請求項23記載の医療機器。
- 前記充填剤粒子が1種又はそれより多くのカーボン又はセラミックナノチューブ、ナノワイヤー又はナノ繊維からなる、請求項23記載の医療機器。
- 前記充填剤粒子が1種又はそれより多くのカーボンナノチューブからなる、請求項28記載の医療機器。
- 前記少なくとも一部材がカテーテルシャフトを含む、請求項1記載の医療機器。
- 前記少なくとも一部材がバルーンを含む、請求項1記載の医療機器。
- 前記医療機器がガイドカテーテルである、請求項1記載の医療機器。
- 前記少なくとも一部材がステントデリバリーカテーテルである、請求項1記載の医療機器。
- 医療機器の少なくとも一部材を製造する方法であって、
ナノ粒子充填剤材料を選択し、
マトリックス材料を選択し、
前記充填剤材料及び前記マトリックス材料からナノコンポジットを製造し、そして
前記ナノコンポジットを用いて医療機器の少なくとも一部材を製造する
ことからなる方法。 - 前記医療機器が経管腔医療機器である、請求項34記載の方法。
- 前記医療機器が多層経管腔医療機器である、請求項35記載の方法。
- 前記少なくとも一部材がある長さのカテーテルシャフトを含む、請求項36記載の方法。
- 前記医療機器の少なくとも一部材を製造する工程が、その長手軸に沿って厚さが徐々に薄くなる1層を設けることを含む、請求項37記載の方法。
- 前記医療機器の少なくとも一部材を製造する工程が、その長手軸に沿う可撓性に変化を与えることを含む、請求項37記載の方法。
- 前記充填剤材料が、複数のカーボンナノチューブ、ナノ繊維又はナノワイヤーを含む、請求項37記載の方法。
- 複数のカーボンナノチューブ、ナノ繊維又はナノワイヤーの少なくとも一部分が、グルコサミン又はカルボン酸を用いて官能化されている、請求項40記載の方法。
- 前記ある長さのシャフトが、該ある長さのシャフトの第1層の少なくとも一部分をカーボンナノ粒子を含む溶液と接触させ、そして前記カーボンナノ粒子の少なくとも一部分の上に第2層を設けることにより設けられる、請求項40記載の方法。
- カーボンナノ粒子の前記溶液が分散剤を更に含む、請求項40記載の方法。
- 前記分散剤がアラビアゴムである、請求項43記載の方法。
- 前記医療機器が心臓血管医療機器である、請求項35記載の方法。
- 前記心臓血管医療機器がバルーンカテーテルである、請求項45記載の方法。
- ポリマー押出物を形成するための、ポリマー押出機を含む装置であって、
該ポリマー押出機は、ポリマー溶融物を押し出すための押出機ヘッドを含み、
該押出機ヘッドは、それに機能的に嵌合している少なくとも1つの超音波振動子を有し、
該少なくとも1つの超音波振動子は、少なくとも1種の変調された超音波を前記押出機ヘッドに伝達するために構成され且つ配置されており、
該少なくとも1種の変調された超音波は、少なくとも1つの振幅及び少なくとも1つの変調を有し、そして
該波の前記少なくとも1つの振幅及び前記少なくとも1つの変調は、少なくとも前記押出機ヘッド全体に実質的に均一の振動を付与する
装置。 - 医療機器を体に、その治療及び診断を行うために治療的に接触させることからなり、該医療機器は少なくとも1種のナノコンポジット材料を含む診療方法。
- 前記診療方法が治療方法である、請求項48記載の方法。
- 前記医療機器が経管腔医療機器である、請求項49記載の方法。
- 前記医療機器がカテーテルを含む、請求項50記載の方法。
- 前記医療機器がバルーンを含む、請求項51記載の方法。
- 前記医療機器がガイドカテーテルである、請求項51記載の方法。
- 前記医療機器がステントデリバリーカテーテルである、請求項51記載の方法。
- 治療が血管形成である、請求項52記載の方法。
- 前記診療方法が診断方法である、請求項48記載の方法。
- 前記医療機器が経管腔医療機器である、請求項56記載の方法。
- 前記医療機器がカテーテルを含む、請求項57記載の方法。
- 診断方法が血管形成である、請求項58記載の方法。
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2006502788A (ja) * | 2002-10-15 | 2006-01-26 | ボストン サイエンティフィック サイムド, インコーポレイテッド | ナノ駆動医療機器 |
JP2006518736A (ja) * | 2003-01-31 | 2006-08-17 | ボストン サイエンティフィック リミティッド | 薬物添加ナノカプセルを用いる局所的薬物デリバリー |
JP2007182665A (ja) * | 2005-12-29 | 2007-07-19 | Hyosung Corp | モジュラスが向上したポリエチレンテレフタレートナノ複合繊維の製造方法 |
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JP2012523327A (ja) * | 2009-04-08 | 2012-10-04 | ナノソルシオネス エス エー デーイー シー ブイ | 周波数および振幅が変化する超音波を用いてポリマーとナノ粒子のナノコンポジットの作製を促進する連続プロセス |
KR20170094756A (ko) * | 2016-02-11 | 2017-08-21 | (주)아폴론 | 폴리 카테터용 조성물 |
KR20170094752A (ko) * | 2016-02-11 | 2017-08-21 | (주)아폴론 | 카테터용 폴리 |
Families Citing this family (342)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10028851B2 (en) | 1997-04-15 | 2018-07-24 | Advanced Cardiovascular Systems, Inc. | Coatings for controlling erosion of a substrate of an implantable medical device |
US8172897B2 (en) | 1997-04-15 | 2012-05-08 | Advanced Cardiovascular Systems, Inc. | Polymer and metal composite implantable medical devices |
US6240616B1 (en) | 1997-04-15 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing a medicated porous metal prosthesis |
EP1056501B1 (en) * | 1998-02-24 | 2005-11-16 | Boston Scientific Limited | High flow rate dialysis catheters and related methods |
US8414543B2 (en) | 1999-10-22 | 2013-04-09 | Rex Medical, L.P. | Rotational thrombectomy wire with blocking device |
ATE402973T1 (de) * | 1999-11-10 | 2008-08-15 | Neil Charles O | Optimierung der nanofüllstoffleistung in polymeren |
US7259448B2 (en) * | 2001-05-07 | 2007-08-21 | Broadcom Corporation | Die-up ball grid array package with a heat spreader and method for making the same |
US7285304B1 (en) | 2003-06-25 | 2007-10-23 | Advanced Cardiovascular Systems, Inc. | Fluid treatment of a polymeric coating on an implantable medical device |
US7989018B2 (en) | 2001-09-17 | 2011-08-02 | Advanced Cardiovascular Systems, Inc. | Fluid treatment of a polymeric coating on an implantable medical device |
US7168605B2 (en) * | 2001-09-18 | 2007-01-30 | Boston Scientific Scimed, Inc. | Microtubes for therapeutic delivery |
US6863683B2 (en) | 2001-09-19 | 2005-03-08 | Abbott Laboratoris Vascular Entities Limited | Cold-molding process for loading a stent onto a stent delivery system |
EP1429833B1 (en) | 2001-09-28 | 2018-02-14 | Boston Scientific Limited | Catheter comprising nanocomposites |
US20030088266A1 (en) * | 2001-11-02 | 2003-05-08 | Bowlin Gary L. | Method of fusing electroprocessed matrices to a substrate |
US7037562B2 (en) * | 2002-01-14 | 2006-05-02 | Vascon Llc | Angioplasty super balloon fabrication with composite materials |
EP1476882A4 (en) * | 2002-01-22 | 2007-01-17 | Nanoset Llc | NANOMAGNETIC SHIELD SUBSTRATE |
WO2003074254A1 (en) * | 2002-02-28 | 2003-09-12 | Scimed Life Systems, Inc. | Ultrasonic assisted apparatus and process |
US20030187495A1 (en) * | 2002-04-01 | 2003-10-02 | Cully Edward H. | Endoluminal devices, embolic filters, methods of manufacture and use |
US7829029B2 (en) * | 2002-05-29 | 2010-11-09 | NanoVibronix, Inv. | Acoustic add-on device for biofilm prevention in urinary catheter |
JP4351832B2 (ja) * | 2002-08-05 | 2009-10-28 | テルモ株式会社 | バルーンカテーテル |
US7794494B2 (en) * | 2002-10-11 | 2010-09-14 | Boston Scientific Scimed, Inc. | Implantable medical devices |
US20040093012A1 (en) | 2002-10-17 | 2004-05-13 | Cully Edward H. | Embolic filter frame having looped support strut elements |
US20040098023A1 (en) * | 2002-11-15 | 2004-05-20 | Scimed Life Systems, Inc. | Embolic device made of nanofibers |
US7162308B2 (en) | 2002-11-26 | 2007-01-09 | Wilson Greatbatch Technologies, Inc. | Nanotube coatings for implantable electrodes |
US20040147955A1 (en) * | 2003-01-28 | 2004-07-29 | Scimed Life Systems, Inc. | Embolic protection filter having an improved filter frame |
KR100512355B1 (ko) * | 2003-02-19 | 2005-09-02 | 주식회사 엘지화학 | 폴리염화비닐 발포체 |
WO2004078785A1 (en) * | 2003-03-03 | 2004-09-16 | Polymers Australia Pty. Limited | Dispersing agents in nanocomposites |
US20040193208A1 (en) * | 2003-03-27 | 2004-09-30 | Scimed Life Systems, Inc. | Radiopaque embolic protection filter membrane |
CN1245220C (zh) | 2003-04-09 | 2006-03-15 | 江苏阳生生物工程有限公司 | 促进皮肤创面快速修复的新型敷料材料 |
US7579077B2 (en) * | 2003-05-05 | 2009-08-25 | Nanosys, Inc. | Nanofiber surfaces for use in enhanced surface area applications |
US7074294B2 (en) * | 2003-04-17 | 2006-07-11 | Nanosys, Inc. | Structures, systems and methods for joining articles and materials and uses therefor |
US20050038498A1 (en) * | 2003-04-17 | 2005-02-17 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
US7972616B2 (en) * | 2003-04-17 | 2011-07-05 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
US20050221072A1 (en) * | 2003-04-17 | 2005-10-06 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
US7056409B2 (en) * | 2003-04-17 | 2006-06-06 | Nanosys, Inc. | Structures, systems and methods for joining articles and materials and uses therefor |
US20060122596A1 (en) * | 2003-04-17 | 2006-06-08 | Nanosys, Inc. | Structures, systems and methods for joining articles and materials and uses therefor |
JP4496360B2 (ja) * | 2003-04-24 | 2010-07-07 | 国立大学法人九州大学 | 医療用高分子ナノ・マイクロファイバー |
JP4871726B2 (ja) * | 2003-04-28 | 2012-02-08 | ナノシス・インク. | 超疎液性表面、その作製法及び用途 |
US7604649B2 (en) * | 2003-04-29 | 2009-10-20 | Rex Medical, L.P. | Distal protection device |
US7331976B2 (en) | 2003-04-29 | 2008-02-19 | Rex Medical, L.P. | Distal protection device |
US7803574B2 (en) | 2003-05-05 | 2010-09-28 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
TWI427709B (zh) * | 2003-05-05 | 2014-02-21 | Nanosys Inc | 用於增加表面面積之應用的奈米纖維表面 |
GB0310300D0 (en) * | 2003-05-06 | 2003-06-11 | Univ Belfast | Nanocomposite drug delivery composition |
US6969396B2 (en) * | 2003-05-07 | 2005-11-29 | Scimed Life Systems, Inc. | Filter membrane with increased surface area |
BRPI0410377A (pt) * | 2003-05-16 | 2006-06-13 | Blue Membranes Gmbh | implantes medicinais revestidos bio-compatìveis |
CA2520122A1 (en) * | 2003-05-16 | 2004-11-25 | Blue Membranes Gmbh | Method for coating substrates with a carbon-based material |
DE10322182A1 (de) * | 2003-05-16 | 2004-12-02 | Blue Membranes Gmbh | Verfahren zur Herstellung von porösem, kohlenstoffbasiertem Material |
DE202004009061U1 (de) * | 2003-05-28 | 2004-08-12 | Blue Membranes Gmbh | Implantate mit funktionalisierten Kohlenstoffoberflächen |
US20040241482A1 (en) * | 2003-06-02 | 2004-12-02 | Grah Michael D. | PVdC film with nanocomposite tie layer |
US7632291B2 (en) * | 2003-06-13 | 2009-12-15 | Trivascular2, Inc. | Inflatable implant |
JP4805148B2 (ja) * | 2003-07-18 | 2011-11-02 | ボストン サイエンティフィック リミテッド | 医療器具 |
JP4617070B2 (ja) * | 2003-07-29 | 2011-01-19 | テルモ株式会社 | 拡張体付カテーテル |
US20050064223A1 (en) * | 2003-09-22 | 2005-03-24 | Bavaro Vincent Peter | Polymeric marker with high radiopacity |
US7198675B2 (en) | 2003-09-30 | 2007-04-03 | Advanced Cardiovascular Systems | Stent mandrel fixture and method for selectively coating surfaces of a stent |
US7618647B2 (en) * | 2003-10-03 | 2009-11-17 | Boston Scientific Scimed, Inc. | Using bucky paper as a therapeutic aid in medical applications |
US20070207179A1 (en) * | 2003-10-14 | 2007-09-06 | Erik Andersen | Medical Device |
US20050084456A1 (en) * | 2003-10-21 | 2005-04-21 | Liping Tang | Functionalized particles |
US20050084513A1 (en) * | 2003-10-21 | 2005-04-21 | Board Of Regents | Nanocoating for improving biocompatibility of medical implants |
US20050096509A1 (en) * | 2003-11-04 | 2005-05-05 | Greg Olson | Nanotube treatments for internal medical devices |
US7163967B2 (en) | 2003-12-01 | 2007-01-16 | Cryovac, Inc. | Method of increasing the gas transmission rate of a film |
WO2005056097A1 (en) * | 2003-12-04 | 2005-06-23 | Boston Scientific Limited | Medical devices |
US20050124976A1 (en) * | 2003-12-04 | 2005-06-09 | Devens Douglas A.Jr. | Medical devices |
JP4808921B2 (ja) * | 2003-12-12 | 2011-11-02 | 川澄化学工業株式会社 | 医療用具及びその製造方法並びに高分子材料とカーボンナノチューブの組成物からなるコーティング剤の製造方法 |
US7335327B2 (en) | 2003-12-31 | 2008-02-26 | Cryovac, Inc. | Method of shrinking a film |
US7854756B2 (en) * | 2004-01-22 | 2010-12-21 | Boston Scientific Scimed, Inc. | Medical devices |
US7702764B1 (en) * | 2004-01-30 | 2010-04-20 | Cisco Technology, Inc. | System and method for testing network protocols |
US8025960B2 (en) | 2004-02-02 | 2011-09-27 | Nanosys, Inc. | Porous substrates, articles, systems and compositions comprising nanofibers and methods of their use and production |
US20110039690A1 (en) | 2004-02-02 | 2011-02-17 | Nanosys, Inc. | Porous substrates, articles, systems and compositions comprising nanofibers and methods of their use and production |
US7537781B2 (en) * | 2004-02-12 | 2009-05-26 | Boston Scientific Scimed, Inc. | Polymer-filler composites for controlled delivery of therapeutic agents from medical articles |
US20050181015A1 (en) * | 2004-02-12 | 2005-08-18 | Sheng-Ping (Samuel) Zhong | Layered silicate nanoparticles for controlled delivery of therapeutic agents from medical articles |
US8974915B2 (en) * | 2004-03-16 | 2015-03-10 | Rensselaer Polytechnic Institute | Block copolymer and nanofiller composites |
US7877150B2 (en) | 2004-03-30 | 2011-01-25 | Medtronic, Inc. | Lead electrode for use in an MRI-safe implantable medical device |
US8989840B2 (en) | 2004-03-30 | 2015-03-24 | Medtronic, Inc. | Lead electrode for use in an MRI-safe implantable medical device |
US9155877B2 (en) | 2004-03-30 | 2015-10-13 | Medtronic, Inc. | Lead electrode for use in an MRI-safe implantable medical device |
US7844343B2 (en) | 2004-03-30 | 2010-11-30 | Medtronic, Inc. | MRI-safe implantable medical device |
US7844344B2 (en) * | 2004-03-30 | 2010-11-30 | Medtronic, Inc. | MRI-safe implantable lead |
US7999455B2 (en) * | 2006-11-13 | 2011-08-16 | Research Triangle Institute | Luminescent device including nanofibers and light stimulable particles disposed on a surface of or at least partially within the nanofibers |
IL161554A0 (en) * | 2004-04-22 | 2004-09-27 | Gali Tech Ltd | Catheter |
US8353867B2 (en) * | 2004-05-04 | 2013-01-15 | Boston Scientific Scimed, Inc. | Medical devices |
US7815624B2 (en) * | 2004-05-18 | 2010-10-19 | Boston Scientific Scimed, Inc. | Medical devices and methods of making the same |
US20050260355A1 (en) * | 2004-05-20 | 2005-11-24 | Jan Weber | Medical devices and methods of making the same |
US7758572B2 (en) * | 2004-05-20 | 2010-07-20 | Boston Scientific Scimed, Inc. | Medical devices and methods including cooling balloons having nanotubes |
US7758892B1 (en) * | 2004-05-20 | 2010-07-20 | Boston Scientific Scimed, Inc. | Medical devices having multiple layers |
US20050277349A1 (en) * | 2004-06-15 | 2005-12-15 | Siemens Westinghouse Power Corporation | High thermal conductivity materials incorporated into resins |
US8568469B1 (en) | 2004-06-28 | 2013-10-29 | Advanced Cardiovascular Systems, Inc. | Stent locking element and a method of securing a stent on a delivery system |
US20110313510A1 (en) * | 2004-06-28 | 2011-12-22 | Abbott Cardiovascular Systems Inc. | Polymer Metal and Composite Implantable Medical Devices |
US7326043B2 (en) * | 2004-06-29 | 2008-02-05 | Cornell Research Foundation, Inc. | Apparatus and method for elevated temperature electrospinning |
US8241554B1 (en) | 2004-06-29 | 2012-08-14 | Advanced Cardiovascular Systems, Inc. | Method of forming a stent pattern on a tube |
US7971333B2 (en) | 2006-05-30 | 2011-07-05 | Advanced Cardiovascular Systems, Inc. | Manufacturing process for polymetric stents |
US7731890B2 (en) | 2006-06-15 | 2010-06-08 | Advanced Cardiovascular Systems, Inc. | Methods of fabricating stents with enhanced fracture toughness |
US8747878B2 (en) | 2006-04-28 | 2014-06-10 | Advanced Cardiovascular Systems, Inc. | Method of fabricating an implantable medical device by controlling crystalline structure |
US8778256B1 (en) | 2004-09-30 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Deformation of a polymer tube in the fabrication of a medical article |
US8747879B2 (en) | 2006-04-28 | 2014-06-10 | Advanced Cardiovascular Systems, Inc. | Method of fabricating an implantable medical device to reduce chance of late inflammatory response |
US20060025848A1 (en) * | 2004-07-29 | 2006-02-02 | Jan Weber | Medical device having a coating layer with structural elements therein and method of making the same |
US9283099B2 (en) | 2004-08-25 | 2016-03-15 | Advanced Cardiovascular Systems, Inc. | Stent-catheter assembly with a releasable connection for stent retention |
US8500797B2 (en) * | 2004-09-08 | 2013-08-06 | Boston Scientific Scimed, Inc. | Medical devices |
US7722578B2 (en) * | 2004-09-08 | 2010-05-25 | Boston Scientific Scimed, Inc. | Medical devices |
US7229471B2 (en) | 2004-09-10 | 2007-06-12 | Advanced Cardiovascular Systems, Inc. | Compositions containing fast-leaching plasticizers for improved performance of medical devices |
US7691932B2 (en) * | 2004-09-27 | 2010-04-06 | 3M Innovative Properties Company | Method of making a composition and nanocomposites therefrom |
JP2006093631A (ja) * | 2004-09-27 | 2006-04-06 | Matsushita Electric Ind Co Ltd | 半導体集積回路の製造方法および半導体集積回路の製造装置 |
US7329702B2 (en) * | 2004-09-27 | 2008-02-12 | 3M Innovative Properties Company | Composition and method of making the same |
US8173062B1 (en) | 2004-09-30 | 2012-05-08 | Advanced Cardiovascular Systems, Inc. | Controlled deformation of a polymer tube in fabricating a medical article |
US7875233B2 (en) | 2004-09-30 | 2011-01-25 | Advanced Cardiovascular Systems, Inc. | Method of fabricating a biaxially oriented implantable medical device |
US8043553B1 (en) | 2004-09-30 | 2011-10-25 | Advanced Cardiovascular Systems, Inc. | Controlled deformation of a polymer tube with a restraining surface in fabricating a medical article |
US8795315B2 (en) | 2004-10-06 | 2014-08-05 | Cook Medical Technologies Llc | Emboli capturing device having a coil and method for capturing emboli |
US20060093642A1 (en) * | 2004-11-03 | 2006-05-04 | Ranade Shrirang V | Method of incorporating carbon nanotubes in a medical appliance, a carbon nanotube medical appliance, and a medical appliance coated using carbon nanotube technology |
JP2006143691A (ja) * | 2004-11-24 | 2006-06-08 | Jfe Engineering Kk | ナノカーボン物質からなる生体組織形成材料 |
DE102004058924A1 (de) | 2004-12-07 | 2006-06-08 | Roche Diagnostics Gmbh | Testelement mit Nanofasern |
US8193270B2 (en) * | 2004-12-14 | 2012-06-05 | 3M Innovative Properties Company | Method of making composites and nanocomposites |
JP2006198393A (ja) * | 2004-12-21 | 2006-08-03 | Shinshu Univ | 医療機器 |
US20060136042A1 (en) * | 2004-12-22 | 2006-06-22 | Scimed Life Systems, Inc. | Vulnerable plaque stent |
US20060149313A1 (en) * | 2004-12-30 | 2006-07-06 | Edward Arguello | Distal protection apparatus with improved wall apposition |
JP2006198078A (ja) * | 2005-01-19 | 2006-08-03 | Terumo Corp | ステント |
US20060165926A1 (en) * | 2005-01-27 | 2006-07-27 | Jan Weber | Medical devices including nanocomposites |
US8280526B2 (en) | 2005-02-01 | 2012-10-02 | Medtronic, Inc. | Extensible implantable medical lead |
US8075906B2 (en) | 2005-02-01 | 2011-12-13 | Boston Scientific Scimed, Inc. | Medical devices having polymeric regions with copolymers containing hydrocarbon and heteroatom-containing monomeric species |
US20060182873A1 (en) * | 2005-02-17 | 2006-08-17 | Klisch Leo M | Medical devices |
US8048028B2 (en) | 2005-02-17 | 2011-11-01 | Boston Scientific Scimed, Inc. | Reinforced medical balloon |
US8945169B2 (en) | 2005-03-15 | 2015-02-03 | Cook Medical Technologies Llc | Embolic protection device |
US8221446B2 (en) | 2005-03-15 | 2012-07-17 | Cook Medical Technologies | Embolic protection device |
US20060224082A1 (en) * | 2005-04-05 | 2006-10-05 | Vetter James W | Methods and devices for removing tissue from a patient and placing a marker in the patient |
US7381048B2 (en) | 2005-04-12 | 2008-06-03 | Advanced Cardiovascular Systems, Inc. | Stents with profiles for gripping a balloon catheter and molds for fabricating stents |
EP1871162B1 (en) * | 2005-04-13 | 2014-03-12 | Nanosys, Inc. | Nanowire dispersion compositions and uses thereof |
US8027736B2 (en) | 2005-04-29 | 2011-09-27 | Medtronic, Inc. | Lead electrode for use in an MRI-safe implantable medical device |
US7853332B2 (en) | 2005-04-29 | 2010-12-14 | Medtronic, Inc. | Lead electrode for use in an MRI-safe implantable medical device |
JP2008540022A (ja) * | 2005-05-17 | 2008-11-20 | ナイキャスト リミテッド | 植込み可能な荷電性医療装置 |
US8033501B2 (en) * | 2005-06-10 | 2011-10-11 | The Boeing Company | Method and apparatus for attaching electrically powered seat track cover to through hole seat track design |
US7850708B2 (en) | 2005-06-20 | 2010-12-14 | Cook Incorporated | Embolic protection device having a reticulated body with staggered struts |
US8109962B2 (en) | 2005-06-20 | 2012-02-07 | Cook Medical Technologies Llc | Retrievable device having a reticulation portion with staggered struts |
FR2887554B1 (fr) * | 2005-06-24 | 2008-04-18 | Arkema Sa | Materiaux polymeres contenant des nanotubes de carbone, leur procede de preparation a partir de pre-melange avec un agent de dispersion |
EP1893689A1 (fr) * | 2005-06-24 | 2008-03-05 | Arkema France | Matériaux polymeres contenant des nanotubes de carbone, leur procede de preparation a partir de pre-melange avec un agent de dispersion |
US20090280064A1 (en) * | 2005-06-24 | 2009-11-12 | Rao Papineni | Transdermal delivery of optical, spect, multimodal, drug or biological cargo laden nanoparticle(s) in small animals or humans |
US9439662B2 (en) | 2005-07-05 | 2016-09-13 | Angioslide Ltd. | Balloon catheter |
US8556851B2 (en) | 2005-07-05 | 2013-10-15 | Angioslide Ltd. | Balloon catheter |
US7771452B2 (en) | 2005-07-12 | 2010-08-10 | Cook Incorporated | Embolic protection device with a filter bag that disengages from a basket |
US7766934B2 (en) | 2005-07-12 | 2010-08-03 | Cook Incorporated | Embolic protection device with an integral basket and bag |
JP2009502261A (ja) * | 2005-07-25 | 2009-01-29 | ナノテクノロジー ビクトリア ピーティーワイ リミテッド | マイクロアレイデバイス |
US7658880B2 (en) | 2005-07-29 | 2010-02-09 | Advanced Cardiovascular Systems, Inc. | Polymeric stent polishing method and apparatus |
US8187298B2 (en) | 2005-08-04 | 2012-05-29 | Cook Medical Technologies Llc | Embolic protection device having inflatable frame |
US20070038290A1 (en) * | 2005-08-15 | 2007-02-15 | Bin Huang | Fiber reinforced composite stents |
US7678841B2 (en) | 2005-08-19 | 2010-03-16 | Cryovac, Inc. | Increasing the gas transmission rate of a film comprising fullerenes |
US9248034B2 (en) | 2005-08-23 | 2016-02-02 | Advanced Cardiovascular Systems, Inc. | Controlled disintegrating implantable medical devices |
US8377092B2 (en) | 2005-09-16 | 2013-02-19 | Cook Medical Technologies Llc | Embolic protection device |
US20100259259A1 (en) * | 2005-09-21 | 2010-10-14 | Markus Zahn | Systems and methods for tuning properties of nanoparticles |
US8632562B2 (en) | 2005-10-03 | 2014-01-21 | Cook Medical Technologies Llc | Embolic protection device |
US8182508B2 (en) | 2005-10-04 | 2012-05-22 | Cook Medical Technologies Llc | Embolic protection device |
US8252017B2 (en) | 2005-10-18 | 2012-08-28 | Cook Medical Technologies Llc | Invertible filter for embolic protection |
US8216269B2 (en) | 2005-11-02 | 2012-07-10 | Cook Medical Technologies Llc | Embolic protection device having reduced profile |
US9440003B2 (en) * | 2005-11-04 | 2016-09-13 | Boston Scientific Scimed, Inc. | Medical devices having particle-containing regions with diamond-like coatings |
US20070112115A1 (en) * | 2005-11-15 | 2007-05-17 | Shalaby Shalaby W | Inorganic-organic hybrid micro-/nanofibers |
US8152831B2 (en) | 2005-11-17 | 2012-04-10 | Cook Medical Technologies Llc | Foam embolic protection device |
US7867169B2 (en) * | 2005-12-02 | 2011-01-11 | Abbott Cardiovascular Systems Inc. | Echogenic needle catheter configured to produce an improved ultrasound image |
US20070135751A1 (en) * | 2005-12-09 | 2007-06-14 | Dicarlo Paul D | Medical devices |
WO2007075585A2 (en) * | 2005-12-16 | 2007-07-05 | Interface Associates, Inc. | Multi-layer balloons for medical applications and methods for manufacturing the same |
US7867547B2 (en) | 2005-12-19 | 2011-01-11 | Advanced Cardiovascular Systems, Inc. | Selectively coating luminal surfaces of stents |
US20070156230A1 (en) | 2006-01-04 | 2007-07-05 | Dugan Stephen R | Stents with radiopaque markers |
US7951185B1 (en) | 2006-01-06 | 2011-05-31 | Advanced Cardiovascular Systems, Inc. | Delivery of a stent at an elevated temperature |
US8663674B2 (en) * | 2006-01-13 | 2014-03-04 | Surmodics, Inc. | Microparticle containing matrices for drug delivery |
US20070191766A1 (en) * | 2006-02-10 | 2007-08-16 | Boston Scientific Scimed, Inc. | Balloon catheter having nanotubes |
EP3613813A1 (en) * | 2006-02-28 | 2020-02-26 | Alchimer | Formation of organic electro-grafted films on the surface of electrically conductive or semi-conductive surfaces |
US20070207182A1 (en) * | 2006-03-06 | 2007-09-06 | Jan Weber | Medical devices having electrically aligned elongated particles |
US7964210B2 (en) | 2006-03-31 | 2011-06-21 | Abbott Cardiovascular Systems Inc. | Degradable polymeric implantable medical devices with a continuous phase and discrete phase |
US7846175B2 (en) | 2006-04-03 | 2010-12-07 | Medrad, Inc. | Guidewire and collapsable filter system |
US20070249754A1 (en) * | 2006-04-25 | 2007-10-25 | Medtronic, Inc. | Methods of modifying polyurethanes using surface treated clay |
US8003156B2 (en) | 2006-05-04 | 2011-08-23 | Advanced Cardiovascular Systems, Inc. | Rotatable support elements for stents |
US8574315B2 (en) * | 2006-05-09 | 2013-11-05 | The University Of Akron | Electrospun structures and methods for forming and using same |
US7794402B2 (en) * | 2006-05-15 | 2010-09-14 | Advanced Cardiovascular Systems, Inc. | Echogenic needle catheter configured to produce an improved ultrasound image |
US7761968B2 (en) | 2006-05-25 | 2010-07-27 | Advanced Cardiovascular Systems, Inc. | Method of crimping a polymeric stent |
US8752267B2 (en) | 2006-05-26 | 2014-06-17 | Abbott Cardiovascular Systems Inc. | Method of making stents with radiopaque markers |
US7951194B2 (en) | 2006-05-26 | 2011-05-31 | Abbott Cardiovascular Sysetms Inc. | Bioabsorbable stent with radiopaque coating |
US20070282434A1 (en) * | 2006-05-30 | 2007-12-06 | Yunbing Wang | Copolymer-bioceramic composite implantable medical devices |
US7959940B2 (en) * | 2006-05-30 | 2011-06-14 | Advanced Cardiovascular Systems, Inc. | Polymer-bioceramic composite implantable medical devices |
US8343530B2 (en) | 2006-05-30 | 2013-01-01 | Abbott Cardiovascular Systems Inc. | Polymer-and polymer blend-bioceramic composite implantable medical devices |
US7842737B2 (en) * | 2006-09-29 | 2010-11-30 | Abbott Cardiovascular Systems Inc. | Polymer blend-bioceramic composite implantable medical devices |
US8486135B2 (en) | 2006-06-01 | 2013-07-16 | Abbott Cardiovascular Systems Inc. | Implantable medical devices fabricated from branched polymers |
US8034287B2 (en) | 2006-06-01 | 2011-10-11 | Abbott Cardiovascular Systems Inc. | Radiation sterilization of medical devices |
EP1873205A1 (en) * | 2006-06-12 | 2008-01-02 | Corning Incorporated | Thermo-responsive blends and uses thereof |
US20080153077A1 (en) * | 2006-06-12 | 2008-06-26 | David Henry | Substrates for immobilizing cells and tissues and methods of use thereof |
US8603530B2 (en) | 2006-06-14 | 2013-12-10 | Abbott Cardiovascular Systems Inc. | Nanoshell therapy |
US8048448B2 (en) | 2006-06-15 | 2011-11-01 | Abbott Cardiovascular Systems Inc. | Nanoshells for drug delivery |
US8535372B1 (en) | 2006-06-16 | 2013-09-17 | Abbott Cardiovascular Systems Inc. | Bioabsorbable stent with prohealing layer |
US8333000B2 (en) | 2006-06-19 | 2012-12-18 | Advanced Cardiovascular Systems, Inc. | Methods for improving stent retention on a balloon catheter |
EP2034927B1 (en) * | 2006-06-20 | 2012-01-25 | Boston Scientific Limited | Medical devices including composites |
US8017237B2 (en) | 2006-06-23 | 2011-09-13 | Abbott Cardiovascular Systems, Inc. | Nanoshells on polymers |
US9072820B2 (en) | 2006-06-26 | 2015-07-07 | Advanced Cardiovascular Systems, Inc. | Polymer composite stent with polymer particles |
US8128688B2 (en) | 2006-06-27 | 2012-03-06 | Abbott Cardiovascular Systems Inc. | Carbon coating on an implantable device |
US20080234810A1 (en) * | 2006-06-28 | 2008-09-25 | Abbott Cardiovascular Systems Inc. | Amorphous Glass-Coated Drug Delivery Medical Device |
US7638344B2 (en) * | 2006-06-28 | 2009-12-29 | Surmodics, Inc. | Active agent eluting matrices with particulates |
US7794776B1 (en) | 2006-06-29 | 2010-09-14 | Abbott Cardiovascular Systems Inc. | Modification of polymer stents with radiation |
US7740791B2 (en) | 2006-06-30 | 2010-06-22 | Advanced Cardiovascular Systems, Inc. | Method of fabricating a stent with features by blow molding |
US20080009938A1 (en) * | 2006-07-07 | 2008-01-10 | Bin Huang | Stent with a radiopaque marker and method for making the same |
US7823263B2 (en) | 2006-07-11 | 2010-11-02 | Abbott Cardiovascular Systems Inc. | Method of removing stent islands from a stent |
US7757543B2 (en) | 2006-07-13 | 2010-07-20 | Advanced Cardiovascular Systems, Inc. | Radio frequency identification monitoring of stents |
US7998404B2 (en) | 2006-07-13 | 2011-08-16 | Advanced Cardiovascular Systems, Inc. | Reduced temperature sterilization of stents |
US7794495B2 (en) | 2006-07-17 | 2010-09-14 | Advanced Cardiovascular Systems, Inc. | Controlled degradation of stents |
US7886419B2 (en) | 2006-07-18 | 2011-02-15 | Advanced Cardiovascular Systems, Inc. | Stent crimping apparatus and method |
ES2289948B1 (es) * | 2006-07-19 | 2008-09-16 | Starlab Barcelona, S.L. | Sensor electrofisiologico. |
US8016879B2 (en) | 2006-08-01 | 2011-09-13 | Abbott Cardiovascular Systems Inc. | Drug delivery after biodegradation of the stent scaffolding |
US9265866B2 (en) * | 2006-08-01 | 2016-02-23 | Abbott Cardiovascular Systems Inc. | Composite polymeric and metallic stent with radiopacity |
US20080124373A1 (en) * | 2006-08-02 | 2008-05-29 | Inframat Corporation | Lumen - supporting devices and methods of making and using |
WO2008016712A2 (en) * | 2006-08-02 | 2008-02-07 | Inframat Corporation | Medical devices and methods of making and using |
US9173733B1 (en) | 2006-08-21 | 2015-11-03 | Abbott Cardiovascular Systems Inc. | Tracheobronchial implantable medical device and methods of use |
US20080051759A1 (en) * | 2006-08-24 | 2008-02-28 | Boston Scientific Scimed, Inc. | Polycarbonate polyurethane venous access devices |
KR20090049094A (ko) * | 2006-09-06 | 2009-05-15 | 코닝 인코포레이티드 | 나노섬유, 나노필름, 및 이들의 제조/사용 방법 |
US8216267B2 (en) | 2006-09-12 | 2012-07-10 | Boston Scientific Scimed, Inc. | Multilayer balloon for bifurcated stent delivery and methods of making and using the same |
US7923022B2 (en) | 2006-09-13 | 2011-04-12 | Advanced Cardiovascular Systems, Inc. | Degradable polymeric implantable medical devices with continuous phase and discrete phase |
US20080071307A1 (en) | 2006-09-19 | 2008-03-20 | Cook Incorporated | Apparatus and methods for in situ embolic protection |
US8394488B2 (en) | 2006-10-06 | 2013-03-12 | Cordis Corporation | Bioabsorbable device having composite structure for accelerating degradation |
US8828419B2 (en) * | 2006-10-06 | 2014-09-09 | Cordis Corporation | Bioabsorbable device having encapsulated additives for accelerating degradation |
JP2008125683A (ja) * | 2006-11-17 | 2008-06-05 | Kanazawa Inst Of Technology | カテーテルおよびその製造方法 |
US7641844B2 (en) * | 2006-12-11 | 2010-01-05 | Cook Incorporated | Method of making a fiber-reinforced medical balloon |
US8099849B2 (en) | 2006-12-13 | 2012-01-24 | Abbott Cardiovascular Systems Inc. | Optimizing fracture toughness of polymeric stent |
US9175422B2 (en) * | 2007-01-22 | 2015-11-03 | The United States Of America As Represented By The Secretary Of The Army | Polymer-micelle complex as an aid to electrospinning |
US20080188825A1 (en) * | 2007-02-01 | 2008-08-07 | Liliana Atanasoska | Catheters and medical balloons |
DE102007005817A1 (de) * | 2007-02-06 | 2008-08-14 | Laser Zentrum Hannover E.V. | Biologisch wirksame Vorrichtung und Verfahren zu ihrer Herstellung |
US9044593B2 (en) | 2007-02-14 | 2015-06-02 | Medtronic, Inc. | Discontinuous conductive filler polymer-matrix composites for electromagnetic shielding |
US10537730B2 (en) | 2007-02-14 | 2020-01-21 | Medtronic, Inc. | Continuous conductive materials for electromagnetic shielding |
US9901434B2 (en) | 2007-02-27 | 2018-02-27 | Cook Medical Technologies Llc | Embolic protection device including a Z-stent waist band |
US8372427B2 (en) | 2007-03-05 | 2013-02-12 | Abbott Cardiovascular Systems Inc. | Therapeutic composition with enhanced endothelium targeting |
AU2008224435B2 (en) | 2007-03-15 | 2014-01-09 | Ortho-Space Ltd. | Prosthetic devices and methods for using same |
WO2008122085A1 (en) * | 2007-04-04 | 2008-10-16 | Newsouth Innovations Pty Limited | Nanocomposites |
EP2139677A4 (en) * | 2007-04-05 | 2010-12-29 | Politechnic Inst Univ New York | IMPROVEMENTS OF NANOCOMPOSITES AND ITS SURFACES |
US8262723B2 (en) | 2007-04-09 | 2012-09-11 | Abbott Cardiovascular Systems Inc. | Implantable medical devices fabricated from polymer blends with star-block copolymers |
US8483842B2 (en) | 2007-04-25 | 2013-07-09 | Medtronic, Inc. | Lead or lead extension having a conductive body and conductive body contact |
US20080287984A1 (en) * | 2007-05-18 | 2008-11-20 | Jan Weber | Medical balloons and methods of making the same |
US7829008B2 (en) | 2007-05-30 | 2010-11-09 | Abbott Cardiovascular Systems Inc. | Fabricating a stent from a blow molded tube |
US7959857B2 (en) | 2007-06-01 | 2011-06-14 | Abbott Cardiovascular Systems Inc. | Radiation sterilization of medical devices |
EP2167180B1 (en) * | 2007-06-01 | 2015-03-04 | Covidien LP | Extension tubes for balloon catheters |
US8202528B2 (en) | 2007-06-05 | 2012-06-19 | Abbott Cardiovascular Systems Inc. | Implantable medical devices with elastomeric block copolymer coatings |
US8293260B2 (en) | 2007-06-05 | 2012-10-23 | Abbott Cardiovascular Systems Inc. | Elastomeric copolymer coatings containing poly (tetramethyl carbonate) for implantable medical devices |
US8425591B1 (en) | 2007-06-11 | 2013-04-23 | Abbott Cardiovascular Systems Inc. | Methods of forming polymer-bioceramic composite medical devices with bioceramic particles |
US8048441B2 (en) | 2007-06-25 | 2011-11-01 | Abbott Cardiovascular Systems, Inc. | Nanobead releasing medical devices |
US7901452B2 (en) | 2007-06-27 | 2011-03-08 | Abbott Cardiovascular Systems Inc. | Method to fabricate a stent having selected morphology to reduce restenosis |
US7955381B1 (en) | 2007-06-29 | 2011-06-07 | Advanced Cardiovascular Systems, Inc. | Polymer-bioceramic composite implantable medical device with different types of bioceramic particles |
DE102007034019A1 (de) * | 2007-07-20 | 2009-01-22 | Biotronik Vi Patent Ag | Stent mit einer Beschichtung oder Füllung einer Kavität |
US7979108B2 (en) * | 2007-08-27 | 2011-07-12 | William Harrison Zurn | Automated vessel repair system, devices and methods |
EP2842582B1 (en) * | 2007-09-06 | 2018-06-20 | Boston Scientific Limited | Medical devices containing silicate and carbon particles |
US9138307B2 (en) | 2007-09-14 | 2015-09-22 | Cook Medical Technologies Llc | Expandable device for treatment of a stricture in a body vessel |
US8419748B2 (en) | 2007-09-14 | 2013-04-16 | Cook Medical Technologies Llc | Helical thrombus removal device |
US8252018B2 (en) | 2007-09-14 | 2012-08-28 | Cook Medical Technologies Llc | Helical embolic protection device |
WO2009052506A1 (en) * | 2007-10-19 | 2009-04-23 | Navilyst Medical, Inc. | Recirculation minimizing catheter |
WO2009055782A1 (en) * | 2007-10-26 | 2009-04-30 | Possis Medical, Inc. | Intravascular guidewire filter system for pulmonary embolism protection and embolism removal or maceration |
US8304595B2 (en) * | 2007-12-06 | 2012-11-06 | Nanosys, Inc. | Resorbable nanoenhanced hemostatic structures and bandage materials |
US8319002B2 (en) * | 2007-12-06 | 2012-11-27 | Nanosys, Inc. | Nanostructure-enhanced platelet binding and hemostatic structures |
US8998974B2 (en) * | 2007-12-17 | 2015-04-07 | Cook Medical Technologies Llc | Woven fabric with carbon nanotube strands |
US9037263B2 (en) | 2008-03-12 | 2015-05-19 | Medtronic, Inc. | System and method for implantable medical device lead shielding |
JP2011515635A (ja) | 2008-03-18 | 2011-05-19 | サン−ゴバン パフォーマンス プラスティックス コーポレイション | 流体移送アセンブリおよび関連方法 |
US8827951B2 (en) | 2008-07-02 | 2014-09-09 | Doron Besser | Balloon catheter system and methods of use thereof |
US8187221B2 (en) * | 2008-07-11 | 2012-05-29 | Nexeon Medsystems, Inc. | Nanotube-reinforced balloons for delivering therapeutic agents within or beyond the wall of blood vessels, and methods of making and using same |
US10086079B2 (en) | 2008-08-11 | 2018-10-02 | Fibralign Corporation | Biocomposites and methods of making the same |
US8049061B2 (en) | 2008-09-25 | 2011-11-01 | Abbott Cardiovascular Systems, Inc. | Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery |
US8076529B2 (en) * | 2008-09-26 | 2011-12-13 | Abbott Cardiovascular Systems, Inc. | Expandable member formed of a fibrous matrix for intraluminal drug delivery |
US8500687B2 (en) | 2008-09-25 | 2013-08-06 | Abbott Cardiovascular Systems Inc. | Stent delivery system having a fibrous matrix covering with improved stent retention |
US8226603B2 (en) * | 2008-09-25 | 2012-07-24 | Abbott Cardiovascular Systems Inc. | Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery |
US8540889B1 (en) | 2008-11-19 | 2013-09-24 | Nanosys, Inc. | Methods of generating liquidphobic surfaces |
US20100159195A1 (en) * | 2008-12-24 | 2010-06-24 | Quincy Iii Roger B | High repellency materials via nanotopography and post treatment |
US8388644B2 (en) | 2008-12-29 | 2013-03-05 | Cook Medical Technologies Llc | Embolic protection device and method of use |
US20100233227A1 (en) * | 2009-03-10 | 2010-09-16 | Boston Scientific Scimed, Inc. | Medical devices having carbon drug releasing layers |
US20100256546A1 (en) * | 2009-04-03 | 2010-10-07 | Davis Scott A | Polycarbonate Polyurethane Venous Access Devices Having Enhanced Strength |
US8636803B2 (en) | 2009-04-07 | 2014-01-28 | Spinal Stabilization Technologies, Llc | Percutaneous implantable nuclear prosthesis |
EP2808054B1 (en) | 2009-04-30 | 2019-01-02 | Medtronic Inc. | Grounding of a shield within an implantable medical lead |
US20100285085A1 (en) * | 2009-05-07 | 2010-11-11 | Abbott Cardiovascular Systems Inc. | Balloon coating with drug transfer control via coating thickness |
US8246576B2 (en) | 2009-05-18 | 2012-08-21 | Surmodics, Inc. | Method and apparatus for delivery of a therapeutic agent with an expandable medical device |
US20110071500A1 (en) * | 2009-09-21 | 2011-03-24 | Navilyst Medical, Inc. | Branched catheter tip |
WO2011041643A2 (en) * | 2009-10-01 | 2011-04-07 | University Of Houston System | Organoclay-polyurea nanocomposites |
US20110137333A1 (en) * | 2009-12-04 | 2011-06-09 | Boston Scientific Scimed, Inc. | Embolic protection device |
FR2954451B1 (fr) * | 2009-12-21 | 2012-03-02 | Technip France | Conduite flexible sous-marine comprenant une couche comprenant une resine polyamide comprenant un silsesquioxane oligomerique polyedrique |
US8361140B2 (en) | 2009-12-29 | 2013-01-29 | Boston Scientific Scimed, Inc. | High strength low opening pressure stent design |
US8328760B2 (en) * | 2010-01-11 | 2012-12-11 | Angiodynamics, Inc. | Occlusion resistant catheter |
US9675780B2 (en) | 2010-01-19 | 2017-06-13 | Angioslide Ltd. | Balloon catheter system and methods of making and use thereof |
US8568471B2 (en) | 2010-01-30 | 2013-10-29 | Abbott Cardiovascular Systems Inc. | Crush recoverable polymer scaffolds |
US8808353B2 (en) | 2010-01-30 | 2014-08-19 | Abbott Cardiovascular Systems Inc. | Crush recoverable polymer scaffolds having a low crossing profile |
WO2012006373A1 (en) | 2010-07-06 | 2012-01-12 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Systems and methods for magnetized stent having growth-promoting properties |
US10065046B2 (en) | 2010-07-15 | 2018-09-04 | Fibralign Corporation | Conductive biopolymer implant for enhancing tissue repair and regeneration using electromagnetic fields |
US8784373B2 (en) * | 2010-09-02 | 2014-07-22 | California Institute Of Technology | Drug delivery by carbon nanotube arrays |
EP2613818B1 (en) | 2010-09-10 | 2019-02-13 | Fibralign Corp. | Biodegradable multilayer constructs |
EP2659034B1 (en) * | 2010-12-29 | 2019-02-20 | University of Pittsburgh - Of the Commonwealth System of Higher Education | System and method for mandrel-less electrospinning |
WO2012096995A2 (en) * | 2011-01-11 | 2012-07-19 | Boston Scientific Scimed, Inc. | Coated medical devices |
US10653511B2 (en) | 2011-01-28 | 2020-05-19 | Merit Medical Systems, Inc. | Electrospun PTFE coated stent and method of use |
US9999746B2 (en) | 2011-03-22 | 2018-06-19 | Angiodynamics, Inc. | High flow catheters |
US9050435B2 (en) | 2011-03-22 | 2015-06-09 | Angiodynamics, Inc. | High flow catheters |
US9861727B2 (en) | 2011-05-20 | 2018-01-09 | Surmodics, Inc. | Delivery of hydrophobic active agent particles |
US10213529B2 (en) | 2011-05-20 | 2019-02-26 | Surmodics, Inc. | Delivery of coated hydrophobic active agent particles |
US8726483B2 (en) | 2011-07-29 | 2014-05-20 | Abbott Cardiovascular Systems Inc. | Methods for uniform crimping and deployment of a polymer scaffold |
US10238769B2 (en) | 2011-10-11 | 2019-03-26 | Fibralign Corporation | Graft for directed vascular and lymphatic regeneration and methods to guide endothelial cell assembly |
WO2013057566A2 (en) | 2011-10-18 | 2013-04-25 | Ortho-Space Ltd. | Prosthetic devices and methods for using same |
CN103165211B (zh) * | 2011-12-15 | 2015-09-30 | 清华大学 | 起搏器电极线及起搏器 |
CN110064076A (zh) | 2012-01-16 | 2019-07-30 | 麦瑞通医疗设备有限公司 | 被旋转纺丝材料覆盖的医疗器械和制造方法 |
US9707339B2 (en) | 2012-03-28 | 2017-07-18 | Angiodynamics, Inc. | High flow rate dual reservoir port system |
US9713704B2 (en) | 2012-03-29 | 2017-07-25 | Bradley D. Chartrand | Port reservoir cleaning system and method |
EP2838609B1 (en) | 2012-04-19 | 2019-03-06 | Medtronic, Inc. | Paired medical lead bodies with braided conductive shields having different physical parameter values |
CN104780952A (zh) | 2012-07-02 | 2015-07-15 | 波士顿科学医学有限公司 | 假体心脏瓣膜形成 |
US20140012304A1 (en) * | 2012-07-03 | 2014-01-09 | Merit Medical Systems, Inc. | Multilayered balloon |
CN104640918A (zh) * | 2012-07-23 | 2015-05-20 | 阿克伦大学 | 含有有机改性蒙脱石的基于聚异丁烯的聚氨酯 |
KR101394396B1 (ko) * | 2012-08-06 | 2014-05-13 | 광주과학기술원 | 공유결합 망상구조를 가지는 다공성 고분자 분리막 및 그 제조방법 |
US9332998B2 (en) | 2012-08-13 | 2016-05-10 | Covidien Lp | Apparatus and methods for clot disruption and evacuation |
US9332999B2 (en) | 2012-08-13 | 2016-05-10 | Covidien Lp | Apparatus and methods for clot disruption and evacuation |
US9204887B2 (en) | 2012-08-14 | 2015-12-08 | W. L. Gore & Associates, Inc. | Devices and systems for thrombus treatment |
US11541154B2 (en) | 2012-09-19 | 2023-01-03 | Merit Medical Systems, Inc. | Electrospun material covered medical appliances and methods of manufacture |
US9198999B2 (en) | 2012-09-21 | 2015-12-01 | Merit Medical Systems, Inc. | Drug-eluting rotational spun coatings and methods of use |
US11246963B2 (en) | 2012-11-05 | 2022-02-15 | Surmodics, Inc. | Compositions and methods for delivery of hydrophobic active agents |
CA2890205C (en) | 2012-11-05 | 2020-12-22 | Surmodics, Inc. | Composition and method for delivery of hydrophobic active agents |
US9205242B2 (en) | 2012-11-19 | 2015-12-08 | Angiodynamics, Inc. | Port septum with integral valve |
WO2014087395A1 (en) | 2012-12-04 | 2014-06-12 | Angioslide Ltd | Balloon catheter and methods of use thereof |
MX2013001220A (es) * | 2013-01-30 | 2014-07-30 | Equipos Médicos Vizcarra S A | Cateter intravenoso de material compuesto polimerico con nanoparticulas orientadas, de bajo coeficiente de friccion y baja adherencia microbiana. |
US20180360586A9 (en) * | 2013-03-07 | 2018-12-20 | Merit Medical Systems, Inc. | Embolic filter balloon |
WO2014159399A1 (en) | 2013-03-13 | 2014-10-02 | Merit Medical Systems, Inc. | Methods, systems, and apparatuses for manufacturing rotational spun appliances |
US10799617B2 (en) | 2013-03-13 | 2020-10-13 | Merit Medical Systems, Inc. | Serially deposited fiber materials and associated devices and methods |
US20140277467A1 (en) | 2013-03-14 | 2014-09-18 | Spinal Stabilization Technologies, Llc | Prosthetic Spinal Disk Nucleus |
US9295479B2 (en) | 2013-03-14 | 2016-03-29 | Spinal Stabilization Technologies, Llc | Surgical device |
WO2015054654A1 (en) | 2013-10-10 | 2015-04-16 | Fibralign Corporation | Method and device for lymphedema treatment |
US9993638B2 (en) | 2013-12-14 | 2018-06-12 | Medtronic, Inc. | Devices, systems and methods to reduce coupling of a shield and a conductor within an implantable medical lead |
US10166321B2 (en) | 2014-01-09 | 2019-01-01 | Angiodynamics, Inc. | High-flow port and infusion needle systems |
KR20150121941A (ko) * | 2014-04-22 | 2015-10-30 | 삼성메디슨 주식회사 | 초음파 프로브 |
US10166372B2 (en) | 2014-06-06 | 2019-01-01 | Cook Medical Technologies Llc | Angioplasty balloon improved with graphene |
US9675478B2 (en) | 2014-06-11 | 2017-06-13 | Abbott Cardiovascular Systems Inc. | Solvent method for forming a polymer scaffolding |
US9381280B2 (en) | 2014-06-13 | 2016-07-05 | Abbott Cardiovascular Systems Inc. | Plasticizers for a biodegradable scaffolding and methods of forming same |
US10279171B2 (en) | 2014-07-23 | 2019-05-07 | Medtronic, Inc. | Methods of shielding implantable medical leads and implantable medical lead extensions |
US10155111B2 (en) | 2014-07-24 | 2018-12-18 | Medtronic, Inc. | Methods of shielding implantable medical leads and implantable medical lead extensions |
WO2016073587A1 (en) | 2014-11-04 | 2016-05-12 | Spinal Stabilization Technologies Llc | Percutaneous implantable nuclear prosthesis |
CA2966748C (en) | 2014-11-04 | 2023-03-21 | Spinal Stabilization Technologies Llc | Percutaneous implantable nuclear prosthesis |
US9999527B2 (en) | 2015-02-11 | 2018-06-19 | Abbott Cardiovascular Systems Inc. | Scaffolds having radiopaque markers |
EP3785677A1 (en) | 2015-02-26 | 2021-03-03 | Merit Medical Systems, Inc. | Layered medical appliances |
US10314696B2 (en) | 2015-04-09 | 2019-06-11 | Boston Scientific Scimed, Inc. | Prosthetic heart valves having fiber reinforced leaflets |
US10426609B2 (en) | 2015-04-09 | 2019-10-01 | Boston Scientific Scimed, Inc. | Fiber reinforced prosthetic heart valve having undulating fibers |
US10299915B2 (en) | 2015-04-09 | 2019-05-28 | Boston Scientific Scimed, Inc. | Synthetic heart valves composed of zwitterionic polymers |
US9700443B2 (en) | 2015-06-12 | 2017-07-11 | Abbott Cardiovascular Systems Inc. | Methods for attaching a radiopaque marker to a scaffold |
US10716671B2 (en) | 2015-07-02 | 2020-07-21 | Boston Scientific Scimed, Inc. | Prosthetic heart valve composed of composite fibers |
US10413403B2 (en) | 2015-07-14 | 2019-09-17 | Boston Scientific Scimed, Inc. | Prosthetic heart valve including self-reinforced composite leaflets |
CN108348227B (zh) | 2015-09-01 | 2021-03-09 | 脊柱稳定技术有限责任公司 | 可植入的核假体 |
US10195023B2 (en) | 2015-09-15 | 2019-02-05 | Boston Scientific Scimed, Inc. | Prosthetic heart valves including pre-stressed fibers |
US10959761B2 (en) | 2015-09-18 | 2021-03-30 | Ortho-Space Ltd. | Intramedullary fixated subacromial spacers |
US11389283B2 (en) * | 2016-05-11 | 2022-07-19 | W. L. Gore & Associates, Inc. | Filter and occluder systems and associated methods and devices |
US10368982B2 (en) | 2016-05-19 | 2019-08-06 | Boston Scientific Scimed, Inc. | Prosthetic valves, valve leaflets and related methods |
US10898446B2 (en) | 2016-12-20 | 2021-01-26 | Surmodics, Inc. | Delivery of hydrophobic active agents from hydrophilic polyether block amide copolymer surfaces |
US11045981B2 (en) | 2017-01-30 | 2021-06-29 | Ortho-Space Ltd. | Processing machine and methods for processing dip-molded articles |
US10857575B2 (en) * | 2017-02-27 | 2020-12-08 | Nanovation Partners LLC | Shelf-life-improved nanostructured implant systems and methods |
JP6946464B2 (ja) | 2017-04-25 | 2021-10-06 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | 生体適合性ポリイソブチレン−繊維複合材料及び方法 |
US11541148B2 (en) | 2018-04-30 | 2023-01-03 | The Regents Of The University Of Michigan | POSS nanocomposite hydrogel for 3D bioprinting |
EP3829468A4 (en) | 2018-09-04 | 2022-08-10 | Spinal Stabilization Technologies LLC | IMPLANTABLE NUCLEAR PROSTHESIS, KITS AND RELATED PROCEDURES |
DE102019121559A1 (de) * | 2019-08-09 | 2021-02-11 | Acandis Gmbh | Medizinische Vorrichtung zur Einfuhr in ein Körperhohlorgan sowie Verfahren zur Herstellung einer medizinischen Vorrichtung |
KR102281872B1 (ko) * | 2020-01-10 | 2021-07-26 | 차의과학대학교 산학협력단 | 두 방향 연신을 포함하는 의료용 튜브의 제조방법 |
GB2623366A (en) * | 2022-10-14 | 2024-04-17 | Liberum Health Ltd | Drug delivery device |
Family Cites Families (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3442736A1 (de) | 1984-11-23 | 1986-06-05 | Tassilo Dr.med. 7800 Freiburg Bonzel | Dilatationskatheter |
US5350395A (en) | 1986-04-15 | 1994-09-27 | Yock Paul G | Angioplasty apparatus facilitating rapid exchanges |
US5040548A (en) | 1989-06-01 | 1991-08-20 | Yock Paul G | Angioplasty mehtod |
SE8702840D0 (sv) * | 1987-07-10 | 1987-07-10 | Plm Ab | Barrierforsterkning |
AU611181B2 (en) | 1987-07-27 | 1991-06-06 | Constar International Inc. | Improvements in and relating to packaging |
US5156594A (en) | 1990-08-28 | 1992-10-20 | Scimed Life Systems, Inc. | Balloon catheter with distal guide wire lumen |
US4950227A (en) * | 1988-11-07 | 1990-08-21 | Boston Scientific Corporation | Stent delivery system |
DE68915150T2 (de) * | 1989-01-30 | 1994-10-13 | Bard Inc C R | Schnell austauschbarer Koronarkatheter. |
ES2043289T3 (es) * | 1989-09-25 | 1993-12-16 | Schneider Usa Inc | La extrusion de capas multiples como procedimiento para hacer balones de angioplastia. |
US5195969A (en) * | 1991-04-26 | 1993-03-23 | Boston Scientific Corporation | Co-extruded medical balloons and catheter using such balloons |
WO1993004117A1 (en) * | 1991-08-12 | 1993-03-04 | Allied-Signal Inc. | Melt process formation of polymer nanocomposite of exfoliated layered material |
US5811447A (en) * | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
WO1993011190A1 (en) | 1991-11-26 | 1993-06-10 | Allied-Signal Inc. | Polymer nanocomposites formed by melt processing of a polymer and an exfoliated layered material derivatized with reactive organo silanes |
US6663881B2 (en) * | 1993-01-28 | 2003-12-16 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
EP0738168B1 (en) * | 1993-10-01 | 2004-01-21 | Boston Scientific Corporation | Medical device balloons containing thermoplastic elastomers |
ATE184799T1 (de) * | 1993-10-27 | 1999-10-15 | Schneider Europ Gmbh | Eingriffskatheter |
JP3373277B2 (ja) * | 1993-12-28 | 2003-02-04 | 住友ゴム工業株式会社 | 塗装ゴルフボール |
US5538510A (en) | 1994-01-31 | 1996-07-23 | Cordis Corporation | Catheter having coextruded tubing |
US5554670A (en) * | 1994-09-12 | 1996-09-10 | Cornell Research Foundation, Inc. | Method of preparing layered silicate-epoxy nanocomposites |
ES2196096T3 (es) | 1994-12-14 | 2003-12-16 | Continental Pet Technologies | Envase transparente que contiene un agente de supresion de oxigeno de policetona alifatica. |
US5534007A (en) | 1995-05-18 | 1996-07-09 | Scimed Life Systems, Inc. | Stent deployment catheter with collapsible sheath |
US5811481A (en) | 1995-06-07 | 1998-09-22 | Elf Atochem North America, Inc. | Lithographic ink |
EP0830381A4 (en) * | 1995-06-09 | 2000-11-22 | William N Drohan | CHITINE HYDROGELS, PRODUCTION METHOD AND USE |
US6126740A (en) * | 1995-09-29 | 2000-10-03 | Midwest Research Institute | Solution synthesis of mixed-metal chalcogenide nanoparticles and spray deposition of precursor films |
US5836926A (en) | 1996-05-13 | 1998-11-17 | Schneider (Usa) Inc | Intravascular catheter |
US5853886A (en) * | 1996-06-17 | 1998-12-29 | Claytec, Inc. | Hybrid nanocomposites comprising layered inorganic material and methods of preparation |
US6016848A (en) * | 1996-07-16 | 2000-01-25 | W. L. Gore & Associates, Inc. | Fluoropolymer tubes and methods of making same |
US6933331B2 (en) * | 1998-05-22 | 2005-08-23 | Nanoproducts Corporation | Nanotechnology for drug delivery, contrast agents and biomedical implants |
AU6239998A (en) | 1997-01-13 | 1998-08-03 | Dendritech Inc. | Nanocomposites of dendritic polymers |
DE69803365T2 (de) * | 1997-02-04 | 2002-10-31 | Bekaert Sa Nv | Beschichtung enthaltend filme aus diamantartigem kohlenstoff und diamantartigem nanokomposit |
US5814064A (en) | 1997-03-06 | 1998-09-29 | Scimed Life Systems, Inc. | Distal protection device |
US5948483A (en) * | 1997-03-25 | 1999-09-07 | The Board Of Trustees Of The University Of Illinois | Method and apparatus for producing thin film and nanoparticle deposits |
EP0981381B1 (en) * | 1997-05-12 | 2007-02-21 | Metabolix, Inc. | Polyhydroxyalkanoates for in vivo applications |
BR9813935A (pt) | 1997-11-07 | 2000-09-19 | Salviac Ltd | Dispositivos de filtragem vascular para remoção de material embólico de fluidos corpóreos |
US6010521A (en) * | 1997-11-25 | 2000-01-04 | Advanced Cardiovasular Systems, Inc. | Catheter member with bondable layer |
NL1007767C2 (nl) * | 1997-12-11 | 1999-06-14 | Dsm Nv | Werkwijze voor de bereiding van een polyamide nanocomposiet samenstelling. |
US6093463A (en) * | 1997-12-12 | 2000-07-25 | Intella Interventional Systems, Inc. | Medical devices made from improved polymer blends |
US5942638A (en) * | 1998-01-05 | 1999-08-24 | The United States Of America As Represented By The Secretary Of The Air Force | Method of functionalizing polycyclic silicones and the resulting compounds |
AU2578499A (en) | 1998-02-03 | 1999-08-16 | Continental Pet Technologies, Inc. | Enhanced oxygen-scavenging polymers, and packaging made therefrom |
KR20010040964A (ko) | 1998-02-13 | 2001-05-15 | 마크 에프. 웍터 | 폴리머 나노복합체 조성물 |
US5980533A (en) * | 1998-06-09 | 1999-11-09 | Scimed Life Systems, Inc. | Stent delivery system |
US5921933A (en) * | 1998-08-17 | 1999-07-13 | Medtronic, Inc. | Medical devices with echogenic coatings |
US6368569B1 (en) * | 1998-10-02 | 2002-04-09 | University Of Kentucky Research Foundation | Method of solubilizing unshortened carbon nanotubes in organic solutions |
US6331262B1 (en) | 1998-10-02 | 2001-12-18 | University Of Kentucky Research Foundation | Method of solubilizing shortened single-walled carbon nanotubes in organic solutions |
TW375629B (en) * | 1998-10-29 | 1999-12-01 | Ind Tech Res Inst | Process for dispersive nanometer polymer composite material |
US20020137834A1 (en) * | 1998-12-07 | 2002-09-26 | Eastman Chemical Company | Polymer/clay nanocomposite comprising a functionalized polymer or oligomer and a process for preparing same |
AU1837000A (en) * | 1998-12-07 | 2000-06-26 | Eastman Chemical Company | A polymer/clay nanocomposite comprising a clay mixture and process for making same |
US6384121B1 (en) * | 1998-12-07 | 2002-05-07 | Eastman Chemical Company | Polymeter/clay nanocomposite comprising a functionalized polymer or oligomer and a process for preparing same |
AU3155700A (en) * | 1999-02-18 | 2000-09-04 | Commonwealth Scientific And Industrial Research Organisation | New biomaterials |
CA2366377A1 (en) * | 1999-03-31 | 2000-10-05 | Brigham And Women's Hospital, Inc. | Nanocomposite surgical materials and method of producing them |
DE19921088C2 (de) * | 1999-04-30 | 2003-08-07 | Magforce Applic Gmbh | Stent zur Offenhaltung gangartiger Strukturen |
EP1054036A1 (en) * | 1999-05-18 | 2000-11-22 | Fina Research S.A. | Reinforced polymers |
JP4310849B2 (ja) * | 1999-05-20 | 2009-08-12 | 株式会社カネカ | 無機結晶を含有する医用カテーテル。 |
US6245849B1 (en) * | 1999-06-02 | 2001-06-12 | Sandia Corporation | Fabrication of ceramic microstructures from polymer compositions containing ceramic nanoparticles |
US6530939B1 (en) * | 1999-07-30 | 2003-03-11 | Incept, Llc | Vascular device having articulation region and methods of use |
AU1330701A (en) | 1999-10-07 | 2001-05-10 | Dow Chemical Company, The | Silica gel composition and method for making |
US6737447B1 (en) * | 1999-10-08 | 2004-05-18 | The University Of Akron | Nitric oxide-modified linear poly(ethylenimine) fibers and uses thereof |
JP2001129075A (ja) | 1999-11-09 | 2001-05-15 | Kanegafuchi Chem Ind Co Ltd | 無機結晶を含有する医用カテーテル。 |
ATE402973T1 (de) | 1999-11-10 | 2008-08-15 | Neil Charles O | Optimierung der nanofüllstoffleistung in polymeren |
DE69934990T2 (de) | 1999-11-23 | 2007-11-15 | Sorin Biomedica Cardio S.R.L., Saluggia | Verfahren zur Übertragung radioaktiver Stoffe auf Stents in der Angioplastie und Bausatz |
US6156350A (en) * | 1999-12-02 | 2000-12-05 | Corazon Technologies, Inc. | Methods and kits for use in preventing restenosis |
EP1268656B1 (en) | 1999-12-29 | 2005-05-25 | Dow Global Technologies Inc. | Thermoplastic olefin nanocomposite based on polypropylene and process for production thereof |
US6414086B1 (en) * | 2000-02-29 | 2002-07-02 | Howmedica Osteonics Corp. | Compositions, processes and methods of improving the wear resistance of prosthetic medical devices |
IL151501A0 (en) * | 2000-03-15 | 2003-04-10 | Orbus Medical Technologies Inc | Coating that promotes endothelial cell adherence |
US6520952B1 (en) * | 2000-03-23 | 2003-02-18 | Neich Medical Co., Ltd. | Ceramic reinforced catheter |
DE60112265T2 (de) * | 2000-03-24 | 2006-05-24 | Hybrid Plastics LLP, Fountain Valley | Nanostrukturierte chemische substanzen als legierende bestandteile in polymeren |
US6447437B1 (en) * | 2000-03-31 | 2002-09-10 | Ut-Battelle, Llc | Method for reducing CO2, CO, NOX, and SOx emissions |
US6702843B1 (en) * | 2000-04-12 | 2004-03-09 | Scimed Life Systems, Inc. | Stent delivery means with balloon retraction means |
WO2001087193A1 (en) * | 2000-05-16 | 2001-11-22 | Rensselaer Polytechnic Institute | Electrically conducting nanocomposite materials for biomedical applications |
US6569214B2 (en) * | 2000-06-01 | 2003-05-27 | U.S. Technology Corporation | Composite polymer blast media |
WO2002050144A2 (en) * | 2000-12-19 | 2002-06-27 | Bausch & Lomb Incorporated | Polymeric biomaterials containing silsesquixane monomers |
US6740191B2 (en) * | 2001-02-22 | 2004-05-25 | Medtronic Ave, Inc. | Through-transmission welding of catheter components |
US6793994B2 (en) * | 2001-03-07 | 2004-09-21 | Honeywell International Inc. | Oxygen scavenging polymer compositions containing ethylene vinyl alcohol copolymers |
US6653365B2 (en) * | 2001-05-01 | 2003-11-25 | Pentron Clinical Technologies, Llc | Dental composite materials and method of manufacture thereof |
US6569932B2 (en) * | 2001-07-06 | 2003-05-27 | Benjamin S. Hsiao | Blends of organic silicon compounds with ethylene-based polymers |
EP1429833B1 (en) | 2001-09-28 | 2018-02-14 | Boston Scientific Limited | Catheter comprising nanocomposites |
JP4351832B2 (ja) | 2002-08-05 | 2009-10-28 | テルモ株式会社 | バルーンカテーテル |
WO2004032799A2 (en) * | 2002-10-11 | 2004-04-22 | Boston Scientific Limited | Implantable medical devices |
-
2002
- 2002-09-27 EP EP02795495.7A patent/EP1429833B1/en not_active Expired - Lifetime
- 2002-09-27 CA CA2456918A patent/CA2456918C/en not_active Expired - Fee Related
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- 2002-09-27 EP EP10182694.9A patent/EP2266501B1/en not_active Expired - Lifetime
- 2002-09-27 AU AU2002360251A patent/AU2002360251A1/en not_active Abandoned
- 2002-09-27 JP JP2003530173A patent/JP2005503865A/ja active Pending
- 2002-09-27 WO PCT/US2002/030726 patent/WO2003026532A2/en active Application Filing
- 2002-09-27 CA CA2457189A patent/CA2457189C/en not_active Expired - Fee Related
- 2002-09-27 US US10/256,388 patent/US7517353B2/en not_active Expired - Fee Related
- 2002-09-27 EP EP11152527.5A patent/EP2319453B1/en not_active Expired - Lifetime
-
2009
- 2009-04-06 US US12/418,849 patent/US8137373B2/en not_active Expired - Fee Related
- 2009-09-21 US US12/563,780 patent/US8133250B2/en not_active Expired - Fee Related
-
2012
- 2012-02-22 US US13/402,141 patent/US9463103B2/en not_active Expired - Fee Related
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US9463103B2 (en) | 2016-10-11 |
CA2457189A1 (en) | 2003-04-03 |
US20030093107A1 (en) | 2003-05-15 |
EP1429683B1 (en) | 2014-12-24 |
AU2002360251A8 (en) | 2003-06-23 |
EP2319453A1 (en) | 2011-05-11 |
EP1429833A2 (en) | 2004-06-23 |
CA2456918A1 (en) | 2003-06-19 |
CA2457189C (en) | 2011-08-09 |
US20090227944A1 (en) | 2009-09-10 |
EP1429683A2 (en) | 2004-06-23 |
WO2003049795A3 (en) | 2003-12-31 |
US20100010440A1 (en) | 2010-01-14 |
JP2005503865A (ja) | 2005-02-10 |
AU2002360251A1 (en) | 2003-06-23 |
US7591831B2 (en) | 2009-09-22 |
WO2003026532A3 (en) | 2004-01-08 |
JP4460296B2 (ja) | 2010-05-12 |
CA2456918C (en) | 2011-02-22 |
US8137373B2 (en) | 2012-03-20 |
AU2002356530A1 (en) | 2003-04-07 |
US8133250B2 (en) | 2012-03-13 |
EP1429833B1 (en) | 2018-02-14 |
EP2266501A2 (en) | 2010-12-29 |
US20120150109A1 (en) | 2012-06-14 |
US7517353B2 (en) | 2009-04-14 |
WO2003026532A2 (en) | 2003-04-03 |
EP2266501B1 (en) | 2016-04-13 |
EP2319453B1 (en) | 2016-07-20 |
EP2266501A3 (en) | 2011-04-27 |
WO2003049795A2 (en) | 2003-06-19 |
US20030065355A1 (en) | 2003-04-03 |
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