JP2005509412A5 - - Google Patents
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- Publication number
- JP2005509412A5 JP2005509412A5 JP2003523491A JP2003523491A JP2005509412A5 JP 2005509412 A5 JP2005509412 A5 JP 2005509412A5 JP 2003523491 A JP2003523491 A JP 2003523491A JP 2003523491 A JP2003523491 A JP 2003523491A JP 2005509412 A5 JP2005509412 A5 JP 2005509412A5
- Authority
- JP
- Japan
- Prior art keywords
- tsh receptor
- subject
- polypeptide sequence
- response
- tsh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000003911 Thyrotropin Receptors Human genes 0.000 claims 35
- 108090000253 Thyrotropin Receptors Proteins 0.000 claims 35
- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 208000023275 Autoimmune disease Diseases 0.000 claims 11
- 210000004698 lymphocyte Anatomy 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 10
- 230000028993 immune response Effects 0.000 claims 10
- 230000004044 response Effects 0.000 claims 10
- 229940124597 therapeutic agent Drugs 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 8
- 238000000034 method Methods 0.000 claims 6
- 230000000890 antigenic effect Effects 0.000 claims 5
- 239000000032 diagnostic agent Substances 0.000 claims 5
- 229940039227 diagnostic agent Drugs 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 210000001124 body fluid Anatomy 0.000 claims 3
- 239000010839 body fluid Substances 0.000 claims 3
- 230000003993 interaction Effects 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 238000003745 diagnosis Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000005784 autoimmunity Effects 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 230000008105 immune reaction Effects 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0120649A GB0120649D0 (en) | 2001-08-23 | 2001-08-23 | Epitope regions of a thyrotrophin (TSH) receptor and uses thereof |
| GB0215212A GB0215212D0 (en) | 2002-07-01 | 2002-07-01 | Epitope regions of a thyrotrophin (TSH) receptor, uses thereof and antibodies thereto |
| PCT/GB2002/003831 WO2003018632A2 (en) | 2001-08-23 | 2002-08-21 | Epitope regions of a thyrotrophin (tsh) receptor, uses thereof and antibodies thereto |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009171358A Division JP5576072B2 (ja) | 2001-08-23 | 2009-07-22 | チロトロフィン（ｔｓｈ）受容体の抗原決定領域、その使用およびその抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005509412A JP2005509412A (ja) | 2005-04-14 |
| JP2005509412A5 true JP2005509412A5 (OSRAM) | 2006-01-05 |
Family
ID=26246470
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003523491A Pending JP2005509412A (ja) | 2001-08-23 | 2002-08-21 | チロトロフィン（ｔｓｈ）受容体の抗原決定領域、その使用およびその抗体 |
| JP2009171358A Expired - Lifetime JP5576072B2 (ja) | 2001-08-23 | 2009-07-22 | チロトロフィン（ｔｓｈ）受容体の抗原決定領域、その使用およびその抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009171358A Expired - Lifetime JP5576072B2 (ja) | 2001-08-23 | 2009-07-22 | チロトロフィン（ｔｓｈ）受容体の抗原決定領域、その使用およびその抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US8298769B2 (OSRAM) |
| EP (3) | EP2383290B1 (OSRAM) |
| JP (2) | JP2005509412A (OSRAM) |
| CN (3) | CN1622958B (OSRAM) |
| ES (3) | ES2732276T3 (OSRAM) |
| WO (1) | WO2003018632A2 (OSRAM) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2383290B1 (en) | 2001-08-23 | 2019-05-08 | Rsr Limited | Epitope regions of a thyrotropin (tsh) receptor, uses thereof and antibodies thereto |
| WO2004050708A2 (en) * | 2002-11-29 | 2004-06-17 | Rsr Limited | Antibody for the thyrotropin receptor and uses thereof |
| ES2382627T3 (es) * | 2004-06-29 | 2012-06-12 | B.R.A.H.M.S Gmbh | Nuevos anticuerpos monoclonales estimuladores o bloqueadores de la tiroides, secuencias peptídicas que corresponden a sus regiones variables, y sus usos en medicina diagnóstica, preventiva y terapéutica |
| GB0418181D0 (en) | 2004-08-13 | 2004-09-15 | Rsr Ltd | Thyrotrophin receptor preparations,thyrotrophin receptor epitopes,antibody and hormone interactions therewith,and uses thereof |
| US20080305098A1 (en) * | 2005-11-21 | 2008-12-11 | Dr. Fenning Biomed Gmbh | Recombinant Polypeptides and Methods for Detecting and/or Quantifying Autoantibodies Against Tsh Receptor |
| JP5165672B2 (ja) * | 2006-03-29 | 2013-03-21 | キングス カレッジ ロンドン | Ｔｓｈｒに対するアゴニスト抗体 |
| US8796039B2 (en) * | 2007-08-06 | 2014-08-05 | Chugai Seiyaku Kabushiki Kaisha | Method for measuring inhibitory activity on ligand-receptor binding |
| EP2367850B1 (en) * | 2008-12-24 | 2015-04-22 | Rsr Limited | Human anti tshr antibodies |
| ES2702315T3 (es) | 2012-08-24 | 2019-02-28 | Univ California | Anticuerpos y vacunas para su uso en tratar cánceres ROR1 e inhibir metástasis |
| WO2015142675A2 (en) | 2014-03-15 | 2015-09-24 | Novartis Ag | Treatment of cancer using chimeric antigen receptor |
| EP3193915A1 (en) | 2014-07-21 | 2017-07-26 | Novartis AG | Combinations of low, immune enhancing. doses of mtor inhibitors and cars |
| WO2016103213A1 (en) * | 2014-12-24 | 2016-06-30 | Apitope International Nv | Composition |
| US11161907B2 (en) | 2015-02-02 | 2021-11-02 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| US12128069B2 (en) | 2015-04-23 | 2024-10-29 | The Trustees Of The University Of Pennsylvania | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
| WO2017027392A1 (en) | 2015-08-07 | 2017-02-16 | Novartis Ag | Treatment of cancer using chimeric cd3 receptor proteins |
| EP3380620B1 (en) | 2015-11-23 | 2024-07-03 | Novartis AG | Optimized lentiviral transfer vectors and uses thereof |
| SG11201805451TA (en) | 2015-12-30 | 2018-07-30 | Novartis Ag | Immune effector cell therapies with enhanced efficacy |
| US11549099B2 (en) | 2016-03-23 | 2023-01-10 | Novartis Ag | Cell secreted minibodies and uses thereof |
| MX2018016330A (es) | 2016-06-27 | 2020-02-17 | Univ California | Combinaciones para tratamiento del cáncer. |
| WO2018111340A1 (en) | 2016-12-16 | 2018-06-21 | Novartis Ag | Methods for determining potency and proliferative function of chimeric antigen receptor (car)-t cells |
| EP4043485A1 (en) | 2017-01-26 | 2022-08-17 | Novartis AG | Cd28 compositions and methods for chimeric antigen receptor therapy |
| JP2020506700A (ja) | 2017-01-31 | 2020-03-05 | ノバルティス アーゲー | 多重特異性を有するキメラｔ細胞受容体タンパク質を用いた癌の治療 |
| WO2018229715A1 (en) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprising anti-cd32b antibodies and methods of use thereof |
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| KR20200069358A (ko) | 2017-10-25 | 2020-06-16 | 노파르티스 아게 | 키메라 항원 수용체 발현 세포의 제조 방법 |
| WO2019210153A1 (en) | 2018-04-27 | 2019-10-31 | Novartis Ag | Car t cell therapies with enhanced efficacy |
| WO2019213282A1 (en) | 2018-05-01 | 2019-11-07 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
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| US20210123075A1 (en) | 2018-06-08 | 2021-04-29 | Novartis Ag | Compositions and methods for immunooncology |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| WO2020092928A1 (en) * | 2018-11-02 | 2020-05-07 | The Regents Of The University Of California | Compositions and methods for diagnosis of cardiovascular disease |
| CN113271945A (zh) | 2018-12-20 | 2021-08-17 | 诺华股份有限公司 | 包含3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物的给药方案和药物组合 |
| EP3924055B1 (en) | 2019-02-15 | 2024-04-03 | Novartis AG | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| JP7483732B2 (ja) | 2019-02-15 | 2024-05-15 | ノバルティス アーゲー | ３－（１－オキソ－５－（ピペリジン－４－イル）イソインドリン－２－イル）ピペリジン－２，６－ジオン誘導体及びその使用 |
| TW202135859A (zh) | 2019-12-20 | 2021-10-01 | 瑞士商諾華公司 | 組合療法 |
| KR20230024967A (ko) | 2020-06-11 | 2023-02-21 | 노파르티스 아게 | Zbtb32 억제제 및 이의 용도 |
| KR20230027056A (ko) | 2020-06-23 | 2023-02-27 | 노파르티스 아게 | 3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법 |
| US20230271940A1 (en) | 2020-08-03 | 2023-08-31 | Novartis Ag | Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途 |
| EP4330381A1 (en) | 2021-04-27 | 2024-03-06 | Novartis AG | Viral vector production system |
| WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
| JP2025529812A (ja) * | 2022-08-31 | 2025-09-09 | シャンハイ シーゼン メディカル テクノロジー カンパニー リミテッド | 甲状腺刺激ホルモン受容体に結合する抗体及びその使用 |
| AU2023369684A1 (en) | 2022-10-26 | 2025-04-17 | Novartis Ag | Lentiviral formulations |
| CN120981456A (zh) | 2023-05-24 | 2025-11-18 | 金橘生物科技公司 | 杂环化合物及其用途 |
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| US4244940A (en) | 1978-09-05 | 1981-01-13 | Bio-Rad Laboratories, Inc. | Single-incubation two-site immunoassay |
| US4514498A (en) | 1982-05-26 | 1985-04-30 | The Board Of Regents, The University Of Texas System | Hybrid cell lines producing monoclonal antibodies directed against Treponema |
| US4472508A (en) | 1982-12-30 | 1984-09-18 | The Beth Israel Hospital Association | Test for detecting and measuring the graves' disease-specific immunoglobulins |
| JPS60500864A (ja) | 1983-02-04 | 1985-06-06 | ワドリ、テクナラジズ、インコーパレイティド | 近縁関係にあるが別個のタンパク質間に存在する共通決定基に対して特異的なハイブリド−マ抗体の製造および特性づけ |
| US4609622A (en) | 1983-05-31 | 1986-09-02 | Interthyr Research Foundation Inc. | Clinical determination and/or quantification of thyrotropin and a variety of thyroid stimulatory or inhibitory factors performed in vitro with an improved thyroid cell line, FRTL-5 |
| US4753894A (en) | 1984-02-08 | 1988-06-28 | Cetus Corporation | Monoclonal anti-human breast cancer antibodies |
| US4661446A (en) | 1985-02-19 | 1987-04-28 | Dana-Farber Cancer Institute, Inc. | Monoclonal antibodies and method of immunizing therewith |
| CA2045131A1 (en) | 1989-01-11 | 1990-07-12 | Frederic E. Wondisford | Biologically active synthetic thyrotropin and cloned gene for producing same |
| WO1990013643A2 (en) | 1989-05-05 | 1990-11-15 | Genentech, Inc. | Glycoprotein hormone receptor molecules |
| US6261800B1 (en) | 1989-05-05 | 2001-07-17 | Genentech, Inc. | Luteinizing hormone/choriogonadotropin (LH/CG) receptor |
| US5614363A (en) | 1990-01-25 | 1997-03-25 | New England Medical Center Hospitals, Inc. | TSH receptor |
| US5744348A (en) | 1989-09-08 | 1998-04-28 | New England Medical Center Hospitals, Inc. | TSH receptor |
| DE68927461T2 (de) * | 1989-12-14 | 1997-03-20 | B.R.A.H.M.S Diagnostica Gmbh, 12099 Berlin | Polypeptide mit Thyrotropinrezeptor-Aktivität, kodierende Nukleinsäuresequenzen für solche Rezeptoren und Verwendung dieser Polypeptide |
| JPH05504683A (ja) | 1989-12-20 | 1993-07-22 | ニコルス インスティテュート ダイアグノスティックス | 組み換えチロトロピン受容体 |
| JPH04149197A (ja) * | 1990-10-12 | 1992-05-22 | Tanabe Seiyaku Co Ltd | 新規ペプチド |
| EP0482598A3 (en) | 1990-10-24 | 1993-05-19 | Ishihara Sangyo Kaisha, Ltd. | Peptide analog of human tsh receptor affective against autoimmune hyperthyroidism |
| US5578496A (en) | 1991-12-19 | 1996-11-26 | Board Of Regents, Baylor College Of Medicine | Detection of autoantibodies associated with the disease myasthenia gravis |
| WO1993015750A1 (en) | 1992-02-10 | 1993-08-19 | Haynes Barton F | Use of synthetic peptides to induce tolerance to pathogenic t and b cell epitopes of autoantigens |
| US5705400A (en) | 1992-03-07 | 1998-01-06 | Rsr Limited | Assay for adrenal autoantigen |
| US5195860A (en) | 1992-07-20 | 1993-03-23 | Trw Inc. | Push-on type fastener for automatic feed and installation equipment |
| JPH06220089A (ja) * | 1993-01-27 | 1994-08-09 | Ishihara Sangyo Kaisha Ltd | ペプチド又はその塩並びにそれらを含有する自己免疫性甲状腺疾患の診断薬又は治療薬 |
| US5639627A (en) | 1993-02-04 | 1997-06-17 | Sumitomo Pharmaceuticals Co., Ltd. | Method for assaying specific antibody |
| DE4328070C1 (de) | 1993-08-20 | 1994-11-24 | Henning Berlin Gmbh | Verfahren zur Bestimmung eines Analyten in einem Volumen einer flüssigen Probe sowie seine Anwendung zur Bestimmung von anti-TSH-Rezeptor-Autoantikörpern in einem Patientenserum |
| JPH0789991A (ja) * | 1993-09-28 | 1995-04-04 | Mitsubishi Chem Corp | 新規なポリペプチドおよびそれを用いるｔｓｈ受容体抗体の測定法 |
| EP0719858A3 (en) | 1994-12-27 | 1997-12-29 | Tosoh Corporation | Myeloma cell line expressing recombinant human thyroid stimulating hormone receptor |
| DE19505266C1 (de) | 1995-02-16 | 1996-10-02 | Brahms Diagnostica Gmbh | Verwendung von polyklonalen humanen anti-hTg-Autoantikörpern als Reagenz für die klinische Diagnostik von Schilddrüsen-Autoimmunerkrankungen sowie Reagenziensatz für eine Bestimmung von anti-hTg-Autoantikörpern in Patientenseren |
| DE19522171C1 (de) | 1995-06-19 | 1996-08-22 | Brahms Diagnostica Gmbh | Verfahren zur Bestimmung von Anti-TSH-Rezeptor-Autoantikörpern |
| US5723343A (en) | 1995-08-28 | 1998-03-03 | University Of Florida | Autoantibodies in patients with acquired hypoparathyroidism and assay method therefor |
| DE19728991A1 (de) | 1996-11-06 | 1999-02-11 | Brahms Diagnostica Gmbh | Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays |
| US5734464A (en) | 1996-11-06 | 1998-03-31 | Cobe Laboratories, Inc. | Red blood cell spillover detection technique |
| DE59712916D1 (de) | 1996-11-06 | 2008-03-20 | Bosch Gmbh Robert | Elektrochemischer messfühler |
| DE19651093C2 (de) * | 1996-12-09 | 1999-06-10 | Brahms Diagnostica Gmbh | Rezeptorbindungsassay zum Nachweis von TSH-Rezeptor-Autoantikörpern sowie Reagenziensatz für die Durchführung eines solchen Rezeptorbindungsassays |
| IL123888A0 (en) | 1997-04-01 | 1998-10-30 | Sankyo Co | Anti-fas antibodies |
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| AU5124599A (en) * | 1998-07-21 | 2000-02-14 | Sandra M McLachlan | Human thyrotropin receptor compositions and use thereof |
| GB9823397D0 (en) * | 1998-10-27 | 1998-12-23 | Rsr Ltd | Assays for thyroid autoantibodies |
| JP4427878B2 (ja) * | 1999-08-20 | 2010-03-10 | 味の素株式会社 | 析出を伴う発酵法によるｌ−グルタミン酸の製造法 |
| EP1078986B1 (en) * | 1999-08-24 | 2007-02-28 | Tosoh Corporation | Secretory thyroid stimulating hormone receptor (TSHR), and method for assaying anti-TSHR antibody using the same |
| DE50010992D1 (de) | 1999-10-12 | 2005-09-22 | Ulrich Loos | Verfahren zur bestimmung von autoantikörpern gegen den tsh-rezeptor |
| EP1242458A2 (en) | 1999-12-13 | 2002-09-25 | Cambridge Antibody Technology Limited | Brain specific binding members |
| EP1259825B1 (de) | 2000-02-21 | 2005-05-11 | B.R.A.H.M.S Aktiengesellschaft | Verfahren zur differentialdiagnostischen bestimmung von gegen den tsh-rezeptor gebildeten autoantikörpern in einer serum- oder plasmaprobe eines patienten |
| NZ521182A (en) | 2000-03-03 | 2004-11-26 | Cambridge Antibody Tech | Human antibodies against eotaxin comprising VH adn VL domains and their use |
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| DE10126968A1 (de) | 2001-06-01 | 2002-12-12 | Ivoclar Vivadent Ag | Farbstoffzusammensetzung zum individuellen Einfärben von Prothesenkunststoffen |
| EP2383290B1 (en) | 2001-08-23 | 2019-05-08 | Rsr Limited | Epitope regions of a thyrotropin (tsh) receptor, uses thereof and antibodies thereto |
| WO2004050708A2 (en) | 2002-11-29 | 2004-06-17 | Rsr Limited | Antibody for the thyrotropin receptor and uses thereof |
| WO2008099185A1 (en) * | 2007-02-15 | 2008-08-21 | R S R Limited | Human monoclonal antibodies to the thyrotropin receptor which act as antagonists |
| EP2367850B1 (en) * | 2008-12-24 | 2015-04-22 | Rsr Limited | Human anti tshr antibodies |
-
2002
- 2002-08-21 EP EP11158927.1A patent/EP2383290B1/en not_active Expired - Lifetime
- 2002-08-21 EP EP02755210.8A patent/EP1456234B1/en not_active Expired - Lifetime
- 2002-08-21 ES ES11158929T patent/ES2732276T3/es not_active Expired - Lifetime
- 2002-08-21 JP JP2003523491A patent/JP2005509412A/ja active Pending
- 2002-08-21 CN CN028164229A patent/CN1622958B/zh not_active Expired - Lifetime
- 2002-08-21 CN CN201310075812.8A patent/CN103224562B/zh not_active Expired - Lifetime
- 2002-08-21 ES ES02755210.8T patent/ES2466377T3/es not_active Expired - Lifetime
- 2002-08-21 ES ES11158927T patent/ES2736165T3/es not_active Expired - Lifetime
- 2002-08-21 US US10/488,074 patent/US8298769B2/en not_active Expired - Fee Related
- 2002-08-21 WO PCT/GB2002/003831 patent/WO2003018632A2/en not_active Ceased
- 2002-08-21 CN CN2010101273436A patent/CN101799476B/zh not_active Expired - Lifetime
- 2002-08-21 EP EP11158929.7A patent/EP2383291B1/en not_active Expired - Lifetime
-
2008
- 2008-12-12 US US12/333,740 patent/US8298771B2/en not_active Expired - Fee Related
- 2008-12-12 US US12/333,714 patent/US8309693B2/en not_active Expired - Fee Related
-
2009
- 2009-07-22 JP JP2009171358A patent/JP5576072B2/ja not_active Expired - Lifetime
-
2012
- 2012-11-09 US US13/673,878 patent/US9751940B2/en not_active Expired - Fee Related
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