JP2005508840A5 - - Google Patents
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- Publication number
- JP2005508840A5 JP2005508840A5 JP2002576895A JP2002576895A JP2005508840A5 JP 2005508840 A5 JP2005508840 A5 JP 2005508840A5 JP 2002576895 A JP2002576895 A JP 2002576895A JP 2002576895 A JP2002576895 A JP 2002576895A JP 2005508840 A5 JP2005508840 A5 JP 2005508840A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- acetylcysteine
- pharmaceutically acceptable
- combination
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 24
- 238000000034 method Methods 0.000 claims 21
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 19
- 229960004308 acetylcysteine Drugs 0.000 claims 19
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 18
- 239000003814 drug Substances 0.000 claims 15
- 229940124597 therapeutic agent Drugs 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 229960005489 paracetamol Drugs 0.000 claims 9
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 8
- 230000001225 therapeutic effect Effects 0.000 claims 7
- 230000000202 analgesic effect Effects 0.000 claims 6
- 239000003242 anti bacterial agent Substances 0.000 claims 6
- 230000001754 anti-pyretic effect Effects 0.000 claims 6
- 239000002221 antipyretic Substances 0.000 claims 6
- 239000003443 antiviral agent Substances 0.000 claims 6
- 230000003115 biocidal effect Effects 0.000 claims 6
- 108010024636 Glutathione Proteins 0.000 claims 4
- 229940124522 antiretrovirals Drugs 0.000 claims 4
- 239000003903 antiretrovirus agent Substances 0.000 claims 4
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 4
- 235000018417 cysteine Nutrition 0.000 claims 4
- 229960003180 glutathione Drugs 0.000 claims 4
- 230000036542 oxidative stress Effects 0.000 claims 4
- 231100000419 toxicity Toxicity 0.000 claims 3
- 230000001988 toxicity Effects 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 231100000331 toxic Toxicity 0.000 claims 2
- 230000002588 toxic effect Effects 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 230000009984 peri-natal effect Effects 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28060001P | 2001-03-30 | 2001-03-30 | |
| US09/833,228 US6566401B2 (en) | 2001-03-30 | 2001-04-11 | N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity |
| PCT/US2002/009442 WO2002078627A2 (en) | 2001-03-30 | 2002-03-28 | N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011168224A Division JP2011225610A (ja) | 2001-03-30 | 2011-08-01 | Ｎ−アセチルシステイン組成物及び薬剤毒性治療または防止方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508840A JP2005508840A (ja) | 2005-04-07 |
| JP2005508840A5 true JP2005508840A5 (enExample) | 2005-12-22 |
Family
ID=26960383
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002576895A Pending JP2005508840A (ja) | 2001-03-30 | 2002-03-28 | Ｎ−アセチルシステイン組成物及び薬剤毒性治療または防止方法 |
| JP2011168224A Pending JP2011225610A (ja) | 2001-03-30 | 2011-08-01 | Ｎ−アセチルシステイン組成物及び薬剤毒性治療または防止方法 |
| JP2014205506A Pending JP2015078185A (ja) | 2001-03-30 | 2014-10-06 | Ｎ−アセチルシステイン組成物及び薬剤毒性治療または防止方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011168224A Pending JP2011225610A (ja) | 2001-03-30 | 2011-08-01 | Ｎ−アセチルシステイン組成物及び薬剤毒性治療または防止方法 |
| JP2014205506A Pending JP2015078185A (ja) | 2001-03-30 | 2014-10-06 | Ｎ−アセチルシステイン組成物及び薬剤毒性治療または防止方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6566401B2 (enExample) |
| EP (1) | EP1379232B1 (enExample) |
| JP (3) | JP2005508840A (enExample) |
| CN (1) | CN100464743C (enExample) |
| AU (1) | AU2002255942B2 (enExample) |
| BR (1) | BR0208563A (enExample) |
| CA (1) | CA2442168C (enExample) |
| ES (1) | ES2550094T3 (enExample) |
| IL (2) | IL158181A0 (enExample) |
| MX (1) | MXPA03008904A (enExample) |
| NZ (1) | NZ528478A (enExample) |
| RU (1) | RU2291689C2 (enExample) |
| WO (1) | WO2002078627A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7662863B2 (en) * | 2003-06-09 | 2010-02-16 | Alan Andrews | Therapeutic agent for the use in reducing alcohol intoxication and reducing or eliminating the negative side effects associated with alcohol ingestion |
| ES2564187T3 (es) | 2005-04-05 | 2016-03-18 | Yale University | Agentes de modulación de glutamato en el tratamiento de trastornos mentales |
| US8993627B2 (en) * | 2005-04-21 | 2015-03-31 | Sentient Lifesciences, Inc. | N-acetylcysteine amide (NAC amide) for the treatment of diseases and conditions associated with oxidative stress |
| US8148356B2 (en) | 2005-08-24 | 2012-04-03 | Cumberland Pharmaceuticals, Inc. | Acetylcysteine composition and uses therefor |
| RU2302236C2 (ru) * | 2005-09-09 | 2007-07-10 | Государственное учреждение научно-исследовательский институт Гриппа Российской академии медицинских наук (ГУ НИИ Гриппа РАМН) | Средство, обладающее антигипоксической и цитопротекторной активностями, используемое для снижения токсичности ремантадина при лечении гриппозной инфекции |
| US20070098790A1 (en) * | 2005-10-31 | 2007-05-03 | David Jiang | Nutritional supplement for the enhancement of the health of the liver |
| US20080139654A1 (en) * | 2006-12-09 | 2008-06-12 | Eric Mott Soderling | Acetaminophen compositions having minimized side effects including reduced hepatotoxicity |
| CA2724023C (en) * | 2008-05-13 | 2014-02-18 | Genmedica Therapeutics Sl | Salicylate conjugates useful for treating metabolic disorders |
| JP2012520342A (ja) * | 2009-03-16 | 2012-09-06 | ジェンメディカ・セラピューティックス・ソシエダッド・リミターダ | 代謝障害を処置するのに有用な抗炎症剤および抗酸化剤のコンジュゲート |
| US20100239552A1 (en) * | 2009-03-16 | 2010-09-23 | Genmedica Therapeutics Sl | Combination Therapies for Treating Metabolic Disorders |
| SG176053A1 (en) * | 2009-05-15 | 2011-12-29 | Intermune Inc | Methods of treating hiv patients with anti-fibrotics |
| US20120122787A1 (en) * | 2009-07-10 | 2012-05-17 | Rong Li | Methods for treating polycystic kidney disease (pkd) or other cyst forming diseases |
| WO2011008976A1 (en) * | 2009-07-15 | 2011-01-20 | Leland Stanford, The Board Of Trustees Of The Junior University | N-acetyl cysteine compositions and methods to improved the therapeutic efficacy of acetaminophen |
| DE102011006425A1 (de) | 2010-03-31 | 2011-10-06 | Awd.Pharma Gmbh & Co. Kg | Pharmazeutische Zubereitung und deren Verwendung |
| US8466197B2 (en) | 2010-12-14 | 2013-06-18 | Genmedica Therapeutics Sl | Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders |
| US20140135396A1 (en) * | 2011-07-05 | 2014-05-15 | Beth Israel Deaconess Medical Center, Inc. | Treatment of Acetaminophen-Induced Liver Damage by the Administration of Modulators of Nitric Oxide |
| US8747894B2 (en) | 2012-05-08 | 2014-06-10 | Alpex Pharma S.A. | Effervescent compositions containing N-acetylcysteine |
| WO2013175479A1 (en) | 2012-05-24 | 2013-11-28 | Hadasit Medical Research Services And Development Ltd. | Compositions comprising isosilybin b for amelioration and prevention of drug- induced toxicity |
| HRP20220112T1 (hr) | 2013-12-24 | 2022-04-15 | Virginia Commonwealth University | Upotreba oksidacijskog sulfata kolesterola (ocs) za liječenje akutne insuficijencije jetre |
| PE20180026A1 (es) | 2015-01-27 | 2018-01-09 | Florengale Llc | Composicion topica curativa |
| CN107921151A (zh) * | 2015-05-27 | 2018-04-17 | 匹兹堡大学联邦系统高等教育 | 降低成像后胰腺炎风险的组合物和方法 |
| BR112017025499A2 (pt) * | 2015-05-28 | 2018-08-07 | Baylor College Medicine | benefícios da suplementação com n-acetil cisteína e glicina para melhorar os níveis de glutationa |
| EP3842040B1 (en) * | 2016-01-11 | 2022-03-09 | Egetis Therapeutics AB | Methods and formulations for treatment of and/or protection against acute liver failure and other hepatotoxic conditions |
| EP4098282A1 (en) | 2016-02-04 | 2022-12-07 | Czap Research And Development, LLC | Controlled-release and stratified cyclodextrin inclusion complex vehicles |
| FI3554491T3 (fi) | 2016-12-15 | 2023-04-26 | Zambon Spa | N-asetyylikysteiini käytettäväksi antibakteerisena aineena |
| CN110214004B (zh) * | 2017-01-24 | 2022-11-22 | 株式会社优盛制药 | 含有对乙酰氨基酚的注射剂组合物 |
| WO2020129509A1 (ja) * | 2018-12-21 | 2020-06-25 | 富士フイルム株式会社 | 光毒性または光アレルギーの測定方法および上記測定方法において使用するための試薬 |
| US11590090B2 (en) | 2019-09-14 | 2023-02-28 | Anzen Pharmaceuticals, LLC | Acetaminophen formulation with protection against toxic effects of overdose |
| GB2588172B (en) * | 2019-10-11 | 2023-05-24 | Blackhawk Partners Ltd | A pharmaceutical composition comprising cannabinoid |
| CN113288890B (zh) * | 2021-06-21 | 2022-02-22 | 南方医科大学南方医院 | N-乙酰-l-半胱氨酸在制备预防和/或治疗运动损伤的药物中的应用 |
| WO2023010088A1 (en) | 2021-07-28 | 2023-02-02 | Pono Lifestyle Colorado, Llc | Nutraceutical formulations to prevent, treat, and inhibit excess cytokines, sars-cov-2 spike proteins, and mrna vaccine spike proteins |
| EP4238559A1 (en) | 2022-03-04 | 2023-09-06 | Centre Hospitalier Universitaire de Caen Normandie | Combinations of acetaminophen and n-acetyl cysteine for the treatment of pain and fever |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US547457A (en) * | 1895-10-08 | Trolley-track | ||
| IT1141406B (it) * | 1980-04-01 | 1986-10-01 | Dob Far Spa | Sali della cefapirina con aminoacidi |
| FR2519988B1 (fr) * | 1982-01-20 | 1985-06-14 | Refarmed Sa | Derives thioliques de l'erythromycine a activite therapeutique, procede de preparation et produits pharmaceutiques dans lesquels ils apparaissent |
| DE3616923A1 (de) | 1986-05-20 | 1987-11-26 | Nattermann A & Cie | Neue pharmazeutische verwendung von 2-phenyl-1,2-benzisoselenazol-3(2h)-on |
| CA1339070C (en) * | 1989-01-26 | 1997-07-29 | Wulf Droge | Treatment of diseases associated with cysteine deficiency |
| IT1248995B (it) * | 1990-06-26 | 1995-02-11 | Italfarmaco Spa | Composizioni farmaceutiche a base di sali ferrosi |
| US5474757A (en) * | 1992-10-16 | 1995-12-12 | Rutgers University | Prevention of acetaminophen overdose toxicity with organosulfur compounds |
| US5762922A (en) * | 1994-01-31 | 1998-06-09 | Ludwig Institute For Cancer Research | Antioxidants and intracellular gluthathione raising agents for therapeutic treatments |
| US5475757A (en) * | 1994-06-07 | 1995-12-12 | At&T Corp. | Secure data transmission method |
| AU4399396A (en) * | 1994-12-19 | 1996-07-10 | Russinsky Limited | Compounds |
| US5750493A (en) * | 1995-08-30 | 1998-05-12 | Raymond F. Schinazi | Method to improve the biological and antiviral activity of protease inhibitors |
| FR2744917B1 (fr) | 1996-02-16 | 1998-04-10 | Kouchner Gerard | Composition therapeutique a base d'acetaminophene |
| US5837729A (en) * | 1996-04-26 | 1998-11-17 | Metatron, Inc. | Methods for treating and preventing HIV infection using acetaminophen and derivatives thereof |
| US5962421A (en) * | 1996-05-16 | 1999-10-05 | Zambon, S.A. | Pharmacological association between N-acetylcysteine and levulose for preventing cellular death and related diseases |
| WO1999001118A2 (en) * | 1997-07-01 | 1999-01-14 | Atherogenics, Inc. | Antioxidant enhancement of therapy for hyperproliferative conditions |
| US7091040B1 (en) * | 1999-01-04 | 2006-08-15 | Innovata Plc | P450/acetaminophen genetically directed enzyme prodrug therapy (GDEPT) |
| IT1312086B1 (it) * | 1999-04-21 | 2002-04-04 | Zambon Spa | Uso della nac per la preparazione di un medicamento adatto allasomministrazione endovenosa per la prevenzione dello stress |
| DE10112325A1 (de) | 2001-03-13 | 2002-10-02 | Fresenius Kabi De Gmbh | Lagerstabile Fertiginfusionslösungen des Paracetamols |
-
2001
- 2001-04-11 US US09/833,228 patent/US6566401B2/en not_active Expired - Lifetime
-
2002
- 2002-03-28 ES ES02725376.4T patent/ES2550094T3/es not_active Expired - Lifetime
- 2002-03-28 EP EP02725376.4A patent/EP1379232B1/en not_active Revoked
- 2002-03-28 IL IL15818102A patent/IL158181A0/xx unknown
- 2002-03-28 WO PCT/US2002/009442 patent/WO2002078627A2/en not_active Ceased
- 2002-03-28 CA CA2442168A patent/CA2442168C/en not_active Expired - Lifetime
- 2002-03-28 CN CNB028077334A patent/CN100464743C/zh not_active Expired - Fee Related
- 2002-03-28 RU RU2003131876/15A patent/RU2291689C2/ru not_active IP Right Cessation
- 2002-03-28 MX MXPA03008904A patent/MXPA03008904A/es active IP Right Grant
- 2002-03-28 JP JP2002576895A patent/JP2005508840A/ja active Pending
- 2002-03-28 BR BRPI0208563-1A patent/BR0208563A/pt not_active IP Right Cessation
- 2002-03-28 AU AU2002255942A patent/AU2002255942B2/en not_active Expired
- 2002-03-28 NZ NZ528478A patent/NZ528478A/en not_active IP Right Cessation
- 2002-11-04 US US10/287,175 patent/US7723389B2/en not_active Expired - Fee Related
-
2003
- 2003-09-30 IL IL158181A patent/IL158181A/en active IP Right Grant
-
2011
- 2011-08-01 JP JP2011168224A patent/JP2011225610A/ja active Pending
-
2014
- 2014-10-06 JP JP2014205506A patent/JP2015078185A/ja active Pending
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