JP2005508840A - N−アセチルシステイン組成物及び薬剤毒性治療または防止方法 - Google Patents

N−アセチルシステイン組成物及び薬剤毒性治療または防止方法 Download PDF

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Publication number
JP2005508840A
JP2005508840A JP2002576895A JP2002576895A JP2005508840A JP 2005508840 A JP2005508840 A JP 2005508840A JP 2002576895 A JP2002576895 A JP 2002576895A JP 2002576895 A JP2002576895 A JP 2002576895A JP 2005508840 A JP2005508840 A JP 2005508840A
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compound
acetylcysteine
acetaminophen
pharmaceutically acceptable
combination
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Japanese (ja)
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JP2005508840A5 (enExample
Inventor
レオナード エイ ハーゼンバーグ
ローサ スティーブン シー デ
ジェイムス アンドラス
レオノア エイ ハーゼンバーグ
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バイオアドヴァンテックス ファーマ インコーポレイテッド
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Application filed by バイオアドヴァンテックス ファーマ インコーポレイテッド filed Critical バイオアドヴァンテックス ファーマ インコーポレイテッド
Publication of JP2005508840A publication Critical patent/JP2005508840A/ja
Publication of JP2005508840A5 publication Critical patent/JP2005508840A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2002576895A 2001-03-30 2002-03-28 N−アセチルシステイン組成物及び薬剤毒性治療または防止方法 Pending JP2005508840A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28060001P 2001-03-30 2001-03-30
US09/833,228 US6566401B2 (en) 2001-03-30 2001-04-11 N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity
PCT/US2002/009442 WO2002078627A2 (en) 2001-03-30 2002-03-28 N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011168224A Division JP2011225610A (ja) 2001-03-30 2011-08-01 N−アセチルシステイン組成物及び薬剤毒性治療または防止方法

Publications (2)

Publication Number Publication Date
JP2005508840A true JP2005508840A (ja) 2005-04-07
JP2005508840A5 JP2005508840A5 (enExample) 2005-12-22

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JP2002576895A Pending JP2005508840A (ja) 2001-03-30 2002-03-28 N−アセチルシステイン組成物及び薬剤毒性治療または防止方法
JP2011168224A Pending JP2011225610A (ja) 2001-03-30 2011-08-01 N−アセチルシステイン組成物及び薬剤毒性治療または防止方法
JP2014205506A Pending JP2015078185A (ja) 2001-03-30 2014-10-06 N−アセチルシステイン組成物及び薬剤毒性治療または防止方法

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JP2011168224A Pending JP2011225610A (ja) 2001-03-30 2011-08-01 N−アセチルシステイン組成物及び薬剤毒性治療または防止方法
JP2014205506A Pending JP2015078185A (ja) 2001-03-30 2014-10-06 N−アセチルシステイン組成物及び薬剤毒性治療または防止方法

Country Status (13)

Country Link
US (2) US6566401B2 (enExample)
EP (1) EP1379232B1 (enExample)
JP (3) JP2005508840A (enExample)
CN (1) CN100464743C (enExample)
AU (1) AU2002255942B2 (enExample)
BR (1) BR0208563A (enExample)
CA (1) CA2442168C (enExample)
ES (1) ES2550094T3 (enExample)
IL (2) IL158181A0 (enExample)
MX (1) MXPA03008904A (enExample)
NZ (1) NZ528478A (enExample)
RU (1) RU2291689C2 (enExample)
WO (1) WO2002078627A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009506030A (ja) * 2005-08-24 2009-02-12 カンバーランド ファーマシューティカルズ,インコーポレーテッド アセチルシステイン組成物及びその使用
JP2012533559A (ja) * 2009-07-15 2012-12-27 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ アセトアミノフェンの治療効果を改善するためのn−アセチルシステイン組成物および方法
JP2018524287A (ja) * 2015-05-27 2018-08-30 ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 造影後の膵炎のリスクを低下させるための組成物及び方法
JP2019501226A (ja) * 2016-01-11 2019-01-17 プレッドファルマ・アーベー 急性肝不全及び他の肝毒性状態を治療及び/又はこれらから保護するための方法及び製剤
WO2020129509A1 (ja) * 2018-12-21 2020-06-25 富士フイルム株式会社 光毒性または光アレルギーの測定方法および上記測定方法において使用するための試薬

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US7662863B2 (en) * 2003-06-09 2010-02-16 Alan Andrews Therapeutic agent for the use in reducing alcohol intoxication and reducing or eliminating the negative side effects associated with alcohol ingestion
EP3753561A1 (en) 2005-04-05 2020-12-23 Yale University Glutamate modulating agents in the treatment of mental disorders
US8993627B2 (en) 2005-04-21 2015-03-31 Sentient Lifesciences, Inc. N-acetylcysteine amide (NAC amide) for the treatment of diseases and conditions associated with oxidative stress
RU2302236C2 (ru) * 2005-09-09 2007-07-10 Государственное учреждение научно-исследовательский институт Гриппа Российской академии медицинских наук (ГУ НИИ Гриппа РАМН) Средство, обладающее антигипоксической и цитопротекторной активностями, используемое для снижения токсичности ремантадина при лечении гриппозной инфекции
US20070098790A1 (en) * 2005-10-31 2007-05-03 David Jiang Nutritional supplement for the enhancement of the health of the liver
US20080139654A1 (en) * 2006-12-09 2008-06-12 Eric Mott Soderling Acetaminophen compositions having minimized side effects including reduced hepatotoxicity
CN102088965B (zh) * 2008-05-13 2013-05-08 根梅迪卡治疗公司 水杨酸盐(酯)缀合物在制备用于治疗代谢性病症的药物中的应用
CN102421424A (zh) * 2009-03-16 2012-04-18 根梅迪卡治疗公司 用于治疗代谢性疾病的组合疗法
US8575217B2 (en) * 2009-03-16 2013-11-05 Genmedica Therapeutics Sl Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders
WO2010132864A1 (en) * 2009-05-15 2010-11-18 Intermune, Inc. Methods of treating hiv patients with anti-fibrotics
WO2011006097A2 (en) * 2009-07-10 2011-01-13 The Brigham And Women's Hospital, Inc. Methods For Treating Toxicity
DE102011006425A1 (de) 2010-03-31 2011-10-06 Awd.Pharma Gmbh & Co. Kg Pharmazeutische Zubereitung und deren Verwendung
US8466197B2 (en) 2010-12-14 2013-06-18 Genmedica Therapeutics Sl Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders
US20140135396A1 (en) * 2011-07-05 2014-05-15 Beth Israel Deaconess Medical Center, Inc. Treatment of Acetaminophen-Induced Liver Damage by the Administration of Modulators of Nitric Oxide
US8747894B2 (en) 2012-05-08 2014-06-10 Alpex Pharma S.A. Effervescent compositions containing N-acetylcysteine
WO2013175479A1 (en) 2012-05-24 2013-11-28 Hadasit Medical Research Services And Development Ltd. Compositions comprising isosilybin b for amelioration and prevention of drug- induced toxicity
SMT202200094T1 (it) 2013-12-24 2022-05-12 Univ Virginia Commonwealth Uso di solfati di colesterolo ossigenati (ocs) per il trattamento dell’insufficienza epatica acuta
EP3250196A4 (en) * 2015-01-27 2018-09-26 Florengale, LLC Healing topical composition
CN115957294A (zh) 2015-05-28 2023-04-14 贝勒医学院 补充n-乙酰半胱氨酸和甘氨酸以改善谷胱甘肽水平的有益效果
SMT202100404T1 (it) 2016-02-04 2021-09-14 Czap Research And Development Llc Veicoli di complessi di inclusione di ciclodestrine stratificati e rilascio controllato
AU2017376391B2 (en) 2016-12-15 2023-06-01 Zambon S.P.A. N-acetylcysteine for use as antibacterial agent
US11040007B2 (en) * 2017-01-24 2021-06-22 Woosung Pharmaceutical Co., Ltd. Injection composition containing acetaminophen
US11590090B2 (en) 2019-09-14 2023-02-28 Anzen Pharmaceuticals, LLC Acetaminophen formulation with protection against toxic effects of overdose
GB2588172B (en) * 2019-10-11 2023-05-24 Blackhawk Partners Ltd A pharmaceutical composition comprising cannabinoid
CN113288890B (zh) * 2021-06-21 2022-02-22 南方医科大学南方医院 N-乙酰-l-半胱氨酸在制备预防和/或治疗运动损伤的药物中的应用
US12357667B2 (en) 2021-07-28 2025-07-15 Pono Lifestyle, Llc Nutraceutical formulations to prevent, treat, and inhibit excess cytokines, SARS-CoV-2 spike proteins, and mRNA vaccine spike proteins
EP4238559A1 (en) 2022-03-04 2023-09-06 Centre Hospitalier Universitaire de Caen Normandie Combinations of acetaminophen and n-acetyl cysteine for the treatment of pain and fever

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WO1999001118A2 (en) * 1997-07-01 1999-01-14 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009506030A (ja) * 2005-08-24 2009-02-12 カンバーランド ファーマシューティカルズ,インコーポレーテッド アセチルシステイン組成物及びその使用
JP2012533559A (ja) * 2009-07-15 2012-12-27 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ アセトアミノフェンの治療効果を改善するためのn−アセチルシステイン組成物および方法
JP2015214576A (ja) * 2009-07-15 2015-12-03 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー アセトアミノフェンの治療効果を改善するためのn‐アセチルシステイン組成物および方法
JP2018524287A (ja) * 2015-05-27 2018-08-30 ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 造影後の膵炎のリスクを低下させるための組成物及び方法
JP2019501226A (ja) * 2016-01-11 2019-01-17 プレッドファルマ・アーベー 急性肝不全及び他の肝毒性状態を治療及び/又はこれらから保護するための方法及び製剤
JP2022019973A (ja) * 2016-01-11 2022-01-27 エゲティス・セラピューティクス・アーベー 急性肝不全及び他の肝毒性状態を治療及び/又はこれらから保護するための方法及び製剤
US11260060B2 (en) 2016-01-11 2022-03-01 Egetis Therapeutics Ab Methods and formulations for treatment of and/or protection against acute liver failure and other hepatotoxic conditions
JP7311267B2 (ja) 2016-01-11 2023-07-19 エゲティス・セラピューティクス・アーベー 急性肝不全及び他の肝毒性状態を治療及び/又はこれらから保護するための方法及び製剤
JP7374163B2 (ja) 2016-01-11 2023-11-06 エゲティス・セラピューティクス・アーベー 急性肝不全及び他の肝毒性状態を治療及び/又はこれらから保護するための方法及び製剤
US12303516B2 (en) 2016-01-11 2025-05-20 Egetis Therapeutics Ab Methods and formulations for treatment of and/or protection against acute liver failure and other hepatotoxic conditions
WO2020129509A1 (ja) * 2018-12-21 2020-06-25 富士フイルム株式会社 光毒性または光アレルギーの測定方法および上記測定方法において使用するための試薬
JPWO2020129509A1 (ja) * 2018-12-21 2021-11-04 富士フイルム株式会社 光毒性または光アレルギーの測定方法および上記測定方法において使用するための試薬

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IL158181A (en) 2012-04-30
JP2011225610A (ja) 2011-11-10
AU2002255942B2 (en) 2007-07-05
RU2003131876A (ru) 2005-04-10
IL158181A0 (en) 2004-03-28
ES2550094T3 (es) 2015-11-04
US20020142991A1 (en) 2002-10-03
EP1379232A2 (en) 2004-01-14
WO2002078627A3 (en) 2003-09-18
WO2002078627A2 (en) 2002-10-10
EP1379232B1 (en) 2015-07-29
US20030069311A1 (en) 2003-04-10
NZ528478A (en) 2007-08-31
CN1507350A (zh) 2004-06-23
RU2291689C2 (ru) 2007-01-20
US6566401B2 (en) 2003-05-20
CN100464743C (zh) 2009-03-04
JP2015078185A (ja) 2015-04-23
CA2442168C (en) 2012-05-29
BR0208563A (pt) 2006-02-21
EP1379232A4 (en) 2008-04-23
US7723389B2 (en) 2010-05-25
MXPA03008904A (es) 2005-03-07
CA2442168A1 (en) 2002-10-10

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