JP2005507891A5 - - Google Patents
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- Publication number
- JP2005507891A5 JP2005507891A5 JP2003530312A JP2003530312A JP2005507891A5 JP 2005507891 A5 JP2005507891 A5 JP 2005507891A5 JP 2003530312 A JP2003530312 A JP 2003530312A JP 2003530312 A JP2003530312 A JP 2003530312A JP 2005507891 A5 JP2005507891 A5 JP 2005507891A5
- Authority
- JP
- Japan
- Prior art keywords
- chito
- oligomer
- range
- treatment
- chain length
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000003381 deacetylation reaction Methods 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-Acetylglucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 4
- 229950006780 N-Acetylglucosamine Drugs 0.000 claims 4
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 4
- 208000009883 Joint Disease Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 201000008482 osteoarthritis Diseases 0.000 claims 3
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims 2
- 229960002442 Glucosamine Drugs 0.000 claims 2
- 201000008804 arthropathy Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 200000000018 inflammatory disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- DJHJJVWPFGHIPH-OODMECLYSA-N Chitin Chemical compound O[C@@H]1C(NC(=O)C)[C@H](O)OC(CO)[C@H]1COC[C@H]1C(NC(C)=O)[C@@H](O)[C@H](COC[C@H]2C([C@@H](O)[C@H](O)C(CO)O2)NC(C)=O)C(CO)O1 DJHJJVWPFGHIPH-OODMECLYSA-N 0.000 claims 1
- 229920002101 Chitin Polymers 0.000 claims 1
- 206010072736 Rheumatic disease Diseases 0.000 claims 1
- 230000003110 anti-inflammatory Effects 0.000 claims 1
- 230000000552 rheumatic Effects 0.000 claims 1
- 230000001568 sexual Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Claims (12)
- キト−オリゴマーの鎖長が約２〜５０の範囲にあり、脱アセチル化度が約０〜７０％の範囲にある、変形性関節炎およびリウマチ性関節炎を含む関節障害、炎症性障害およびその他のリウマチ性症状を含む群から選択される障害の治療用医薬製造のための、Ｎ−アセチルグルコサミン（ＮＡＧ）およびグルコサミンのキト−オリゴマーの使用。
- キト−オリゴマーの脱アセチル化度が約３０〜５０％の範囲にある請求項１の使用。
- キト−オリゴマーの少なくとも約１０重量％が２〜１２の鎖長をもつ請求項１の使用。
- キト−オリゴマーの約１５〜７５重量％が２〜１２の鎖長をもつ請求項１の使用。
- 変形性関節炎およびリウマチ性関節炎を含む群から選択される関節障害の治療用医薬製造のための請求項１による使用。
- 治療が対象者の関節障害の症状を緩和する請求項１の使用。
- 医薬品が経口投与用である請求項１の使用。
- キト−オリゴマーの鎖長が約２〜５０の範囲にあり、脱アセチル化度が約０〜７０％の範囲にあるＮ−アセチルグルコサミン（ＮＡＧ）およびグルコサミンのキト−オリゴマーを含む、変形性関節炎およびリウマチ性関節炎を含む関節障害、炎症性障害およびその他のリウマチ性症状を含む群から選択される障害の治療用医薬組成物。
- キト−オリゴマーの脱アセチル化度が約３０〜５０％の範囲にある請求項８の医薬組成物。
- キト−オリゴマーの少なくとも約１０重量％が２〜１２の鎖長をもつ請求項８の医薬組成物。
- キト−オリゴマーの約１５〜７５重量％が２〜１２の鎖長をもつ請求項１０の医薬組成物。
- 約３５〜約５０％の範囲にある脱アセチル化度を有する水溶性部分脱アセチル化キチンを含む、抗炎症治療および関節障害治療用の医薬組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IS6085A IS6085A (is) | 2001-09-26 | 2001-09-26 | Lyfjablanda með kítósan óligómerum |
| PCT/IS2002/000016 WO2003026677A1 (en) | 2001-09-26 | 2002-09-26 | Pharmaceutical composition comprising chito-oligomers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005507891A JP2005507891A (ja) | 2005-03-24 |
| JP2005507891A5 true JP2005507891A5 (ja) | 2006-01-12 |
| JP4613008B2 JP4613008B2 (ja) | 2011-01-12 |
Family
ID=36700489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003530312A Expired - Lifetime JP4613008B2 (ja) | 2001-09-26 | 2002-09-26 | キト−オリゴマーを含む医薬組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7985741B2 (ja) |
| EP (1) | EP1435976B1 (ja) |
| JP (1) | JP4613008B2 (ja) |
| KR (1) | KR20040062548A (ja) |
| AT (1) | ATE359797T1 (ja) |
| CA (1) | CA2507926C (ja) |
| DE (1) | DE60219653T2 (ja) |
| DK (1) | DK1435976T3 (ja) |
| ES (1) | ES2284935T3 (ja) |
| IS (2) | IS6085A (ja) |
| PT (1) | PT1435976E (ja) |
| SI (1) | SI1435976T1 (ja) |
| WO (1) | WO2003026677A1 (ja) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002351576A1 (en) * | 2001-12-13 | 2003-07-09 | Ism Biopolymer Inc. | Method of modulating release of saccharides and uses thereof |
| GB0321996D0 (en) * | 2003-09-19 | 2003-10-22 | Novartis Nutrition Ag | Organic compounds |
| EP1670486A4 (en) * | 2003-10-01 | 2009-04-01 | Optimer Pharmaceuticals Inc | TREATMENT OF A CONDITION IN A MAMMALIAN WITH ADMINISTRATION OF AMINO SUGAR AND USES THEREOF |
| CN101141968A (zh) * | 2003-11-24 | 2008-03-12 | 浩鼎生技公司 | 给予化合物治疗哺乳动物的病况及其应用方法 |
| WO2005112948A1 (ja) * | 2004-05-21 | 2005-12-01 | Tottori University | 創傷の治療又は処置のための薬剤 |
| EP1917218B1 (en) * | 2005-06-14 | 2017-05-17 | Genís hf. | Compositions of partially deacetylated chitin derivatives |
| WO2007001283A2 (en) * | 2005-06-16 | 2007-01-04 | E.I. Dupont De Nemours And Company | Chemical synthesis of low molecular weight polyglucosamines and polygalactosamines |
| US7485718B2 (en) | 2005-06-16 | 2009-02-03 | E. I. Du Pont De Nemours And Company | Chemical synthesis of low molecular weight polyglucosamines and polygalactosamines |
| KR100831335B1 (ko) * | 2006-06-22 | 2008-05-22 | 부경대학교 산학협력단 | 인간 피부 섬유아세포에서 메트릭스메탈로프로테이나제-2의 발현 및 활성을 억제시키는키토올리고사카라이드 화합물 및 이를 함유한 메트릭스메탈로프로테이나제-2 억제제 |
| US20110212186A1 (en) * | 2008-07-18 | 2011-09-01 | Johannes Gislason | Composition for treating autoimmune disorders |
| KR20100060634A (ko) * | 2008-11-28 | 2010-06-07 | (주)아모레퍼시픽 | 미토콘드리아 활성화를 위한 조성물 |
| KR101729137B1 (ko) * | 2009-07-28 | 2017-04-26 | (주)아모레퍼시픽 | 키토올리고당을 함유하는 피로회복용 조성물 |
| JP6141265B2 (ja) | 2011-06-03 | 2017-06-07 | マグワイア アビー， エルエルシー | 関節の潤滑性を改善するための方法、組成物及び物品 |
| EP3058826A1 (en) | 2011-09-08 | 2016-08-24 | Novozymes BioAG A/S | Seed treatment methods and compositions |
| CN104093680B (zh) | 2011-09-14 | 2016-08-24 | 诺维信生物农业公司 | 组合使用脂壳寡糖和/或壳寡糖与解磷微生物促植物生长 |
| AU2012312003B2 (en) * | 2011-09-23 | 2015-10-22 | Novozymes Bioag A/S | Chitooligosaccharides and methods for use in enhancing plant growth |
| MX2014003411A (es) * | 2011-09-23 | 2015-03-19 | Novozymes Bioag As | Quitooligosacaridos y metodos para el uso en el mejoramiento del crecimiento del maiz. |
| US9474828B2 (en) | 2012-04-23 | 2016-10-25 | Genis Hf. | Self-hardening bioactive cement compositions with partially deacetylated chitin as bone graft substitutes |
| JP6285497B2 (ja) * | 2016-06-07 | 2018-02-28 | 株式会社エバーライフ | 鶏冠抽出物含有経口組成物及び鶏冠抽出物の香味に由来する摂取困難性の改善方法 |
| KR101673368B1 (ko) | 2016-07-14 | 2016-11-08 | 김기혁 | 공정가스 반응물의 콜드트랩 장치 |
| WO2023205718A2 (en) * | 2022-04-21 | 2023-10-26 | Hassan Ameer E | Methods of treating inflammation |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5919122B2 (ja) * | 1976-10-12 | 1984-05-02 | 味の素株式会社 | 水溶性部分脱アセチル化キチン及びその製造法 |
| US4532134A (en) * | 1981-04-06 | 1985-07-30 | Malette William Graham | Method of achieving hemostasis, inhibiting fibroplasia, and promoting tissue regeneration in a tissue wound |
| JP2527317B2 (ja) * | 1986-12-19 | 1996-08-21 | ライオン株式会社 | 骨疾患治療剤 |
| US6184037B1 (en) * | 1996-05-17 | 2001-02-06 | Genemedicine, Inc. | Chitosan related compositions and methods for delivery of nucleic acids and oligonucleotides into a cell |
| WO1998025631A1 (en) * | 1996-12-13 | 1998-06-18 | Lescarden, Inc. | Treatment of osteoarthritis by administering poly-n-acetyl-d-glucosamine |
| JP3062592B2 (ja) * | 1997-05-30 | 2000-07-10 | 農林水産省食品総合研究所長 | ２−アセチルアミノ−４−Ｏ−（２−アミノ−２−デオキシ−β−Ｄ −グルコピラノシル）−２−デオキシ−Ｄ −グルコースおよびその塩の製造法 |
| US6492350B2 (en) * | 2000-01-27 | 2002-12-10 | Jdc (Hawaii) Inc. | Chitin oligosaccharides and/or chitosan oligosaccharides for preventing or treating common cold or treating pain |
| EP1127574A1 (en) * | 2000-02-22 | 2001-08-29 | Food Industry Research and Development Institute | Use of chitinous materials for inhibiting cellular nitric oxide production |
| CA2313836C (en) * | 2000-03-15 | 2009-06-09 | Cargill, Incorporated | Chitosan and method of preparing chitosan |
| US20020119949A1 (en) * | 2001-02-26 | 2002-08-29 | Asa Hellman | Prophylactic teat treatment |
| EP1917218B1 (en) | 2005-06-14 | 2017-05-17 | Genís hf. | Compositions of partially deacetylated chitin derivatives |
-
2001
- 2001-09-26 IS IS6085A patent/IS6085A/is unknown
-
2002
- 2002-09-26 SI SI200230558T patent/SI1435976T1/sl unknown
- 2002-09-26 AT AT02777769T patent/ATE359797T1/de active
- 2002-09-26 DE DE60219653T patent/DE60219653T2/de not_active Expired - Lifetime
- 2002-09-26 EP EP02777769A patent/EP1435976B1/en not_active Expired - Lifetime
- 2002-09-26 KR KR10-2004-7004323A patent/KR20040062548A/ko not_active Application Discontinuation
- 2002-09-26 ES ES02777769T patent/ES2284935T3/es not_active Expired - Lifetime
- 2002-09-26 WO PCT/IS2002/000016 patent/WO2003026677A1/en active IP Right Grant
- 2002-09-26 US US10/490,637 patent/US7985741B2/en active Active
- 2002-09-26 JP JP2003530312A patent/JP4613008B2/ja not_active Expired - Lifetime
- 2002-09-26 CA CA2507926A patent/CA2507926C/en not_active Expired - Lifetime
- 2002-09-26 DK DK02777769T patent/DK1435976T3/da active
- 2002-09-26 PT PT02777769T patent/PT1435976E/pt unknown
-
2004
- 2004-03-22 IS IS7193A patent/IS2783B/is unknown
-
2011
- 2011-06-20 US US13/164,397 patent/US8415326B2/en not_active Expired - Lifetime
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